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Effect of arsenic trioxide plus etoposide, solumedrol, high‑dose cytarabine and cisplatin chemotherapy on the treatment of relapsed or refractory ALK+ anaplastic large cell lymphoma

  • Authors:
    • Yi Ding
    • Huina Lu
    • Yan Dong
    • Bing Xiu
    • Aibin Liang
    • Wenjun Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, P.R. China
    Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 268
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    Published online on: May 4, 2023
       https://doi.org/10.3892/ol.2023.13854
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Abstract

It has been reported that arsenic trioxide (ATO) regulates lymphoma cell cycle, apoptosis, autophagy and mitochondrial activity, while it synergizes with other cytotoxic agents. In addition, ATO targets anaplastic lymphoma kinase (ALK)‑fusion oncoprotein to repress anaplastic large cell lymphoma (ALCL). The current study aimed to investigate the efficacy and safety of ATO plus etoposide, solumedrol, high‑dose cytarabine and cisplatin (ESHAP) chemotherapy compared with ESHAP chemotherapy alone in patients with relapsed or refractory (R/R) ALK+ ALCL. A total of 24 patients with R/R ALK+ ALCL were enrolled in the present study. Among them, 11 patients were treated with ATO plus ESHAP, while the remaining 13 patients received ESHAP chemotherapy alone. Subsequently, treatment response, event‑free survival (EFS), overall survival (OS) and adverse event (AEs) rates were recorded. Both complete response (72.7% vs. 53.8%; P=0.423) and objective response (81.8% vs. 69.2%; P=0.649) rates were higher in the ATO plus ESHAP group compared with the ESHAP group. However, statistical significance was not reached. In addition, EFS was significantly prolonged (P=0.047), while OS was not significantly increased (P=0.261) in the ATO plus ESHAP group compared with the ESHAP group. More specifically, the 3‑year accumulating EFS and OS rates were 59.7 and 77.1% in the ATO plus ESHAP group, respectively, and 13.8 and 59.8% in the ESHAP group, respectively. The majority of AEs, such as thrombocytopenia (81.8% vs. 46.2%; P=0.105), fever (81.8% vs. 46.2%; P=0.105) and dyspnea (36.4% vs. 15.4%; P=0.182), were more prevalent in the ATO plus ESHAP group compared with the ESHAP group. However, no statistical significance was observed. In conclusion, the current study indicated that ATO plus ESHAP chemotherapy could exert a superior efficacy compared with ESHAP chemotherapy alone in patients with R/R ALK+ ALCL.
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Copy and paste a formatted citation
Spandidos Publications style
Ding Y, Lu H, Dong Y, Xiu B, Liang A and Zhang W: Effect of arsenic trioxide plus etoposide, solumedrol, high‑dose cytarabine and cisplatin chemotherapy on the treatment of relapsed or refractory ALK+ anaplastic large cell lymphoma. Oncol Lett 25: 268, 2023.
APA
Ding, Y., Lu, H., Dong, Y., Xiu, B., Liang, A., & Zhang, W. (2023). Effect of arsenic trioxide plus etoposide, solumedrol, high‑dose cytarabine and cisplatin chemotherapy on the treatment of relapsed or refractory ALK+ anaplastic large cell lymphoma. Oncology Letters, 25, 268. https://doi.org/10.3892/ol.2023.13854
MLA
Ding, Y., Lu, H., Dong, Y., Xiu, B., Liang, A., Zhang, W."Effect of arsenic trioxide plus etoposide, solumedrol, high‑dose cytarabine and cisplatin chemotherapy on the treatment of relapsed or refractory ALK+ anaplastic large cell lymphoma". Oncology Letters 25.6 (2023): 268.
Chicago
Ding, Y., Lu, H., Dong, Y., Xiu, B., Liang, A., Zhang, W."Effect of arsenic trioxide plus etoposide, solumedrol, high‑dose cytarabine and cisplatin chemotherapy on the treatment of relapsed or refractory ALK+ anaplastic large cell lymphoma". Oncology Letters 25, no. 6 (2023): 268. https://doi.org/10.3892/ol.2023.13854
Copy and paste a formatted citation
x
Spandidos Publications style
Ding Y, Lu H, Dong Y, Xiu B, Liang A and Zhang W: Effect of arsenic trioxide plus etoposide, solumedrol, high‑dose cytarabine and cisplatin chemotherapy on the treatment of relapsed or refractory ALK+ anaplastic large cell lymphoma. Oncol Lett 25: 268, 2023.
APA
Ding, Y., Lu, H., Dong, Y., Xiu, B., Liang, A., & Zhang, W. (2023). Effect of arsenic trioxide plus etoposide, solumedrol, high‑dose cytarabine and cisplatin chemotherapy on the treatment of relapsed or refractory ALK+ anaplastic large cell lymphoma. Oncology Letters, 25, 268. https://doi.org/10.3892/ol.2023.13854
MLA
Ding, Y., Lu, H., Dong, Y., Xiu, B., Liang, A., Zhang, W."Effect of arsenic trioxide plus etoposide, solumedrol, high‑dose cytarabine and cisplatin chemotherapy on the treatment of relapsed or refractory ALK+ anaplastic large cell lymphoma". Oncology Letters 25.6 (2023): 268.
Chicago
Ding, Y., Lu, H., Dong, Y., Xiu, B., Liang, A., Zhang, W."Effect of arsenic trioxide plus etoposide, solumedrol, high‑dose cytarabine and cisplatin chemotherapy on the treatment of relapsed or refractory ALK+ anaplastic large cell lymphoma". Oncology Letters 25, no. 6 (2023): 268. https://doi.org/10.3892/ol.2023.13854
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