Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December-2022 Volume 24 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2022 Volume 24 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Potential of blood exosomal ENAH, SEPT9, EGF, MMP‑9 and CXCL8 for the early screening of breast cancer

  • Authors:
    • Zijing Zhang
    • Hongying Wang
    • Yiting Jin
    • Chengyu Chu
    • Jinsong Bai
    • Juntian Huang
    • Lemei Yang
    • Feng Tang
    • Liping Zou
    • Shuyang Wang
    • Qiang Zou
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China, Department of Clinical Medicine, Shanghai Medical College, Fudan University, Shanghai 200433, P.R. China, Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, P.R. China, Department of Pathology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 460
    |
    Published online on: November 3, 2022
       https://doi.org/10.3892/ol.2022.13580
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Exosomal contents have been recognized as candidate biomarkers for cancer screening and prognosis. The current study aimed to evaluate the potential of the expression levels of exosomal enabled homolog (ENAH), septin 9 (SEPT9), epidermal growth factor (EGF), matrix metalloproteinase‑9 (MMP‑9) and C‑X‑C motif chemokine ligand 8 (CXCL8) in the blood for the early screening of breast cancer. Therefore, exosomes were extracted and purified from the peripheral blood of 47 patients with breast cancer, 63 disease controls (DCs) and 33 healthy controls (HCs). Subsequently, the exosomal mRNA expression levels of ENAH, SEPT9, EGF, MMP‑9 and CXCL8 were detected by reverse transcription‑quantitative polymerase chain reaction. The results showed that the exosomal levels of ENAH and EGF were significantly higher in patients with breast cancer compared with DCs and HCs (both P<0.001). In addition, receiver operating characteristic curves revealed that exosomal ENAH was able to discriminate patients with breast cancer from DCs [area under the curve (AUC), 0.841] and HCs (AUC, 0.859). However, exosomal EGF was only able to discriminate patients with breast cancer from HCs (AUC, 0.776). Furthermore, the levels of exosomal SEPT9 were lower in patients with breast cancer compared with DCs and HCs (P=0.021), and exosomal SEPT9 expression levels exhibited good potential in the discrimination of patients with breast cancer from DCs (AUC, 0.717) and HCs (AUC, 0.830). However, no significant difference was detected in exosomal levels of MMP‑9 and CXCL8 among the three groups, and these RNAs showed no discriminative ability. In addition, in patients with breast cancer, the exosomal levels of ENAH were associated with molecular subtypes (P=0.010), while those of MMP‑9 were associated with a Ki‑67 index of ≥30% (P=0.011). In conclusion, the exosomal levels of ENAH, SEPT9 and EGF in blood samples were able to identify patients with breast cancer, thus providing a novel approach for the early screening of breast cancer.
View Figures

Figure 1

Figure 2

View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Smolarz B, Nowak AZ and Romanowicz H: Breast cancer-epidemiology, classification, pathogenesis and treatment (Review of Literature). Cancers (Basel). 14:25692022. View Article : Google Scholar : PubMed/NCBI

3 

Cao W, Chen HD, Yu YW, Li N and Chen WQ: Changing profiles of cancer burden worldwide and in China: A secondary analysis of the global cancer statistics 2020. Chin Med J (Engl). 134:783–791. 2021. View Article : Google Scholar : PubMed/NCBI

4 

Fan X, Zhang B, He Y, Zhou X, Zhang Y, Ma L, Li X and Wu J: Burden of disease due to cancer-China, 2000–2019. China CDC Wkly. 4:306–311. 2022. View Article : Google Scholar : PubMed/NCBI

5 

Mahanani MR, Valkov M, Agaeva A, Kaucher S, Pikalova LV, Grishchenko MY, Zhuikova LD, Jaehn P and Winkler V: Comparison of female breast cancer between Russia and Germany: A population-based study on time trends and stage at diagnosis. Cancer Epidemiol. 80:1022142022. View Article : Google Scholar : PubMed/NCBI

6 

Miller KD, Nogueira L, Devasia T, Mariotto AB, Yabroff KR, Jemal A, Kramer J and Siegel RL: Cancer treatment and survivorship statistics, 2022. CA Cancer J Clin. 72:409–436. 2022. View Article : Google Scholar : PubMed/NCBI

7 

Jani C, Salcicciol I, Rupal A, Al Omari O, Goodall R, Salciccioli JD, Marshall DC, Hanbury G, Singh H, Weissmann L and Shalhoub J: Trends in breast cancer mortality between 2001 and 2017: An observational study in the European Union and the United Kingdom. JCO Glob Oncol. 7:1682–1693. 2021. View Article : Google Scholar : PubMed/NCBI

