Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April-2023 Volume 25 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2023 Volume 25 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.pdf
Article Open Access

Expression pattern, tumor immune landscape, and prognostic value of N7‑methylguanosine regulators in bladder urothelial carcinoma

  • Authors:
    • Chi Zhang
    • Jiangnan Xia
    • Simiao Zhang
    • Jing Li
    • Tian Zhou
    • Kaiwen Hu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, P.R. China, School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China, School of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, P.R. China, Department of Oncology, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410021, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 169
    |
    Published online on: March 10, 2023
       https://doi.org/10.3892/ol.2023.13755
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

N7‑Methylguanosine (m7G) modification is important in post‑transcriptional regulation. dysregulation of m7G RNA modification has been reported to be markedly associated with cancer. However, its importance in bladder urothelial carcinoma (BLCA) remains poorly characterized. The present study systematically analyzed mRNA gene expression data and clinical information from The Cancer Genome Atlas and further constructed robust risk signatures for the four regulators of m7G RNA modification (nudix hydrolase 11, gem nuclear organelle‑associated protein 5, eukaryotic translation initiation factor 3 subunit D and cytoplasmic FMR1 interacting protein 1). The differential expression and cell function of m7G‑related genes in bladder cancer cells were verified by reverse transcription‑quantitative PCR, Cell Counting Kit‑8 and colony formation assays. The four‑gene‑based model could accurately predict the prognosis of BLCA. Nomogram‑based clinical decisions had a higher net benefit compared with that of individual predictors. Through immune infiltration analysis, it was found that immune cell infiltration affected the prognosis of patients with BLCA. Finally, the present study identified potential therapeutics that differ between high and low‑risk groups based on four genes. In summary, the current findings revealed an essential role for m7G RNA modification regulators in BLCA, and developed risk signatures as promising prognostic markers in patients with BLCA.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

Figure 11

Figure 12

Figure 13

Figure 14

Figure 15

View References

1 

Richters A, Aben KKH and Kiemeney L: The global burden of urinary bladder cancer: An update. World J Urol. 38:1895–1904. 2020. View Article : Google Scholar : PubMed/NCBI

2 

Zhu CZ, Ting HN, Ng KH and Ong TA: A review on the accuracy of bladder cancer detection methods. J Cancer. 10:4038–4044. 2019. View Article : Google Scholar : PubMed/NCBI

3 

Cathomas R, Lorch A, Bruins HM, Compérat EM, Cowan NC, Efstathiou JA, Fietkau R, Gakis G, Hernández V, Espinós EL, et al: The 2021 updated European association of urology guidelines on metastatic urothelial carcinoma. Eur Urol. 81:95–103. 2022. View Article : Google Scholar : PubMed/NCBI

4 

Kanehisa M and Bork P: Bioinformatics in the post-sequence era. Nat Genet. 33 (Suppl):S305–S310. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Foulkes AC, Watson DS, Griffiths CEM, Warren RB, Huber W and Barnes MR: Research techniques made simple: Bioinformatics for genome-scale biology. J Invest Dermatol. 137:e163–e168. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Zafeiris D, Rutella S and Ball GR: An artificial neural network integrated pipeline for biomarker discovery using Alzheimer's disease as a case study. Comput Struct Biotechnol J. 16:77–87. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Xie R, Xie M, Zhu L, Chiu JWY, Lam W and Yap DYH: The relationship of pyroptosis-related genes, patient outcomes, and tumor-infiltrating cells in bladder urothelial carcinoma (BLCA). Front Pharmacol. 13:9309512022. View Article : Google Scholar : PubMed/NCBI

8 

Xu C, Song L, Peng H, Yang Y, Liu Y, Pei D, Guo J, Liu N, Liu J, Li X, et al: Clinical eosinophil-associated genes can serve as a reliable predictor of bladder urothelial cancer. Front Mol Biosci. 9:9634552022. View Article : Google Scholar : PubMed/NCBI

9 

Jin K, Qiu S, Jin D, Zhou X, Zheng X, Li J, Liao X, Yang L and Wei Q: Development of prognostic signature based on immune-related genes in muscle-invasive bladder cancer: Bioinformatics analysis of TCGA database. Aging (Albany NY). 13:1859–1871. 2021. View Article : Google Scholar : PubMed/NCBI

