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Six autoantibodies as potential differential biomarkers of hepatocellular carcinoma vs. liver cirrhosis and chronic hepatitis: A prospective multi‑institutional study

  • Authors:
    • Rei Okada
    • Yuichiro Otsuka
    • Osamu Yokosuka
    • Naoya Kato
    • Fumio Imazaki
    • Isamu Hoshino
    • Nobuyuki Sugiura
    • Hideaki Mizumoto
    • Ryousaku Azemoto
    • Kazuki Kato
    • Hideaki Shimada
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, School of Medicine, Toho University, Tokyo 143‑8541, Japan, Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba‑shi, Chiba 260‑8677, Japan, Department of Surgery, Chiba Cancer Center, Chiba‑shi, Chiba 260‑8717, Japan, Department of Gastroenterology, Japan Community Health Care Organization Chiba Hospital, Chiba‑shi, Chiba 260‑8710, Japan, Department of Gastroenterology, Funabashi Municipal Medical Center, Funabashi, Chiba 273‑8588, Japan, Department of Gastroenterology, Kimitsu Chuo Hospital, Kimitsu, Chiba 292‑8535, Japan, Department of Gastroenterology, Japan Community Health Care Organization Funabashi Central Hospital, Funabashi, Chiba 273‑8556, Japan
    Copyright: © Okada et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 367
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    Published online on: August 31, 2022
       https://doi.org/10.3892/ol.2022.13487
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Abstract

Serum autoantibodies respond not only to tumor‑associated antigens of hepatocellular carcinoma (HCC) but also to those of liver cirrhosis (LC) and chronic hepatitis (CH). The present prospective multi‑institutional study evaluated the diagnostic properties of six autoantibodies in distinguishing HCC from LC and CH. A total of 416 participants were enrolled: 149 With HCC, 76 with LC, 103 with CH and 88 healthy controls. Titers of serum autoantibodies to Sui1, RalA, p62, p53, c‑myc and NY‑ESO‑1 were determined using enzyme‑linked immunosorbent assays. All six antibodies were positive for HCC: s‑Sui1‑Abs (44%), s‑RalA‑Abs (23%), s‑p62‑Abs (21%), s‑p53‑Abs (13%), s‑c‑myc‑Abs (11%) and s‑NY‑ESO‑1‑Abs (6%). The positivity rates of all six antibodies combined were 5% for healthy controls, 52% for CH, 58% for LC and 66% for HCC. The positivity rates of s‑Sui1‑Abs, s‑RalA‑Abs and s‑p53‑Abs were higher for HCC compared with those of LC and CH. However, the positivity rates of s‑p62‑Abs, s‑c‑myc‑Abs and s‑NY‑ESO‑1‑Abs for HCC were not higher compared with those for LC and CH. Overall, autoantibodies were useful in differentiating patients with HCC from healthy individuals. However, they were not specific to HCC and were also present in the sera of individuals with CH and LC. These autoantibodies may be induced during the development of HCC. Clinical trial registration number: UMIN000014530 (date of registration 2011/07/11).
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Copy and paste a formatted citation
Spandidos Publications style
Okada R, Otsuka Y, Yokosuka O, Kato N, Imazaki F, Hoshino I, Sugiura N, Mizumoto H, Azemoto R, Kato K, Kato K, et al: Six autoantibodies as potential differential biomarkers of hepatocellular carcinoma vs. liver cirrhosis and chronic hepatitis: A prospective multi‑institutional study. Oncol Lett 24: 367, 2022.
APA
Okada, R., Otsuka, Y., Yokosuka, O., Kato, N., Imazaki, F., Hoshino, I. ... Shimada, H. (2022). Six autoantibodies as potential differential biomarkers of hepatocellular carcinoma vs. liver cirrhosis and chronic hepatitis: A prospective multi‑institutional study. Oncology Letters, 24, 367. https://doi.org/10.3892/ol.2022.13487
MLA
Okada, R., Otsuka, Y., Yokosuka, O., Kato, N., Imazaki, F., Hoshino, I., Sugiura, N., Mizumoto, H., Azemoto, R., Kato, K., Shimada, H."Six autoantibodies as potential differential biomarkers of hepatocellular carcinoma vs. liver cirrhosis and chronic hepatitis: A prospective multi‑institutional study". Oncology Letters 24.4 (2022): 367.
Chicago
Okada, R., Otsuka, Y., Yokosuka, O., Kato, N., Imazaki, F., Hoshino, I., Sugiura, N., Mizumoto, H., Azemoto, R., Kato, K., Shimada, H."Six autoantibodies as potential differential biomarkers of hepatocellular carcinoma vs. liver cirrhosis and chronic hepatitis: A prospective multi‑institutional study". Oncology Letters 24, no. 4 (2022): 367. https://doi.org/10.3892/ol.2022.13487
Copy and paste a formatted citation
x
Spandidos Publications style
Okada R, Otsuka Y, Yokosuka O, Kato N, Imazaki F, Hoshino I, Sugiura N, Mizumoto H, Azemoto R, Kato K, Kato K, et al: Six autoantibodies as potential differential biomarkers of hepatocellular carcinoma vs. liver cirrhosis and chronic hepatitis: A prospective multi‑institutional study. Oncol Lett 24: 367, 2022.
APA
Okada, R., Otsuka, Y., Yokosuka, O., Kato, N., Imazaki, F., Hoshino, I. ... Shimada, H. (2022). Six autoantibodies as potential differential biomarkers of hepatocellular carcinoma vs. liver cirrhosis and chronic hepatitis: A prospective multi‑institutional study. Oncology Letters, 24, 367. https://doi.org/10.3892/ol.2022.13487
MLA
Okada, R., Otsuka, Y., Yokosuka, O., Kato, N., Imazaki, F., Hoshino, I., Sugiura, N., Mizumoto, H., Azemoto, R., Kato, K., Shimada, H."Six autoantibodies as potential differential biomarkers of hepatocellular carcinoma vs. liver cirrhosis and chronic hepatitis: A prospective multi‑institutional study". Oncology Letters 24.4 (2022): 367.
Chicago
Okada, R., Otsuka, Y., Yokosuka, O., Kato, N., Imazaki, F., Hoshino, I., Sugiura, N., Mizumoto, H., Azemoto, R., Kato, K., Shimada, H."Six autoantibodies as potential differential biomarkers of hepatocellular carcinoma vs. liver cirrhosis and chronic hepatitis: A prospective multi‑institutional study". Oncology Letters 24, no. 4 (2022): 367. https://doi.org/10.3892/ol.2022.13487
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