Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
June-2023 Volume 25 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2023 Volume 25 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Predictive factors and a novel nomogram for recurrence of primary retroperitoneal liposarcoma: Comprehensive analysis of 128 cases

  • Authors:
    • Zhi-Yuan Yu
    • Jing-Wang Gao
    • Na Liu
    • Si-Xin Zhou
    • Xu-Dong Zhao
    • Pei-Yu Li
  • View Affiliations / Copyright

    Affiliations: School of Medicine, Nankai University, Tianjin 300071, P.R. China, Medical School of Chinese People's Liberation Army, Beijing 100853, P.R. China, Medical School of Chinese People's Liberation Army, Beijing 100853, P.R. China, Department of General Surgery, The First Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China, Department of General Surgery, The First Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 257
    |
    Published online on: April 28, 2023
       https://doi.org/10.3892/ol.2023.13843
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Since primary retroperitoneal liposarcoma (PRPLS) is rare in the clinic, related clinical studies are lacking. The present study was designed to investigate the predictive factors of short‑term (≤1 year) recurrence (STR) and construct a novel nomogram of local recurrence‑free survival (LRFS) for surgically resected PRPLS. A total of 128 PRPLS cases who underwent radical surgery were retrospectively analyzed. Based on the interval from the operation to tumor recurrence, the predictors of STR were screened using univariate and multivariate logistic regression analyses. Cox proportional hazard regression models were applied to identify the predictors of LRFS. Furthermore, the independent predictors acquired from multivariate analyses were used to construct a nomogram. Multivariate logistic regression analysis revealed that age ≥55 years [odds ratio (OR)=5.607, P=0.010], operative time ≥260 min (OR=9.716, P=0.005) and tumor necrosis (OR=3.781, P=0.037) were independent risk factors of STR for PRPLS. In the Cox regression analysis, clinical symptoms [hazard ratio (HR)=1.746, P=0.017], resection method (OR=0.370, P=0.021) and de‑differentiated histological subtype (HR=1.975, P=0.048) were identified as independent predictors of LRFS. Subsequently, the independent predictors acquired from multivariate analyses were used to construct a nomogram for LRFS. Age, operative time, tumor necrosis, clinical symptoms, resection method and histological subtype were related to recurrence for surgically resected PRPLS and a novel nomogram was constructed based on the above predictors.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Bagaria SP, Gabriel E and Mann GN: Multiply recurrent retroperitoneal liposarcoma. J Surg Oncol. 117:62–68. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Li Y, Wu G, Zhang Y, Yang W, Wang X, Duan L, Niu L, Chen J, Zhou W, Liu J, et al: Development and validation of a prognostic model to predict the prognosis of patients with retroperitoneal liposarcoma: A large international population-based cohort study. Front Oncol. 12:8578272022. View Article : Google Scholar : PubMed/NCBI

3 

Muratori F, Frenos F, Bettini L, Matera D, Mondanelli N, Scorianz M, Cuomo P, Scoccianti G, Beltrami G, Greto D, et al: Liposarcoma: Clinico-pathological analysis, prognostic factors and survival in a series of 307 patients treated at a single institution. J Orthop Sci. 23:1038–1044. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Salerno KE and Baldini EH: Role of radiation therapy in retroperitoneal sarcoma. J Natl Compr Canc Netw. 20:845–849. 2022. View Article : Google Scholar : PubMed/NCBI

5 

Molina G, Hull MA, Chen YL, DeLaney TF, De Amorim Bernstein K, Choy E, Cote G, Harmon DC, Mullen JT and Haynes AB: Preoperative radiation therapy combined with radical surgical resection is associated with a lower rate of local recurrence when treating unifocal, primary retroperitoneal liposarcoma. J Surg Oncol. 114:814–820. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Lewis JJ, Leung D, Woodruff JM and Brennan MF: Retroperitoneal soft-tissue sarcoma: Analysis of 500 patients treated and followed at a single institution. Ann Surg. 228:355–365. 1998. View Article : Google Scholar : PubMed/NCBI

7 

Neuhaus SJ, Barry P, Clark MA, Hayes AJ, Fisher C and Thomas JM: Surgical management of primary and recurrent retroperitoneal liposarcoma. Br J Surg. 92:246–252. 2015. View Article : Google Scholar

