Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2022 Volume 24 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2022 Volume 24 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Efficacy of a combined tool for stage I non‑small cell lung cancer against lymph node metastasis

  • Authors:
    • Takeo Nakada
    • Mitsuo Yabe
    • Takashi Ohtsuka
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Division of Thoracic Surgery, The Jikei University School of Medicine, Tokyo 105‑8471, Japan
    Copyright: © Nakada et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 332
    |
    Published online on: August 9, 2022
       https://doi.org/10.3892/ol.2022.13452
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

In patients with clinical stage I non‑small cell lung cancer (NSCLC), the prediction of occult lymph node metastasis (LNM) based on a combination of morphology using high‑resolution computed tomography (HRCT) and metabolism using positron emission tomography (PET)‑CT is unknown. The present study evaluated the use of predictive radiological tools, chest CT and PET‑CT, for occult LNM in patients with clinical stage I NSCLC. The records of patients who underwent lobectomy between July 2014 and November 2021 were retrospectively reviewed. The differences in clinicopathological parameters, including CT and PET, between the LNM and non‑LNM groups were assessed. Pure solid tumor was defined as a consolidation‑to‑tumor ratio of 1. The optimal cut‑off value for predictive radiological tools for LNM was assessed according to the area under the receiver operating characteristic (ROC) curve. The present study included 288 patients, of whom 39 (13.5%) had LNM; of these 38 (97.4%) were pure solid type. Larger consolidation size (CS), higher maximal standardized uptake (SUVmax) value and histological type were statistically associated with LNM (all P<0.05). The optimal cutoff values of CS and SUVmax for predicting LNM were 19 mm and 5.5 respectively, as assessed using the area under the ROC curve. The combination of CS ≥19 mm and SUVmax ≥5.5 demonstrated a markedly higher odds ratio (9.184; 95% CI, 4.345‑19.407) than each parameter individually. The minimum values of CS and SUVmax associated with LNM were 10 mm and 0.8 respectively. Pure solid formation and CS as morphology and SUVmax as metabolism were useful tools that complemented each other in predicting LNM. The combined method of evaluating SUVmax and CS may identify eligibility for LN dissection. However, considering the minimum values of CS and SUVmax in LNM, it cannot affirm the omission of LN dissection for cases that do not meet the combined criteria using HRCT and PET‑CT.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

National Comprehensive Cancer Network®, . NCCN Clinical Practice Guideline in Oncology (NCCN Guideline®) Non-small cell lung cancer. https://www2.tri-kobe.org/nccn/guideline/lung/englishJune 10–2019

2 

Goldstraw P, Chansky K, Crowley J, Rami-Porta R, Asamura H, Eberhardt WE, Nicholson AG, Groome P, Mitchell A, Bolejack V, et al: The IASLC lung cancer staging project: Proposals for revision of the TNM stage groupings in the forthcoming (Eighth) edition of the TNM classification for lung cancer. J Thorac Oncol. 11:39–51. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Kim H, Goo JM, Kim YT and Park CM: Consolidation-to-tumor ratio and tumor disappearance ratio are not independent prognostic factors for the patients with resected lung adenocarcinomas. Lung Cancer. 137:123–128. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Hattori A, Hirayama S, Matsunaga T, Hayashi T, Takamochi K, Oh S and Suzuki K: Distinct clinicopathologic characteristics and prognosis based on the presence of ground glass opacity component in clinical stage IA lung adenocarcinoma. J Thorac Oncol. 14:265–275. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Ye T, Deng L, Wang S, Xiang J, Zhang Y, Hu H, Sun Y, Li Y, Shen L, Xie L, et al: Lung adenocarcinomas manifesting as radiological part-solid nodules define a special clinical subtype. J Thorac Oncol. 14:617–627. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Miyoshi T, Aokage K, Katsumata S, Tane K, Ishii G and Tsuboi M: Ground-glass opacity is a strong prognosticator for pathologic stage IA lung adenocarcinoma. Ann Thorac Surg. 108:249–255. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Fischer B, Lassen U, Mortensen J, Larsen S, Loft A, Bertelsen A, Ravn J, Clementsen P, Høgholm A, Larsen K, et al: Preoperative staging of lung cancer with combined PET-CT. N Engl J Med. 361:32–39. 2009. View Article : Google Scholar : PubMed/NCBI

