Open Access

Role of the tumor immune microenvironment in tumor immunotherapy (Review)

  • Authors:
    • Changsheng Zhou
    • Qianqian Liu
    • Yi Xiang
    • Xin Gou
    • Wengang Li
  • View Affiliations

  • Published online on: December 20, 2021     https://doi.org/10.3892/ol.2021.13171
  • Article Number: 53
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Tumor immunotherapy is considered to be a novel and promising therapy for tumors and it has recently become a hot research topic. The clinical success of tumor immunotherapy has been notable, but it has been less than totally satisfactory because tumor immunotherapy has performed poorly in numerous patients although it has shown appreciable efficacy in some patients. A minority of patients demonstrate durable responses but the majority of patients do not respond to tumor immunotherapy as the tumor immune microenvironment is different in different patients for different tumor types. The success of tumor immunotherapy may be affected by the heterogeneity of the tumor immune microenvironment and its components, as these vary widely during neoplastic progression. The deepening of research and the development of technology have improved our understanding of the complexity and heterogeneity of the tumor immune microenvironment and its components, and their effects on response to tumor immunotherapy. Therefore, investigating the tumor immune microenvironment and its components and elucidating their association with tumor immunotherapy should improve the ability to study, predict and guide immunotherapeutic responsiveness, and uncover new therapeutic targets.
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February-2022
Volume 23 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zhou C, Liu Q, Xiang Y, Gou X and Li W: Role of the tumor immune microenvironment in tumor immunotherapy (Review). Oncol Lett 23: 53, 2022
APA
Zhou, C., Liu, Q., Xiang, Y., Gou, X., & Li, W. (2022). Role of the tumor immune microenvironment in tumor immunotherapy (Review). Oncology Letters, 23, 53. https://doi.org/10.3892/ol.2021.13171
MLA
Zhou, C., Liu, Q., Xiang, Y., Gou, X., Li, W."Role of the tumor immune microenvironment in tumor immunotherapy (Review)". Oncology Letters 23.2 (2022): 53.
Chicago
Zhou, C., Liu, Q., Xiang, Y., Gou, X., Li, W."Role of the tumor immune microenvironment in tumor immunotherapy (Review)". Oncology Letters 23, no. 2 (2022): 53. https://doi.org/10.3892/ol.2021.13171