Roles of ABCA1 in cancer (Review)

  • Authors:
    • Kun Wu
    • Longwei Zou
    • Xiaoyong Lei
    • Xiaoyan Yang
  • View Affiliations

  • Published online on: August 19, 2022     https://doi.org/10.3892/ol.2022.13469
  • Article Number: 349
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Abstract

Studies have indicated that anticancer drugs targeting cholesterol metabolism have clinical significance. From the perspective of the mechanism of cholesterol excretion from cells, ATP‑binding cassette (ABC)A1 has an essential role that cannot be ignored. ABCA1 is located on the cell membrane and able to mediate the efflux of lipids, such as intracellular cholesterol, thereby initiating reverse cholesterol transport to reduce the intracellular cholesterol level. Therefore, inducing the expression of ABCA1 may become a new breakthrough point in cancer therapy.
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October-2022
Volume 24 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Wu K, Zou L, Lei X and Yang X: Roles of ABCA1 in cancer (Review). Oncol Lett 24: 349, 2022
APA
Wu, K., Zou, L., Lei, X., & Yang, X. (2022). Roles of ABCA1 in cancer (Review). Oncology Letters, 24, 349. https://doi.org/10.3892/ol.2022.13469
MLA
Wu, K., Zou, L., Lei, X., Yang, X."Roles of ABCA1 in cancer (Review)". Oncology Letters 24.4 (2022): 349.
Chicago
Wu, K., Zou, L., Lei, X., Yang, X."Roles of ABCA1 in cancer (Review)". Oncology Letters 24, no. 4 (2022): 349. https://doi.org/10.3892/ol.2022.13469