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Ki67 for evaluating the prognosis of gastrointestinal stromal tumors: A systematic review and meta‑analysis

  • Authors:
    • Ji Li
    • An-Ran Wang
    • Xiao-Dong Chen
    • Hong Pan
    • Shi-Qiang Li
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Chongqing Western Hospital, Chongqing 400051, P.R. China, Department of Radiology, Army Medical Center of PLA, Chongqing 400042, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 189
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    Published online on: April 27, 2022
       https://doi.org/10.3892/ol.2022.13309
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Abstract

Overexpression of Ki67 is observed in tumor cells, and it has been suggested to be a marker for cancer prognosis. However, the relationship between Ki67 expression and the risk of recurrence of gastrointestinal stromal tumors (GISTs) remains poorly defined. In the present study, a meta‑analysis was used to examine the associations between Ki67 levels and GIST recurrence. Studies reporting GIST and Ki67 were found by searching Cochrane Library, PubMed and Embase until October 14, 2021. The Newcastle‑Ottawa Scale (NOS) was used to verify the quality of the evidence. Totally, 1682 patient cases were included. The odds ratio (OR) estimates and 95% confidence interval (CI) for each publication were determined by a fixed‑effects (Mantel‑Haenszel) model. A total of 20 studies that fulfilled the inclusion criteria were finally included in the analysis. The average score of quality evaluation was 6.4 points according to NOS. It was found that Ki67 levels were significantly higher in the NIH L group compared with the NIH VL group (OR: 0.51; 95% CI: 0.26‑0.99; P=0.04; P heterogeneity=0.44). There was also greater Ki67 overexpression in the NIH I group compared with the NIH L group (OR: 0.45, 95% CI: 0.31‑0.65; P<0.0001; P heterogeneity=0.32), while Ki67 levels were greater in the NIH H group than in the NIH I group (OR: 0.20; 95% CI: 0.15‑0.28; P<0.00001; P heterogeneity=0.56). In conclusion, Ki67 overexpression may be a useful marker of the risk of recurrent GIST transformation.
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1 

El-Menyar A, Mekkodathil A and Al-Thani H: Diagnosis and management of gastrointestinal stromal tumors: An up-to-date literature review. J Cancer Res Ther. 13:889–900. 2017.PubMed/NCBI

2 

Schaefer IM, Mariño-Enríquez A and Fletcher JA: What is new in gastrointestinal stromal tumor? Adv Anat Pathol. 24:259–267. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Nishida T, Blay JY, Hirota S, Kitagawa Y and Kang YK: The standard diagnosis, treatment, and follow-up of gastrointestinal stromal tumors based on guidelines. Gastric Cancer. 19:3–14. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Demetri GD, von Mehren M, Antonescu CR, DeMatteo RP, Ganjoo KN, Maki RG, Pisters PW, Raut CP, Riedel RF, Schuetze S, et al: NCCN task force report: Update on the management of patients with gastrointestinal stromal tumors. J Natl Compr Canc Netw. 8 (Suppl 2):S1–S44. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Miettinen M and Lasota J: Histopathology of gastrointestinal stromal tumor. J Surg Oncol. 104:865–873. 2011. View Article : Google Scholar : PubMed/NCBI

6 

van der Graaf WTA, Tielen R, Bonenkamp JJ, Lemmens V, Verhoeven RHA and de Wilt JHW: Nationwide trends in the incidence and outcome of patients with gastrointestinal stromal tumour in the imatinib era. Br J Surg. 105:1020–1027. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Ma GL, Murphy JD, Martinez ME and Sicklick JK: Epidemiology of gastrointestinal stromal tumors in the era of histology codes: Results of a population-based study. Cancer Epidemiol Biomarkers Prev. 24:298–302. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Joensuu H: Risk stratification of patients diagnosed with gastrointestinal stromal tumor. Hum Pathol. 39:1411–1419. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Kitamura Y: Gastrointestinal stromal tumors: Past, present, and future. J Gastroenterol. 43:499–508. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Scholzen T and Gerdes J: The Ki-67 protein: From the known and the unknown. J Cell Physiol. 182:311–322. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Isola J, Helin H and Kallioniemi OP: Immunoelectron-microscopic localization of a proliferation-associated antigen Ki-67 in MCF-7 cells. Histochem J. 22:498–506. 1990. View Article : Google Scholar : PubMed/NCBI

