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A novel prednisone premedication protocol significantly decreases infusion‑related reactions of rituximab in newly diagnosed diffuse large B‑cell lymphoma

  • Authors:
    • Jianghua Ding
    • Zhaohui Leng
    • Hong Gu
    • Xiang Jing
  • View Affiliations / Copyright

    Affiliations: Department of Hematology and Oncology, Jiujiang University Clinical Medicine College and Affiliated Hospital, Jiujiang, Jiangxi 332000, P.R. China, Department of Hematology and Oncology, Ruichang City People Hospital, Ruichang, Jiangxi 332200, P.R. China, Department of Hematology and Oncology, Lushan City People Hospital, Lushan, Jiangxi 332800, P.R. China
    Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 258
    |
    Published online on: April 28, 2023
       https://doi.org/10.3892/ol.2023.13844
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Abstract

Rituximab is a widely used anti‑CD20 monoclonal antibody with a high incidence of infusion‑related reactions (IRRs) during administration. Reducing the incidence of IRRs remains problematic in hematological practices. In the present study, a novel strategy of a prednisone pretreatment regimen was designed similar to the combination of rituximab, cyclophosphamide, epirubicin, vincristine and prednisone (R‑CHOP) with the aim of exploring the effect on the incidence of IRRs to rituximab in patients with diffuse large B‑cell lymphoma (DLBCL). A prospective, randomized (1:1) and controlled study was conducted in three regional hospitals in two groups (n=44 for each group): i) A control group treated with standard R‑CHOP‑like regimen; and ii) a group receiving a prednisone‑pretreatment, modified R‑CHOP‑like protocol for newly diagnosed patients with DLBCL. The primary endpoint was to assess the incidence of IRRs to rituximab, as well as the association of IRRs with the efficacy of treatment. The second endpoint involved clinical outcomes. The total incidence of IRRs to rituximab in the treatment group was significantly lower compared with that in the control group (15.9 vs. 43.2%; P=0.0051). The different grade incidence of IRRs was lower in the treatment group compared with that in the control group (P=0.0053). In total, 29.5% of patients (26/88) experienced >1 IRR episode. The incidence of IRRs in the pre‑treatment group was decreased compared with that in the control group in the 1st cycle (15.9 vs. 43.2%; P=0.0051) and 2nd cycle (6.8 vs. 27.3%; P=0.0107). The overall response rate was similar between the two groups (P>0.05). Median progression‑free survival and median overall survival time were not statistically distinct between the two groups (P=0.5244 and P=0.5778, respectively). Grade ≥III toxicities mainly included vomiting and nausea (<20%), leukopenia and granulocytopenia (<20%), and alopecia (<25%). No death events were reported. Apart from IRRs to rituximab, the incidence of other adverse events was similar in both groups. The novel prednisone‑pretreatment R‑CHOP‑like protocol in the present study significantly decreased the total and different grade incidences of IRRs to rituximab among newly diagnosed patients with DLBCL. This clinical trial was retrospectively registered with the Chinese Clinical Trial Registry (registration number, ChiCTR2300070327; date of registration, 10 April 2023).
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Copy and paste a formatted citation
Spandidos Publications style
Ding J, Leng Z, Gu H and Jing X: A novel prednisone premedication protocol significantly decreases infusion‑related reactions of rituximab in newly diagnosed diffuse large B‑cell lymphoma. Oncol Lett 25: 258, 2023.
APA
Ding, J., Leng, Z., Gu, H., & Jing, X. (2023). A novel prednisone premedication protocol significantly decreases infusion‑related reactions of rituximab in newly diagnosed diffuse large B‑cell lymphoma. Oncology Letters, 25, 258. https://doi.org/10.3892/ol.2023.13844
MLA
Ding, J., Leng, Z., Gu, H., Jing, X."A novel prednisone premedication protocol significantly decreases infusion‑related reactions of rituximab in newly diagnosed diffuse large B‑cell lymphoma". Oncology Letters 25.6 (2023): 258.
Chicago
Ding, J., Leng, Z., Gu, H., Jing, X."A novel prednisone premedication protocol significantly decreases infusion‑related reactions of rituximab in newly diagnosed diffuse large B‑cell lymphoma". Oncology Letters 25, no. 6 (2023): 258. https://doi.org/10.3892/ol.2023.13844
Copy and paste a formatted citation
x
Spandidos Publications style
Ding J, Leng Z, Gu H and Jing X: A novel prednisone premedication protocol significantly decreases infusion‑related reactions of rituximab in newly diagnosed diffuse large B‑cell lymphoma. Oncol Lett 25: 258, 2023.
APA
Ding, J., Leng, Z., Gu, H., & Jing, X. (2023). A novel prednisone premedication protocol significantly decreases infusion‑related reactions of rituximab in newly diagnosed diffuse large B‑cell lymphoma. Oncology Letters, 25, 258. https://doi.org/10.3892/ol.2023.13844
MLA
Ding, J., Leng, Z., Gu, H., Jing, X."A novel prednisone premedication protocol significantly decreases infusion‑related reactions of rituximab in newly diagnosed diffuse large B‑cell lymphoma". Oncology Letters 25.6 (2023): 258.
Chicago
Ding, J., Leng, Z., Gu, H., Jing, X."A novel prednisone premedication protocol significantly decreases infusion‑related reactions of rituximab in newly diagnosed diffuse large B‑cell lymphoma". Oncology Letters 25, no. 6 (2023): 258. https://doi.org/10.3892/ol.2023.13844
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