Open Access

Role and therapeutic targeting of glutamine metabolism in non‑small cell lung cancer (Review)

  • Authors:
    • Lei Zhou
    • Qi Zhang
    • Qing Zhu
    • Yuan Zhan
    • Yong Li
    • Xuan Huang
  • View Affiliations

  • Published online on: March 7, 2023     https://doi.org/10.3892/ol.2023.13745
  • Article Number: 159
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The Warburg effect indicates that cancer cells survive through glycolysis under aerobic conditions; as such, the topic of cancer metabolism has aroused interest. It is requisite to further explore cancer metabolism, as it helps to simultaneously explain the process of carcinogenesis and guide therapy. The flexible metabolism of cancer cells, which is the result of metabolic reprogramming, can meet the basic needs of cells, even in a nutrition‑deficient environment. Glutamine is the most abundant non‑essential amino acid in the circulation, and along with glucose, comprise the two basic nutrients of cancer cell metabolism. Glutamine is crucial in non‑small cell lung cancer (NSCLC) cells and serves an important role in supporting cell growth, activating signal transduction and maintaining redox homeostasis. In this perspective, the present review aims to provide a new therapeutic strategy of NSCLC through inhibiting the metabolism of glutamine. This review not only summarizes the significance of glutamine metabolism in NSCLC cells, but also enumerates traditional glutamine inhibitors along with new targets. It also puts forward the concept of combination therapy and patient stratification with the aim of comprehensively showing the effect and prospect of targeted glutamine metabolism in NSCLC therapy. This review was completed by searching for keywords including ‘glutamine’, ‘NSCLC’ and ‘therapy’ on PubMed, and screening out articles.
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April-2023
Volume 25 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhou L, Zhang Q, Zhu Q, Zhan Y, Li Y and Huang X: Role and therapeutic targeting of glutamine metabolism in non‑small cell lung cancer (Review). Oncol Lett 25: 159, 2023
APA
Zhou, L., Zhang, Q., Zhu, Q., Zhan, Y., Li, Y., & Huang, X. (2023). Role and therapeutic targeting of glutamine metabolism in non‑small cell lung cancer (Review). Oncology Letters, 25, 159. https://doi.org/10.3892/ol.2023.13745
MLA
Zhou, L., Zhang, Q., Zhu, Q., Zhan, Y., Li, Y., Huang, X."Role and therapeutic targeting of glutamine metabolism in non‑small cell lung cancer (Review)". Oncology Letters 25.4 (2023): 159.
Chicago
Zhou, L., Zhang, Q., Zhu, Q., Zhan, Y., Li, Y., Huang, X."Role and therapeutic targeting of glutamine metabolism in non‑small cell lung cancer (Review)". Oncology Letters 25, no. 4 (2023): 159. https://doi.org/10.3892/ol.2023.13745