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Article

Usefulness of blood biomarkers for predicting venous thromboembolism in Japanese patients with cancer

  • Authors:
    • Yohei Harada
    • Akemi Sato
    • Atsujiro Nishioka
    • Shinsuke Ogusu
    • Masanori Matsumoto
    • Eisaburo Sueoka
    • Atsushi Kawaguchi
    • Shinya Kimura
    • Naoko Sueoka-αragane
  • View Affiliations / Copyright

    Affiliations: Division of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Saga University, Saga 849‑8501, Japan, Department of Clinical Laboratory Medicine, Faculty of Medicine, Saga University, Saga 849‑8501, Japan, Department of Blood Transfusion Medicine, Nara Medical University, Kashihara, Nara 634‑8521, Japan, Education and Research Center for Community Medicine, Faculty of Medicine, Saga University, Saga 849‑8501, Japan
  • Article Number: 180
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    Published online on: March 17, 2023
       https://doi.org/10.3892/ol.2023.13766
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Abstract

Prospective studies on risk factors for the occurrence of venous thromboembolism (VTE) in Asian patients with cancer are limited. Therefore, the present study assessed risk factors for VTE, including multiple blood biomarkers and risk scores consisting of several risk factors, in Japanese patients receiving anticancer drug therapy. In this single‑center, prospective, observational study, 200 patients with six types of cancer were enrolled and followed for 1 year to observe the occurrence of symptomatic or asymptomatic VTE. The present study evaluated risk factors, Khorana and Vienna cancer and thrombosis study (CATS) scores at enrollment, and longitudinal data on various blood biomarkers. A Vienna CATS score of ≥3 was significantly associated with VTE occurrence (HR, 2.8; 95% CI, 0.9‑8.7; P=0.045). In multivariable analysis, there was a significant association between VTE and the presence of pancreatic cancer (HR, 3.2; 95% CI, 1.1‑8.8; P=0.028) and high soluble fibrin (HR, 3.7; 95% CI, 1.1‑7.8; P=0.036). Covariate analysis using the propensity score also showed a significant association with hemoglobin dichotomized at <100 g/l (HR, 3.9; 95% CI, 1.1‑14.0; P=0.034). Longitudinal data indicated that VTE was associated with soluble fibrin baseline values and an increase in D‑dimer levels over time. The present results suggested that blood biomarkers are beneficial for predicting the risk of VTE in Japanese patients with cancer. The present study also provided novel evidence for the importance of measuring soluble fibrin in patients with cancer.
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1 

Khorana AA, Francis CW, Culakova E, Kuderer NM and Lyman GH: Thromboembolism is a leading cause of death in cancer patients receiving outpatient chemotherapy. J Thromb Haemost. 5:632–634. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Heit JA, Silverstein MD, Mohr DN, Petterson TM, O'Fallon WM and Melton LJ III: Risk factors for deep vein thrombosis and pulmonary embolism: A population-based case-control study. Arch Intern Med. 160:809–815. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Silverstein MD, Heit JA, Mohr DN, Petterson TM, O'Fallon WM and Melton LJ III: Trends in the incidence of deep vein thrombosis and pulmonary embolism: A 25-year population-based study. Arch Intern Med. 158:585–593. 1998. View Article : Google Scholar : PubMed/NCBI

4 

Khorana AA, Kuderer NM, Culakova E, Lyman GH and Francis CW: Development and validation of a predictive model for chemotherapy-associated thrombosis. Blood. 111:4902–4907. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Khorana AA and Connolly GC: Assessing risk of venous thromboembolism in the patient with cancer. J Clin Oncol. 27:4839–4847. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Ay C, Vormittag R, Dunkler D, Simanek R, Chiriac AL, Drach J, Quehenberger P, Wagner O, Zielinski C and Pabinger I: D-dimer and prothrombin fragment 1 + 2 predict venous thromboembolism in patients with cancer: Results from the Vienna cancer and thrombosis study. J Clin Oncol. 27:4124–4129. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Ay C, Dunkler D, Marosi C, Chiriac AL, Vormittag R, Simanek R, Quehenberger P, Zielinski C and Pabinger I: Prediction of venous thromboembolism in cancer patients. Blood. 116:5377–5382. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Louzada ML, Carrier M, Lazo-Langner A, Dao V, Kovacs MJ, Ramsay TO, Rodger MA, Zhang J, Lee AY, Meyer G and Wells PS: Development of a clinical prediction rule for risk stratification of recurrent venous thromboembolism in patients with cancer-associated venous thromboembolism. Circulation. 126:448–454. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Verso M, Agnelli G, Barni S, Gasparini G and LaBianca R: A modified Khorana risk assessment score for venous thromboembolism in cancer patients receiving chemotherapy: The protecht score. Intern Emerg Med. 7:291–292. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Muñoz Martín AJ, Ortega I, Font C, Pachón V, Castellón V, Martínez-Marín V, Salgado M, Martínez E, Calzas J, Rupérez A, et al: Multivariable clinical-genetic risk model for predicting venous thromboembolic events in patients with cancer. Br J Cancer. 118:1056–1061. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Pelzer U, Sinn M, Stieler J and Riess H: Primary pharmacological prevention of thromboembolic events in ambulatory patients with advanced pancreatic cancer treated with chemotherapy? Dtsch Med Wochenschr. 138:2084–2088. 2013.(In German). PubMed/NCBI

