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Review Open Access

Lipid metabolism of cancer stem cells (Review)

  • Authors:
    • Huihui Liu
    • Zhengyang Zhang
    • Lian Song
    • Jie Gao
    • Yanfang Liu
  • View Affiliations / Copyright

    Affiliations: Department of Medical Imaging, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 119
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    Published online on: February 9, 2022
       https://doi.org/10.3892/ol.2022.13239
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Abstract

Cancer stem cells (CSCs), also termed cancer‑­initiating cells, are a special subset of cells with high self‑replicating and self‑renewing abilities that can differentiate into various cell types under certain conditions. A number of studies have demonstrated that CSCs have distinct metabolic properties. The reprogramming of energy metabolism enables CSCs to meet the needs of self‑renewal and stemness maintenance. Increasing evidence supports the view that alterations in lipid metabolism, including an increase in fatty acid (FA) uptake, de novo lipogenesis, formation of lipid droplets and mitochondrial FA oxidation, are involved in CSC regulation. In the present review, the metabolic characteristics of CSCs, particularly in lipid metabolism, were summarized. In addition, the potential mechanisms of CSC lipid metabolism in treatment resistance were discussed. Given their significance in cancer biology, targeting CSC metabolism may serve an important role in future cancer treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Liu H, Zhang Z, Song L, Gao J and Liu Y: Lipid metabolism of cancer stem cells (Review). Oncol Lett 23: 119, 2022.
APA
Liu, H., Zhang, Z., Song, L., Gao, J., & Liu, Y. (2022). Lipid metabolism of cancer stem cells (Review). Oncology Letters, 23, 119. https://doi.org/10.3892/ol.2022.13239
MLA
Liu, H., Zhang, Z., Song, L., Gao, J., Liu, Y."Lipid metabolism of cancer stem cells (Review)". Oncology Letters 23.4 (2022): 119.
Chicago
Liu, H., Zhang, Z., Song, L., Gao, J., Liu, Y."Lipid metabolism of cancer stem cells (Review)". Oncology Letters 23, no. 4 (2022): 119. https://doi.org/10.3892/ol.2022.13239
Copy and paste a formatted citation
x
Spandidos Publications style
Liu H, Zhang Z, Song L, Gao J and Liu Y: Lipid metabolism of cancer stem cells (Review). Oncol Lett 23: 119, 2022.
APA
Liu, H., Zhang, Z., Song, L., Gao, J., & Liu, Y. (2022). Lipid metabolism of cancer stem cells (Review). Oncology Letters, 23, 119. https://doi.org/10.3892/ol.2022.13239
MLA
Liu, H., Zhang, Z., Song, L., Gao, J., Liu, Y."Lipid metabolism of cancer stem cells (Review)". Oncology Letters 23.4 (2022): 119.
Chicago
Liu, H., Zhang, Z., Song, L., Gao, J., Liu, Y."Lipid metabolism of cancer stem cells (Review)". Oncology Letters 23, no. 4 (2022): 119. https://doi.org/10.3892/ol.2022.13239
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