12 

du Manoir S, Guillaud P, Camus E, Seigneurin D and Brugal G: Ki-67 labeling in postmitotic cells defines different Ki-67 pathways within the 2c compartment. Cytometry. 12:455–463. 1991. View Article : Google Scholar : PubMed/NCBI

13 

Hutchins JR, Toyoda Y, Hegemann B, Poser I, Hériché JK, Sykora MM, Augsburg M, Hudecz O, Buschhorn BA, Bulkescher J, et al: Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science. 328:593–599. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Visapää H, Bui M, Huang Y, Seligson D, Tsai H, Pantuck A, Figlin R, Rao JY, Belldegrun A, Horvath S and Palotie A: Correlation of Ki-67 and gelsolin expression to clinical outcome in renal clear cell carcinoma. Urology. 61:845–850. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Li H, Ren G, Cai R, Chen J, Wu X and Zhao J: A correlation research of Ki67 index, CT features, and risk stratification in gastrointestinal stromal tumor. Cancer Med. 7:4467–4474. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Zhang H and Liu Q: Prognostic indicators for gastrointestinal stromal tumors: A review. Transl Oncol. 13:1008122020. View Article : Google Scholar : PubMed/NCBI

17 

Wang JP, Liu L, Li ZA, Wang Q, Wang XY and Lin J: Ki-67 labelling index is related to the risk classification and prognosis of gastrointestinal stromal tumours: A retrospective study. Gastroenterol Hepatol. 44:103–114. 2021.(In English, Spanish). View Article : Google Scholar : PubMed/NCBI

18 

Liu X, Qiu H, Zhang P, Feng X, Chen T, Li Y, Tao K, Li G, Sun X and Zhou Z; China Gastrointestinal Stromal Tumor Study Group (CN-GIST), : Ki-67 labeling index may be a promising indicator to identify ‘very high-risk’ gastrointestinal stromal tumor: A multicenter retrospective study of 1022 patients. Hum Pathol. 74:17–24. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Sahin S, Ekinci O, Seckin S and Dursun A: Proliferation markers RacGAP1 and Ki-67 in gastrointestinal stromal tumors by immunohistochemistry with respect to clinicopathological features and different risk stratification systems. Int J Clin Exp Pathol. 10:11723–11736. 2017.PubMed/NCBI

20 

Demir L, Ekinci N, Erten C, Kucukzeybek Y, Alacacioglu A, Somali I, Can A, Dirican A, Bayoglu V, Akyol M, et al: Does immunohistochemistry provide additional prognostic data in gastrointestinal stromal tumors? Asian Pac J Cancer Prev. 14:4751–4758. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Zhou Y, Hu W, Chen P, Abe M, Shi L, Tan SY, Li Y and Zong L: Ki67 is a biological marker of malignant risk of gastrointestinal stromal tumors: A systematic review and meta-analysis. Medicine (Baltimore). 96:e79112017. View Article : Google Scholar : PubMed/NCBI

22 

Nakamura N, Yamamoto H, Yao T, Oda Y, Nishiyama K, Imamura M, Yamada T, Nawata H and Tsuneyoshi M: Prognostic significance of expressions of cell-cycle regulatory proteins in gastrointestinal stromal tumor and the relevance of the risk grade. Hum Pathol. 36:828–837. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Pleşea IE, Chiuţu L, Bordu SI, Georgescu I, Georgescu EF, Ciobanu D, Mărgăritescu ND, Comănescu V and Nemeş R: Gastrointestinal stromal tumors-a clinical-morphological study on 15 cases. Rom J Morphol Embryol. 55 (Suppl 2):S513–S523. 2014.PubMed/NCBI