8 

The Japan Lung Cancer Society, . Japanese guideline for lung cancer treatment. https://www.haigan.gr.jp/guideline/2018/1/1/180101050100.htmlJune 10–2019

9 

Shirai K, Abe T, Saitoh JI, Mizukami T, Irie D, Takakusagi Y, Shiba S, Okano N, Ebara T, Ohno T and Nakano T: Maximum standardized uptake value on FDG-PET predicts survival in stage I non-small cell lung cancer following carbon ion radiotherapy. Oncol Lett. 13:4420–4426. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Li L, Ren S, Zhang Y, Guan Y, Zhao J, Liu J, Wang Q, Chen G, Chen H, Xiang J and Fu X: Risk factors for predicting the occult nodal metastasis in T1-2N0M0 NSCLC patients staged by PET/CT: Potential value in the clinic. Lung Cancer. 81:213–217. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Kaseda K, Asakura K, Kazama A and Ozawa Y: Risk factors for predicting occult lymph node metastasis in patients with clinical stage I non-small cell lung cancer staged by integrated fluorodeoxyglucose positron emission tomography/computed tomography. World J Surg. 40:2976–2983. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Nakada T and Kuroda H: Narrative review of optimal prognostic radiological tools using computed tomography for T1N0-staged non-small cell lung cancer. J Thorac Dis. 13:3171–3181. 2021. View Article : Google Scholar : PubMed/NCBI

13 

Hishida T, Miyaoka E, Yokoi K, Tsuboi M, Asamura H, Kiura K, Takahashi K, Dosaka-Akita H, Kobayashi H, Date H, et al: Lobe-specific nodal dissection for clinical stage I and II NSCLC: Japanese multi-institutional retrospective study using a propensity score analysis. J Thorac Oncol. 11:1529–1537. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Hattori A, Suzuki K, Takamochi K, Wakabayashi M, Aokage K, Saji H and Watanabe SI; Japan Clinical Oncology Group Lung Cancer Surgical Study Group, : Prognostic impact of a ground-glass opacity component in clinical stage IA non-small cell lung cancer. J Thorac Cardiovasc Surg. 161:1469–1480. 2021. View Article : Google Scholar : PubMed/NCBI

15 

Suzuki K, Watanabe SI, Wakabayashi M, Saji H, Aokage K, Moriya Y, Yoshino I, Tsuboi M, Nakamura S, Nakamura K, et al: A single-arm study of sublobar resection for ground-glass opacity dominant peripheral lung cancer. J Thorac Cardiovasc Surg. 163:289–301.e2. 2022. View Article : Google Scholar : PubMed/NCBI

16 

Hattori A, Matsunaga T, Takamochi K, Oh S and Suzuki K: Clinical significance of positron emission tomography in subcentimeter non-small cell lung cancer. Ann Thorac Surg. 103:1614–1620. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Kuroda H, Nakada T, Oya Y, Takahashi Y, Matsusita H and Sakakura N: Clinical adjustability of radiological tools in patients with surgically resected cT1N0-staged non-small-cell lung cancer from the long-term survival evaluation. J Thorac Dis. 12:6655–6662. 2020. View Article : Google Scholar : PubMed/NCBI

18 

Kim H, Goo JM, Kim YT and Park CM: Validation of the eighth edition clinical T categorization system for clinical stage IA, resected lung adenocarcinomas: Prognostic implications of the ground-glass opacity component. J Thorac Oncol. 15:580–588. 2020. View Article : Google Scholar : PubMed/NCBI

19 

Chiang XH, Hsu HH, Hsieh MS, Chang CH, Tsai TM, Liao HC, Tsou KC, Lin MW and Chen JS: Propensity-matched analysis comparing survival after sublobar resection and lobectomy for cT1N0 LUNG ADENOCARCINoma. Ann Surg Oncol. 27:703–715. 2020. View Article : Google Scholar : PubMed/NCBI