8 

Yu W, Hurley J, Roberts D, Chakrabortty SK, Enderle D, Noerholm M, Breakefield XO and Skog JK: Exosome-based liquid biopsies in cancer: Opportunities and challenges. Ann Oncol. 32:466–477. 2021. View Article : Google Scholar : PubMed/NCBI

9 

Liu M, Mo F, Song X, He Y, Yuan Y, Yan J, Yang Y, Huang J and Zhang S: Exosomal hsa-miR-21-5p is a biomarker for breast cancer diagnosis. PeerJ. 9:e121472021. View Article : Google Scholar : PubMed/NCBI

10 

Wang X, Qian T, Bao S, Zhao H, Chen H, Xing Z, Li Y, Zhang M, Meng X, Wang C, et al: Circulating exosomal miR-363-5p inhibits lymph node metastasis by downregulating PDGFB and serves as a potential noninvasive biomarker for breast cancer. Mol Oncol. 15:2466–2479. 2021. View Article : Google Scholar : PubMed/NCBI

11 

Liu J, Peng X, Liu Y, Hao R, Zhao R, Zhang L, Zhao F, Liu Q, Liu Y and Qi Y: The diagnostic value of serum exosomal Has_circ_0000615 for breast cancer patients. Int J Gen Med. 14:4545–4554. 2021. View Article : Google Scholar : PubMed/NCBI

12 

Di Modugno F, DeMonte L, Balsamo M, Bronzi G, Nicotra MR, Alessio M, Jager E, Condeelis JS, Santoni A, Natali PG and Nisticò P: Molecular cloning of hMena (ENAH) and its splice variant hMena+11a: Epidermal growth factor increases their expression and stimulates hMena+11a phosphorylation in breast cancer cell lines. Cancer Res. 67:2657–2665. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Ahuja N, Ashok C, Natua S, Pant D, Cherian A, Pandkar MR, Yadav P, Vishnu NSS, Mishra J, Samaiya A and Shukla S: Hypoxia-induced TGF-β-RBFOX2-ESRP1 axis regulates human MENA alternative splicing and promotes EMT in breast cancer. NAR Cancer. 2:zcaa0212020. View Article : Google Scholar : PubMed/NCBI

14 

Zeng Y, Cao Y, Liu L, Zhao J, Zhang T, Xiao L, Jia M, Tian Q, Yu H, Chen S and Cai Y: SEPT9_i1 regulates human breast cancer cell motility through cytoskeletal and RhoA/FAK signaling pathway regulation. Cell Death Dis. 10:7202019. View Article : Google Scholar : PubMed/NCBI

15 

Devlin L, Okletey J, Perkins G, Bowen JR, Nakos K, Montagna C and Spiliotis ET: Proteomic profiling of the oncogenic septin 9 reveals isoform-specific interactions in breast cancer cells. Proteomics. 21:e21001552021. View Article : Google Scholar : PubMed/NCBI

16 

Lu C, Zhao Y, Wang J, Shi W, Dong F, Xin Y, Zhao X and Liu C: Breast cancer cell-derived extracellular vesicles transfer miR-182-5p and promote breast carcinogenesis via the CMTM7/EGFR/AKT axis. Mol Med. 27:782021. View Article : Google Scholar : PubMed/NCBI

17 

Kavarthapu R, Anbazhagan R and Dufau ML: Crosstalk between PRLR and EGFR/HER2 signaling pathways in breast cancer. Cancers (Basel). 13:46852021. View Article : Google Scholar : PubMed/NCBI

18 

Hong OY, Jang HY, Lee YR, Jung SH, Youn HJ and Kim JS: Inhibition of cell invasion and migration by targeting matrix metalloproteinase-9 expression via sirtuin 6 silencing in human breast cancer cells. Sci Rep. 12:121252022. View Article : Google Scholar : PubMed/NCBI

19 

Cancemi P, Buttacavoli M, Roz E and Feo S: Expression of alpha-enolase (ENO1), Myc promoter-binding protein-1 (MBP-1) and matrix metalloproteinases (MMP-2 and MMP-9) reflect the nature and aggressiveness of breast tumors. Int J Mol Sci. 20:39522019. View Article : Google Scholar : PubMed/NCBI

20 

Mishra A, Suman KH, Nair N, Majeed J and Tripathi V: An updated review on the role of the CXCL8-CXCR1/2 axis in the progression and metastasis of breast cancer. Mol Biol Rep. 48:6551–6561. 2021. View Article : Google Scholar : PubMed/NCBI

21 

Ruffini PA: The CXCL8-CXCR1/2 axis as a therapeutic target in breast cancer stem-like cells. Front Oncol. 9:402019. View Article : Google Scholar : PubMed/NCBI

22 

Wang RX, Ji P, Gong Y, Shao ZM and Chen S: Value of CXCL8-CXCR1/2 axis in neoadjuvant chemotherapy for triple-negative breast cancer patients: A retrospective pilot study. Breast Cancer Res Treat. 181:561–570. 2020. View Article : Google Scholar : PubMed/NCBI

23 

Breast Cancer Committee of Chinese Anti-Cancer Association, . Chinese Anti-Cancer Association Breast Cancer Diagnosis and Treatment Guidelines and Standards (2021). China Oncology. 31:954–1040. 2021.

