Open Access

A safety study on ultra‑high or moderate static magnetic fields combined with platycodin D against lung cancer

  • Authors:
    • Xingxing Yang
    • Biao Yu
    • Chuanying Xi
    • Chao Song
    • Rui Yang
    • Wei Wang
    • Xin Wang
    • Xuhan Zhang
    • Chuanlin Feng
    • Xinyu Wang
    • Guofeng Cheng
    • Yansong Chen
    • Yong Zhu
  • View Affiliations

  • Published online on: September 4, 2023     https://doi.org/10.3892/ol.2023.14040
  • Article Number: 453
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Due to the serious side effects of chemotherapy drugs against lung cancer, and the antitumor properties and high safety of magnetic fields, the present study combined moderate or ultra‑high intensity statics magnetic fields (SMFs) with platycodin D (PD) to explore the antitumor efficiency and biosafety. The antitumor effects of PD with or without moderate and ultra‑high SMFs on A549 cells bearing mice were compared. Mouse body weight, food/water intake, hematology routine, blood biochemistry, tumor weight and tissues hematoxylin and eosin (H&E) staining were examined. Behavior was measured using the elevated plus maze, open field and vital signs tests. The combined targets of PD and SMFs were detected using RNA‑sequencing (RNA‑seq). The results showed that the antitumor effect of 22 Tesla (T) SMF group was 3.6‑fold higher compared with that of the 2 mg/kg PD group (tumor growth inhibition=10.08%), while the antitumor effect of 150 mT SMF was only 1.56‑fold higher compared with that of PD. Although PD reduced the food intake, there was no significant difference in body weight, water intake or food consumption among PD and SMF groups. Behavioral results indicated that PD ameliorated dysphoria in mice, but SMFs reduced this effect. However, no significant abnormalities were found in routine blood, blood biochemistry test, H&E staining or organ index, except renal index which was reduced by PD with or without SMFs. RNA‑sequencing (RNA‑seq) demonstrated that SMFs and PD synergistically targeted the expression of genes associated with tumor growth, inflammation and neurological disease. The present study showed the antitumor efficacy and biosafety of moderate or ultra‑high SMF combined with PD, which exhibited only few side effects in the treatment of lung cancer, thus supporting further research for the clinical application of magnetic fields.
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October-2023
Volume 26 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yang X, Yu B, Xi C, Song C, Yang R, Wang W, Wang X, Zhang X, Feng C, Wang X, Wang X, et al: A safety study on ultra‑high or moderate static magnetic fields combined with platycodin D against lung cancer. Oncol Lett 26: 453, 2023
APA
Yang, X., Yu, B., Xi, C., Song, C., Yang, R., Wang, W. ... Zhu, Y. (2023). A safety study on ultra‑high or moderate static magnetic fields combined with platycodin D against lung cancer. Oncology Letters, 26, 453. https://doi.org/10.3892/ol.2023.14040
MLA
Yang, X., Yu, B., Xi, C., Song, C., Yang, R., Wang, W., Wang, X., Zhang, X., Feng, C., Wang, X., Cheng, G., Chen, Y., Zhu, Y."A safety study on ultra‑high or moderate static magnetic fields combined with platycodin D against lung cancer". Oncology Letters 26.4 (2023): 453.
Chicago
Yang, X., Yu, B., Xi, C., Song, C., Yang, R., Wang, W., Wang, X., Zhang, X., Feng, C., Wang, X., Cheng, G., Chen, Y., Zhu, Y."A safety study on ultra‑high or moderate static magnetic fields combined with platycodin D against lung cancer". Oncology Letters 26, no. 4 (2023): 453. https://doi.org/10.3892/ol.2023.14040