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Case Report Open Access

Acute promyelocytic leukemia with additional chromosome abnormalities in a patient positive for HIV: A case report and literature review

  • Authors:
    • Xiao-Lan Li
    • Min Li
    • Ling-Zhi Wang
    • Juan Tian
    • Zi-Wei Shi
    • Kui Song
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The First Affiliated Hospital of Jishou University, Jishou, Hunan 416000, P.R. China, Department of Pharmacy, The First Affiliated Hospital of Jishou University, Jishou, Hunan 416000, P.R. China, Department of Hematology, The First Affiliated Hospital of Jishou University, Jishou, Hunan 416000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 274
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    Published online on: April 19, 2024
       https://doi.org/10.3892/ol.2024.14407
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Abstract

Acute promyelocytic leukemia (APL), especially cases of high‑risk with complex chromosomes (CK), is rare in individuals infected with human immunodeficiency virus (HIV), making the establishment of therapeutic approaches challenging; often the treatment is individualized. This report describes a 49‑year‑old female patient with HIV who was diagnosed with high‑risk APL with a new CK translocation and presents a literature review. At diagnosis, the patient presented with typical t(15;17)(q24;q21) with additional abnormalities, including add(5)(q15), add(5)(q31), add(7)(q11.2) and add(12) (p13). The results of acute myeloid leukemia mutation analysis suggested positivity for calreticulin and lysine methyltransferase 2C genes. The patient received all‑trans retinoic acid combined with arsenic trioxide and chemotherapy, with morphologically complete remission after the first cycle of chemotherapy. The present report provided preliminary data for future clinical research.
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Copy and paste a formatted citation
Spandidos Publications style
Li X, Li M, Wang L, Tian J, Shi Z and Song K: Acute promyelocytic leukemia with additional chromosome abnormalities in a patient positive for HIV: A case report and literature review. Oncol Lett 27: 274, 2024.
APA
Li, X., Li, M., Wang, L., Tian, J., Shi, Z., & Song, K. (2024). Acute promyelocytic leukemia with additional chromosome abnormalities in a patient positive for HIV: A case report and literature review. Oncology Letters, 27, 274. https://doi.org/10.3892/ol.2024.14407
MLA
Li, X., Li, M., Wang, L., Tian, J., Shi, Z., Song, K."Acute promyelocytic leukemia with additional chromosome abnormalities in a patient positive for HIV: A case report and literature review". Oncology Letters 27.6 (2024): 274.
Chicago
Li, X., Li, M., Wang, L., Tian, J., Shi, Z., Song, K."Acute promyelocytic leukemia with additional chromosome abnormalities in a patient positive for HIV: A case report and literature review". Oncology Letters 27, no. 6 (2024): 274. https://doi.org/10.3892/ol.2024.14407
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Li M, Wang L, Tian J, Shi Z and Song K: Acute promyelocytic leukemia with additional chromosome abnormalities in a patient positive for HIV: A case report and literature review. Oncol Lett 27: 274, 2024.
APA
Li, X., Li, M., Wang, L., Tian, J., Shi, Z., & Song, K. (2024). Acute promyelocytic leukemia with additional chromosome abnormalities in a patient positive for HIV: A case report and literature review. Oncology Letters, 27, 274. https://doi.org/10.3892/ol.2024.14407
MLA
Li, X., Li, M., Wang, L., Tian, J., Shi, Z., Song, K."Acute promyelocytic leukemia with additional chromosome abnormalities in a patient positive for HIV: A case report and literature review". Oncology Letters 27.6 (2024): 274.
Chicago
Li, X., Li, M., Wang, L., Tian, J., Shi, Z., Song, K."Acute promyelocytic leukemia with additional chromosome abnormalities in a patient positive for HIV: A case report and literature review". Oncology Letters 27, no. 6 (2024): 274. https://doi.org/10.3892/ol.2024.14407
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