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Association between Ki67 expression and therapeutic outcome in colon cancer

  • Authors:
    • Qi Liu
    • Dongmei Ran
    • Liping Wang
    • Jiajun Feng
    • Wei Deng
    • Dongdong Mei
    • Yifan Peng
    • Changzheng Du
  • View Affiliations / Copyright

    Affiliations: Key University Laboratory of Metabolism and Health of Guangdong, Department of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong 518055, P.R. China, Department of Pathology, Southern University of Science and Technology Hospital, Shenzhen, Guangdong 518055, P.R. China, Digestive Tumor Center, Southern University of Science and Technology Hospital, Shenzhen, Guangdong 518055, P.R. China, Department of General Surgery, Southern University of Science and Technology Hospital, Shenzhen, Guangdong 518055, P.R. China, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Unit III & Ostomy Service, Gastrointestinal Cancer Center, Peking University Cancer Hospital & Institute, Beijing 100142, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 272
    |
    Published online on: May 10, 2023
       https://doi.org/10.3892/ol.2023.13858
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Abstract

Ki67 is a commonly used proliferation marker in pathological diagnosis of tumors; however, its prognostic value in colon cancer is controversial. A total of 312 consecutive patients with stage I‑III colon cancer who underwent radical surgery with or without adjuvant chemotherapy were included in the present study. Ki67 expression was assessed using immunohistochemistry and was classified according to 25% intervals. The association between Ki67 expression and clinicopathological features was analyzed. Long‑term postoperative survival, including disease‑free survival (DFS) and overall survival, was calculated, and its association with Ki67 was analyzed. High Ki67 expression (>50%) was associated with improved DFS in patients treated with adjuvant chemotherapy postoperatively, but not in patients who received surgery alone (P=0.138). Ki67 expression was significantly associated with histological differentiation of the tumor (P=0.01), while it was not associated with other clinicopathological factors. Multivariate analysis demonstrated that pathological T and N stage were independent prognostic factors. In conclusion, high Ki67 expression was associated with a good therapeutic outcome in patients receiving adjuvant chemotherapy in colon cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Q, Ran D, Wang L, Feng J, Deng W, Mei D, Peng Y and Du C: Association between Ki67 expression and therapeutic outcome in colon cancer. Oncol Lett 25: 272, 2023.
APA
Liu, Q., Ran, D., Wang, L., Feng, J., Deng, W., Mei, D. ... Du, C. (2023). Association between Ki67 expression and therapeutic outcome in colon cancer. Oncology Letters, 25, 272. https://doi.org/10.3892/ol.2023.13858
MLA
Liu, Q., Ran, D., Wang, L., Feng, J., Deng, W., Mei, D., Peng, Y., Du, C."Association between Ki67 expression and therapeutic outcome in colon cancer". Oncology Letters 25.6 (2023): 272.
Chicago
Liu, Q., Ran, D., Wang, L., Feng, J., Deng, W., Mei, D., Peng, Y., Du, C."Association between Ki67 expression and therapeutic outcome in colon cancer". Oncology Letters 25, no. 6 (2023): 272. https://doi.org/10.3892/ol.2023.13858
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Q, Ran D, Wang L, Feng J, Deng W, Mei D, Peng Y and Du C: Association between Ki67 expression and therapeutic outcome in colon cancer. Oncol Lett 25: 272, 2023.
APA
Liu, Q., Ran, D., Wang, L., Feng, J., Deng, W., Mei, D. ... Du, C. (2023). Association between Ki67 expression and therapeutic outcome in colon cancer. Oncology Letters, 25, 272. https://doi.org/10.3892/ol.2023.13858
MLA
Liu, Q., Ran, D., Wang, L., Feng, J., Deng, W., Mei, D., Peng, Y., Du, C."Association between Ki67 expression and therapeutic outcome in colon cancer". Oncology Letters 25.6 (2023): 272.
Chicago
Liu, Q., Ran, D., Wang, L., Feng, J., Deng, W., Mei, D., Peng, Y., Du, C."Association between Ki67 expression and therapeutic outcome in colon cancer". Oncology Letters 25, no. 6 (2023): 272. https://doi.org/10.3892/ol.2023.13858
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