Open Access

Malignant adipocytic tumours: A 20‑year single‑centre retrospective study

  • Authors:
    • Fernando Mendoza-Moreno
    • Belén Matías-García
    • Ana Quiroga-Valcárcel
    • Francisca García-Moreno Nisa
    • Cristina Díez-Corral
    • Alma Blázquez-Martín
    • Cristina Vera-Mansilla
    • Enrique Ovejero-Merino
    • Manuel Díez-Alonso
    • Lucía Diego-García
    • Melchor Alvarez-Mon
    • Miguel A. Ortega
    • Alberto Gutiérrez-Calvo
  • View Affiliations

  • Published online on: April 21, 2023     https://doi.org/10.3892/ol.2023.13833
  • Article Number: 247
  • Copyright: © Mendoza-Moreno et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Adipocytic tumours are the most common soft tissue neoplasms. Among them, liposarcoma is the most frequent malignant neoplasm. However, to the best of our knowledge, no previously published study has assessed the evolution and oncological prognosis of the different subtypes of liposarcoma at the retroperitoneal level compared with at other locations. The present study is a retrospective observational study in which all patients were operated on between October 2000 and January 2020 with a histological diagnosis of liposarcoma. Variables, such as age, sex, location, histological type, recurrence, type of treatment and mortality, among others, were analysed. The patients were divided into two groups: Group A (retroperitoneal location) and group B (non‑retroperitoneal location). A total of 52 patients with a diagnosis of liposarcoma (17 women and 35 men) and a mean age of 57.2±15.9 years were assessed. A total of 16 patients were classified into group A and 36 into group B. The OR of recurrence was 1.5 (P=0.02) for R1 vs. R0 resection in group A. The OR of recurrence in group B for R1 vs. R0 resection was 1.8 (P=0.77), whereas for R2 vs. R0 resection, the OR was 69 (P=0.011). In conclusion, 52 cases of malignant adipocytic tumours collected during 2000‑2020 were analysed with the new World Health Organization classification (updated 2020). Although its recurrence potential and capacity for distant metastasis depended on each histological type, surgical treatment with unaffected margins was the main prognostic factor for survival. The present study identified differences in relation to the survival of each histological subtype and its location, finding greater survival in dedifferentiated liposarcoma, myxoid liposarcoma and pleomorphic liposarcoma located at the extraperitoneal level than in the retroperitoneal location. Resectability was not influenced by liposarcoma location.
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June-2023
Volume 25 Issue 6

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Spandidos Publications style
Mendoza-Moreno F, Matías-García B, Quiroga-Valcárcel A, García-Moreno Nisa F, Díez-Corral C, Blázquez-Martín A, Vera-Mansilla C, Ovejero-Merino E, Díez-Alonso M, Diego-García L, Diego-García L, et al: Malignant adipocytic tumours: A 20‑year single‑centre retrospective study. Oncol Lett 25: 247, 2023
APA
Mendoza-Moreno, F., Matías-García, B., Quiroga-Valcárcel, A., García-Moreno Nisa, F., Díez-Corral, C., Blázquez-Martín, A. ... Gutiérrez-Calvo, A. (2023). Malignant adipocytic tumours: A 20‑year single‑centre retrospective study. Oncology Letters, 25, 247. https://doi.org/10.3892/ol.2023.13833
MLA
Mendoza-Moreno, F., Matías-García, B., Quiroga-Valcárcel, A., García-Moreno Nisa, F., Díez-Corral, C., Blázquez-Martín, A., Vera-Mansilla, C., Ovejero-Merino, E., Díez-Alonso, M., Diego-García, L., Alvarez-Mon, M., Ortega, M. A., Gutiérrez-Calvo, A."Malignant adipocytic tumours: A 20‑year single‑centre retrospective study". Oncology Letters 25.6 (2023): 247.
Chicago
Mendoza-Moreno, F., Matías-García, B., Quiroga-Valcárcel, A., García-Moreno Nisa, F., Díez-Corral, C., Blázquez-Martín, A., Vera-Mansilla, C., Ovejero-Merino, E., Díez-Alonso, M., Diego-García, L., Alvarez-Mon, M., Ortega, M. A., Gutiérrez-Calvo, A."Malignant adipocytic tumours: A 20‑year single‑centre retrospective study". Oncology Letters 25, no. 6 (2023): 247. https://doi.org/10.3892/ol.2023.13833