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Review

Roles of ABCA1 in cancer (Review)

  • Authors:
    • Kun Wu
    • Longwei Zou
    • Xiaoyong Lei
    • Xiaoyan Yang
  • View Affiliations / Copyright

    Affiliations: School of Pharmacy, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, P.R. China
  • Article Number: 349
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    Published online on: August 19, 2022
       https://doi.org/10.3892/ol.2022.13469
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Abstract

Studies have indicated that anticancer drugs targeting cholesterol metabolism have clinical significance. From the perspective of the mechanism of cholesterol excretion from cells, ATP‑binding cassette (ABC)A1 has an essential role that cannot be ignored. ABCA1 is located on the cell membrane and able to mediate the efflux of lipids, such as intracellular cholesterol, thereby initiating reverse cholesterol transport to reduce the intracellular cholesterol level. Therefore, inducing the expression of ABCA1 may become a new breakthrough point in cancer therapy.
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1 

Bian X, Liu R, Meng Y, Xing D, Xu D and Lu Z: Lipid metabolism and cancer. J Exp Med. 218:e202016062021. View Article : Google Scholar : PubMed/NCBI

2 

Chang YC, Lee TS and Chiang AN: Quercetin enhances ABCA1 expression and cholesterol efflux through a p38-dependent pathway in macrophages. J Lipid Res. 53:1840–1850. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Wang J, Wang WJ, Zhai L and Zhang DF: Association of cholesterol with risk of pancreatic cancer: A meta-analysis. World J Gastroenterol. 21:3711–3719. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Lee BH, Taylor MG, Robinet P, Smith JD, Schweitzer J, Sehayek E, Falzarano SM, Magi-Galluzzi C, Klein EA and Ting AH: Dysregulation of cholesterol homeostasis in human prostate cancer through loss of ABCA1. Cancer Res. 73:1211–1218. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Phillips MC: Molecular mechanisms of cellular cholesterol efflux. J Biol Chem. 289:24020–24029. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Chushi L, Wei W, Kangkang X, Yongzeng F, Ning X and Xiaolei C: HMGCR is up-regulated in gastric cancer and promotes the growth and migration of the cancer cells. Gene. 587:42–47. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Wang W, Lokman NA, Noye TM, Macpherson AM, Oehler MK and Ricciardelli C: ABCA1 is associated with the development of acquired chemotherapy resistance and predicts poor ovarian cancer outcome. Cancer Drug Resist. 4:485–502. 2021.PubMed/NCBI

8 

Jacobo-Albavera L, Domínguez-Pérez M, Medina-Leyte DJ, González-Garrido A and Villarreal-Molina T: The role of the ATP-binding cassette A1 (ABCA1) in human disease. Int J Mol Sci. 22:15932021. View Article : Google Scholar : PubMed/NCBI

9 

Luo X, Cheng C, Tan Z, Li N, Tang M, Yang L and Cao Y: Emerging roles of lipid metabolism in cancer metastasis. Mol Cancer. 16:762017. View Article : Google Scholar : PubMed/NCBI

10 

Adlakha YK, Khanna S, Singh R, Singh VP, Agrawal A and Saini N: Pro-apoptotic miRNA-128-2 modulates ABCA1, ABCG1 and RXRα expression and cholesterol homeostasis. Cell Death Dis. 4:e7802013. View Article : Google Scholar : PubMed/NCBI

11 

Yue S, Li J, Lee SY, Lee HJ, Shao T, Song B, Cheng L, Masterson TA, Liu X, Ratliff TL and Cheng JX: Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness. Cell Metab. 19:393–406. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Qiu Z, Yuan W, Chen T, Zhou C, Liu C, Huang Y, Han D and Huang Q: HMGCR positively regulated the growth and migration of glioblastoma cells. Gene. 576:22–27. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Ashida S, Kawada C and Inoue K: Stromal regulation of prostate cancer cell growth by mevalonate pathway enzymes HMGCS1 and HMGCR. Oncol Lett. 14:6533–6542. 2017.PubMed/NCBI

14 

Xiong T, Xu G, Huang XL, Lu KQ, Xie WQ, Yin K and Tu J: ATP-binding cassette transporter A1: A promising therapy target for prostate cancer. Mol Clin Oncol. 8:9–14. 2018.PubMed/NCBI