24 

Peker K, Sayar I, Gelincik I, Bulut G, Kökenek Ünal TD, Şenol S, Gökçe A and Isik A: The diagnostic importance of matrix metalloproteinase-7 and nestin in gastrointestinal stromal tumors. Med Sci Monit. 20:674–680. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Tsumuraya M, Kato H, Miyachi K, Sasaki K, Tsubaki M, Akimoto K and Sunagawa M: Comprehensive analysis of genes involved in the malignancy of gastrointestinal stromal tumors. Anticancer Res. 30:2705–2715. 2010.PubMed/NCBI

26 

Jiang L, Cao M, Hu J and Chen J: Expression of PIN1 in gastrointestinal stromal tumours and its clinical significance. Anticancer Res. 36:1275–1280. 2016.PubMed/NCBI

27 

Güler B, Özyılmaz F, Tokuç B, Can N and Taştekin E: Histopathological features of gastrointestinal stromal tumors and the contribution of DOG1 expression to the diagnosis. Balkan Med J. 32:388–396. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Wang H, Chen P, Liu XX, Zhao W, Shi L, Gu XW, Zhu CR, Zhu HH and Zong L: Prognostic impact of gastrointestinal bleeding and expression of PTEN and Ki-67 on primary gastrointestinal stromal tumors. World J Surg Oncol. 12:892014. View Article : Google Scholar : PubMed/NCBI

29 

Zhao WY, Xu J, Wang M, Zhang ZZ, Tu L, Wang CJ, Lin TL, Shen YY, Liu Q and Cao H: Prognostic value of Ki67 index in gastrointestinal stromal tumors. Int J Clin Exp Pathol. 7:2298–2304. 2014.PubMed/NCBI

30 

Nanding A, Tang L, Cai L, Chen H, Geng J, Liu X, Ning X, Li X and Zhang Q: Low ING4 protein expression detected by paraffin-section immunohistochemistry is associated with poor prognosis in untreated patients with gastrointestinal stromal tumors. Gastric Cancer. 17:87–96. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Lu C, Liu L, Wu X and Xu W: CD133 and Ki-67 expression is associated with gastrointestinal stromal tumor prognosis. Oncol Lett. 6:1289–1294. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Segales-Rojas P, Lino-Silva LS, Aguilar-Cruz E and Salcedo-Hernández RA: Association of ki67 index with recurrence in gastrointestinal stromal tumors. J Gastrointest Cancer. 49:543–547. 2018. View Article : Google Scholar : PubMed/NCBI

33 

Jiang J and Cao XY, Suo J, Wang YP, He L and Cao XY: Evaluation of malignancy using Ki-67, p53, EGFR and COX-2 expressions in gastrointestinal stromal tumors. World J Gastroenterol. 18:2569–2575. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Liu LC, Xu WT, Wu X, Zhao P, Lv YL and Chen L: Overexpression of carbonic anhydrase II and Ki-67 proteins in prognosis of gastrointestinal stromal tumors. World J Gastroenterol. 19:2473–2480. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Alghamdi HM, Amr SS, Shawarby MA, Sheikh SS, Alsayyah AA, Alamri AM, Ismail MH, Almarhabi A, Alrefaee MA and Ahmed MI: Gastrointestinal stromal tumors. A clinicopathological study. Saudi Med J. 40:126–130. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Ngo QD, Pham QT, Phan DAT, Hoang AV, Hua TNH and Nguyen ST: Molecular and clinicopathological features of gastrointestinal stromal tumors in vietnamese patients. J Pathol Transl Med. 53:361–368. 2019. View Article : Google Scholar : PubMed/NCBI

37 

Podda M, Ferraro G, Di Saverio S, Cois A, Nardello O, Poillucci G, Marino MV and Pisanu A: Association between gastrointestinal stromal tumors and other malignancies: It is only a matter of time ? A case series and an overview of systematic reviews. J Gastrointest Cancer. 51:914–924. 2020. View Article : Google Scholar : PubMed/NCBI

38 

Tepeoğlu M, Özgün G, Tunca MZ, Tezcaner T and Özdemir BH: Gastrointestinal stromal tumors: A clinicopathological and immunohistochemical study of 65 cases. Turk Patoloji Derg. 34:207–214. 2018.PubMed/NCBI

