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Article Open Access

Auranofin induces urothelial carcinoma cell death via
reactive oxygen species production and synergy with cisplatin

  • Authors:
    • San-Yuan Chen
    • Chun-Nun Chao
    • Hsin-Yi Huang
    • Chiung-Yao Fang
  • View Affiliations / Copyright

    Affiliations: Department of Chinese Medicine, Ditmanson Medical Foundation, Chiayi Christian Hospital, Chiayi 60002, Taiwan, R.O.C., Department of Pediatrics, Ditmanson Medical Foundation, Chiayi Christian Hospital, Chiayi 60002, Taiwan, R.O.C., Department of Medical Research, Ditmanson Medical Foundation, Chiayi Christian Hospital, Chiayi 60002, Taiwan, R.O.C.
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 61
    |
    Published online on: December 27, 2021
       https://doi.org/10.3892/ol.2021.13179
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Abstract

Urothelial carcinoma (UC) is one of the most common cancer types of the urinary tract. UC is associated with poor 5‑year survival rate, and resistance to cisplatin‑based therapy remains a challenge for invasive bladder cancer treatment. Therefore, there is an urgent need to develop new drugs for advanced UC therapy. Auranofin (AF) was developed over 30 years ago for the treatment of rheumatoid arthritis and has been reported to exert an antitumor effect by increasing the level of reactive oxygen species (ROS) in cancer cells. The aim of the present study was to examine the effects of AF on cancer cell proliferation, cell cycle and apoptosis, either alone or in combination with cisplatin. AF induced cell death in two separate cell lines, HT 1376 and BFTC 909, in a concentration‑ and time‑dependent manner by inducing cell cycle arrest. However, the distribution of cells in different phases of the cell cycle differed between the two cell lines, with G0/G1 cell cycle arrest in HT 1376 cells and S phase arrest in BFTC 909 cells. In addition, AF induced apoptosis in HT 1376, as well as redox imbalance in both HT 1376 and BFTC 909 cells. Cell viability was rescued following treatment with N‑acetyl‑L‑cysteine, a ROS scavenger. Furthermore, AF treatment synergistically increased the cytotoxicity of HT 1376 and BFTC 909 cells when combined with cisplatin treatment. These findings suggest that AF may represent a potential candidate drug against UC and increase the therapeutic effect of cisplatin.
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View References

1 

Yaxley JP: Urinary tract cancers: An overview for general practice. J Family Med Prim Care. 5:533–538. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

3 

Lenis AT, Lec PM, Chamie K and Mshs MD: Bladder cancer: A review. JAMA. 324:1980–1991. 2020. View Article : Google Scholar : PubMed/NCBI

4 

Griffiths TR; Action on Bladder Cancer, : Current perspectives in bladder cancer management. Int J Clin Pract. 67:435–448. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Ritch CR, Velasquez MC, Kwon D, Becerra MF, Soodana-Prakash N, Atluri VS, Almengo K, Alameddine M, Kineish O, Kava BR, et al: Use and validation of the AUA/SUO risk grouping for nonmuscle invasive bladder cancer in a contemporary cohort. J Urol. 203:505–511. 2020. View Article : Google Scholar : PubMed/NCBI

6 

Yafi FA, Aprikian AG, Chin JL, Fradet Y, Izawa J, Estey E, Fairey A, Rendon R, Cagiannos I, Lacombe L, et al: Contemporary outcomes of 2287 patients with bladder cancer who were treated with radical cystectomy: A Canadian multicentre experience. BJU Int. 108:539–545. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Perera M, McGrath S, Sengupta S, Crozier J, Bolton D and Lawrentschuk N: Pelvic lymph node dissection during radical cystectomy for muscle-invasive bladder cancer. Nat Rev Urol. 15:686–692. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Patel VG, Oh WK and Galsky MD: Treatment of muscle-invasive and advanced bladder cancer in 2020. CA Cancer J Clin. 70:404–423. 2020. View Article : Google Scholar : PubMed/NCBI

9 

Chamie K, Litwin MS, Bassett JC, Daskivich TJ, Lai J, Hanley JM, Konety BR and Saigal CS; Urologic Diseases in America Project, : Recurrence of high-risk bladder cancer: A population-based analysis. Cancer. 119:3219–3227. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Sabharwal SS and Schumacker PT: Mitochondrial ROS in cancer: Initiators, amplifiers or an Achilles' heel? Nat Rev Cancer. 14:709–721. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, Squadrito F, Altavilla D and Bitto A: Oxidative stress: Harms and benefits for human health. Oxid Med Cell Longev. 2017:84167632017. View Article : Google Scholar : PubMed/NCBI