15 

Guo D, Reinitz F, Youssef M, Hong C, Nathanson D, Akhavan D, Kuga D, Amzajerdi AN, Soto H, Zhu S, et al: An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway. Cancer Discov. 1:442–456. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Touvier M, Fassier P, His M, Norat T, Chan DS, Blacher J, Hercberg S, Galan P, Druesne-Pecollo N and Latino-Martel P: Cholesterol and breast cancer risk: A systematic review and meta-analysis of prospective studies. Br J Nutr. 114:347–357. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Zhou P, Li B, Liu B, Chen T and Xiao J: Prognostic role of serum total cholesterol and high-density lipoprotein cholesterol in cancer survivors: A systematic review and meta-analysis. Clin Chim Acta. 477:94–104. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Guillaumond F, Bidaut G, Ouaissi M, Servais S, Gouirand V, Olivares O, Lac S, Borge L, Roques J, Gayet O, et al: Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma. Proc Natl Acad Sci USA. 112:2473–2478. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Menter DG, Ramsauer VP, Harirforoosh S, Chakraborty K, Yang P, His L, Newman RA and Krishnan K: Differential effects of pravastatin and simvastatin on the growth of tumor cells from different organ sites. PLoS One. 6:e288132011. View Article : Google Scholar : PubMed/NCBI

20 

Li J, Gu D, Lee SS, Song B, Bandyopadhyay S, Chen S, Konieczny SF, Ratliff TL, Liu X, Xie J and Cheng JX: Abrogating cholesterol esterification suppresses growth and metastasis of pancreatic cancer. Oncogene. 35:6378–6388. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Zhou T, Zhan J, Fang W, Zhao Y, Yang Y, Hou X, Zhang Z, He X, Zhang Y, Huang Y and Zhang L: Serum low-density lipoprotein and low-density lipoprotein expression level at diagnosis are favorable prognostic factors in patients with small-cell lung cancer (SCLC). BMC Cancer. 17:2692017. View Article : Google Scholar : PubMed/NCBI

22 

Cruz PM, Mo H, McConathy WJ, Sabnis N and Lacko AG: The role of cholesterol metabolism and cholesterol transport in carcinogenesis: A review of scientific findings, relevant to future cancer therapeutics. Front Pharmacol. 4:1192013. View Article : Google Scholar : PubMed/NCBI

23 

Folkerd EJ and Dowsett M: Influence of sex hormones on cancer progression. J Clin Oncol. 28:4038–4044. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Phillips MC: Is ABCA1 a lipid transfer protein? J Lipid Res. 59:749–763. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Saxena K and Shipley GG: Structural studies of detergent-solubilized and vesicle-reconstituted low-density lipoprotein (LDL) receptor. Biochemistry. 36:15940–15948. 1997. View Article : Google Scholar : PubMed/NCBI

26 

Vedhachalam C, Duong PT, Nickel M, Nguyen D, Dhanasekaran P, Saito H, Rothblat GH, Lund-Katz S and Phillips MC: Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-I and formation of high density lipoprotein particles. J Biol Chem. 282:25123–25130. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Nagao K, Tomioka M and Ueda K: Function and regulation of ABCA1-membrane meso-domain organization and reorganization. FEBS J. 278:3190–3203. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Takahashi Y and Smith JD: Cholesterol efflux to apolipoprotein AI involves endocytosis and resecretion in a calcium-dependent pathway. Proc Natl Acad Sci USA. 96:11358–11363. 1999. View Article : Google Scholar : PubMed/NCBI

29 

Lu R, Arakawa R, Ito-Osumi C, Iwamoto N and Yokoyama S: ApoA-I facilitates ABCA1 recycle/accumulation to cell surface by inhibiting its intracellular degradation and increases HDL generation. Arterioscler Thromb Vasc Biol. 28:1820–1824. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Hamon Y, Broccardo C, Chambenoit O, Luciani MF, Toti F, Chaslin S, Freyssinet JM, Devaux PF, McNeish J, Marguet D and Chimini G: ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine. Nat Cell Biol. 2:399–406. 2000. View Article : Google Scholar : PubMed/NCBI

