Open Access

Emerging role of BAD and DAD1 as potential targets and biomarkers in cancer (Review)

  • Authors:
    • Yulou Luo
    • You Wu
    • Hai Huang
    • Na Yi
    • Yan Chen
  • View Affiliations

  • Published online on: September 28, 2021     https://doi.org/10.3892/ol.2021.13072
  • Article Number: 811
  • Copyright: © Luo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

As key regulators of apoptosis, BAD and defender against apoptotic cell death 1 (DAD1) are associated with cancer initiation and progression. Multiple studies have demonstrated that BAD and DAD1 serve critical roles in several types of cancer and perform various functions, such as participating in cellular apoptosis, invasion and chemosensitivity, as well as their role in diagnostic/prognostic judgement, etc. Investigating the detailed mechanisms of the cancerous effects of the two proteins will contribute to enriching the options for targeted therapy, and may improve clinical treatment of cancer. The present review summarizes research advances regarding the associations of BAD and DAD1 with cancer, and a hypothesis on the feasible relationship and interaction mechanism between the two proteins is proposed. Furthermore, the present review highlights the potential of the two proteins as therapeutic targets and valuable diagnostic and prognostic biomarkers.
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December-2021
Volume 22 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Luo Y, Wu Y, Huang H, Yi N and Chen Y: Emerging role of BAD and DAD1 as potential targets and biomarkers in cancer (Review). Oncol Lett 22: 811, 2021
APA
Luo, Y., Wu, Y., Huang, H., Yi, N., & Chen, Y. (2021). Emerging role of BAD and DAD1 as potential targets and biomarkers in cancer (Review). Oncology Letters, 22, 811. https://doi.org/10.3892/ol.2021.13072
MLA
Luo, Y., Wu, Y., Huang, H., Yi, N., Chen, Y."Emerging role of BAD and DAD1 as potential targets and biomarkers in cancer (Review)". Oncology Letters 22.6 (2021): 811.
Chicago
Luo, Y., Wu, Y., Huang, H., Yi, N., Chen, Y."Emerging role of BAD and DAD1 as potential targets and biomarkers in cancer (Review)". Oncology Letters 22, no. 6 (2021): 811. https://doi.org/10.3892/ol.2021.13072