12 

Cohen Z, Maimon Y, Samuels N and Berger R: Role of reactive oxygen species in the anticancer activity of botanicals: Comparing sensitivity profiles. Oncol Lett. 13:2642–2648. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Kumari S, Badana AK, Mohan GM, Shailender G and Malla R: Reactive oxygen species: A key constituent in cancer survival. Biomark Insights. 13:11772719187553912018. View Article : Google Scholar : PubMed/NCBI

14 

Trachootham D, Alexandre J and Huang P: Targeting cancer cells by ROS-mediated mechanisms: A radical therapeutic approach? Nat Rev Drug Discov. 8:579–591. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Moloney JN and Cotter TG: ROS signalling in the biology of cancer. Semin Cell Dev Biol. 80:50–64. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Chen SY, Huang HY, Lin HP and Fang CY: Piperlongumine induces autophagy in biliary cancer cells via reactive oxygen species-activated Erk signaling pathway. Int J Mol Med. 44:1687–1696. 2019.PubMed/NCBI

17 

Lin S, Li Y, Zamyatnin AA Jr, Werner J and Bazhin AV: Reactive oxygen species and colorectal cancer. J Cell Physiol. 233:5119–5132. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Huang H, Xie H, Pan Y, Zheng K, Xia Y and Chen W: Plumbagin triggers ER stress-mediated apoptosis in prostate cancer cells via induction of ROS. Cell Physiol Biochem. 45:267–280. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Zhang L, Li J, Zong L, Chen X, Chen K, Jiang Z, Nan L, Li X, Li W, Shan T, et al: Reactive oxygen species and targeted therapy for pancreatic cancer. Oxid Med Cell Longev. 2016:16167812016. View Article : Google Scholar : PubMed/NCBI

20 

Sharma V, Joseph C, Ghosh S, Agarwal A, Mishra MK and Sen E: Kaempferol induces apoptosis in glioblastoma cells through oxidative stress. Mol Cancer Ther. 6:2544–2553. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Zou Z, Chang H, Li H and Wang S: Induction of reactive oxygen species: An emerging approach for cancer therapy. Apoptosis. 22:1321–1335. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Gorrini C, Harris IS and Mak TW: Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov. 12:931–947. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Chaffman M, Brogden RN, Heel RC, Speight TM and Avery GS: Auranofin. A preliminary review of its pharmacological properties and therapeutic use in rheumatoid arthritis. Drugs. 27:378–424. 1984. View Article : Google Scholar : PubMed/NCBI

24 

Lee D, Xu IM, Chiu DK, Leibold J, Tse AP, Bao MH, Yuen VW, Chan CY, Lai RK, Chin DW, et al: Induction of oxidative stress through inhibition of thioredoxin reductase 1 is an effective therapeutic approach for hepatocellular carcinoma. Hepatology. 69:1768–1786. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Wen C, Wang H, Wu X, He L, Zhou Q, Wang F, Chen S, Huang L, Chen J, Wang H, et al: ROS-mediated inactivation of the PI3K/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin. Cell Death Dis. 10:8092019. View Article : Google Scholar : PubMed/NCBI

26 

Oh BM, Lee SJ, Cho HJ, Park YS, Kim JT, Yoon SR, Lee SC, Lim JS, Kim BY, Choe YK and Lee HG: Cystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via glutathione reductase activity in colorectal cancer. Cell Death Dis. 8:e30532017. View Article : Google Scholar : PubMed/NCBI

27 

Shimada K, Fujii T, Anai S, Fujimoto K and Konishi N: ROS generation via NOX4 and its utility in the cytological diagnosis of urothelial carcinoma of the urinary bladder. BMC Urol. 11:222011. View Article : Google Scholar : PubMed/NCBI

28 

Miyata Y, Matsuo T, Sagara Y, Ohba K, Ohyama K and Sakai H: A mini-review of reactive oxygen species in urological cancer: Correlation with NADPH oxidases, angiogenesis, and apoptosis. Int J Mol Sci. 18:22142017. View Article : Google Scholar : PubMed/NCBI

29 

Chou TC and Talaly P: A simple generalized equation for the analysis of multiple inhibitions of michaelis-menten kinetic systems. J Biol Chem. 252:6438–6442. 1977. View Article : Google Scholar : PubMed/NCBI