31 

Landry YD, Denis M, Nandi S, Bell S, Vaughan AM and Zha X: ATP-binding cassette transporter A1 expression disrupts raft membrane microdomains through its ATPase-related functions. J Biol Chem. 281:36091–36101. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Santamarina-Fojo S, Remaley AT, Neufeld EB and Brewer HB Jr: Regulation and intracellular trafficking of the ABCA1 transporter. J Lipid Res. 42:1339–1345. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Koseki M, Hirano K, Masuda D, Ikegami C, Tanaka M, Ota A, Sandoval JC, Nakagawa-Toyama Y, Sato SB, Kobayashi T, et al: Increased lipid rafts and accelerated lipopolysaccharide-induced tumor necrosis factor-alpha secretion in Abca1-deficient macrophages. J Lipid Res. 48:299–306. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Tang SL, Chen WJ, Yin K, Zhao GJ, Mo ZC, Lv YC, Ouyang XP, Yu XH, Kuang HJ, Jiang ZS, et al: PAPP-A negatively regulates ABCA1, ABCG1 and SR-B1 expression by inhibiting LXRα through the IGF-I-mediated signaling pathway. Atherosclerosis. 222:344–354. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Wang N, Silver DL, Thiele C and Tall AR: ATP-binding cassette transporter A1 (ABCA1) functions as a cholesterol efflux regulatory protein. J Biol Chem. 276:23742–23747. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Smith JD, Le Goff W, Settle M, Brubaker G, Waelde C, Horwitz A and Oda MN: ABCA1 mediates concurrent cholesterol and phospholipid efflux to apolipoprotein A-I. J Lipid Res. 45:635–644. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Tall AR: An overview of reverse cholesterol transport. Eur Heart J. 19 (Suppl A):A31–A35. 1998.PubMed/NCBI

38 

Qian H, Zhao X, Cao P, Lei J, Yan N and Gong X: Structure of the human lipid exporter ABCA1. Cell. 169:1228–1239.e10. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Kang MH, Singaraja R and Hayden MR: Adenosine-triphosphate-binding cassette transporter-1 trafficking and function. Trends Cardiovasc Med. 20:41–49. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Yoshioka Y, Sasaki J, Yamamoto M, Saitoh K, Nakaya S and Kubokawa M: Quantitation by (1)H-NMR of dolichol, cholesterol and choline-containing lipids in extracts of normal and phathological thyroid tissue. NMR Biomed. 13:377–383. 2000. View Article : Google Scholar : PubMed/NCBI

41 

Ding X, Zhang W, Li S and Yang H: The role of cholesterol metabolism in cancer. Am J Cancer Res. 9:219–227. 2019.PubMed/NCBI

42 

Kitahara CM, Berrington de González A, Freedman ND, Huxley R, Mok Y, Jee SH and Samet JM: Total cholesterol and cancer risk in a large prospective study in Korea. J Clin Oncol. 29:1592–1598. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Huang B, Song BL and Xu C: Cholesterol metabolism in cancer: Mechanisms and therapeutic opportunities. Nat Metab. 2:132–141. 2020. View Article : Google Scholar : PubMed/NCBI

44 

Tabas I: Consequences of cellular cholesterol accumulation: Basic concepts and physiological implications. J Clin Invest. 110:905–911. 2002. View Article : Google Scholar : PubMed/NCBI

45 

Prochazka L, Koudelka S, Dong LF, Stursa J, Goodwin J, Neca J, Slavik J, Ciganek M, Masek J, Kluckova K, et al: Mitochondrial targeting overcomes ABCA1-dependent resistance of lung carcinoma to α-tocopheryl succinate. Apoptosis. 18:286–299. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Schimanski S, Wild PJ, Treeck O, Horn F, Sigruener A, Rudolph C, Blaszyk H, Klinkhammer-Schalke M, Ortmann O, Hartmann A and Schmitz G: Expression of the lipid transporters ABCA3 and ABCA1 is diminished in human breast cancer tissue. Horm Metab Res. 42:102–109. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Dufour J, Viennois E, De Boussac H, Baron S and Lobaccaro JM: Oxysterol receptors, AKT and prostate cancer. Curr Opin Pharmacol. 12:724–728. 2012. View Article : Google Scholar : PubMed/NCBI

48 

Maslyanko M, Harris RD and Mu D: Connecting cholesterol efflux factors to lung cancer biology and therapeutics. Int J Mol Sci. 22:72092021. View Article : Google Scholar : PubMed/NCBI

49 

Silvente-Poirot S and Poirot M: Cancer. Cholesterol and cancer, in the balance. Science. 343:1445–1446. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Smith B and Land H: Anticancer activity of the cholesterol exporter ABCA1 gene. Cell Rep. 2:580–590. 2012. View Article : Google Scholar : PubMed/NCBI

