lncRNA DSCAM‑AS1 facilitates the progression of endometrial cancer via miR‑136‑5p

Li,Luhong; Chen,Peipei; Huang,Bingbing; Cai,Peiya

doi:10.3892/ol.2021.13086

lncRNA DSCAM‑AS1 facilitates the progression of endometrial cancer via miR‑136‑5p

Authors:
- Luhong Li
- Peipei Chen
- Bingbing Huang
- Peiya Cai
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Affiliations: Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 362000, P.R. China, Department of Obstetrics and Gynecology, Fujian Medical University, Quanzhou, Fujian 362000, P.R. China
Published online on: October 12, 2021 https://doi.org/10.3892/ol.2021.13086
Article Number: 825
Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Previous studies have indicated that long non‑coding RNA (lncRNA) down syndrome cell adhesion molecule antisense 1 (DSCAM‑AS1) serves an oncogenic role in numerous cancer types. However, its role in endometrial cancer (EC) remains largely unknown. In the present study, DSCAM‑AS1 expression levels in EC tissues and cells and their normal counterparts were analyzed using reverse transcription‑quantitative. In vitro and in vivo experiments were conducted to validate the functions of DSCAM‑AS1 in EC. It was revealed that DSCAM‑AS1 was expressed at a high level in EC tissues and cells after analyzing patient data and data obtained from The Cancer Genome Atlas. Notably, it was also revealed that high DSCAM‑AS1 expression was associated with a less favorable overall survival in patients with EC. Knockdown of DSCAM‑AS1 was able to suppress EC cell proliferation by upregulating cell apoptosis in vitro. Furthermore, it was revealed that DSCAM‑AS1 acted as a microRNA (miR)‑136‑5p sponge to exert its oncogenic roles in EC. Collectively and to the best of our knowledge, the current results provided first evidence that DSCAM‑AS1 stimulated EC progression by regulating miR‑136‑5p, which may improve the understanding of the roles of ncRNAs in EC, and may help identify novel targets for anticancer treatment.

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