Open Access

Neoantigens and their potential applications in tumor immunotherapy (Review)

  • Authors:
    • Xianzhu Fang
    • Zhiliang Guo
    • Jinqing Liang
    • Jiao Wen
    • Yuanyuan Liu
    • Xiumei Guan
    • Hong Li
  • View Affiliations

  • Published online on: January 21, 2022     https://doi.org/10.3892/ol.2022.13208
  • Article Number: 88
  • Copyright: © Fang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The incidence of malignant tumors is increasing, the majority of which are associated with high morbidity and mortality rates worldwide. The traditional treatment method for malignant tumors is surgery, coupled with radiotherapy or chemotherapy. However, these therapeutic strategies are frequently accompanied with adverse side effects. Over recent decades, tumor immunotherapy shown promise in demonstrating notable efficacy for the treatment of cancer. With the development of sequencing technology and bioinformatics algorithms, neoantigens have become compelling targets for cancer immunotherapy due to high levels of immunogenicity. In addition, neoantigen‑based vaccines have demonstrated potential for cancer therapy, primarily by augmenting T‑cell responses. Neoantigens have also been shown to be effective in immune checkpoint blockade therapy. Therefore, neoantigens may serve to be predictive biomarkers and synergistic treatment targets in cancer immunotherapy. The aim of the present review was to provide an overview of the recent progress in the classification, screening and clinical application of neoantigens for cancer therapy.
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March-2022
Volume 23 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Fang X, Guo Z, Liang J, Wen J, Liu Y, Guan X and Li H: Neoantigens and their potential applications in tumor immunotherapy (Review). Oncol Lett 23: 88, 2022
APA
Fang, X., Guo, Z., Liang, J., Wen, J., Liu, Y., Guan, X., & Li, H. (2022). Neoantigens and their potential applications in tumor immunotherapy (Review). Oncology Letters, 23, 88. https://doi.org/10.3892/ol.2022.13208
MLA
Fang, X., Guo, Z., Liang, J., Wen, J., Liu, Y., Guan, X., Li, H."Neoantigens and their potential applications in tumor immunotherapy (Review)". Oncology Letters 23.3 (2022): 88.
Chicago
Fang, X., Guo, Z., Liang, J., Wen, J., Liu, Y., Guan, X., Li, H."Neoantigens and their potential applications in tumor immunotherapy (Review)". Oncology Letters 23, no. 3 (2022): 88. https://doi.org/10.3892/ol.2022.13208