51 

Liu K, Zhang W, Tan J, Ma J and Zhao J: MiR-200b-3p functions as an oncogene by targeting ABCA1 in lung adenocarcinoma. Technol Cancer Res Treat. 18:15330338198925902019. View Article : Google Scholar : PubMed/NCBI

52 

Huang CX, Zhang YL, Wang JF, Jiang JY and Bao JL: MCP-1 impacts RCT by repressing ABCA1, ABCG1, and SR-BI through PI3K/Akt posttranslational regulation in HepG2 cells. J Lipid Res. 54:1231–1240. 2013. View Article : Google Scholar : PubMed/NCBI

53 

Thysell E, Surowiec I, Hörnberg E, Crnalic S, Widmark A, Johansson AI, Stattin P, Bergh A, Moritz T, Antti H and Wikström P: Metabolomic characterization of human prostate cancer bone metastases reveals increased levels of cholesterol. PLoS One. 5:e141752010. View Article : Google Scholar : PubMed/NCBI

54 

Murai T, Maruyama Y, Mio K, Nishiyama H, Suga M and Sato C: Low cholesterol triggers membrane microdomain-dependent CD44 shedding and suppresses tumor cell migration. J Biol Chem. 286:1999–2007. 2011. View Article : Google Scholar : PubMed/NCBI

55 

Ramprasad OG, Srinivas G, Rao KS, Joshi P, Thiery JP, Dufour S and Pande G: Changes in cholesterol levels in the plasma membrane modulate cell signaling and regulate cell adhesion and migration on fibronectin. Cell Motil Cytoskeleton. 64:199–216. 2007. View Article : Google Scholar : PubMed/NCBI

56 

Plösch T, Gellhaus A, van Straten EM, Wolf N, Huijkman NC, Schmidt M, Dunk CE, Kuipers F and Winterhager E: The liver X receptor (LXR) and its target gene ABCA1 are regulated upon low oxygen in human trophoblast cells: A reason for alterations in preeclampsia? Placenta. 31:910–918. 2010. View Article : Google Scholar : PubMed/NCBI

57 

Ohno Y, Ohori M, Nakashima J, Okubo H, Satake N, Hashimoto T and Tachibana M: Association between preoperative serum total cholesterol level and biochemical recurrence in prostate cancer patients who underwent radical prostatectomy. Mol Clin Oncol. 4:1073–1077. 2016. View Article : Google Scholar : PubMed/NCBI

58 

Buchwald H: Cholesterol inhibition, cancer, and chemotherapy. Lancet. 339:1154–1156. 1992. View Article : Google Scholar : PubMed/NCBI

59 

Cerovska E, Elsnerova K, Vaclavikova R and Soucek P: The role of membrane transporters in ovarian cancer chemoresistance and prognosis. Expert Opin Drug Metab Toxicol. 13:741–753. 2017. View Article : Google Scholar : PubMed/NCBI

60 

Amaar YG and Reeves ME: RASSF1C regulates miR-33a and EMT marker gene expression in lung cancer cells. Oncotarget. 10:123–132. 2019. View Article : Google Scholar : PubMed/NCBI

61 

Di Nicolantonio F, Mercer SJ, Knight LA, Gabriel FG, Whitehouse PA, Sharma S, Fernando A, Glaysher S, Di Palma S, Johnson P, et al: Cancer cell adaptation to chemotherapy. BMC Cancer. 5:782005. View Article : Google Scholar : PubMed/NCBI

62 

Shang Y, Zhang Z, Liu Z, Feng B, Ren G, Li K, Zhou L, Sun Y, Li M, Zhou J, et al: miR-508-5p regulates multidrug resistance of gastric cancer by targeting ABCB1 and ZNRD1. Oncogene. 33:3267–3276. 2014. View Article : Google Scholar : PubMed/NCBI

63 

Gottesman MM, Fojo T and Bates SE: Multidrug resistance in cancer: Role of ATP-dependent transporters. Nat Rev Cancer. 2:48–58. 2002. View Article : Google Scholar : PubMed/NCBI

64 

Moitra K: Overcoming multidrug resistance in cancer stem cells. Biomed Res Int. 2015:6357452015. View Article : Google Scholar : PubMed/NCBI

65 

Bachmeier BE, Iancu CM, Killian PH, Kronski E, Mirisola V, Angelini G, Jochum M, Nerlich AG and Pfeffer U: Overexpression of the ATP binding cassette gene ABCA1 determines resistance to Curcumin in M14 melanoma cells. Mol Cancer. 8:1292009. View Article : Google Scholar : PubMed/NCBI

