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Efficacy and safety of humanized CD19 CAR‑T as a salvage therapy for recurrent CNSL of B‑ALL following murine CD19 CAR‑T cell therapy

  • Authors:
    • Xin Li
    • Mei-Jing Liu
    • Nan Mou
    • Zhen-Xing Yang
    • Jia  Wang
    • Juan Mu
    • Hai-Bo Zhu
    • Qi Deng
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Tianjin First Central Hospital, Tianjin 300192, P.R. China, Shanghai Genbase Biotechnology Co., Ltd., Tianjin 201210, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 788
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    Published online on: September 16, 2021
       https://doi.org/10.3892/ol.2021.13049
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Abstract

The present study aimed to compare the differences between the humanized CD19 chimeric antigen receptor (CAR)‑T cell therapy and the murine CD19 CAR‑T therapy in recurrent B‑acute lymphoblastic leukemia (B‑ALL). A 62‑year‑old male patient who had B‑ALL (BCR/ABL+) for 4 years was diagnosed with relapsed central nervous system leukemia (CNSL). After several courses of high dose methotrexate combined with intrathecal chemotherapy, the patient received murine CD19 CAR‑T therapy and achieved complete response (CR). The patient was diagnosed with relapsed CNSL again 15 months after his murine CD19 CAR‑T therapy, and was therefore enrolled in the humanized CD19 CAR‑T therapy. Subsequently, the present study aimed to compare murine and humanized CD19 CAR‑T cells against Nalm‑6 cells in vitro and in mice. The patient initially achieved CR from his murine CD19 CAR‑T therapy with Grade 1 cytokine‑release syndrome (CRS) and Grade 1 CAR‑T cell‑related encephalopathy syndrome (CRES). The patient then achieved CR again from his humanized CD19 CAR‑T therapy with Grade 1 CRS and Grade 2 CRES. Peak levels of CD19 CAR‑T cells were higher in humanized CD19 CAR‑T therapy than those in murine CD19 CAR‑T therapy 7 days after infusion in the peripheral blood, in bone marrow and in cerebrospinal fluid (CSF). The cytokine levels were higher in humanized CD19 CAR‑T therapy than those in murine CD19 CAR‑T therapy in the peripheral blood and in CSF. The cytotoxicity to Nalm‑6 cells was higher in humanized CD19 CAR‑T cells than that in murine CD19 CAR‑T cells in vitro. In Nalm‑6 BALB/c mice, the median survival time of mice in the murine CD19 CAR‑T group was 35 days, while it was 43 days in the humanized CD19 CAR‑T group. In conclusion, humanized CD19 CAR‑T cell therapy had a better curative effect than that of murine CD19 CAR‑T therapy, and may be used as a salvage treatment for recurrent B‑ALL after treatment with murine CD19 CAR‑T therapy.
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1 

Rozovski U, Ohanian M, Ravandi F, Garcia-Manero G, Faderl S, Pierce S, Cortes J and Estrov Z: Incidence of and risk factors for involvement of the central nervous system in acute myeloid leukemia. Leuk Lymphoma. 56:1392–1397. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Aoki J, Ishiyama K, Taniguchi S, Fukuda T, Ohashi K, Ogawa H, Kanamori H, Eto T, Iwato K, Sakamaki H, et al: Outcome of allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia patients with central nervous system involvement. Biol Blood Marrow Transplant. 20:2029–2033. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Krishnan S, Wade R, Moorman AV, Mitchell C, Kinsey SE, Eden TO, Parker C, Vora A, Richards S and Saha V: Temporal changes in the incidence and pattern of central nervous system relapses in children with acute lymphoblastic leukaemia treated on four consecutive Medical Research Council trials, 1985–2001. Leukemia. 24:450–459. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Jin MW, Xu SM and An Q: Central nervous disease in pediatric patients during acute lymphoblastic leukemia (ALL): A review. Eur Rev Med Pharmacol Sci. 22:6015–6019. 2018.PubMed/NCBI

5 

Irving BA and Weiss A: The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways. Cell. 64:891–901. 1991. View Article : Google Scholar : PubMed/NCBI

6 

Davila ML, Riviere I, Wang X, Bartido S, Park J, Curran K, Chung SS, Stefanski J, Borquez-Ojeda O, Olszewska M, et al: Efficacy and toxicity management of 19–28z CAR T cell therapy in B cell acute lymphoblastic leukemia. Sci Transl Med. 6:224ra252014. View Article : Google Scholar : PubMed/NCBI

7 

Lee DW, Kochenderfer JN, Stetler-Stevenson M, Cui YK, Delbrook C, Feldman SA, Fry TJ, Orentas R, Sabatino M, Shah NN, et al: T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: A phase 1 dose-escalation trial. Lancet. 385:517–528. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Neelapu SS, Tummala S, Kebriaei P, Wierda W, Gutierrez C, Locke FL, Komanduri KV, Lin Y, Jain N, Daver N, et al: Chimeric antigen receptor T-cell therapy - assessment and management of toxicities. Nat Rev Clin Oncol. 15:47–62. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Lee DW, Gardner R, Porter DL, Louis CU, Ahmed N, Jensen M, Grupp SA and Mackall CL: Current concepts in the diagnosis and management of cytokine release syndrome. Blood. 124:188–195. 2014.Erratum in: Blood 128: 1533, 2016. View Article : Google Scholar : PubMed/NCBI

