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LINC01207 promotes prostate cancer progression by sponging miR‑1182 to upregulate AKT3

  • Authors:
    • Daming Qin
    • Cheng Ni
    • Biyong Tan
    • Shengfei Huang
    • Bingqing Deng
    • Zhihua Huang
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi Clinical College of Wuhan University, Enshi, Hubei 445000, P.R. China, Department of Ultrasonography, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi Clinical College of Wuhan University, Enshi, Hubei 445000, P.R. China
    Copyright: © Qin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 57
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    Published online on: December 21, 2021
       https://doi.org/10.3892/ol.2021.13175
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Abstract

Prostate cancer (PC) is recognized as a common malignancy in male patients. Long non‑coding RNA (lncRNA) has been implicated in the development of PC. Recently, long intergenic non‑protein coding RNA 1207 (LINC01207) has been reported to regulate the carcinogenesis of multiple cancer types. However, its role in the progression of PC remains to be determined. The aim of the present study was to investigate the expression profile, clinicopathological implication and molecular mechanism of action of LINC01207 in the progression of PC. LINC01207 expression levels were compared between PC tumor and paired normal tissue samples from The Cancer Genome Atlas. The expression of LINC01207 was further analyzed in PC cell lines and a normal prostatic cell line. The role of LINC01207 in proliferation, migration and invasion of PC cells was examined using small interfering RNA‑mediated silencing. Western blot analysis was used to investigate the changes in protein levels underlying the mechanism of action of LINC01207. The role of LINC01207 in tumorigenesis was evaluated in a xenograft model. LINC01207 was upregulated in PC tumor samples from TCGA data compared with paired normal tissue. LINC01207 expression was significantly increased in PC cells and tumor tissues compared with in normal prostate cells (RWPE1) and normal prostate tissues, respectively. Furthermore, LINC01207 silencing inhibited PC cell proliferation and colony formation and induced apoptosis. Mechanistic experiments showed that LINC01207 promoted carcinogenesis by sponging miR‑1182 to regulate the protein levels of AKT3 in PC cell lines. Thus, the findings of the present study indicated that LINC01207 might play a role in the tumorigenesis of PC and may serve as a therapeutic target for PC treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Qin D, Ni C, Tan B, Huang S, Deng B and Huang Z: LINC01207 promotes prostate cancer progression by sponging miR‑1182 to upregulate AKT3. Oncol Lett 23: 57, 2022.
APA
Qin, D., Ni, C., Tan, B., Huang, S., Deng, B., & Huang, Z. (2022). LINC01207 promotes prostate cancer progression by sponging miR‑1182 to upregulate AKT3. Oncology Letters, 23, 57. https://doi.org/10.3892/ol.2021.13175
MLA
Qin, D., Ni, C., Tan, B., Huang, S., Deng, B., Huang, Z."LINC01207 promotes prostate cancer progression by sponging miR‑1182 to upregulate AKT3". Oncology Letters 23.2 (2022): 57.
Chicago
Qin, D., Ni, C., Tan, B., Huang, S., Deng, B., Huang, Z."LINC01207 promotes prostate cancer progression by sponging miR‑1182 to upregulate AKT3". Oncology Letters 23, no. 2 (2022): 57. https://doi.org/10.3892/ol.2021.13175
Copy and paste a formatted citation
x
Spandidos Publications style
Qin D, Ni C, Tan B, Huang S, Deng B and Huang Z: LINC01207 promotes prostate cancer progression by sponging miR‑1182 to upregulate AKT3. Oncol Lett 23: 57, 2022.
APA
Qin, D., Ni, C., Tan, B., Huang, S., Deng, B., & Huang, Z. (2022). LINC01207 promotes prostate cancer progression by sponging miR‑1182 to upregulate AKT3. Oncology Letters, 23, 57. https://doi.org/10.3892/ol.2021.13175
MLA
Qin, D., Ni, C., Tan, B., Huang, S., Deng, B., Huang, Z."LINC01207 promotes prostate cancer progression by sponging miR‑1182 to upregulate AKT3". Oncology Letters 23.2 (2022): 57.
Chicago
Qin, D., Ni, C., Tan, B., Huang, S., Deng, B., Huang, Z."LINC01207 promotes prostate cancer progression by sponging miR‑1182 to upregulate AKT3". Oncology Letters 23, no. 2 (2022): 57. https://doi.org/10.3892/ol.2021.13175
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