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Expression level comparison of marker genes related to early embryonic development and tumor growth

  • Authors:
    • Qiu-Chen Cai
    • Da-Lun Li
    • Ying Zhang
    • Yun-Yi Liu
    • Pei Fang
    • Si-Qin Zheng
    • Yue-Yan Zhang
    • Ya-Kun Yang
    • Chun Hou
    • Cheng-Wei Gao
    • Qi-Shun Zhu
    • Chuan-Hai Cao
  • View Affiliations / Copyright

    Affiliations: School of Life Sciences, Yunnan University, Kunming, Yunnan 650500, P.R. China, School of Ecology and Environmental Science, Yunnan University, Kunming, Yunnan 650500, P.R. China, School of Chemical Science and Technology, Yunnan University, Kunming, Yunnan 650500, P.R. China, Taneja College of Pharmacy, University of South Florida, Tampa, FL 33612, USA
    Copyright: © Cai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 444
    |
    Published online on: October 26, 2022
       https://doi.org/10.3892/ol.2022.13564
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Abstract

In tumor research, the occurrence and origin of tumors are the fundamental problems. In the 1970s, the basic discussion of the developmental biology problem of tumors was proposed, and it was believed that tumorigenesis is closely related to developmental biology. Tumors are abnormal biological structures in organisms, and their biological behavior is very similar to that of the early embryo. Many tumor‑related genes also serve regulatory roles in the normal development and differentiation of embryos. However, it remains unclear whether gene expression in early embryos has any similarities with tumor cells. In this study, to compare the similarities and differences in gene expression between early embryos and tumor cells, reverse transcription‑quantitative PCR was conducted to determine and compare the relative expression levels of nine tumor‑related genes in the brain glioma cell line, T98G, and in the early embryo of Spodoptera litura, which is fast‑growing, low‑cost, easily accessible and easy to observe. The expression of tumor‑related genes in early embryos and the similarity of regulatory mechanisms between early embryonic development and tumor growth were explored. In conclusion, tumor growth may be regarded as an abnormal embryogenic activation that happens in the organs of adult individuals.
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Copy and paste a formatted citation
Spandidos Publications style
Cai Q, Li D, Zhang Y, Liu Y, Fang P, Zheng S, Zhang Y, Yang Y, Hou C, Gao C, Gao C, et al: Expression level comparison of marker genes related to early embryonic development and tumor growth. Oncol Lett 24: 444, 2022.
APA
Cai, Q., Li, D., Zhang, Y., Liu, Y., Fang, P., Zheng, S. ... Cao, C. (2022). Expression level comparison of marker genes related to early embryonic development and tumor growth. Oncology Letters, 24, 444. https://doi.org/10.3892/ol.2022.13564
MLA
Cai, Q., Li, D., Zhang, Y., Liu, Y., Fang, P., Zheng, S., Zhang, Y., Yang, Y., Hou, C., Gao, C., Zhu, Q., Cao, C."Expression level comparison of marker genes related to early embryonic development and tumor growth". Oncology Letters 24.6 (2022): 444.
Chicago
Cai, Q., Li, D., Zhang, Y., Liu, Y., Fang, P., Zheng, S., Zhang, Y., Yang, Y., Hou, C., Gao, C., Zhu, Q., Cao, C."Expression level comparison of marker genes related to early embryonic development and tumor growth". Oncology Letters 24, no. 6 (2022): 444. https://doi.org/10.3892/ol.2022.13564
Copy and paste a formatted citation
x
Spandidos Publications style
Cai Q, Li D, Zhang Y, Liu Y, Fang P, Zheng S, Zhang Y, Yang Y, Hou C, Gao C, Gao C, et al: Expression level comparison of marker genes related to early embryonic development and tumor growth. Oncol Lett 24: 444, 2022.
APA
Cai, Q., Li, D., Zhang, Y., Liu, Y., Fang, P., Zheng, S. ... Cao, C. (2022). Expression level comparison of marker genes related to early embryonic development and tumor growth. Oncology Letters, 24, 444. https://doi.org/10.3892/ol.2022.13564
MLA
Cai, Q., Li, D., Zhang, Y., Liu, Y., Fang, P., Zheng, S., Zhang, Y., Yang, Y., Hou, C., Gao, C., Zhu, Q., Cao, C."Expression level comparison of marker genes related to early embryonic development and tumor growth". Oncology Letters 24.6 (2022): 444.
Chicago
Cai, Q., Li, D., Zhang, Y., Liu, Y., Fang, P., Zheng, S., Zhang, Y., Yang, Y., Hou, C., Gao, C., Zhu, Q., Cao, C."Expression level comparison of marker genes related to early embryonic development and tumor growth". Oncology Letters 24, no. 6 (2022): 444. https://doi.org/10.3892/ol.2022.13564
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