10 

Brudno JN and Kochenderfer JN: Toxicities of chimeric antigen receptor T cells: Recognition and management. Blood. 127:3321–3330. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Maude SL, Barrett D, Teachey DT and Grupp SA: Managing cytokine release syndrome associated with novel T cell-engaging therapies. Cancer J. 20:119–122. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Hu Y, Sun J, Wu Z, Yu J, Cui Q, Pu C, Liang B, Luo Y, Shi J, Jin A, et al: Predominant cerebral cytokine release syndrome in CD19-directed chimeric antigen receptor-modified T cell therapy. J Hematol Oncol. 9:702016. View Article : Google Scholar : PubMed/NCBI

13 

Lamers CH, Willemsen R, van Elzakker P, van Steenbergen-Langeveld S, Broertjes M, Oosterwijk-Wakka J, Oosterwijk E, Sleijfer S, Debets R and Gratama JW: Immune responses to transgene and retroviral vector in patients treated with ex vivo-engineered T cells. Blood. 117:72–82. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Grupp SA, Kalos M, Barrett D, Aplenc R, Porter DL, Rheingold SR, Teachey DT, Chew A, Hauck B, Wright JF, et al: Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. N Engl J Med. 368:1509–1518. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Mulazzani M, Fräßle SP, von Mücke-Heim I, Langer S, Zhou X, Ishikawa-Ankerhold H, Leube J, Zhang W, Dötsch S, Svec M, et al: Long-term in vivo microscopy of CAR T cell dynamics during eradication of CNS lymphoma in mice. Proc Natl Acad Sci USA. 116:24275–24284. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Turtle CJ, Hanafi LA, Berger C, Gooley TA, Cherian S, Hudecek M, Sommermeyer D, Melville K, Pender B, Budiarto TM, et al: CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients. J Clin Invest. 126:2123–2138. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Sommermeyer D, Hill T, Shamah SM, Salter AI, Chen Y, Mohler KM and Riddell SR: Fully human CD19-specific chimeric antigen receptors for T-cell therapy. Leukemia. 31:2191–2199. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Song DG, Ye Q, Poussin M, Liu L, Figini M and Powell DJ Jr: A fully human chimeric antigen receptor with potent activity against cancer cells but reduced risk for off-tumor toxicity. Oncotarget. 6:21533–21546. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Zhao Y, Liu Z, Wang X, Wu H, Zhang J, Yang J, Zhang F, Liu L, Long J, Lu P, et al: Treatment with humanized selective CD19CAR-T cells shows efficacy in highly treated B-ALL patients who have relapsed after receiving murine-based CD19CAR-T therapies. Clin Cancer Res. 25:5595–5607. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Demehri S, Corbin A, Loriaux M, Druker BJ and Deininger MW: Establishment of a murine model of aggressive systemic mastocytosis/mast cell leukemia. Exp Hematol. 34:284–288. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Tsukahara T, Ohmine K, Yamamoto C, Uchibori R, Ido H, Teruya T, Urabe M, Mizukami H, Kume A, Nakamura M, et al: CD19 target-engineered T-cells accumulate at tumor lesions in human B-cell lymphoma xenograft mouse models. Biochem Biophys Res Commun. 438:84–89. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Liu D and Zhao J: Cytokine release syndrome: Grading, modeling, and new therapy. J Hematol Oncol. 11:1212018. View Article : Google Scholar : PubMed/NCBI

