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Case Report Open Access

Misdiagnosis of angioimmunoblastic T‑cell lymphoma: A case report

  • Authors:
    • Yan Li
    • Xiaohan Gao
    • Ling-Zhijie Kong
    • Jie Li
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 250
    |
    Published online on: April 26, 2023
       https://doi.org/10.3892/ol.2023.13836
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Abstract

Angioimmunoblastic T‑cell lymphoma (AITL) is a specific subtype of peripheral T‑cell lymphoma that is challenging to diagnose due to the lack of specific pathological characteristics. This report describes the case of a 56‑year‑old man with Hodgkin lymphoma in whom the gene rearrangement results were positive for TCRβDB+Jβ1/2. Pathological and immunochemical examinations revealed a diagnosis of lymphoma that was a composite of AITL and focal classical Hodgkin lymphoma. Unfortunately, he died soon after the correct diagnosis was made. This case shows that a combination of immunohistochemistry and gene rearrangement analysis can increase the diagnostic accuracy for AITL. A review of the literature on the misdiagnosis of AITL indicates that this disease progresses rapidly with a high mortality rate. Our experience, in this case, highlights the need for early diagnosis.
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1 

Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD and Jaffe ES: The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 127:2375–2390. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Lachenal F, Berger F, Ghesquières H, Biron P, Hot A, Callet-Bauchu E, Chassagne C, Coiffier B, Durieu I, Rousset H and Salles G: Angioimmunoblastic T-cell lymphoma: Clinical and laboratory features at diagnosis in 77 patients. Medicine (Baltimore). 86:282–292. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Federico M, Rudiger T, Bellei M, Nathwani BN, Luminari S, Coiffier B, Harris NL, Jaffe ES, Pileri SA, Savage KJ, et al: Clinicopathologic characteristics of angioimmunoblastic T-cell lymphoma: Analysis of the international peripheral T-cell lymphoma project. J Clin Oncol. 31:240–246. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Lunning MA and Vose JM: Angioimmunoblastic T-cell lymphoma: The many-faced lymphoma. Blood. 129:1095–1102. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Xie Y and Jaffe ES: How I Diagnose angioimmunoblastic T-cell lymphoma. Am J Clin Pathol. 156:1–14. 2021. View Article : Google Scholar : PubMed/NCBI

6 

Dunleavy K, Wilson WH and Jaffe ES: Angioimmunoblastic T cell lymphoma: Pathobiological insights and clinical implicationsl. Curr Opin Hematol. 14:348–453. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Basha BM, Bryant SC, Rech KL, Feldman AL, Vrana JA, Shi M, Reed KA and King RL: Application of a 5 marker panel to the routine diagnosis of peripheral T-cell lymphoma with T-follicular helper phenotype. Am J Surg Pathol. 43:1282–1290. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Xu J, Tang Y, Zhao S, Zhang W, Xiu Y, Liu T and Wu Y: Angioimmunoblastic T-cell lymphoma with coexisting plasma cell myeloma: A case report and review of the literature. Tohoku J Exp Med. 235:283–288. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Xie C, Li X, Zeng H and Qian W: Molecular insights into pathogenesis and targeted therapy of peripheral T cell lymphoma. Exp Hematol Oncol. 9:302020. View Article : Google Scholar : PubMed/NCBI

10 

Botros N, Cerroni L, Shawwa A, Green PJ, Greer W, Pasternak S and Walsh NM: Cutaneous manifestations of angioimmunoblastic T-cell lymphoma: Clinical and pathological characteristics. Am J Dermatopathol. 37:274–283. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Zhu WY, Yang W, Xu XH, Shen JL and Zhang CY: An Angioimmunoblastic T cell lymphoma patient misdiagnosed as systemic lupus erythematosus: A case report and literature review. Clin Misdiagnosis Mistherapy. 29:14–17. 2016.(In Chinese).