10 

Chen X, Xu R, He D, Zhang Y, Chen H, Zhu Y, Cheng Y, Liu R, Zhu R, Gong L, et al: CD8(+) T effector and immune checkpoint signatures predict prognosis and responsiveness to immunotherapy in bladder cancer. Oncogene. 40:6223–6234. 2021. View Article : Google Scholar : PubMed/NCBI

11 

Liu Z, Tang Q, Qi T, Othmane B, Yang Z, Chen J, Hu J and Zu X: A robust hypoxia risk score predicts the clinical outcomes and tumor microenvironment immune characters in bladder cancer. Front Immunol. 12:7252232021. View Article : Google Scholar : PubMed/NCBI

12 

Olkhov-Mitsel E, Hodgson A, Liu SK, Vesprini D, Bayani J, Bartlett JMS, Xu B and Downes MR: Upregulation of IFNγ-mediated chemokines dominate the immune transcriptome of muscle-invasive urothelial carcinoma. Sci Rep. 12:7162022. View Article : Google Scholar : PubMed/NCBI

13 

Boccaletto P, Magnus M, Almeida C, Zyla A, Astha A, Pluta R, Baginski B, Jankowska E, Dunin-Horkawicz S, Wirecki TK, et al: RNArchitecture: A database and a classification system of RNA families, with a focus on structural information. Nucleic Acids Res. 46:D202–D205. 2018.PubMed/NCBI

14 

Jühling F, Mörl M, Hartmann RK, Sprinzl M, Stadler PF and Pütz J: tRNAdb 2009: Compilation of tRNA sequences and tRNA genes. Nucleic Acids Res. 37:D159–D162. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Edmonds CG, Crain PF, Gupta R, Hashizume T, Hocart CH, Kowalak JA, Pomerantz SC, Stetter KO and McCloskey JA: Posttranscriptional modification of tRNA in thermophilic archaea (Archaebacteria). J Bacteriol. 173:3138–3148. 1991. View Article : Google Scholar : PubMed/NCBI

16 

Luo Y, Yao Y, Wu P, Zi X, Sun N and He J: The potential role of N(7)-methylguanosine (m7G) in cancer. J Hematol Oncol. 15:632022. View Article : Google Scholar : PubMed/NCBI

17 

Li XY, Wang SL, Chen DH, Liu H, You JX, Su LX and Yang XT: Construction and validation of a m7G-related gene-based prognostic model for gastric cancer. Front Oncol. 12:8614122022. View Article : Google Scholar : PubMed/NCBI

18 

Tomikawa C: 7-methylguanosine modifications in transfer RNA (tRNA). Int J Mol Sci. 19:40802018. View Article : Google Scholar : PubMed/NCBI

19 

Yang Z, Zhang S, Xia T, Fan Y, Shan Y, Zhang K, Xiong J, Gu M and You B: RNA modifications meet tumors. Cancer Manag Res. 14:3223–3243. 2022. View Article : Google Scholar : PubMed/NCBI

20 

Rong D, Sun G, Wu F, Cheng Y, Sun G, Jiang W, Li X, Zhong Y, Wu L, Zhang C, et al: Epigenetics: Roles and therapeutic implications of non-coding RNA modifications in human cancers. Mol Ther Nucleic Acids. 25:67–82. 2021. View Article : Google Scholar : PubMed/NCBI

21 

Zhang M, Song J, Yuan W, Zhang W and Sun Z: Roles of RNA methylation on tumor immunity and clinical implications. Front Immunol. 12:6415072021. View Article : Google Scholar : PubMed/NCBI

22 

Furuichi Y: Discovery of m(7)G-cap in eukaryotic mRNAs. Proc Jpn Acad Ser B Phys Biol Sci. 91:394–409. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Reddy R, Singh R and Shimba S: Methylated cap structures in eukaryotic RNAs: Structure, synthesis and functions. Pharmacol Ther. 54:249–267. 1992. View Article : Google Scholar : PubMed/NCBI

24 

R Core Team R, . A language and environment for statistical computing. R Foundation for Statistical Computing; Vienna: 2012, http://www.R-project.org/