23 

Maude SL, Frey N, Shaw PA, Aplenc R, Barrett DM, Bunin NJ, Chew A, Gonzalez VE, Zheng Z, Lacey SF, et al: Chimeric antigen receptor T cells for sustained remissions in leukemia. N Engl J Med. 371:1507–1517. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Kochenderfer JN, Dudley ME, Carpenter RO, Kassim SH, Rose JJ, Telford WG, Hakim FT, Halverson DC, Fowler DH, Hardy NM, et al: Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation. Blood. 122:4129–4139. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Turtle CJ, Hay KA, Hanafi LA, Li D, Cherian S, Chen X, Wood B, Lozanski A, Byrd JC, Heimfeld S, et al: Durable molecular remissions in chronic lymphocytic leukemia treated with CD19-specific chimeric antigen receptor modified T cells after failure of ibrutinib. J Clin Oncol. 35:3010–3020. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Johnson LA and June CH: Driving gene-engineered T cell immunotherapy of cancer. Cell Res. 27:38–58. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Lowe KL, Mackall CL, Norry E, Amado R, Jakobsen BK and Binder G: Fludarabine and neurotoxicity in engineered T-cell therapy. Gene Ther. 25:176–191. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Jain MD, Bachmeier CA, Phuoc VH and Chavez JC: Axicabtagene ciloleucel (KTE-C19), an anti CD19 CAR T therapy for the treatment of relapsed/refractory aggressive B cell non Hodgkin's lymphoma. Ther Clin Risk Manag. 14:1007–1017. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Gust J, Hay KA, Hanafi LA, Li D, Myerson D, Gonzalez-Cuyar LF, Yeung C, Liles WC, Wurfel M, Lopez JA, et al: Endothelial activation and bloodbrain barrier disruption in neurotoxicity after adoptive immunotherapy with CD19 CAR T cells. Cancer Discov. 7:1404–1419. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Gardner RA, Finney O, Annesley C, Brakke H, Summers C, Leger K, Bleakley M, Brown C, Mgebroff S, Kelly-Spratt KS, et al: Intent-to-treat leukemia remission by CD19 CAR T cells of defined formulation and dose in children and young adults. Blood. 129:3322–3331. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Brentjens RJ, Rivière I, Park JH, Davila ML, Wang X, Stefanski J, Taylor C, Yeh R, Bartido S, Borquez-Ojeda O, et al: Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias. Blood. 118:4817–4828. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Mirzaei HR, Pourghadamyari H, Rahmati M, Mohammadi A, Nahand JS, Rezaei A, Mirzaei H and Hadjati J: Gene-knocked out chimeric antigen receptor (CAR) T cells: Tuning up for the next generation cancer immunotherapy. Cancer Lett. 423:95–104. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Johnson LA, Scholler J, Ohkuri T, Kosaka A, Patel PR, McGettigan SE, Nace AK, Dentchev T, Thekkat P, Loew A, et al: Rational development and characterization of humanized anti-EGFR variant III chimeric antigen receptor T cells for glioblastoma. Sci Transl Med. 7:275ra222015. View Article : Google Scholar : PubMed/NCBI

34 

Alonso-Camino V, Sánchez-Martín D, Compte M, Nuñez-Prado N, Diaz RM, Vile R and Alvarez-Vallina L: CARbodies: Human antibodies against cell surface tumor antigens selected from repertoires displayed on T cell chimeric antigen receptors. Mol Ther Nucleic Acids. 2:e932013. View Article : Google Scholar : PubMed/NCBI

35 

Zhao Y, Wang QJ, Yang S, Kochenderfer JN, Zheng Z, Zhong X, Sadelain M, Eshhar Z, Rosenberg SA and Morgan RA: A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity. J Immunol. 183:5563–5574. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li X, Liu M, Mou N, Yang Z, Wang J, Mu J, Zhu H and Deng Q: Efficacy and safety of humanized CD19 CAR‑T as a salvage therapy for recurrent CNSL of B‑ALL following murine CD19 CAR‑T cell therapy. Oncol Lett 22: 788, 2021.
APA
Li, X., Liu, M., Mou, N., Yang, Z., Wang, J., Mu, J. ... Deng, Q. (2021). Efficacy and safety of humanized CD19 CAR‑T as a salvage therapy for recurrent CNSL of B‑ALL following murine CD19 CAR‑T cell therapy. Oncology Letters, 22, 788. https://doi.org/10.3892/ol.2021.13049
MLA
Li, X., Liu, M., Mou, N., Yang, Z., Wang, J., Mu, J., Zhu, H., Deng, Q."Efficacy and safety of humanized CD19 CAR‑T as a salvage therapy for recurrent CNSL of B‑ALL following murine CD19 CAR‑T cell therapy". Oncology Letters 22.5 (2021): 788.
Chicago
Li, X., Liu, M., Mou, N., Yang, Z., Wang, J., Mu, J., Zhu, H., Deng, Q."Efficacy and safety of humanized CD19 CAR‑T as a salvage therapy for recurrent CNSL of B‑ALL following murine CD19 CAR‑T cell therapy". Oncology Letters 22, no. 5 (2021): 788. https://doi.org/10.3892/ol.2021.13049
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Liu M, Mou N, Yang Z, Wang J, Mu J, Zhu H and Deng Q: Efficacy and safety of humanized CD19 CAR‑T as a salvage therapy for recurrent CNSL of B‑ALL following murine CD19 CAR‑T cell therapy. Oncol Lett 22: 788, 2021.
APA
Li, X., Liu, M., Mou, N., Yang, Z., Wang, J., Mu, J. ... Deng, Q. (2021). Efficacy and safety of humanized CD19 CAR‑T as a salvage therapy for recurrent CNSL of B‑ALL following murine CD19 CAR‑T cell therapy. Oncology Letters, 22, 788. https://doi.org/10.3892/ol.2021.13049
MLA
Li, X., Liu, M., Mou, N., Yang, Z., Wang, J., Mu, J., Zhu, H., Deng, Q."Efficacy and safety of humanized CD19 CAR‑T as a salvage therapy for recurrent CNSL of B‑ALL following murine CD19 CAR‑T cell therapy". Oncology Letters 22.5 (2021): 788.
Chicago
Li, X., Liu, M., Mou, N., Yang, Z., Wang, J., Mu, J., Zhu, H., Deng, Q."Efficacy and safety of humanized CD19 CAR‑T as a salvage therapy for recurrent CNSL of B‑ALL following murine CD19 CAR‑T cell therapy". Oncology Letters 22, no. 5 (2021): 788. https://doi.org/10.3892/ol.2021.13049
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