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Han C, Bellone S, Siegel ER, Altwerger G, Menderes G, Bonazzoli E, Egawa-Takata T, Pettinella F, Bianchi A, Riccio F, et al: A novel multiple biomarker panel for the early detection of high-grade serous ovarian carcinoma. Gynecol Oncol. 149:585–591. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Luo C, Wang L, Zhang Y, Lu M, Lu B, Cai J, Chen H and Dai M: Advances in breast cancer screening modalities and status of global screening programs. Chronic Dis Transl Med. 8:112–123. 2022.PubMed/NCBI

27 

Ren W, Chen M, Qiao Y and Zhao F: Global guidelines for breast cancer screening: A systematic review. Breast. 64:85–99. 2022. View Article : Google Scholar : PubMed/NCBI

28 

Ding R, Xiao Y, Mo M, Zheng Y, Jiang YZ and Shao ZM: Breast cancer screening and early diagnosis in Chinese women. Cancer Biol Med. 19:450–467. 2022. View Article : Google Scholar : PubMed/NCBI

29 

Mann RM, Hooley R, Barr RG and Moy L: Novel approaches to screening for breast cancer. Radiology. 297:266–285. 2020. View Article : Google Scholar : PubMed/NCBI

30 

Wang H, Shu L, Niu N, Zhao C, Lu S, Li Y, Wang H, Liu Y, Zou T, Zou J, et al: Novel lncRNAs with diagnostic or prognostic value screened out from breast cancer via bioinformatics analyses. PeerJ. 10:e136412022. View Article : Google Scholar : PubMed/NCBI

31 

Jia L, Li G, Ma N, Zhang A, Zhou Y, Ren L and Dong D: Soluble POSTN is a novel biomarker complementing CA153 and CEA for breast cancer diagnosis and metastasis prediction. BMC Cancer. 22:7602022. View Article : Google Scholar : PubMed/NCBI

32 

Veyssiere H, Bidet Y, Penault-Llorca F, Radosevic-Robin N and Durando X: Circulating proteins as predictive and prognostic biomarkers in breast cancer. Clin Proteomics. 19:252022. View Article : Google Scholar : PubMed/NCBI

33 

Na-Er A, Xu YY, Liu YH and Gan YJ: Upregulation of serum exosomal SUMO1P3 predicts unfavorable prognosis in triple negative breast cancer. Eur Rev Med Pharmacol Sci. 25:154–160. 2021.PubMed/NCBI

34 

Lakshmi S, Hughes TA and Priya S: Exosomes and exosomal RNAs in breast cancer: A status update. Eur J Cancer. 144:252–268. 2021. View Article : Google Scholar : PubMed/NCBI

35 

Zokaei E, Darbeheshti F and Rezaei N: Prospect of exosomal circular RNAs in breast cancer: Presents and future. Mol Biol Rep. 49:6997–7011. 2022. View Article : Google Scholar : PubMed/NCBI

36 

Li QL, Su YL, Zeng M and Shen WX: Enabled homolog shown to be a potential biomarker and prognostic indicator for breast cancer by bioinformatics analysis. Clin Invest Med. 41:E186–E195. 2019. View Article : Google Scholar : PubMed/NCBI

37 

Matsui S, Kagara N, Mishima C, Naoi Y, Shimoda M, Shimomura A, Shimazu K, Kim SJ and Noguchi S: Methylation of the SEPT9_v2 promoter as a novel marker for the detection of circulating tumor DNA in breast cancer patients. Oncol Rep. 36:2225–2235. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Khambri D, Suyuthie HD, Hilbertina N, Yetti H and Purwanto DJ: Matrix metalloproteinase-9 as prognostic factor for the treatment of HER-2 enriched breast cancer. Asian Pac J Cancer Prev. 23:1013–1021. 2022. View Article : Google Scholar : PubMed/NCBI

39 

Yotsumoto F, Tokunaga E, Oki E, Maehara Y, Yamada H, Nakajima K, Nam SO, Miyata K, Koyanagi M, Doi K, et al: Molecular hierarchy of heparin-binding EGF-like growth factor-regulated angiogenesis in triple-negative breast cancer. Mol Cancer Res. 11:506–517. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Fang QI, Wang X, Luo G, Yu M, Zhang X and Xu N: Increased CXCL8 expression is negatively correlated with the overall survival of patients with ER-Negative breast cancer. Anticancer Res. 37:4845–4852. 2017.PubMed/NCBI