25 

Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, Simonovic M, Doncheva NT, Morris JH, Bork P, et al: STRING v11: Protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 47:D607–D613. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Tang Z, Li C, Kang B, Gao G, Li C and Zhang Z: GEPIA: A web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 45:W98–W102. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Li T, Fan J, Wang B, Traugh N, Chen Q, Liu JS, Li B and Liu XS: TIMER: A web server for comprehensive analysis of tumor-infiltrating immune cells. Cancer Res. 77:e108–e110. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Geeleher P, Cox N and Huang RS: pRRophetic: An R package for prediction of clinical chemotherapeutic response from tumor gene expression levels. PLoS One. 9:e1074682014. View Article : Google Scholar : PubMed/NCBI

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Lai H, Cheng X, Liu Q, Luo W, Liu M, Zhang M, Miao J, Ji Z, Lin GN, Song W, et al: Single-cell RNA sequencing reveals the epithelial cell heterogeneity and invasive subpopulation in human bladder cancer. Int J Cancer. 149:2099–2115. 2021. View Article : Google Scholar : PubMed/NCBI

31 

Huang Z, Yan Y, Wang T, Wang Z, Cai J, Cao X, Yang C, Zhang F, Wu G and Shen B: Identification of ENO1 as a prognostic biomarker and molecular target among ENOs in bladder cancer. J Transl Med. 20:3152022. View Article : Google Scholar : PubMed/NCBI

32 

Liu J, Zhou Z, Jiang Y, Lin Y, Yang Y, Tian C, Liu J, Lin H and Huang B: EPHA3 could be a novel prognosis biomarker and correlates with immune infiltrates in bladder cancer. Cancers (Basel). 15:6212023. View Article : Google Scholar : PubMed/NCBI

33 

Yu X, Luo B, Lin J and Zhu Y: Alternative splicing event associated with immunological features in bladder cancer. Front Oncol. 12:9660882023. View Article : Google Scholar : PubMed/NCBI

34 

Chen Z, Zhu W, Zhu S, Sun K, Liao J, Liu H, Dai Z, Han H, Ren X, Yang Q, et al: METTL1 promotes hepatocarcinogenesis via m(7) G tRNA modification-dependent translation control. Clin Transl Med. 11:e6612021. View Article : Google Scholar : PubMed/NCBI

35 

Zhu J, Liu X, Chen W, Liao Y, Liu J, Yuan L, Ruan J and He J: Association of RNA m7G modification gene polymorphisms with pediatric glioma risk. Biomed Res Int. 2023:36783272023. View Article : Google Scholar : PubMed/NCBI

36 

Han H, Yang C, Ma J, Zhang S, Zheng S, Ling R, Sun K, Guo S, Huang B and Liang Y: N(7)-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis. Nat Commun. 13:14782022. View Article : Google Scholar : PubMed/NCBI

37 

Xia P, Zhang H, Xu K, Jiang X, Gao M, Wang G, Liu Y, Yao Y, Chen X, Ma W, et al: MYC-targeted WDR4 promotes proliferation, metastasis, and sorafenib resistance by inducing CCNB1 translation in hepatocellular carcinoma. Cell Death Dis. 12:6912021. View Article : Google Scholar : PubMed/NCBI

38 

Xu C, Ishikawa H, Izumikawa K, Li L, He H, Nobe Y, Yamauchi Y, Shahjee HM, Wu XH, Yu YT, et al: Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly. Genes Dev. 30:2376–2390. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Li XY, Zhao ZJ, Wang JB, Shao YH, Hui-Liu, You JX and Yang XT: m7G methylation-related genes as biomarkers for predicting overall survival outcomes for hepatocellular carcinoma. Front Bioeng Biotechnol. 10:8497562022. View Article : Google Scholar : PubMed/NCBI

40 

Shao J, Wang S, West-Szymanski D, Karpus J, Shah S, Ganguly S, Smith J, Zu Y, He C, Li Z, et al: Cell-free DNA 5-hydroxymethylcytosine is an emerging marker of acute myeloid leukemia. Sci Rep. 12:124102022. View Article : Google Scholar : PubMed/NCBI