66 

Hou H, Kang Y, Li Y, Zeng Y, Ding G and Shang J: miR-33a expression sensitizes Lgr5+ HCC-CSCs to doxorubicin via ABCA1. Neoplasma. 64:81–91. 2017. View Article : Google Scholar : PubMed/NCBI

67 

Iwasaki H, Okabe T, Takara K, Yoshida Y, Hanashiro K and Oku H: Down-regulation of lipids transporter ABCA1 increases the cytotoxicity of nitidine. Cancer Chemother Pharmacol. 66:953–959. 2010. View Article : Google Scholar : PubMed/NCBI

68 

Sun M, Yang C, Zheng J, Wang M, Chen M, Le DQS, Kjems J and Bünger CE: Enhanced efficacy of chemotherapy for breast cancer stem cells by simultaneous suppression of multidrug resistance and antiapoptotic cellular defense. Acta Biomater. 28:171–182. 2015. View Article : Google Scholar : PubMed/NCBI

69 

Chen JH, Zheng YL, Xu CQ, Gu LZ, Ding ZL, Qin L, Wang Y, Fu R, Wan YF and Hu CP: Valproic acid (VPA) enhances cisplatin sensitivity of non-small cell lung cancer cells via HDAC2 mediated down regulation of ABCA1. Biol Chem. 398:785–792. 2017. View Article : Google Scholar : PubMed/NCBI

70 

Ma Y, Li X, Cheng S, Wei W and Li Y: MicroRNA-106a confers cisplatin resistance in non-small cell lung cancer A549 cells by targeting adenosine triphosphatase-binding cassette A1. Mol Med Rep. 11:625–632. 2015. View Article : Google Scholar : PubMed/NCBI

71 

Heilos D, Röhrl C, Pirker C, Englinger B, Baier D, Mohr T, Schwaiger M, Iqbal SM, van Schoonhoven S, Klavins K, et al: Altered membrane rigidity via enhanced endogenous cholesterol synthesis drives cancer cell resistance to destruxins. Oncotarget. 9:25661–25680. 2018. View Article : Google Scholar : PubMed/NCBI

72 

Wali VB, Bachawal SV and Sylvester PW: Suppression in mevalonate synthesis mediates antitumor effects of combined statin and gamma-tocotrienol treatment. Lipids. 44:925–934. 2009. View Article : Google Scholar : PubMed/NCBI

73 

Chen W, Li L, Wang J, Zhang R, Zhang T, Wu Y, Wang S and Xing D: The ABCA1-efferocytosis axis: A new strategy to protect against atherosclerosis. Clin Chim Acta. 518:1–8. 2021. View Article : Google Scholar : PubMed/NCBI

74 

Srivastava N: ATP binding cassette transporter A1-key roles in cellular lipid transport and atherosclerosis. Mol Cell Biochem. 237:155–164. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wu K, Zou L, Lei X and Yang X: Roles of ABCA1 in cancer (Review). Oncol Lett 24: 349, 2022.
APA
Wu, K., Zou, L., Lei, X., & Yang, X. (2022). Roles of ABCA1 in cancer (Review). Oncology Letters, 24, 349. https://doi.org/10.3892/ol.2022.13469
MLA
Wu, K., Zou, L., Lei, X., Yang, X."Roles of ABCA1 in cancer (Review)". Oncology Letters 24.4 (2022): 349.
Chicago
Wu, K., Zou, L., Lei, X., Yang, X."Roles of ABCA1 in cancer (Review)". Oncology Letters 24, no. 4 (2022): 349. https://doi.org/10.3892/ol.2022.13469
Copy and paste a formatted citation
x
Spandidos Publications style
Wu K, Zou L, Lei X and Yang X: Roles of ABCA1 in cancer (Review). Oncol Lett 24: 349, 2022.
APA
Wu, K., Zou, L., Lei, X., & Yang, X. (2022). Roles of ABCA1 in cancer (Review). Oncology Letters, 24, 349. https://doi.org/10.3892/ol.2022.13469
MLA
Wu, K., Zou, L., Lei, X., Yang, X."Roles of ABCA1 in cancer (Review)". Oncology Letters 24.4 (2022): 349.
Chicago
Wu, K., Zou, L., Lei, X., Yang, X."Roles of ABCA1 in cancer (Review)". Oncology Letters 24, no. 4 (2022): 349. https://doi.org/10.3892/ol.2022.13469
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