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Association between the expression levels of ADAMTS16 and BMP2 and tumor budding in hepatocellular carcinoma

  • Authors:
    • Di Jiang
    • Shaoshao Xu
    • Chuanpeng Zhang
    • Chuanbing Hu
    • Lei Li
    • Mingming Zhang
    • Haiyan Wu
    • Dongchang Yang
    • Yanrong Liu
  • View Affiliations / Copyright

    Affiliations: Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China, Medical Research Center, Affiliated Hospital of Jining Medical University, Jining, Shandong 272029, P.R. China, Department of Pediatric Surgery, Affiliated Hospital of Jining Medical University, Jining, Shandong 272029, P.R. China, Department of Pathology, Affiliated Hospital of Jining Medical University, Jining, Shandong 272029, P.R. China, Department of Medical Equipment, Affiliated Hospital of Jining Medical University, Jining, Shandong 272029, P.R. China, Department of Surgery, Affiliated Hospital of Jining Medical University, Jining, Shandong 272029, P.R. China
    Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 256
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    Published online on: April 27, 2023
       https://doi.org/10.3892/ol.2023.13842
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Abstract

Tumor budding (TB) has become a crucial factor for predicting the malignancy grade and prognostic outcome for multiple types of solid cancer. Studies have investigated the prognostic value of TB in hepatocellular carcinoma (HCC). However, its molecular mechanism in HCC remains unclear. To the best of our knowledge, the present study was the first to compare the expression of differentially expressed genes (DEGs) between TB‑positive (TB‑pos) and TB‑negative HCC tissues. In the present study, total RNA was extracted from 40 HCC tissue specimens and then sequenced. According to Gene Ontology (GO) functional annotation, upregulated DEGs were markedly associated with embryonic kidney development‑related GO terms, which suggested that the TB process may at least partly mimic the process of embryonic kidney development. Subsequently, two genes, a disintegrin and metalloproteinase domain with thrombospondin motifs 16 (ADAMTS16) and bone morphogenetic protein 2 (BMP2), were screened and verified through immunohistochemical analysis of HCC tissue microarrays. According to the immunohistochemical results, ADAMTS16 and BMP2 were upregulated in TB‑pos HCC samples, and BMP2 expression was increased in budding cells compared with the tumor center. Additionally, through cell culture experiments, it was demonstrated that ADAMTS16 and BMP2 may promote TB of liver cancer, thus promoting the malignant progression of liver cancer. Further analysis revealed that ADAMTS16 expression was associated with necrosis and cholestasis, and BMP2 expression was associated with the Barcelona Clinic Liver Cancer stage and the vessels encapsulating tumor clusters. Overall, the findings of the present study provided insights into the possible mechanisms of TB in HCC and revealed potential anti‑HCC therapeutic targets.
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View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Yang JD, Hainaut P, Gores GJ, Amadou A, Plymoth A and Roberts LR: A global view of hepatocellular carcinoma: Trends, risk, prevention and management. Nat Rev Gastroenterol Hepatol. 16:589–604. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Turajlic S and Swanton C: Metastasis as an evolutionary process. Science. 352:169–175. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Hase K, Shatney C, Johnson D, Trollope M and Vierra M: Prognostic value of tumor ‘budding’ in patients with colorectal cancer. Dis Colon Rectum. 36:627–635. 1993. View Article : Google Scholar : PubMed/NCBI

6 

Koike M, Kodera Y, Itoh Y, Nakayama G, Fujiwara M, Hamajima N and Nakao A: Multivariate analysis of the pathologic features of esophageal squamous cell cancer: Tumor budding is a significant independent prognostic factor. Ann Surg Oncol. 15:1977–1982. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Luo WR, Gao F, Li SY and Yao KT: Tumour budding and the expression of cancer stem cell marker aldehyde dehydrogenase 1 in nasopharyngeal carcinoma. Histopathology. 61:1072–1081. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Masuda R, Kijima H, Imamura N, Aruga N, Nakamura Y, Masuda D, Takeichi H, Kato N, Nakagawa T, Tanaka M, et al: Tumor budding is a significant indicator of a poor prognosis in lung squamous cell carcinoma patients. Mol Med Rep. 6:937–943. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Karamitopoulou E, Zlobec I, Born D, Kondi-Pafiti A, Lykoudis P, Mellou A, Gennatas K, Gloor B and Lugli A: Tumour budding is a strong and independent prognostic factor in pancreatic cancer. Eur J Cancer. 49:1032–1039. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Grigore AD, Jolly MK, Jia D, Farach-Carson MC and Levine H: Tumor budding: The name is EMT. Partial EMT. J Clin Med. 5:512016. View Article : Google Scholar : PubMed/NCBI