41 

Lee JH, Horak CE, Khanna C, Meng Z, Yu LR, Veenstra TD and Steeg PS: Alterations in Gemin5 expression contribute to alternative mRNA splicing patterns and tumor cell motility. Cancer Res. 68:639–644. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Wollen KL, Hagen L, Vågbø CB, Rabe R, Iveland TS, Aas PA, Sharma A, Sporsheim B, Erlandsen HO, Palibrk V, et al: ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA. J Transl Med. 19:2872021. View Article : Google Scholar : PubMed/NCBI

43 

Limaye AJ, Whittaker MK, Bendzunas GN, Cowell JK and Kennedy EJ: Targeting the WASF3 complex to suppress metastasis. Pharmacol Res. 182:1063022022. View Article : Google Scholar : PubMed/NCBI

44 

Chang JW, Kuo WH, Lin CM, Chen WL, Chan SH, Chiu MF, Chang IS, Jiang SS, Tsai FY, Chen CH, et al: Wild-type p53 upregulates an early onset breast cancer-associated gene GAS7 to suppress metastasis via GAS7-CYFIP1-mediated signaling pathway. Oncogene. 37:4137–4150. 2018. View Article : Google Scholar : PubMed/NCBI

45 

Teng Y, Qin H, Bahassan A, Bendzunas NG, Kennedy EJ and Cowell JK: The WASF3-NCKAP1-CYFIP1 complex is essential for breast cancer metastasis. Cancer Res. 76:5133–5142. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Morrison BH, Bauer JA, Kalvakolanu DV and Lindner DJ: Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells. J Biol Chem. 276:24965–24970. 2001. View Article : Google Scholar : PubMed/NCBI

47 

Grisanzio C, Werner L, Takeda D, Awoyemi BC, Pomerantz MM, Yamada H, Sooriakumaran P, Robinson BD, Leung R, Schinzel AC, et al: Genetic and functional analyses implicate the NUDT11, HNF1B, and SLC22A3 genes in prostate cancer pathogenesis. Proc Natl Acad Sci U S A. 109:11252–11257. 2012. View Article : Google Scholar : PubMed/NCBI

48 

Bandyopadhyay A, Lakshmanan V, Matsumoto T, Chang EC and Maitra U: Moe1 and spInt6, the fission yeast homologues of mammalian translation initiation factor 3 subunits p66 (eIF3d) and p48 (eIF3e), respectively, are required for stable association of eIF3 subunits. J Biol Chem. 277:2360–2367. 2002. View Article : Google Scholar : PubMed/NCBI

49 

Yu X, Zheng B and Chai R: Lentivirus-mediated knockdown of eukaryotic translation initiation factor 3 subunit D inhibits proliferation of HCT116 colon cancer cells. Biosci Rep. 34:e001612014. View Article : Google Scholar : PubMed/NCBI

50 

Sudo H, Tsuji AB, Sugyo A, Kohda M, Sogawa C, Yoshida C, Harada YN, Hino O and Saga T: Knockdown of COPA, identified by loss-of-function screen, induces apoptosis and suppresses tumor growth in mesothelioma mouse model. Genomics. 95:210–216. 2010. View Article : Google Scholar : PubMed/NCBI

51 

Fan Y and Guo Y: Knockdown of eIF3D inhibits breast cancer cell proliferation and invasion through suppressing the Wnt/β-catenin signaling pathway. Int J Clin Exp Pathol. 8:10420–10427. 2015.PubMed/NCBI

52 

Golob-Schwarzl N, Krassnig S, Toeglhofer AM, Park YN, Gogg-Kamerer M, Vierlinger K, Schröder F, Rhee H, Schicho R, Fickert P and Haybaeck J: New liver cancer biomarkers: PI3K/AKT/mTOR pathway members and eukaryotic translation initiation factors. Eur J Cancer. 83:56–70. 2017. View Article : Google Scholar : PubMed/NCBI

53 

Hershey JW: The role of eIF3 and its individual subunits in cancer. Biochim Biophys Acta. 1849:792–800. 2015. View Article : Google Scholar : PubMed/NCBI

54 

Sesen J, Cammas A, Scotland SJ, Elefterion B, Lemarié A, Millevoi S, Mathew LK, Seva C, Toulas C, Moyal ECJ and Skuli N: Int6/eIF3e is essential for proliferation and survival of human glioblastoma cells. Int J Mol Sci. 15:2172–2190. 2014. View Article : Google Scholar : PubMed/NCBI