8 

Singer S, Antonescu CR, Riedel E and Brennan MF: Histologic subtype and margin of resection predict pattern of recurrence and survival for retroperitoneal liposarcoma. Ann Surg. 238:358–371. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Wu YX, Liu JY, Liu JJ, Yan P, Tang B, Cui YH, Zhao YL, Shi Y, Hao YX, Yu PW and Qian F: A retrospective, single-center cohort study on 65 patients with primary retroperitoneal liposarcoma. Oncol Lett. 15:1799–1810. 2018.PubMed/NCBI

10 

Yan Y, Xia S, Teng D, Hu S, Li S, Wang Y, Du X and Li R: Resection outcomes for primary and local recurrent retroperitoneal liposarcoma patients. Ann Transl Med. 8:14502020. View Article : Google Scholar : PubMed/NCBI

11 

Sun P, Ma R, Liu G, Wang L, Chang H and Li Y: Pathological prognostic factors of retroperitoneal liposarcoma: Comprehensive clinicopathological analysis of 124 cases. Ann Transl Med. 9:5742021. View Article : Google Scholar : PubMed/NCBI

12 

Xue G, Wang Z, Li C, Lv A, Tian X, Wu J, Qiu H and Hao C: A novel nomogram for predicting local recurrence-free survival after surgical resection for retroperitoneal liposarcoma from a Chinese tertiary cancer center. Int J Clin Oncol. 26:145–153. 2021. View Article : Google Scholar : PubMed/NCBI

13 

Sánchez-Hidalgo JM, Rufián-Peña S, Durán-Martínez M, Arjona-Sánchez Á, Salcedo-Leal I, Lopez-Cillero P and Briceño-Delgado J: Risk factors of early recurrence in retroperitoneal liposarcoma. Cir Esp (Engl Ed). 96:568–576. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Gronchi A, Miah AB, Dei Tos AP, Abecassis N, Bajpai J, Bauer S, Biagini R, Bielack S, Blay JY, Bolle S, et al: Soft tissue and visceral sarcomas: ESMO-EURACAN-GENTURIS clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 32:1348–1365. 2021. View Article : Google Scholar : PubMed/NCBI

15 

Nassif EF, Cope B, Traweek R, Witt RG, Erstad DJ, Scally CP, Thirasastr P, Zarzour MA, Ludwig J, Benjamin R, et al: Real-world use of palbociclib monotherapy in retroperitoneal liposarcomas at a large volume sarcoma center. Int J Cancer. 150:2012–2024. 2022. View Article : Google Scholar : PubMed/NCBI

16 

Zhuang A, Wu Q, Tong H, Zhang Y and Lu W: Development and validation of a nomogram for predicting recurrence-free survival of surgical resected retroperitoneal liposarcoma. Cancer Manag Res. 13:6633–6639. 2021. View Article : Google Scholar : PubMed/NCBI

17 

Xiao J, Liu J, Chen M, Liu W and He X: Diagnosis and prognosis of retroperitoneal liposarcoma: A single Asian center cohort of 57 cases. J Oncol. 2021:75940272021. View Article : Google Scholar : PubMed/NCBI

18 

Spolverato G, Chiminazzo V, Lorenzoni G, Fiore M, Radaelli S, Sanfilippo R, Sangalli C, Barisella M, Callegaro D and Gronchi A: Oncological outcomes after major vascular resections for primary retroperitoneal liposarcoma. Eur J Surg Oncol. 47:3004–3010. 2021. View Article : Google Scholar : PubMed/NCBI

19 

Littau MJ, Kulshrestha S, Bunn C, Agnew S, Sweigert P, Luchette FA and Baker MS: The importance of the margin of resection and radiotherapy in retroperitoneal liposarcoma. Am J Surg. 221:554–560. 2021. View Article : Google Scholar : PubMed/NCBI

20 

Miao CL, Zhang LL, Tseng WW, Qiu FB, Lu WQ, Dai YG, Rao XS, Li WJ, Zhang GK, Chen J, et al: A better overall survival (OS) for total (ipsilateral) retroperitoneal lipectomy than standard complete resection in patients with retroperitoneal liposarcoma: A comparative multi-institutional study. Ann Transl Med. 10:7852022. View Article : Google Scholar : PubMed/NCBI

