Open Access

Additional diagnostic value of the monocyte to red blood cell count ratio and the product of lymphocyte count and albumin concentration in lung cancer management

  • Authors:
    • Xin-Xin Chen
    • Si-Ting Zhao
    • Xian-Miao Yang
    • Shan-Chuan He
    • Fen-Hong Qian
  • View Affiliations

  • Published online on: February 15, 2023     https://doi.org/10.3892/ol.2023.13721
  • Article Number: 135
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study aimed to evaluate the potential of the monocyte to red blood cell count ratio (MRR), the neutrophil to red blood cell count ratio (NRR), the lymphocyte to red blood cell count ratio (LRR) and the product of lymphocyte count and albumin concentration (LA) for the diagnosis of lung cancer. The cases of 216 patients with newly diagnosed lung cancer and 184 healthy volunteers were retrospectively analysed. The MRR and NRR were found to be higher in patients with lung cancer compared with those in healthy controls, while the LRR and LA were lower. The receiver operating characteristic curve analysis revealed that of the four markers, the MRR and LA yielded a higher area under the curve (AUC) (MRR: AUC, 0.810; 95% CI, 0.768‑0.847; and LA: AUC, 0.721; 95% CI, 0.674‑0.764). The combination of MRR, LA, carcinoembryonic antigen (CEA) and cytokeratin 19 fragment antigen 21‑1 (CYFRA21‑1) achieved the highest diagnostic value when compared with other single or combined markers (AUC, 0.882; 95% CI, 0.846‑0.912; sensitivity, 81.9%; specificity, 81.0%). As the disease progressed, the MRR tended to increase, while LA exhibited a decreasing trend. Binary logistic regression analysis revealed an increase in the MRR, as well as in CEA and CYFRA21‑1 concentrations, and a decrease in the LA, which could all be possible risk factors for lung cancer. Differences in the MRR and LA between patients with early stage (IA‑IIIA) lung cancer and healthy controls were observed. Further analysis revealed that the MRR also exhibited the potential to detect early stage (IA‑IIIA) lung cancer in the model. The present findings demonstrated that the MRR and LA may be used as auxiliary biomarkers for the diagnosis of lung cancer and could partly indicate disease progression.
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April-2023
Volume 25 Issue 4

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Copy and paste a formatted citation
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Spandidos Publications style
Chen X, Zhao S, Yang X, He S and Qian F: Additional diagnostic value of the monocyte to red blood cell count ratio and the product of lymphocyte count and albumin concentration in lung cancer management. Oncol Lett 25: 135, 2023
APA
Chen, X., Zhao, S., Yang, X., He, S., & Qian, F. (2023). Additional diagnostic value of the monocyte to red blood cell count ratio and the product of lymphocyte count and albumin concentration in lung cancer management. Oncology Letters, 25, 135. https://doi.org/10.3892/ol.2023.13721
MLA
Chen, X., Zhao, S., Yang, X., He, S., Qian, F."Additional diagnostic value of the monocyte to red blood cell count ratio and the product of lymphocyte count and albumin concentration in lung cancer management". Oncology Letters 25.4 (2023): 135.
Chicago
Chen, X., Zhao, S., Yang, X., He, S., Qian, F."Additional diagnostic value of the monocyte to red blood cell count ratio and the product of lymphocyte count and albumin concentration in lung cancer management". Oncology Letters 25, no. 4 (2023): 135. https://doi.org/10.3892/ol.2023.13721