Open Access

Gallbladder neuroendocrine carcinoma: A report of two cases and literature review

  • Authors:
    • Yong Liao
    • We Cao
    • Zhongkang Li
    • Xin Xu
    • Ye Zhang
    • Zhihu Liu
    • Jie Miao
    • Yang Zhou
    • Zhongguang Zhen
    • Dengxiang Liu
    • Hui Li
    • Lichao Chai
    • Yan Wei
    • Xiaochong Zhang
    • Le Zhang
    • Jitao Wang
    • Yanpeng Tian
  • View Affiliations

  • Published online on: April 13, 2023     https://doi.org/10.3892/ol.2023.13815
  • Article Number: 229
  • Copyright: © Liao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gallbladder neuroendocrine carcinoma (GB‑NEC) is a rare, aggressive neuroendocrine carcinoma that arises from the gallbladder. Patients with GB‑NEC usually have a poor prognosis. The present study described two cases diagnosed with GB‑NEC and reviewed the literature to improve knowledge of GB‑NEC. The present study reported on two cases of GB‑NEC in male patients aged 65 and 66 years, respectively. Both patients underwent surgical resection. Postoperative pathology confirmed that one case had mixed adeno‑neuroendocrine carcinoma and the other had large cell neuroendocrine carcinoma. In addition, both patients had uneventful recoveries following surgery and received cisplatin‑etoposide combination chemotherapy. The present study summarized the two cases and reviewed the literature to improve understanding of GB‑NEC. The results revealed that radiological findings of GB‑NEC are non‑specific. The present study demonstrated that surgical resection was still the most effective therapy and that postoperative adjuvant chemotherapy could markedly improve the prognosis of patients with GB‑NEC.
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June-2023
Volume 25 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Liao Y, Cao W, Li Z, Xu X, Zhang Y, Liu Z, Miao J, Zhou Y, Zhen Z, Liu D, Liu D, et al: Gallbladder neuroendocrine carcinoma: A report of two cases and literature review. Oncol Lett 25: 229, 2023
APA
Liao, Y., Cao, W., Li, Z., Xu, X., Zhang, Y., Liu, Z. ... Tian, Y. (2023). Gallbladder neuroendocrine carcinoma: A report of two cases and literature review. Oncology Letters, 25, 229. https://doi.org/10.3892/ol.2023.13815
MLA
Liao, Y., Cao, W., Li, Z., Xu, X., Zhang, Y., Liu, Z., Miao, J., Zhou, Y., Zhen, Z., Liu, D., Li, H., Chai, L., Wei, Y., Zhang, X., Zhang, L., Wang, J., Tian, Y."Gallbladder neuroendocrine carcinoma: A report of two cases and literature review". Oncology Letters 25.6 (2023): 229.
Chicago
Liao, Y., Cao, W., Li, Z., Xu, X., Zhang, Y., Liu, Z., Miao, J., Zhou, Y., Zhen, Z., Liu, D., Li, H., Chai, L., Wei, Y., Zhang, X., Zhang, L., Wang, J., Tian, Y."Gallbladder neuroendocrine carcinoma: A report of two cases and literature review". Oncology Letters 25, no. 6 (2023): 229. https://doi.org/10.3892/ol.2023.13815