12 

Song C, Shargall Y, Li H, Tian B, Chen S, Miao J, Fu Y, You B and Hu B: Prevalence of venous thromboembolism after lung surgery in China: A single-centre, prospective cohort study involving patients undergoing lung resections without perioperative venous thromboembolism prophylaxis†. Eur J Cardiothorac Surg. 55:455–460. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Lee JO, Lee JY, Chun EJ, Choi SI, Kim JW, Kim SH, Kim YJ, Lee KW, Kim JH, Lee JS and Bang SM: Incidence and predictors of venous thromboembolism in medically ill hospitalized elderly cancer patients: A prospective observational study. Support Care Cancer. 27:2507–2515. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Kitayama H, Kondo T, Sugiyama J, Kurimoto K, Nishino Y, Hirayama M and Tsuji Y: Venous thromboembolism in hospitalized patients receiving chemotherapy for malignancies at Japanese community hospital: Prospective observational study. BMC Cancer. 17:3512017. View Article : Google Scholar : PubMed/NCBI

15 

Khorana AA, Francis CW, Culakova E, Kuderer NM and Lyman GH: Frequency, risk factors, and trends for venous thromboembolism among hospitalized cancer patients. Cancer. 110:2339–2346. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Oh SY, Kim JH, Lee KW, Bang SM, Hwang JH, Oh D and Lee JS: Venous thromboembolism in patients with pancreatic adenocarcinoma: Lower incidence in Asian ethnicity. Thromb Res. 122:485–490. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Wiredu C, Haynes N, Guerra C and Ky B: Racial and ethnic disparities in cancer-associated thrombosis. Thromb Haemost. 122:662–665. 2022. View Article : Google Scholar : PubMed/NCBI

18 

Lee LH, Gallus A, Jindal R, Wang C and Wu CC: Incidence of venous thromboembolism in Asian populations: A systematic review. Thromb Haemost. 117:2243–2260. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Ashrani AA, Silverstein MD, Rooke TW, Lahr BD, Petterson TM, Bailey KR, Melton LJ III and Heit JA: Impact of venous thromboembolism, venous stasis syndrome, venous outflow obstruction and venous valvular incompetence on quality of life and activities of daily living: A nested case-control study. Vasc Med. 15:387–397. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Reitter EM, Kaider A, Ay C, Quehenberger P, Marosi C, Zielinski C and Pabinger I: Longitudinal analysis of hemostasis biomarkers in cancer patients during antitumor treatment. J Thromb Haemost. 14:294–305. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Tanaka S; Members of The Subcommittee for Preparing Guidelines for Ultrasound Diagnosis of Venous Thrombosis of Lower Extremities of The Terminology and Diagnostic Criteria Committee, Japan Society of Ultrasonics in Medicine, . Nishigami K, Taniguchi N, Matsuo H, Hirai T, Kaneda S, Ogasawara M, Satoh H and Tobe H: Criteria for ultrasound diagnosis of deep venous thrombosis of lower extremities. J Med Ultrason (2001). 35:33–36. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Sørensen HT, Mellemkjaer L, Steffensen FH, Olsen JH and Nielsen GL: The risk of a diagnosis of cancer after primary deep venous thrombosis or pulmonary embolism. N Engl J Med. 338:1169–1173. 1998. View Article : Google Scholar : PubMed/NCBI

23 

Ay C, Simanek R, Vormittag R, Dunkler D, Alguel G, Koder S, Kornek G, Marosi C, Wagner O, Zielinski C and Pabinger I: High plasma levels of soluble P-selectin are predictive of venous thromboembolism in cancer patients: Results from the Vienna cancer and thrombosis study (CATS). Blood. 112:2703–2708. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Charlson ME, Pompei P, Ales KL and MacKenzie CR: A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chronic Dis. 40:373–383. 1987. View Article : Google Scholar : PubMed/NCBI