11 

De Smedt L, Palmans S, Andel D, Govaere O, Boeckx B, Smeets D, Galle E, Wouters J, Barras D, Suffiotti M, et al: Expression profiling of budding cells in colorectal cancer reveals an EMT-like phenotype and molecular subtype switching. Br J Cancer. 116:58–65. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Kairaluoma V, Kemi N, Pohjanen VM, Saarnio J and Helminen O: Tumour budding and tumour-stroma ratio in hepatocellular carcinoma. Br J Cancer. 123:38–45. 2020. View Article : Google Scholar : PubMed/NCBI

13 

Wei L, Delin Z, Kefei Y, Hong W, Jiwei H and Yange Z: A classification based on tumor budding and immune score for patients with hepatocellular carcinoma. Oncoimmunology. 9:16724952019. View Article : Google Scholar : PubMed/NCBI

14 

Zhang D, Qian C, Wei H and Qian X: Identification of the prognostic value of tumor microenvironment-related genes in esophageal squamous cell carcinoma. Front Mol Biosci. 7:5994752020. View Article : Google Scholar : PubMed/NCBI

15 

Sakamoto N, Oue N, Noguchi T, Sentani K, Anami K, Sanada Y, Yoshida K and Yasui W: Serial analysis of gene expression of esophageal squamous cell carcinoma: ADAMTS16 is upregulated in esophageal squamous cell carcinoma. Cancer Sci. 101:1038–1044. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Mersakova S, Janikova K, Kalman M, Marcinek J, Grendar M, Vojtko M, Kycina R, Pindura M, Janik J, Mikolajcik P, et al: Cancer stem cell marker expression and methylation status in patients with colorectal cancer. Oncol Lett. 24:2312022. View Article : Google Scholar : PubMed/NCBI

17 

Raida M, Clement JH, Ameri K, Han C, Leek RD and Harris AL: Expression of bone morphogenetic protein 2 in breast cancer cells inhibits hypoxic cell death. Int J Oncol. 26:1465–1470. 2005.PubMed/NCBI

18 

Yang S, Pham LK, Liao CP, Frenkel B, Reddi AH and Roy-Burman P: A novel bone morphogenetic protein signaling in heterotypic cell interactions in prostate cancer. Cancer Res. 68:198–205. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Hsu YL, Huang MS, Yang CJ, Hung JY, Wu LY and Kuo PL: Lung tumor-associated osteoblast-derived bone morphogenetic protein-2 increased epithelial-to-mesenchymal transition of cancer by Runx2/Snail signaling pathway. J Biol Chem. 286:37335–37346. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Wu G, Huang F, Chen Y, Zhuang Y, Huang Y and Xie Y: High levels of BMP2 promote liver cancer growth via the activation of myeloid-derived suppressor cells. Front Oncol. 10:1942020. View Article : Google Scholar : PubMed/NCBI

21 

Liu Z, Sun J, Wang X and Cao Z: MicroRNA-129-5p promotes proliferation and metastasis of hepatocellular carcinoma by regulating the BMP2 gene. Exp Ther Med. 21:2572021. View Article : Google Scholar : PubMed/NCBI

22 

Robinson MD, McCarthy DJ and Smyth GK: edgeR: A bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 26:139–140. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Benjamini Y and Hochberg Y: Controlling the false discovery rate-a practical and powerful approach to multiple testing. J Roy Statist Soc B. 57:289–300. 1995.