12 

Pircher A, Verdorfer I, Brunner A, Hopfinger G and Steurer M: Paraneoplastic phenomena and diagnostic challenges in angioimmunoblastic T-cell lymphoma (AITL): Report of two cases and review of the literature. In Vivo. 28:327–332. 2014.PubMed/NCBI

13 

Cortés JR and Palomero T: The curious origins of angioimmunoblastic T-cell lymphoma. Curr Opin Hematol. 23:434–443. 2016. View Article : Google Scholar : PubMed/NCBI

14 

de Leval L, Rickman DS, Thielen C, Reynies Ad, Huang YL, Delsol G, Lamant L, Leroy K, Brière J, Molina T, et al: The gene expression profile of nodal peripheral T-cell lymphoma demonstrates a molecular link between angioimmunoblastic T-cell lymphoma (AITL) and follicular helper T (TFH) cells. Blood. 109:4952–4963. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Grogg KL, Attygalle AD, Macon WR, Remstein ED, Kurtin PJ and Dogan A: Expression of CXCL13, a chemokine highly upregulated in germinal center T-helper cells, distinguishes angioimmunoblastic T-cell lymphoma from peripheral T-cell lymphoma, unspecified. Mod Pathol. 19:1101–1107. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Aung NY, Ohtake H, Iwaba A, Kato T, Ohe R, Tajima K, Nagase T and Yamakawa M: Angioimmunoblastic T-cell lymphoma with dual genotype of TCR and IgH genes. Pathol Res Pract. 207:317–321. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Hopfinger G and Staber P: Current standard in diagnostic and therapy of peripheral T-cell lymphoma. Dtsch Med Wochenschr. 144:1400–1404. 2019.(In German). View Article : Google Scholar : PubMed/NCBI

18 

Laforga JB, Gasent JM and Vaquero M: Potential misdiagnosis of angioimmunoblastic T-cell lymphoma with Hodgkin's lymphoma: A case report. Acta Cytol. 54 (5 Suppl):S840–S844. 2010.PubMed/NCBI

19 

Gao X, Huang W, Li W, Xie J, Zheng Y and Zhou X: Clinicopathologic analysis of angioimmunoblastic T-cell lymphoma with Hodgkin/Reed-Sternberg-like cells. Zhonghua Bing Li Xue Za Zhi. 44:553–558. 2015.(In Chinese). PubMed/NCBI

20 

Parekh V and Peker D: EBV-related primary splenic lymphocyte-depleted classical Hodgkin lymphoma. J Clin Pathol. 68:947–950. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Ferrarini I, Rigo A, Visco C, Krampera M and Vinante F: The evolving knowledge on T and NK cells in classic Hodgkin lymphoma: Insights into novel subsets populating the immune microenvironment. Cancers (Basel). 12:37572020. View Article : Google Scholar : PubMed/NCBI

22 

Connors JM: Hodgkin lymphoma: Outsmarting HRS cells. Blood. 136:2362–2364. 2020. View Article : Google Scholar : PubMed/NCBI

23 

Moccia AA, Aeppli S, Güsewell S, Bargetzi M, Caspar C, Brülisauer D, Ebnöther M, Fehr M, Fischer N, Ghilardi G, et al: Clinical characteristics and outcome of patients over 60 years with Hodgkin lymphoma treated in Switzerland. Hematol Oncol. 39:196–204. 2021. View Article : Google Scholar : PubMed/NCBI

24 

Lin HN, Liu CY, Hong YC, Pai JT, Yang CF, Yu YB, Hsiao LT, Chiou TJ, Liu JH, Gau JP, et al: Clinical features and prognostic factors of angioimmunoblastic T-cell lymphoma in Taiwan: A single-institution experience. Leuk Lymphoma. 51:2208–2214. 2010. View Article : Google Scholar : PubMed/NCBI

25 

van den Akker TA and Chen H: Angioimmunoblastic T-cell lymphoma masquerading as granulomatous lymphadenitis: Fine needle aspiration cytology, clinical and radiology correlation. Diagn Cytopathol. 49:555–558. 2021. View Article : Google Scholar : PubMed/NCBI

26 

Ellis C, Ramirez J and LaFond AA: Angioimmunoblastic T-cell lymphoma mimicking diffuse large B-cell lymphoma. Cutis. 102:179–182. 2018.PubMed/NCBI

27 

Keefe M, Buntinx-Krieg T and Contestable J: Angioimmunoblastic T-cell Lymphoma mimicking DRESS syndrome. Cutis. 109:E29–E32. 2022. View Article : Google Scholar : PubMed/NCBI