25 

Dempfle CE, Zips S, Ergül H and Heene DL; Fibrin Assay Comparative Trial study group, : The fibrin assay comparison trial (FACT): Evaluation of 23 quantitative D-dimer assays as basis for the development of D-dimer calibrators. FACT study group. Thromb Haemost. 85:671–678. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Favaloro EJ and Thachil J: Reporting of D-dimer data in COVID-19: Some confusion and potential for misinformation. Clin Chem Lab Med. 58:1191–1199. 2020. View Article : Google Scholar : PubMed/NCBI

27 

Lutsey PL, Cushman M, Steffen LM, Green D, Barr RG, Herrington D, Ouyang P and Folsom AR: Plasma hemostatic factors and endothelial markers in four racial/ethnic groups: The MESA study. J Thromb Haemost. 4:2629–2635. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Tang L and Hu Y: Ethnic diversity in the genetics of venous thromboembolism. Thromb Haemost. 114:901–909. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Yu YB, Gau JP, Liu CY, Yang MH, Chiang SC, Hsu HC, Hong YC, Hsiao LT, Liu JH, Chiou TJ, et al: A nation-wide analysis of venous thromboembolism in 497,180 cancer patients with the development and validation of a risk-stratification scoring system. Thromb Haemost. 108:225–235. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Lee CH, Lin LJ, Cheng CL, Kao Yang YH, Chen JY and Tsai LM: Incidence and cumulative recurrence rates of venous thromboembolism in the Taiwanese population. J Thromb Haemost. 8:1515–1523. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Nakamura M, Miyata T, Ozeki Y, Takayama M, Komori K, Yamada N, Origasa H, Satokawa H, Maeda H, Tanabe N, et al: Current venous thromboembolism management and outcomes in Japan. Circ J. 78:708–717. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Khorana AA, Francis CW, Culakova E and Lyman GH: Risk factors for chemotherapy-associated venous thromboembolism in a prospective observational study. Cancer. 104:2822–2829. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Ay C, Jungbauer LV, Sailer T, Tengler T, Koder S, Kaider A, Panzer S, Quehenberger P, Pabinger I and Mannhalter C: High concentrations of soluble P-selectin are associated with risk of venous thromboembolism and the P-selectin Thr715 variant. Clin Chem. 53:1235–1243. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Tsuji A, Wada H, Matsumoto T, Abe Y, Ota S, Yamada N, Sugiyama T, Sudo A, Onishi K, Nakatani K, et al: Elevated levels of soluble fibrin in patients with venous thromboembolism. Int J Hematol. 88:448–453. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Wada H, Kobayashi T, Abe Y, Hatada T, Yamada N, Sudo A, Uchida A and Nobori T: Elevated levels of soluble fibrin or D-dimer indicate high risk of thrombosis. J Thromb Haemost. 4:1253–1258. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Dempfle CE, Wurst M, Smolinski M, Lorenz S, Osika A, Olenik D, Fiedler F and Borggrefe M: Use of soluble fibrin antigen instead of D-dimer as fibrin-related marker may enhance the prognostic power of the ISTH overt DIC score. Thromb Haemost. 91:812–818. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Aota T, Wada H, Yamashita Y, Matsumoto T, Ohishi K, Suzuki K, Imai H, Usui M, Isaji S, Asakura H, et al: An evaluation of the modified diagnostic criteria for DIC established by the Japanese society of thrombosis and hemostasis. Clin Appl Thromb Hemost. 23:579–584. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Yukizawa Y, Inaba Y, Watanabe S, Yajima S, Kobayashi N, Ishida T, Iwamoto N, Choe H and Saito T: Association between venous thromboembolism and plasma levels of both soluble fibrin and plasminogen-activator inhibitor 1 in 170 patients undergoing total hip arthroplasty. Acta Orthop. 83:14–21. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Yukizawa Y, Inaba Y, Kobayashi N, Ike H, Kubota S and Saito T: Selective pharmacological prophylaxis based on individual risk assessment using plasma levels of soluble fibrin and plasminogen-activator inhibitor-1 following total hip arthroplasty. Mod Rheumatol. 24:835–839. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Ay C, Pabinger I and Cohen AT: Cancer-associated venous thromboembolism: Burden, mechanisms, and management. Thromb Haemost. 117:219–230. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Bockenstedt P: D-dimer in venous thromboembolism. N Engl J Med. 349:1203–1204. 2003. View Article : Google Scholar : PubMed/NCBI

