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Case Report Open Access

Inflammatory myofibroblastic tumor of the urinary bladder with FN1‑ALK gene fusion: A case report

  • Authors:
    • Seung-Myoung Son
    • Chang Gok Woo
    • Ok-Jun Lee
    • Yong June Kim
    • Ho-Chang Lee
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, North Chungcheong 28644, Republic of Korea, Department of Urology, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, North Chungcheong 28644, Republic of Korea
    Copyright: © Son et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 227
    |
    Published online on: April 13, 2023
       https://doi.org/10.3892/ol.2023.13813
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Abstract

Inflammatory myofibroblastic tumors (IMTs), which are rare tumors, exhibit myofibroblastic differentiation, often with anaplastic lymphoma kinase (ALK) gene rearrangements. A subset of IMTs identified in the urinary tract have been shown to harbor a fibronectin 1 (FN1)‑ALK gene fusion. In this case report, a case of an IMT with FN1‑ALK fusion in the urinary bladder was presented, and its clinicopathological characteristics were reviewed. A 45‑year‑old female was referred to Chungbuk National University Hospital with gross hematuria. Cystoscopy revealed a solid mass in the bladder. The patient subsequently underwent transurethral resection of the lesion. The mass comprised stellate and spindled myofibroblastic cells that were arranged in loose fascicles, with a myxoid background and a mixed inflammatory infiltrate. Immunohistochemical analysis revealed that the tumor cells were positive for vimentin, cytokeratin AE1/AE3 and ALK, and focal‑positive for desmin. Targeted next‑generation sequencing was subsequently employed to identify the FN1‑ALK fusion. To date, the patient has undergone outpatient follow‑up for 18 months, with no signs of tumor recurrence. To conclude, in total, FN1 has been identified as an ALK fusion partner almost exclusively in cases of genitourinary IMTs [13 bladder IMTs (including the present case) and two uterine IMTs]. In the present case, the FN1‑ALK fusion was found to involve ALK exon 19 and FN1 exon 23. By contrast, the majority of the other IMTs with an ALK fusion have involved ALK exon 20, whereas ALK fusion involving ALK exon 18 or 19 has been reported only in genitourinary IMTs. Therefore, the FN1‑ALK fusion involving ALK exon 18 or 19 may be specific to a subset of IMTs arising in the urinary bladder.
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Copy and paste a formatted citation
Spandidos Publications style
Son S, Woo CG, Lee O, Kim YJ and Lee H: Inflammatory myofibroblastic tumor of the urinary bladder with FN1‑ALK gene fusion: A case report. Oncol Lett 25: 227, 2023.
APA
Son, S., Woo, C.G., Lee, O., Kim, Y.J., & Lee, H. (2023). Inflammatory myofibroblastic tumor of the urinary bladder with FN1‑ALK gene fusion: A case report. Oncology Letters, 25, 227. https://doi.org/10.3892/ol.2023.13813
MLA
Son, S., Woo, C. G., Lee, O., Kim, Y. J., Lee, H."Inflammatory myofibroblastic tumor of the urinary bladder with FN1‑ALK gene fusion: A case report". Oncology Letters 25.6 (2023): 227.
Chicago
Son, S., Woo, C. G., Lee, O., Kim, Y. J., Lee, H."Inflammatory myofibroblastic tumor of the urinary bladder with FN1‑ALK gene fusion: A case report". Oncology Letters 25, no. 6 (2023): 227. https://doi.org/10.3892/ol.2023.13813
Copy and paste a formatted citation
x
Spandidos Publications style
Son S, Woo CG, Lee O, Kim YJ and Lee H: Inflammatory myofibroblastic tumor of the urinary bladder with FN1‑ALK gene fusion: A case report. Oncol Lett 25: 227, 2023.
APA
Son, S., Woo, C.G., Lee, O., Kim, Y.J., & Lee, H. (2023). Inflammatory myofibroblastic tumor of the urinary bladder with FN1‑ALK gene fusion: A case report. Oncology Letters, 25, 227. https://doi.org/10.3892/ol.2023.13813
MLA
Son, S., Woo, C. G., Lee, O., Kim, Y. J., Lee, H."Inflammatory myofibroblastic tumor of the urinary bladder with FN1‑ALK gene fusion: A case report". Oncology Letters 25.6 (2023): 227.
Chicago
Son, S., Woo, C. G., Lee, O., Kim, Y. J., Lee, H."Inflammatory myofibroblastic tumor of the urinary bladder with FN1‑ALK gene fusion: A case report". Oncology Letters 25, no. 6 (2023): 227. https://doi.org/10.3892/ol.2023.13813
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