30 

Chou TC and Talalay P: Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul. 22:27–55. 1984. View Article : Google Scholar : PubMed/NCBI

31 

Chou TC: Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev. 58:621–681. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Otto T and Sicinski P: Cell cycle proteins as promising targets in cancer therapy. Nat Rev Cancer. 17:93–115. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Malumbres M: Cyclin-dependent kinases. Genome Biol. 15:1222014. View Article : Google Scholar : PubMed/NCBI

34 

Sgambato A, Cittadini A, Faraglia B and Weinstein IB: Multiple functions of p27(Kip1) and its alterations in tumor cells: A review. J Cell Physiol. 183:18–27. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Roskoski R Jr: Cyclin-dependent protein serine/threonine kinase inhibitors as anticancer drugs. Pharmacol Res. 139:471–488. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Shen T and Huang S: The role of Cdc25A in the regulation of cell proliferation and apoptosis. Anticancer Agents Med Chem. 12:631–639. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Bartek J and Lukas J: Mammalian G1- and S-phase checkpoints in response to DNA damage. Curr Opin Cell Biol. 13:738–747. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Falck J, Petrini JH, Williams BR, Lukas J and Bartek J: The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways. Nat Genet. 30:290–294. 2002. View Article : Google Scholar : PubMed/NCBI

39 

Falck J, Mailand N, Syljuåsen RG, Bartek J and Lukas J: The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature. 410:842–847. 2001. View Article : Google Scholar : PubMed/NCBI

40 

Drayton RM and Catto JW: Molecular mechanisms of cisplatin resistance in bladder cancer. Expert Rev Anticancer Ther. 12:271–281. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Kim SJ, Kim HS and Seo YR: Understanding of ROS-inducing strategy in anticancer therapy. Oxid Med Cell Longev. 2019:53816922019. View Article : Google Scholar : PubMed/NCBI

42 

Kirtonia A, Gala K, Fernandes SG, Pandya G, Pandey AK, Sethi G, Khattar E and Garg M: Repurposing of drugs: An attractive pharmacological strategy for cancer therapeutics. Semin Cancer Biol. 68:258–278. 2021. View Article : Google Scholar : PubMed/NCBI

43 

Hernandez JJ, Pryszlak M, Smith L, Yanchus C, Kurji N, Shahani VM and Molinski SV: Giving drugs a second chance: Overcoming regulatory and financial hurdles in repurposing approved drugs as cancer therapeutics. Front Oncol. 7:2732017. View Article : Google Scholar : PubMed/NCBI

44 

Onodera T, Momose I and Kawada M: Potential anticancer activity of auranofin. Chem Pharm Bull (Tokyo). 67:186–191. 2019. View Article : Google Scholar : PubMed/NCBI

45 

Zhang X, Selvaraju K, Saei AA, D'Arcy P, Zubarev RA, Arnér ES and Linder S: Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug. Biochimie. 162:46–54. 2019. View Article : Google Scholar : PubMed/NCBI

46 

Hwang-Bo H, Jeong JW, Han MH, Park C, Hong SH, Kim GY, Moon SK, Cheong J, Kim WJ, Yoo YH and Choi YH: Auranofin, an inhibitor of thioredoxin reductase, induces apoptosis in hepatocellular carcinoma Hep3B cells by generation of reactive oxygen species. Gen Physiol Biophys. 36:117–128. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Cui XY, Park SH and Park WH: Auranofin inhibits the proliferation of lung cancer cells via necrosis and caspase-dependent apoptosis. Oncol Rep. 44:2715–2724. 2020. View Article : Google Scholar : PubMed/NCBI

48 

Karsa M, Kosciolek A, Bongers A, Mariana A, Failes T, Gifford AJ, Kees UR, Cheung LC, Kotecha RS, Arndt GM, et al: Exploiting the reactive oxygen species imbalance in high-risk paediatric acute lymphoblastic leukaemia through auranofin. Br J Cancer. 125:55–64. 2021. View Article : Google Scholar : PubMed/NCBI

49 

Kuczler MD, Olseen AM, Pienta KJ and Amend SR: ROS-induced cell cycle arrest as a mechanism of resistance in polyaneuploid cancer cells (PACCs). Prog Biophys Mol Biol. 165:3–7. 2021. View Article : Google Scholar : PubMed/NCBI

50 

Nadal R and Bellmunt J: Management of metastatic bladder cancer. Cancer Treat Rev. 76:10–21. 2019. View Article : Google Scholar : PubMed/NCBI

