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Minecoside promotes apoptotic progression through STAT3 inactivation in breast cancer cells

  • Authors:
    • Buyun Kim
    • Ki Yong Lee
    • Byoungduck Park
  • View Affiliations / Copyright

    Affiliations: College of Pharmacy, Keimyung University, Dalseo‑Gu, Daegu, North Gyeongsang 704‑701, Republic of Korea, College of Pharmacy, Korea University, Sejong 339‑770, Republic of Korea
    Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 94
    |
    Published online on: January 27, 2022
       https://doi.org/10.3892/ol.2022.13214
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Abstract

Breast cancer is one of the most common malignant tumors in women worldwide, and is a major cause of mortality and morbidity in cancer patients. Constitutive activation of STAT3 has been found in a variety of malignant tumors, including breast cancer. Since STAT3 activation is capable of regulating various important features of tumor cells, identification of a novel STAT3 inhibitor is considered a potential strategy for treating breast cancer. The aim of the present study was to examine whether minecoside (MIN), an active compound extracted from Veronica peregrina L., exerts an antitumor effect by inhibiting STAT3 signaling pathway in MDA‑MB‑231 cells. The results revealed that MIN inhibited the constitutive STAT3 activation in a dose‑ and time‑dependent manner. MIN also blocked the nuclear translocation of STAT3 and suppressed STAT3‑DNA binding. In addition, MIN downregulated the STAT3‑mediated expression of proteins such as Bcl‑xL, Bcl‑2, CXCR4, VEGF, and cyclin D1. Subsequently, MIN promoted the caspase‑dependent apoptosis in MDA‑MB‑231 cells. Overall, results of the present study provide evidence that MIN exerted anticancer activity via inhibition of the STAT3 signaling pathway. Further studies using animal models are required to determine the potential of this molecule as an anticancer drug.
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Copy and paste a formatted citation
Spandidos Publications style
Kim B, Lee KY and Park B: Minecoside promotes apoptotic progression through STAT3 inactivation in breast cancer cells. Oncol Lett 23: 94, 2022.
APA
Kim, B., Lee, K.Y., & Park, B. (2022). Minecoside promotes apoptotic progression through STAT3 inactivation in breast cancer cells. Oncology Letters, 23, 94. https://doi.org/10.3892/ol.2022.13214
MLA
Kim, B., Lee, K. Y., Park, B."Minecoside promotes apoptotic progression through STAT3 inactivation in breast cancer cells". Oncology Letters 23.3 (2022): 94.
Chicago
Kim, B., Lee, K. Y., Park, B."Minecoside promotes apoptotic progression through STAT3 inactivation in breast cancer cells". Oncology Letters 23, no. 3 (2022): 94. https://doi.org/10.3892/ol.2022.13214
Copy and paste a formatted citation
x
Spandidos Publications style
Kim B, Lee KY and Park B: Minecoside promotes apoptotic progression through STAT3 inactivation in breast cancer cells. Oncol Lett 23: 94, 2022.
APA
Kim, B., Lee, K.Y., & Park, B. (2022). Minecoside promotes apoptotic progression through STAT3 inactivation in breast cancer cells. Oncology Letters, 23, 94. https://doi.org/10.3892/ol.2022.13214
MLA
Kim, B., Lee, K. Y., Park, B."Minecoside promotes apoptotic progression through STAT3 inactivation in breast cancer cells". Oncology Letters 23.3 (2022): 94.
Chicago
Kim, B., Lee, K. Y., Park, B."Minecoside promotes apoptotic progression through STAT3 inactivation in breast cancer cells". Oncology Letters 23, no. 3 (2022): 94. https://doi.org/10.3892/ol.2022.13214
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