Usefulness of blood biomarkers for predicting venous thromboembolism in Japanese patients with cancer

  • Authors:
    • Yohei Harada
    • Akemi Sato
    • Atsujiro Nishioka
    • Shinsuke Ogusu
    • Masanori Matsumoto
    • Eisaburo Sueoka
    • Atsushi Kawaguchi
    • Shinya Kimura
    • Naoko Sueoka-αragane
  • View Affiliations

  • Published online on: March 17, 2023     https://doi.org/10.3892/ol.2023.13766
  • Article Number: 180
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Abstract

Prospective studies on risk factors for the occurrence of venous thromboembolism (VTE) in Asian patients with cancer are limited. Therefore, the present study assessed risk factors for VTE, including multiple blood biomarkers and risk scores consisting of several risk factors, in Japanese patients receiving anticancer drug therapy. In this single‑center, prospective, observational study, 200 patients with six types of cancer were enrolled and followed for 1 year to observe the occurrence of symptomatic or asymptomatic VTE. The present study evaluated risk factors, Khorana and Vienna cancer and thrombosis study (CATS) scores at enrollment, and longitudinal data on various blood biomarkers. A Vienna CATS score of ≥3 was significantly associated with VTE occurrence (HR, 2.8; 95% CI, 0.9‑8.7; P=0.045). In multivariable analysis, there was a significant association between VTE and the presence of pancreatic cancer (HR, 3.2; 95% CI, 1.1‑8.8; P=0.028) and high soluble fibrin (HR, 3.7; 95% CI, 1.1‑7.8; P=0.036). Covariate analysis using the propensity score also showed a significant association with hemoglobin dichotomized at <100 g/l (HR, 3.9; 95% CI, 1.1‑14.0; P=0.034). Longitudinal data indicated that VTE was associated with soluble fibrin baseline values and an increase in D‑dimer levels over time. The present results suggested that blood biomarkers are beneficial for predicting the risk of VTE in Japanese patients with cancer. The present study also provided novel evidence for the importance of measuring soluble fibrin in patients with cancer.
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May-2023
Volume 25 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Harada Y, Sato A, Nishioka A, Ogusu S, Matsumoto M, Sueoka E, Kawaguchi A, Kimura S and Sueoka-αragane N: Usefulness of blood biomarkers for predicting venous thromboembolism in Japanese patients with cancer. Oncol Lett 25: 180, 2023.
APA
Harada, Y., Sato, A., Nishioka, A., Ogusu, S., Matsumoto, M., Sueoka, E. ... Sueoka-αragane, N. (2023). Usefulness of blood biomarkers for predicting venous thromboembolism in Japanese patients with cancer. Oncology Letters, 25, 180. https://doi.org/10.3892/ol.2023.13766
MLA
Harada, Y., Sato, A., Nishioka, A., Ogusu, S., Matsumoto, M., Sueoka, E., Kawaguchi, A., Kimura, S., Sueoka-αragane, N."Usefulness of blood biomarkers for predicting venous thromboembolism in Japanese patients with cancer". Oncology Letters 25.5 (2023): 180.
Chicago
Harada, Y., Sato, A., Nishioka, A., Ogusu, S., Matsumoto, M., Sueoka, E., Kawaguchi, A., Kimura, S., Sueoka-αragane, N."Usefulness of blood biomarkers for predicting venous thromboembolism in Japanese patients with cancer". Oncology Letters 25, no. 5 (2023): 180. https://doi.org/10.3892/ol.2023.13766