42 

Khorana AA, Carrier M, Garcia DA and Lee AYY: Guidance for the prevention and treatment of cancer-associated venous thromboembolism. J Thromb Thrombolysis. 41:81–91. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Carrier M, Abou-Nassar K, Mallick R, Tagalakis V, Shivakumar S, Schattner A, Kuruvilla P, Hill D, Spadafora S, Marquis K, et al: Apixaban to prevent venous thromboembolism in patients with cancer. N Engl J Med. 380:711–719. 2019. View Article : Google Scholar : PubMed/NCBI

44 

Khorana AA, Soff GA, Kakkar AK, Vadhan-Raj S, Riess H, Wun T, Streiff MB, Garcia DA, Liebman HA, Belani CP, et al: Rivaroxaban for thromboprophylaxis in high-risk ambulatory patients with cancer. N Engl J Med. 380:720–728. 2019. View Article : Google Scholar : PubMed/NCBI

45 

Prandoni P, Lensing AW, Piccioli A, Bernardi E, Simioni P, Girolami B, Marchiori A, Sabbion P, Prins MH, Noventa F and Girolami A: Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosis. Blood. 100:3484–3488. 2002. View Article : Google Scholar : PubMed/NCBI

46 

Mansfield A, Tafur AJ, Wang CE, Kourelis TV, Wysokinska EM and Yang P: Predictors of active cancer thromboembolic outcomes: Validation of the Khorana score among patients with lung cancer. J Thromb Haemost. 14:1773–1778. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Vathiotis I, Dimakakos EP, Boura P, Ntineri A, Charpidou A, Gerotziafas G and Syrigos K: Khorana score: Νew predictor of early mortality in patients with lung adenocarcinoma. Clin Appl Thromb Hemost. 24:1347–1351. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Harada Y, Sato A, Nishioka A, Ogusu S, Matsumoto M, Sueoka E, Kawaguchi A, Kimura S and Sueoka-αragane N: Usefulness of blood biomarkers for predicting venous thromboembolism in Japanese patients with cancer. Oncol Lett 25: 180, 2023.
APA
Harada, Y., Sato, A., Nishioka, A., Ogusu, S., Matsumoto, M., Sueoka, E. ... Sueoka-αragane, N. (2023). Usefulness of blood biomarkers for predicting venous thromboembolism in Japanese patients with cancer. Oncology Letters, 25, 180. https://doi.org/10.3892/ol.2023.13766
MLA
Harada, Y., Sato, A., Nishioka, A., Ogusu, S., Matsumoto, M., Sueoka, E., Kawaguchi, A., Kimura, S., Sueoka-αragane, N."Usefulness of blood biomarkers for predicting venous thromboembolism in Japanese patients with cancer". Oncology Letters 25.5 (2023): 180.
Chicago
Harada, Y., Sato, A., Nishioka, A., Ogusu, S., Matsumoto, M., Sueoka, E., Kawaguchi, A., Kimura, S., Sueoka-αragane, N."Usefulness of blood biomarkers for predicting venous thromboembolism in Japanese patients with cancer". Oncology Letters 25, no. 5 (2023): 180. https://doi.org/10.3892/ol.2023.13766
Copy and paste a formatted citation
x
Spandidos Publications style
Harada Y, Sato A, Nishioka A, Ogusu S, Matsumoto M, Sueoka E, Kawaguchi A, Kimura S and Sueoka-αragane N: Usefulness of blood biomarkers for predicting venous thromboembolism in Japanese patients with cancer. Oncol Lett 25: 180, 2023.
APA
Harada, Y., Sato, A., Nishioka, A., Ogusu, S., Matsumoto, M., Sueoka, E. ... Sueoka-αragane, N. (2023). Usefulness of blood biomarkers for predicting venous thromboembolism in Japanese patients with cancer. Oncology Letters, 25, 180. https://doi.org/10.3892/ol.2023.13766
MLA
Harada, Y., Sato, A., Nishioka, A., Ogusu, S., Matsumoto, M., Sueoka, E., Kawaguchi, A., Kimura, S., Sueoka-αragane, N."Usefulness of blood biomarkers for predicting venous thromboembolism in Japanese patients with cancer". Oncology Letters 25.5 (2023): 180.
Chicago
Harada, Y., Sato, A., Nishioka, A., Ogusu, S., Matsumoto, M., Sueoka, E., Kawaguchi, A., Kimura, S., Sueoka-αragane, N."Usefulness of blood biomarkers for predicting venous thromboembolism in Japanese patients with cancer". Oncology Letters 25, no. 5 (2023): 180. https://doi.org/10.3892/ol.2023.13766
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