55 

Feng X, Li J and Liu P: The biological roles of translation initiation factor 3b. Int J Biol Sci. 14:1630–1635. 2018. View Article : Google Scholar : PubMed/NCBI

56 

Wolf DA, Lin Y, Duan H and Cheng Y: eIF-Three to Tango: Emerging functions of translation initiation factor eIF3 in protein synthesis and disease. J Mol Cell Biol. 12:403–409. 2020. View Article : Google Scholar : PubMed/NCBI

57 

Yin Y, Long J, Sun Y, Li H, Jiang E, Zeng C and Zhu W: The function and clinical significance of eIF3 in cancer. Gene. 673:130–133. 2018. View Article : Google Scholar : PubMed/NCBI

58 

Luo Y, Chen L, Zhou Q, Xiong Y, Wang G, Liu X, Xiao Y, Ju L and Wang X: Identification of a prognostic gene signature based on an immunogenomic landscape analysis of bladder cancer. J Cell Mol Med. 24:13370–13382. 2020. View Article : Google Scholar : PubMed/NCBI

59 

Undi RB, Filiberti A, Ali N and Huycke MM: Cellular carcinogenesis: Role of polarized macrophages in cancer initiation. Cancers (Basel). 14:28112022. View Article : Google Scholar : PubMed/NCBI

60 

Scheper W, Kelderman S, Fanchi LF, Linnemann C, Bendle G, de Rooij MAJ, Hirt C, Mezzadra R, Slagter M, Dijkstra K, et al: Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers. Nat Med. 25:89–94. 2019. View Article : Google Scholar : PubMed/NCBI

61 

Elia I, Rowe JH, Johnson S, Joshi S, Notarangelo G, Kurmi K, Weiss S, Freeman GJ, Sharpe AH and Haigi MC: Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8(+) T cells. Cell Metab. 34:1137–1150.e1136. 2022. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang C, Xia J, Zhang S, Li J, Zhou T and Hu K: Expression pattern, tumor immune landscape, and prognostic value of N7‑methylguanosine regulators in bladder urothelial carcinoma. Oncol Lett 25: 169, 2023.
APA
Zhang, C., Xia, J., Zhang, S., Li, J., Zhou, T., & Hu, K. (2023). Expression pattern, tumor immune landscape, and prognostic value of N7‑methylguanosine regulators in bladder urothelial carcinoma. Oncology Letters, 25, 169. https://doi.org/10.3892/ol.2023.13755
MLA
Zhang, C., Xia, J., Zhang, S., Li, J., Zhou, T., Hu, K."Expression pattern, tumor immune landscape, and prognostic value of N7‑methylguanosine regulators in bladder urothelial carcinoma". Oncology Letters 25.4 (2023): 169.
Chicago
Zhang, C., Xia, J., Zhang, S., Li, J., Zhou, T., Hu, K."Expression pattern, tumor immune landscape, and prognostic value of N7‑methylguanosine regulators in bladder urothelial carcinoma". Oncology Letters 25, no. 4 (2023): 169. https://doi.org/10.3892/ol.2023.13755
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang C, Xia J, Zhang S, Li J, Zhou T and Hu K: Expression pattern, tumor immune landscape, and prognostic value of N7‑methylguanosine regulators in bladder urothelial carcinoma. Oncol Lett 25: 169, 2023.
APA
Zhang, C., Xia, J., Zhang, S., Li, J., Zhou, T., & Hu, K. (2023). Expression pattern, tumor immune landscape, and prognostic value of N7‑methylguanosine regulators in bladder urothelial carcinoma. Oncology Letters, 25, 169. https://doi.org/10.3892/ol.2023.13755
MLA
Zhang, C., Xia, J., Zhang, S., Li, J., Zhou, T., Hu, K."Expression pattern, tumor immune landscape, and prognostic value of N7‑methylguanosine regulators in bladder urothelial carcinoma". Oncology Letters 25.4 (2023): 169.
Chicago
Zhang, C., Xia, J., Zhang, S., Li, J., Zhou, T., Hu, K."Expression pattern, tumor immune landscape, and prognostic value of N7‑methylguanosine regulators in bladder urothelial carcinoma". Oncology Letters 25, no. 4 (2023): 169. https://doi.org/10.3892/ol.2023.13755
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team