28 

Trimech M, Letourneau A, Missiaglia E, De Prijck B, Nagy-Hulliger M, Somja J, Vivario M, Gaulard P, Lambert F, Bisig B and de Leval L: Angioimmunoblastic T-cell lymphoma and chronic lymphocytic Leukemia/small lymphocytic lymphoma: A novel form of composite lymphoma potentially mimicking Richter syndrome. Am J Surg Pathol. 45:773–786. 2021. View Article : Google Scholar : PubMed/NCBI

29 

Papadi B, Polski JM, Clarkson DR and Liu-Dumlao TO: Atypical angioimmunoblastic T-cell lymphomas masquerading as systemic polyclonal B-immunoblastic proliferation. Virchows Arch. 461:323–331. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Smithberger ES, Rezania D, Chavan RN, Lien MH, Cualing HD and Messina JL: Primary cutaneous angioimmunoblastic T-cell lymphoma histologically mimicking an inflammatory dermatosis. J Drugs Dermatol. 9:851–855. 2010.PubMed/NCBI

31 

Ahsanuddin AN, Brynes RK and Li S: Peripheral blood polyclonal plasmacytosis mimicking plasma cell leukemia in patients with angioimmunoblastic T-cell lymphoma: Report of 3 cases and review of the literature. Int J Clin Exp Pathol. 4:416–420. 2011.PubMed/NCBI

32 

Han P, Yang L, Yan W and Tian D: Angioimmunoblastic T-cell lymphoma mimicking drug fever and infectious etiology after a thyroidectomy: A case report. Medicine. 98:e169322019. View Article : Google Scholar : PubMed/NCBI

33 

Kaffenberger B, Haverkos B, Tyler K, Wong HK, Porcu P and Gru AA: Extranodal marginal zone Lymphoma-like presentations of angioimmunoblastic T-cell lymphoma: A T-cell lymphoma masquerading as a B-cell lymphoproliferative disorder. Am J Dermatopathol. 37:604–613. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Szablewski V, Dereure O, René C, Tempier A, Durand L, Alame M, Cacheux V and Costes-Martineau V: Cutaneous localization of angioimmunoblastic T-cell lymphoma may masquerade as B-cell lymphoma or classical Hodgkin lymphoma: A histologic diagnostic pitfall. J Cutan Pathol. 46:102–110. 2019.PubMed/NCBI

35 

Suárez AE, Artiga MJ, Santonja C, Montes-Moreno S, De Pablo P, Requena L, Piris MA and Rodríguez-Pinilla SM: Angioimmunoblastic T-cell lymphoma with a clonal plasma cell proliferation that underwent immunoglobulin isotype switch in the skin, coinciding with cutaneous disease progression. J Cutan Pathol. 43:1203–1210. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Gao X, Kong L and Li J: Misdiagnosis of angioimmunoblastic T‑cell lymphoma: A case report. Oncol Lett 25: 250, 2023.
APA
Li, Y., Gao, X., Kong, L., & Li, J. (2023). Misdiagnosis of angioimmunoblastic T‑cell lymphoma: A case report. Oncology Letters, 25, 250. https://doi.org/10.3892/ol.2023.13836
MLA
Li, Y., Gao, X., Kong, L., Li, J."Misdiagnosis of angioimmunoblastic T‑cell lymphoma: A case report". Oncology Letters 25.6 (2023): 250.
Chicago
Li, Y., Gao, X., Kong, L., Li, J."Misdiagnosis of angioimmunoblastic T‑cell lymphoma: A case report". Oncology Letters 25, no. 6 (2023): 250. https://doi.org/10.3892/ol.2023.13836
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Gao X, Kong L and Li J: Misdiagnosis of angioimmunoblastic T‑cell lymphoma: A case report. Oncol Lett 25: 250, 2023.
APA
Li, Y., Gao, X., Kong, L., & Li, J. (2023). Misdiagnosis of angioimmunoblastic T‑cell lymphoma: A case report. Oncology Letters, 25, 250. https://doi.org/10.3892/ol.2023.13836
MLA
Li, Y., Gao, X., Kong, L., Li, J."Misdiagnosis of angioimmunoblastic T‑cell lymphoma: A case report". Oncology Letters 25.6 (2023): 250.
Chicago
Li, Y., Gao, X., Kong, L., Li, J."Misdiagnosis of angioimmunoblastic T‑cell lymphoma: A case report". Oncology Letters 25, no. 6 (2023): 250. https://doi.org/10.3892/ol.2023.13836
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