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Scott RW, Crighton D and Olson MF: Modeling and imaging 3-dimensional collective cell invasion. J Vis Exp. 35252011.PubMed/NCBI

26 

Pfisterer L and Korff T: Spheroid-based in vitro angiogenesis model. Methods Mol Biol. 1430:167–177. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Muenst S, Läubli H, Soysal SD, Zippelius A, Tzankov A and Hoeller S: The immune system and cancer evasion strategies: Therapeutic concepts. J Intern Med. 279:541–562. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Aust S, Felix S, Auer K, Bachmayr-Heyda A, Kenner L, Dekan S, Meier SM, Gerner C, Grimm C and Pils D: Absence of PD-L1 on tumor cells is associated with reduced MHC I expression and PD-L1 expression increases in recurrent serous ovarian cancer. Sci Rep. 7:429292017. View Article : Google Scholar : PubMed/NCBI

29 

Baloche V, Rivière J, Tran TBT, Gelin A, Bawa O, Signolle N, Diop MBK, Dessen P, Beq S, David M and Busson P: Serial transplantation unmasks galectin-9 contribution to tumor immune escape in the MB49 murine model. Sci Rep. 11:52272021. View Article : Google Scholar : PubMed/NCBI

30 

Liao J, Li JZ, Xu J, Xu Y, Wen WP, Zheng L and Li L: High S100A9+ cell density predicts a poor prognosis in hepatocellular carcinoma patients after curative resection. Aging (Albany NY). 13:16367–16380. 2021. View Article : Google Scholar : PubMed/NCBI

31 

Liang F, Cao W, Wang Y, Li L, Zhang G and Wang Z: The prognostic value of tumor budding in invasive breast cancer. Pathol Res Pract. 209:269–275. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Prall F: Tumour budding in colorectal carcinoma. Histopathology. 50:151–162. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Morodomi T, Isomoto H, Shirouzu K, Kakegawa K, Irie K and Morimatsu M: An index for estimating the probability of lymph node metastasis in rectal cancers. Lymph node metastasis and the histopathology of actively invasive regions of cancer. Cancer. 63:539–543. 1989. View Article : Google Scholar : PubMed/NCBI

34 

Ueno H, Murphy J, Jass JR, Mochizuki H and Talbot IC: Tumour ‘budding’ as an index to estimate the potential of aggressiveness in rectal cancer. Histopathology. 40:127–132. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Mitrovic B, Schaeffer DF, Riddell RH and Kirsch R: Tumor budding in colorectal carcinoma: Time to take notice. Mod Pathol. 25:1315–1325. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Satoh K, Nimura S, Aoki M, Hamasaki M, Koga K, Iwasaki H, Yamashita Y, Kataoka H and Nabeshima K: Tumor budding in colorectal carcinoma assessed by cytokeratin immunostaining and budding areas: Possible involvement of c-Met. Cancer Sci. 105:1487–1495. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Rogers AC, Gibbons D, Hanly AM, Hyland JM, O'Connell PR, Winter DC and Sheahan K: Prognostic significance of tumor budding in rectal cancer biopsies before neoadjuvant therapy. Mod Pathol. 27:156–162. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Li A and Machesky LM: Melanoblasts on the move: Rac1 sets the pace. Small GTPases. 3:115–119. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Gupta S and Maitra A: EMT: Matter of life or death? Cell. 164:840–842. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Yu M, Bardia A, Wittner BS, Stott SL, Smas ME, Ting DT, Isakoff SJ, Ciciliano JC, Wells MN, Shah AM, et al: Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science. 339:580–584. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Li T, Zhou J, Jiang Y, Zhao Y, Huang J, Li W, Huang Z, Chen Z, Tang X, Chen H and Yang Z: The novel protein ADAMTS16 promotes gastric carcinogenesis by targeting IFI27 through the NF-κb signaling pathway. Int J Mol Sci. 23:110222022. View Article : Google Scholar : PubMed/NCBI

42 

Wu CX, Lin GS, Lin ZX, Zhang JD, Chen L, Liu SY, Tang WL, Qiu XX and Zhou CF: Peritumoral edema on magnetic resonance imaging predicts a poor clinical outcome in malignant glioma. Oncol Lett. 10:2769–2776. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Almishri W, Swain LA, D'Mello C, Le TS, Urbanski SJ and Nguyen HH: ADAM metalloproteinase domain 17 regulates cholestasis-associated liver injury and sickness behavior development in mice. Front Immunol. 12:7791192022. View Article : Google Scholar : PubMed/NCBI

44 

Guo J, Guo M and Zheng J: Inhibition of BONE MORPHOGENETIC PROtein 2 suppresses the stemness maintenance of cancer stem cells in hepatocellular carcinoma via the MAPK/ERK pathway. Cancer Manag Res. 13:773–785. 2021. View Article : Google Scholar : PubMed/NCBI