39 

Wei SC, Xu L, Li WH, Li Y, Guo SF, Sun XR and Li WW: Risk stratification in GIST: Shape quantification with CT is a predictive factor. Eur Radiol. 30:1856–1865. 2020. View Article : Google Scholar : PubMed/NCBI

40 

Taniguchi K, Suzuki A, Serizawa A, Kotake S, Ito S, Suzuki K, Yamada T, Noguchi T, Amano K, Ota M, et al: Rapid flow cytometry of gastrointestinal stromal tumours closely matches the modified fletcher classification. Anticancer Res. 41:131–136. 2021. View Article : Google Scholar : PubMed/NCBI

41 

Joensuu H, Hohenberger P and Corless CL: Gastrointestinal stromal tumour. Lancet. 382:973–983. 2013. View Article : Google Scholar : PubMed/NCBI

42 

McCarter MD, Antonescu CR, Ballman KV, Maki RG, Pisters PW, Demetri GD, Blanke CD, von Mehren M, Brennan MF, McCall L, et al: Microscopically positive margins for primary gastrointestinal stromal tumors: Analysis of risk factors and tumor recurrence. J Am Coll Surg. 215:53–60. 2021. View Article : Google Scholar : PubMed/NCBI

43 

Gold JS, Gönen M, Gutiérrez A, Broto JM, García-del-Muro X, Smyrk TC, Maki RG, Singer S, Brennan MF, Antonescu CR, et al: Development and validation of a prognostic nomogram for recurrence-free survival after complete surgical resection of localised primary gastrointestinal stromal tumour: A retrospective analysis. Lancet Oncol. 10:1045–1052. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Zhi X, Zhou X, Wang W and Xu Z: Practical role of mutation analysis for imatinib treatment in patients with advanced gastrointestinal stromal tumors: A meta-analysis. PLoS One. 8:e792752013. View Article : Google Scholar : PubMed/NCBI

45 

Yan L, Zou L, Zhao W, Wang Y, Liu B, Yao H and Yu H: Clinicopathological significance of c-KIT mutation in gastrointestinal stromal tumors: A systematic review and meta-analysis. Sci Rep. 5:137182015. View Article : Google Scholar : PubMed/NCBI

46 

Wozniak A, Rutkowski P, Schöffski P, Ray-Coquard I, Hostein I, Schildhaus HU, Le Cesne A, Bylina E, Limon J, Blay JY, et al: Tumor genotype is an independent prognostic factor in primary gastrointestinal stromal tumors of gastric origin: A european multicenter analysis based on ConticaGIST. Clin Cancer Res. 20:6105–6116. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Rubió-Casadevall J, Borràs JL, Carmona-García MC, Ameijide A, Gonzalez-Vidal A, Ortiz MR, Bosch R, Riu F, Parada D, Martí E, et al: Correlation between mutational status and survival and second cancer risk assessment in patients with gastrointestinal stromal tumors: A population-based study. World J Surg Oncol. 13:472015. View Article : Google Scholar : PubMed/NCBI

48 

Gerdes J, Schwab U, Lemke H and Stein H: Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int J Cancer. 31:13–20. 1983. View Article : Google Scholar : PubMed/NCBI

49 

Belev B, Brčić I, Prejac J, Golubić ZA, Vrbanec D, Božikov J, Alerić I, Boban M and Razumović JJ: Role of Ki-67 as a prognostic factor in gastrointestinal stromal tumors. World J Gastroenterol. 19:523–527. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Jia YF, Xiao DJ, Ma XL, Song YY, Hu R, Kong Y, Zheng Y, Han SY, Hong RL and Wang YS: Differentiated embryonic chondrocyte-expressed gene 1 is associated with hypoxia-inducible factor 1α and Ki67 in human gastric cancer. Diagn Pathol. 8:372013. View Article : Google Scholar : PubMed/NCBI

51 

Seidal T and Edvardsson H: Expression of c-kit (CD117) and Ki67 provides information about the possible cell of origin and clinical course of gastrointestinal stromal tumours. Histopathology. 34:416–424. 1999. View Article : Google Scholar : PubMed/NCBI

