Open Access

Near complete remission of a locally advanced giant melanoma of the vulva following hypo‑fractionated radiotherapy and immune checkpoint inhibitors: A case report

  • Authors:
    • Shuang Chen
    • Xuemei Deng
    • Chen Xie
    • Qingke Dong
    • Hongru Yang
  • View Affiliations

  • Published online on: November 2, 2022     https://doi.org/10.3892/ol.2022.13578
  • Article Number: 458
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Melanoma is known to be insensitive to radiotherapy; however, the present study reports the case of a patient with vulvar malignant melanoma in which near complete remission of the target area was observed after implementing immune checkpoint inhibitors (ICIs) and hypo‑fractionated radiotherapy (HFRT). The patient was treated with an intensity‑modulated radiation therapy technique that delivered a hypo‑fractionated dose of 3,000 cGy in six fractions. After 3 days, the patient underwent immunotherapy with two cycles of 240 mg triprizumab every 2 weeks. Tumors that underwent radiotherapy had markedly decreased in size and a near complete remission of the melanoma was observed 4 months after radiotherapy. However, the metastases in the liver and lungs continued to grow, new metastases appeared in the abdominal subcutaneous tissue and enlarged lymph nodes were observed in the pelvic area. The results of the present study indicated that ICIs and HFRT exert a marked local effect, but no abscopal effect.
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December-2022
Volume 24 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Chen S, Deng X, Xie C, Dong Q and Yang H: Near complete remission of a locally advanced giant melanoma of the vulva following hypo‑fractionated radiotherapy and immune checkpoint inhibitors: A case report. Oncol Lett 24: 458, 2022
APA
Chen, S., Deng, X., Xie, C., Dong, Q., & Yang, H. (2022). Near complete remission of a locally advanced giant melanoma of the vulva following hypo‑fractionated radiotherapy and immune checkpoint inhibitors: A case report. Oncology Letters, 24, 458. https://doi.org/10.3892/ol.2022.13578
MLA
Chen, S., Deng, X., Xie, C., Dong, Q., Yang, H."Near complete remission of a locally advanced giant melanoma of the vulva following hypo‑fractionated radiotherapy and immune checkpoint inhibitors: A case report". Oncology Letters 24.6 (2022): 458.
Chicago
Chen, S., Deng, X., Xie, C., Dong, Q., Yang, H."Near complete remission of a locally advanced giant melanoma of the vulva following hypo‑fractionated radiotherapy and immune checkpoint inhibitors: A case report". Oncology Letters 24, no. 6 (2022): 458. https://doi.org/10.3892/ol.2022.13578