21 

Naszai M, Kurjan A and Maughan TS: The prognostic utility of pre-treatment neutrophil-to-lymphocyte-ratio (NLR) in colorectal cancer: A systematic review and meta-analysis. Cancer Med. 10:5983–5997. 2021. View Article : Google Scholar : PubMed/NCBI

22 

Guthrie GJK, Charles KA, Roxburgh CSD, Horgan PG, McMillan DC and Clarke SJ: The systemic inflammation-based neutrophil-lymphocyte ratio: Experience in patients with cancer. Crit Rev Oncol Hematol. 88:218–230. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Dehner CA, Hagemann IS and Chrisinger JSA: Retroperitoneal dedifferentiated liposarcoma. Am J Clin Pathol. 156:920–925. 2021. View Article : Google Scholar : PubMed/NCBI

24 

Liu W, Zou B, Tang M, Li X, Huang M, Chen W and Miao C: Prediction of intraoperative bleeding and blood transfusion in patients with recurrent retroperitoneal liposarcoma: A retrospective study. Ann Transl Med. 10:9862022. View Article : Google Scholar : PubMed/NCBI

25 

Ishii K, Yokoyama Y, Nishida Y, Koike H, Yamada S, Kodera Y, Sassa N, Gotoh M and Nagino M: Characteristics of primary and repeated recurrent retroperitoneal liposarcoma: Outcomes after aggressive surgeries at a single institution. Jpn J Clin Oncol. 50:1412–1418. 2020. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yu Z, Gao J, Liu N, Zhou S, Zhao X and Li P: Predictive factors and a novel nomogram for recurrence of primary retroperitoneal liposarcoma: Comprehensive analysis of 128 cases. Oncol Lett 25: 257, 2023.
APA
Yu, Z., Gao, J., Liu, N., Zhou, S., Zhao, X., & Li, P. (2023). Predictive factors and a novel nomogram for recurrence of primary retroperitoneal liposarcoma: Comprehensive analysis of 128 cases. Oncology Letters, 25, 257. https://doi.org/10.3892/ol.2023.13843
MLA
Yu, Z., Gao, J., Liu, N., Zhou, S., Zhao, X., Li, P."Predictive factors and a novel nomogram for recurrence of primary retroperitoneal liposarcoma: Comprehensive analysis of 128 cases". Oncology Letters 25.6 (2023): 257.
Chicago
Yu, Z., Gao, J., Liu, N., Zhou, S., Zhao, X., Li, P."Predictive factors and a novel nomogram for recurrence of primary retroperitoneal liposarcoma: Comprehensive analysis of 128 cases". Oncology Letters 25, no. 6 (2023): 257. https://doi.org/10.3892/ol.2023.13843
Copy and paste a formatted citation
x
Spandidos Publications style
Yu Z, Gao J, Liu N, Zhou S, Zhao X and Li P: Predictive factors and a novel nomogram for recurrence of primary retroperitoneal liposarcoma: Comprehensive analysis of 128 cases. Oncol Lett 25: 257, 2023.
APA
Yu, Z., Gao, J., Liu, N., Zhou, S., Zhao, X., & Li, P. (2023). Predictive factors and a novel nomogram for recurrence of primary retroperitoneal liposarcoma: Comprehensive analysis of 128 cases. Oncology Letters, 25, 257. https://doi.org/10.3892/ol.2023.13843
MLA
Yu, Z., Gao, J., Liu, N., Zhou, S., Zhao, X., Li, P."Predictive factors and a novel nomogram for recurrence of primary retroperitoneal liposarcoma: Comprehensive analysis of 128 cases". Oncology Letters 25.6 (2023): 257.
Chicago
Yu, Z., Gao, J., Liu, N., Zhou, S., Zhao, X., Li, P."Predictive factors and a novel nomogram for recurrence of primary retroperitoneal liposarcoma: Comprehensive analysis of 128 cases". Oncology Letters 25, no. 6 (2023): 257. https://doi.org/10.3892/ol.2023.13843
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team