Open Access

Six autoantibodies as potential differential biomarkers of hepatocellular carcinoma vs. liver cirrhosis and chronic hepatitis: A prospective multi‑institutional study

  • Authors:
    • Rei Okada
    • Yuichiro Otsuka
    • Osamu Yokosuka
    • Naoya Kato
    • Fumio Imazaki
    • Isamu Hoshino
    • Nobuyuki Sugiura
    • Hideaki Mizumoto
    • Ryousaku Azemoto
    • Kazuki Kato
    • Hideaki Shimada
  • View Affiliations

  • Published online on: August 31, 2022     https://doi.org/10.3892/ol.2022.13487
  • Article Number: 367
  • Copyright: © Okada et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Serum autoantibodies respond not only to tumor‑associated antigens of hepatocellular carcinoma (HCC) but also to those of liver cirrhosis (LC) and chronic hepatitis (CH). The present prospective multi‑institutional study evaluated the diagnostic properties of six autoantibodies in distinguishing HCC from LC and CH. A total of 416 participants were enrolled: 149 With HCC, 76 with LC, 103 with CH and 88 healthy controls. Titers of serum autoantibodies to Sui1, RalA, p62, p53, c‑myc and NY‑ESO‑1 were determined using enzyme‑linked immunosorbent assays. All six antibodies were positive for HCC: s‑Sui1‑Abs (44%), s‑RalA‑Abs (23%), s‑p62‑Abs (21%), s‑p53‑Abs (13%), s‑c‑myc‑Abs (11%) and s‑NY‑ESO‑1‑Abs (6%). The positivity rates of all six antibodies combined were 5% for healthy controls, 52% for CH, 58% for LC and 66% for HCC. The positivity rates of s‑Sui1‑Abs, s‑RalA‑Abs and s‑p53‑Abs were higher for HCC compared with those of LC and CH. However, the positivity rates of s‑p62‑Abs, s‑c‑myc‑Abs and s‑NY‑ESO‑1‑Abs for HCC were not higher compared with those for LC and CH. Overall, autoantibodies were useful in differentiating patients with HCC from healthy individuals. However, they were not specific to HCC and were also present in the sera of individuals with CH and LC. These autoantibodies may be induced during the development of HCC. Clinical trial registration number: UMIN000014530 (date of registration 2011/07/11).
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October-2022
Volume 24 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Okada R, Otsuka Y, Yokosuka O, Kato N, Imazaki F, Hoshino I, Sugiura N, Mizumoto H, Azemoto R, Kato K, Kato K, et al: Six autoantibodies as potential differential biomarkers of hepatocellular carcinoma vs. liver cirrhosis and chronic hepatitis: A prospective multi‑institutional study. Oncol Lett 24: 367, 2022
APA
Okada, R., Otsuka, Y., Yokosuka, O., Kato, N., Imazaki, F., Hoshino, I. ... Shimada, H. (2022). Six autoantibodies as potential differential biomarkers of hepatocellular carcinoma vs. liver cirrhosis and chronic hepatitis: A prospective multi‑institutional study. Oncology Letters, 24, 367. https://doi.org/10.3892/ol.2022.13487
MLA
Okada, R., Otsuka, Y., Yokosuka, O., Kato, N., Imazaki, F., Hoshino, I., Sugiura, N., Mizumoto, H., Azemoto, R., Kato, K., Shimada, H."Six autoantibodies as potential differential biomarkers of hepatocellular carcinoma vs. liver cirrhosis and chronic hepatitis: A prospective multi‑institutional study". Oncology Letters 24.4 (2022): 367.
Chicago
Okada, R., Otsuka, Y., Yokosuka, O., Kato, N., Imazaki, F., Hoshino, I., Sugiura, N., Mizumoto, H., Azemoto, R., Kato, K., Shimada, H."Six autoantibodies as potential differential biomarkers of hepatocellular carcinoma vs. liver cirrhosis and chronic hepatitis: A prospective multi‑institutional study". Oncology Letters 24, no. 4 (2022): 367. https://doi.org/10.3892/ol.2022.13487