51 

von der Maase H, Sengelov L, Roberts JT, Ricci S, Dogliotti L, Oliver T, Moore MJ, Zimmermann A and Arning M: Long-term survival results of a randomized trial comparing gemcitabine plus cisplatin, with methotrexate, vinblastine, doxorubicin, plus cisplatin in patients with bladder cancer. J Clin Oncol. 23:4602–4608. 2005. View Article : Google Scholar : PubMed/NCBI

52 

Roberts JT, von der Maase H, Sengeløv L, Conte PF, Dogliotti L, Oliver T, Moore MJ, Zimmermann A and Arning M: Long-term survival results of a randomized trial comparing gemcitabine/cisplatin and methotrexate/vinblastine/doxorubicin/cisplatin in patients with locally advanced and metastatic bladder cancer. Ann Oncol. 17 (Suppl 5):v118–v122. 2006. View Article : Google Scholar : PubMed/NCBI

53 

Narayan RS, Molenaar P, Teng J, Cornelissen FMG, Roelofs I, Menezes R, Dik R, Lagerweij T, Broersma Y, Petersen N, et al: A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities. Nat Commun. 11:29352020. View Article : Google Scholar : PubMed/NCBI

54 

Dasari S and Tchounwou PB: Cisplatin in cancer therapy: Molecular mechanisms of action. Eur J Pharmacol. 740:364–378. 2014. View Article : Google Scholar : PubMed/NCBI

55 

Saad SY, Najjar TA and Alashari M: Role of non-selective adenosine receptor blockade and phosphodiesterase inhibition in cisplatin-induced nephrogonadal toxicity in rats. Clin Exp Pharmacol Physiol. 31:862–867. 2004. View Article : Google Scholar : PubMed/NCBI

56 

Liu X, Wang W, Yin Y, Li M, Li H, Xiang H, Xu A, Mei X, Hong B and Lin W: A high-throughput drug screen identifies auranofin as a potential sensitizer of cisplatin in small cell lung cancer. Invest New Drugs. 37:1166–1176. 2019. View Article : Google Scholar : PubMed/NCBI

57 

He W, Xia Y, Cao P, Hong L, Zhang T, Shen X, Zheng P, Shen H, Liang G and Zou P: Curcuminoid WZ35 synergize with cisplatin by inducing ROS production and inhibiting TrxR1 activity in gastric cancer cells. J Exp Clin Cancer Res. 38:2072019. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen S, Chao C, Huang H and Fang C: Auranofin induces urothelial carcinoma cell death via <br />reactive oxygen species production and synergy with cisplatin. Oncol Lett 23: 61, 2022.
APA
Chen, S., Chao, C., Huang, H., & Fang, C. (2022). Auranofin induces urothelial carcinoma cell death via <br />reactive oxygen species production and synergy with cisplatin. Oncology Letters, 23, 61. https://doi.org/10.3892/ol.2021.13179
MLA
Chen, S., Chao, C., Huang, H., Fang, C."Auranofin induces urothelial carcinoma cell death via <br />reactive oxygen species production and synergy with cisplatin". Oncology Letters 23.2 (2022): 61.
Chicago
Chen, S., Chao, C., Huang, H., Fang, C."Auranofin induces urothelial carcinoma cell death via <br />reactive oxygen species production and synergy with cisplatin". Oncology Letters 23, no. 2 (2022): 61. https://doi.org/10.3892/ol.2021.13179
Copy and paste a formatted citation
x
Spandidos Publications style
Chen S, Chao C, Huang H and Fang C: Auranofin induces urothelial carcinoma cell death via <br />reactive oxygen species production and synergy with cisplatin. Oncol Lett 23: 61, 2022.
APA
Chen, S., Chao, C., Huang, H., & Fang, C. (2022). Auranofin induces urothelial carcinoma cell death via <br />reactive oxygen species production and synergy with cisplatin. Oncology Letters, 23, 61. https://doi.org/10.3892/ol.2021.13179
MLA
Chen, S., Chao, C., Huang, H., Fang, C."Auranofin induces urothelial carcinoma cell death via <br />reactive oxygen species production and synergy with cisplatin". Oncology Letters 23.2 (2022): 61.
Chicago
Chen, S., Chao, C., Huang, H., Fang, C."Auranofin induces urothelial carcinoma cell death via <br />reactive oxygen species production and synergy with cisplatin". Oncology Letters 23, no. 2 (2022): 61. https://doi.org/10.3892/ol.2021.13179
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