41 

Melchionna R, Iapicca P, Di Modugno F, Trono P, Sperduti I, Fassan M, Cataldo I, Rusev BC, Lawlor RT, Diodoro MG, et al: The pattern of hMENA isoforms is regulated by TGF-β1 in pancreatic cancer and may predict patient outcome. Oncoimmunology. 5:e12215562016. View Article : Google Scholar : PubMed/NCBI

42 

Wasserkort R, Kalmar A, Valcz G, Spisak S, Krispin M, Toth K, Tulassay Z, Sledziewski AZ and Molnar B: Aberrant septin 9 DNA methylation in colorectal cancer is restricted to a single CpG island. BMC Cancer. 13:3982013. View Article : Google Scholar : PubMed/NCBI

43 

Bai C, Ma X, Wang X and Chen X: Correlation between pathological features and protein expressions of TfR1, VEGF and MMP-9 in patients with osteosarcoma. Am J Transl Res. 14:4562–4572. 2022.PubMed/NCBI

44 

Kong L, Qi R, Zhou G and Ding S: Correlation analysis of survivin, ING4, CXCL8 and VEGF expression in prostate cancer tissue. Am J Transl Res. 13:13784–13790. 2021.PubMed/NCBI

45 

Hacisalihoglu UP and Dogan MA: Expression of estrogen and progesterone receptors, HER2 protein and Ki-67 proliferation index in breast carcinoma in both tumor tissue and tissue microarray. Biotech Histochem. 97:298–305. 2022. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang Z, Wang H, Jin Y, Chu C, Bai J, Huang J, Yang L, Tang F, Zou L, Wang S, Wang S, et al: Potential of blood exosomal ENAH, SEPT9, EGF, MMP‑9 and CXCL8 for the early screening of breast cancer. Oncol Lett 24: 460, 2022.
APA
Zhang, Z., Wang, H., Jin, Y., Chu, C., Bai, J., Huang, J. ... Zou, Q. (2022). Potential of blood exosomal ENAH, SEPT9, EGF, MMP‑9 and CXCL8 for the early screening of breast cancer. Oncology Letters, 24, 460. https://doi.org/10.3892/ol.2022.13580
MLA
Zhang, Z., Wang, H., Jin, Y., Chu, C., Bai, J., Huang, J., Yang, L., Tang, F., Zou, L., Wang, S., Zou, Q."Potential of blood exosomal ENAH, SEPT9, EGF, MMP‑9 and CXCL8 for the early screening of breast cancer". Oncology Letters 24.6 (2022): 460.
Chicago
Zhang, Z., Wang, H., Jin, Y., Chu, C., Bai, J., Huang, J., Yang, L., Tang, F., Zou, L., Wang, S., Zou, Q."Potential of blood exosomal ENAH, SEPT9, EGF, MMP‑9 and CXCL8 for the early screening of breast cancer". Oncology Letters 24, no. 6 (2022): 460. https://doi.org/10.3892/ol.2022.13580
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Z, Wang H, Jin Y, Chu C, Bai J, Huang J, Yang L, Tang F, Zou L, Wang S, Wang S, et al: Potential of blood exosomal ENAH, SEPT9, EGF, MMP‑9 and CXCL8 for the early screening of breast cancer. Oncol Lett 24: 460, 2022.
APA
Zhang, Z., Wang, H., Jin, Y., Chu, C., Bai, J., Huang, J. ... Zou, Q. (2022). Potential of blood exosomal ENAH, SEPT9, EGF, MMP‑9 and CXCL8 for the early screening of breast cancer. Oncology Letters, 24, 460. https://doi.org/10.3892/ol.2022.13580
MLA
Zhang, Z., Wang, H., Jin, Y., Chu, C., Bai, J., Huang, J., Yang, L., Tang, F., Zou, L., Wang, S., Zou, Q."Potential of blood exosomal ENAH, SEPT9, EGF, MMP‑9 and CXCL8 for the early screening of breast cancer". Oncology Letters 24.6 (2022): 460.
Chicago
Zhang, Z., Wang, H., Jin, Y., Chu, C., Bai, J., Huang, J., Yang, L., Tang, F., Zou, L., Wang, S., Zou, Q."Potential of blood exosomal ENAH, SEPT9, EGF, MMP‑9 and CXCL8 for the early screening of breast cancer". Oncology Letters 24, no. 6 (2022): 460. https://doi.org/10.3892/ol.2022.13580
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team