45 

Zuo WH, Zeng P, Chen X, Lu YJ, Li A and Wu JB: Promotive effects of bone morphogenetic protein 2 on angiogenesis in hepatocarcinoma via multiple signal pathways. Sci Rep. 6:374992016. View Article : Google Scholar : PubMed/NCBI

46 

Raida M, Clement JH, Leek RD, Ameri K, Bicknell R, Niederwieser D and Harris AL: Bone morphogenetic protein 2 (BMP-2) and induction of tumor angiogenesis. J Cancer Res Clin Oncol. 131:741–750. 2005. View Article : Google Scholar : PubMed/NCBI

47 

Renne SL, Woo HY, Allegra S, Rudini N, Yano H, Donadon M, Viganò L, Akiba J, Lee HS, Rhee H, et al: Vessels encapsulating tumor clusters (VETC) is a powerful predictor of aggressive hepatocellular carcinoma. Hepatology. 71:183–195. 2020. View Article : Google Scholar : PubMed/NCBI

48 

Rodriguez MI, Peralta-Leal A, O'Valle F, Rodriguez-Vargas JM, Gonzalez-Flores A, Majuelos-Melguizo J, López L, Serrano S, de Herreros AG, Rodríguez-Manzaneque JC, et al: PARP-1 regulates metastatic melanoma through modulation of vimentin-induced malignant transformation. PLoS Genet. 9:e10035312013. View Article : Google Scholar : PubMed/NCBI

49 

Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, et al: The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 133:704–715. 2008. View Article : Google Scholar : PubMed/NCBI

50 

Wang MH, Zhou XM, Zhang MY, Shi L, Xiao RW, Zeng LS, Yang XZ, Zheng XFS, Wang HY and Mai SJ: BMP2 promotes proliferation and invasion of nasopharyngeal carcinoma cells via mTORC1 pathway. Aging (Albany NY). 9:1326–1340. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jiang D, Xu S, Zhang C, Hu C, Li L, Zhang M, Wu H, Yang D and Liu Y: Association between the expression levels of ADAMTS16 and BMP2 and tumor budding in hepatocellular carcinoma. Oncol Lett 25: 256, 2023.
APA
Jiang, D., Xu, S., Zhang, C., Hu, C., Li, L., Zhang, M. ... Liu, Y. (2023). Association between the expression levels of ADAMTS16 and BMP2 and tumor budding in hepatocellular carcinoma. Oncology Letters, 25, 256. https://doi.org/10.3892/ol.2023.13842
MLA
Jiang, D., Xu, S., Zhang, C., Hu, C., Li, L., Zhang, M., Wu, H., Yang, D., Liu, Y."Association between the expression levels of ADAMTS16 and BMP2 and tumor budding in hepatocellular carcinoma". Oncology Letters 25.6 (2023): 256.
Chicago
Jiang, D., Xu, S., Zhang, C., Hu, C., Li, L., Zhang, M., Wu, H., Yang, D., Liu, Y."Association between the expression levels of ADAMTS16 and BMP2 and tumor budding in hepatocellular carcinoma". Oncology Letters 25, no. 6 (2023): 256. https://doi.org/10.3892/ol.2023.13842
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang D, Xu S, Zhang C, Hu C, Li L, Zhang M, Wu H, Yang D and Liu Y: Association between the expression levels of ADAMTS16 and BMP2 and tumor budding in hepatocellular carcinoma. Oncol Lett 25: 256, 2023.
APA
Jiang, D., Xu, S., Zhang, C., Hu, C., Li, L., Zhang, M. ... Liu, Y. (2023). Association between the expression levels of ADAMTS16 and BMP2 and tumor budding in hepatocellular carcinoma. Oncology Letters, 25, 256. https://doi.org/10.3892/ol.2023.13842
MLA
Jiang, D., Xu, S., Zhang, C., Hu, C., Li, L., Zhang, M., Wu, H., Yang, D., Liu, Y."Association between the expression levels of ADAMTS16 and BMP2 and tumor budding in hepatocellular carcinoma". Oncology Letters 25.6 (2023): 256.
Chicago
Jiang, D., Xu, S., Zhang, C., Hu, C., Li, L., Zhang, M., Wu, H., Yang, D., Liu, Y."Association between the expression levels of ADAMTS16 and BMP2 and tumor budding in hepatocellular carcinoma". Oncology Letters 25, no. 6 (2023): 256. https://doi.org/10.3892/ol.2023.13842
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