52 

Nilsson B, Bümming P, Meis-Kindblom JM, Odén A, Dortok A, Gustavsson B, Sablinska K and Kindblom LG: Gastrointestinal stromal tumors: The incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era-a population-based study in western Sweden. Cancer. 103:821–829. 2005. View Article : Google Scholar : PubMed/NCBI

53 

Nagasako Y, Misawa K, Kohashi S, Hasegawa K, Okawa Y, Sano H, Takada A and Sato H: Evaluation of malignancy using Ki-67 labeling index for gastric stromal tumor. Gastric Cancer. 6:168–172. 2003. View Article : Google Scholar : PubMed/NCBI

54 

Gumurdulu D, Erdogan S, Kayaselcuk F, Seydaoglu G, Parsak CK, Demircan O and Tuncer I: Expression of COX-2, PCNA, Ki-67 and p53 in gastrointestinal stromal tumors and its relationship with histopathological parameters. World J Gastroenterol. 13:426–431. 2007. View Article : Google Scholar : PubMed/NCBI

55 

Wong NA, Young R, Malcomson RD, Nayar AG, Jamieson LA, Save VE, Carey FA, Brewster DH, Han C and Al-Nafussi A: Prognostic indicators for gastrointestinal stromal tumours: A clinicopathological and immunohistochemical study of 108 resected cases of the stomach. Histopathology. 43:118–126. 2003. View Article : Google Scholar : PubMed/NCBI

56 

Kramer K, Knippschild U, Mayer B, Bögelspacher K, Spatz H, Henne-Bruns D, Agaimy A, Schwab M and Schmieder M: Impact of age and gender on tumor related prognosis in gastrointestinal stromal tumors (GIST). BMC Cancer. 15:572015. View Article : Google Scholar : PubMed/NCBI

57 

Hohenberger P, Ronellenfitsch U, Oladeji O, Pink D, Ströbel P, Wardelmann E and Reichardt P: Pattern of recurrence in patients with ruptured primary gastrointestinal stromal tumour. Br J Surg. 97:1854–1859. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li J, Wang A, Chen X, Pan H and Li S: Ki67 for evaluating the prognosis of gastrointestinal stromal tumors: A systematic review and meta‑analysis. Oncol Lett 23: 189, 2022.
APA
Li, J., Wang, A., Chen, X., Pan, H., & Li, S. (2022). Ki67 for evaluating the prognosis of gastrointestinal stromal tumors: A systematic review and meta‑analysis. Oncology Letters, 23, 189. https://doi.org/10.3892/ol.2022.13309
MLA
Li, J., Wang, A., Chen, X., Pan, H., Li, S."Ki67 for evaluating the prognosis of gastrointestinal stromal tumors: A systematic review and meta‑analysis". Oncology Letters 23.6 (2022): 189.
Chicago
Li, J., Wang, A., Chen, X., Pan, H., Li, S."Ki67 for evaluating the prognosis of gastrointestinal stromal tumors: A systematic review and meta‑analysis". Oncology Letters 23, no. 6 (2022): 189. https://doi.org/10.3892/ol.2022.13309
Copy and paste a formatted citation
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Spandidos Publications style
Li J, Wang A, Chen X, Pan H and Li S: Ki67 for evaluating the prognosis of gastrointestinal stromal tumors: A systematic review and meta‑analysis. Oncol Lett 23: 189, 2022.
APA
Li, J., Wang, A., Chen, X., Pan, H., & Li, S. (2022). Ki67 for evaluating the prognosis of gastrointestinal stromal tumors: A systematic review and meta‑analysis. Oncology Letters, 23, 189. https://doi.org/10.3892/ol.2022.13309
MLA
Li, J., Wang, A., Chen, X., Pan, H., Li, S."Ki67 for evaluating the prognosis of gastrointestinal stromal tumors: A systematic review and meta‑analysis". Oncology Letters 23.6 (2022): 189.
Chicago
Li, J., Wang, A., Chen, X., Pan, H., Li, S."Ki67 for evaluating the prognosis of gastrointestinal stromal tumors: A systematic review and meta‑analysis". Oncology Letters 23, no. 6 (2022): 189. https://doi.org/10.3892/ol.2022.13309
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