20 

Su H, Dai C, She Y, Ren Y, Zhang L, Xie H, Xie D, Jiang G and Chen C: Which T descriptor is more predictive of recurrence after sublobar resection: Whole tumour size versus solid component size? Eur J Cardiothorac Surg. 54:1028–1036. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Hattori A, Matsunaga T, Takamochi K, Oh S and Suzuki K: Importance of ground glass opacity component in clinical stage IA radiologic invasive lung cancer. Ann Thorac Surg. 104:313–320. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Takenaka T, Yamazaki K, Miura N, Mori R and Takeo S: The prognostic impact of tumor volume in patients with clinical stage IA non-small cell lung cancer. J Thorac Oncol. 11:1074–1080. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Fu F, Zhang Y, Wen Z, Zheng D, Gao Z, Han H, Deng L, Wang S, Liu Q, Li Y, et al: Distinct prognostic factors in patients with stage I non-small cell lung cancer with radiologic part-solid or solid lesions. J Thorac Oncol. 14:2133–2142. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, et al: International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol. 6:44–285. 2011. View Article : Google Scholar

25 

Hayashi H, Ashizawa K, Ogihara Y, Nishida A, Matsumoto K, Yamasaki N, Nagayasu T, Fukuda M, Honda S and Uetani M: Comparison between solid component size on thin-section CT and pathologic lymph node metastasis and local invasion in T1 lung adenocarcinoma. Jpn J Radiol. 35:109–115. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Sakakura N, Inaba Y, Yatabe Y, Mizuno T, Kuroda H, Yoshimura K and Sakao Y: Estimation of the pathological invasive size of pulmonary adenocarcinoma using high-resolution computed tomography of the chest: A consideration based on lung and mediastinal window settings. Lung Cancer. 95:51–56. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Taira N, Atsumi E, Nakachi S, Takamatsu R, Yohena T, Kawasaki H, Kawabata T and Yoshimi N: Comparison of GLUT-1, SGLT-1, and SGLT-2 expression in false-negative and true-positive lymph nodes during the 18F-FDG PET/CT mediastinal nodal staging of non-small cell lung cancer. Lung Cancer. 123:30–35. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Park HK, Jeon K, Koh WJ, Suh GY, Kim H, Kwon OJ, Chung MP, Lee KS, Shim YM, Han J and Um SW: Occult nodal metastasis in patients with non-small cell lung cancer at clinical stage IA by PET/CT. Respirology. 15:1179–1184. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Nambu A, Kato S, Sato Y, Okuwaki H, Nishikawa K, Saito A, Matsumoto K, Ichikawa T and Araki T: Relationship between maximum standardized uptake value (SUVmax) of lung cancer and lymph node metastasis on FDG-PET. Ann Nucl Med. 23:269–275. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Nakada T, Yabe M and Ohtsuka T: Efficacy of a combined tool for stage I non‑small cell lung cancer against lymph node metastasis. Oncol Lett 24: 332, 2022.
APA
Nakada, T., Yabe, M., & Ohtsuka, T. (2022). Efficacy of a combined tool for stage I non‑small cell lung cancer against lymph node metastasis. Oncology Letters, 24, 332. https://doi.org/10.3892/ol.2022.13452
MLA
Nakada, T., Yabe, M., Ohtsuka, T."Efficacy of a combined tool for stage I non‑small cell lung cancer against lymph node metastasis". Oncology Letters 24.4 (2022): 332.
Chicago
Nakada, T., Yabe, M., Ohtsuka, T."Efficacy of a combined tool for stage I non‑small cell lung cancer against lymph node metastasis". Oncology Letters 24, no. 4 (2022): 332. https://doi.org/10.3892/ol.2022.13452
Copy and paste a formatted citation
x
Spandidos Publications style
Nakada T, Yabe M and Ohtsuka T: Efficacy of a combined tool for stage I non‑small cell lung cancer against lymph node metastasis. Oncol Lett 24: 332, 2022.
APA
Nakada, T., Yabe, M., & Ohtsuka, T. (2022). Efficacy of a combined tool for stage I non‑small cell lung cancer against lymph node metastasis. Oncology Letters, 24, 332. https://doi.org/10.3892/ol.2022.13452
MLA
Nakada, T., Yabe, M., Ohtsuka, T."Efficacy of a combined tool for stage I non‑small cell lung cancer against lymph node metastasis". Oncology Letters 24.4 (2022): 332.
Chicago
Nakada, T., Yabe, M., Ohtsuka, T."Efficacy of a combined tool for stage I non‑small cell lung cancer against lymph node metastasis". Oncology Letters 24, no. 4 (2022): 332. https://doi.org/10.3892/ol.2022.13452
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team