Primary malignant melanoma of the bladder collides with high‑grade non‑invasive urothelial papillary carcinoma:
A case report
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- Published online on: October 31, 2022 https://doi.org/10.3892/ol.2022.13571
- Article Number: 451
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Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
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Abstract
The present study reported a case of primary malignant melanoma of the bladder colliding with high‑grade non‑invasive urothelial papillary carcinoma with clinical, pathologic and immunohistochemical analysis, and reviewed the relevant literature. A 74‑year‑old male presented with hematuria; B ultrasound and computed tomography revealed a solid mass in the bladder and transurethral resection of the bladder lesion was performed. Microscopically, the tumors were composed of morphologically diverse malignant melanomas (95%) and high‑grade non‑invasive urothelial papillary carcinoma (5%), with no closely related or transitional regions. Immunohistochemistry indicated that malignant melanoma cells expressed HMB45, Melan‑A and S‑100, whereas they did not express any epithelial markers. The urothelial carcinomas expressed broad‑spectrum cytokeratin and GATA3, and were negative for melanoma markers. The diagnosis of collision tumor between primary malignant melanoma of bladder and high‑grade non‑invasive urothelial papillary carcinoma depends on clinical and pathological examinations; this pathology is prone to recurrence and metastasis and has a poor prognosis.
