Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December-2024 Volume 28 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2024 Volume 28 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data1.pdf
    • Supplementary_Data2.pdf
Article Open Access

Association of human papillomavirus 16 and 18 with ovarian cancer risk: Insights from a meta‑analysis

  • Authors:
    • Tan Minh Le
    • Hong Duc Thi Nguyen
    • Junghwan Cho
    • Nora Jee‑Young Park
    • Hyung Soo Han
    • Gun Oh Chong
    • Incheol Seo
  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Science, Graduate School, Kyungpook National University, Daegu 41944, Republic of Korea, Clinical Omics Institute, Kyungpook National University, Daegu 41405, Republic of Korea, Department of Immunology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea
    Copyright: © Le et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 556
    |
    Published online on: September 19, 2024
       https://doi.org/10.3892/ol.2024.14689
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Ovarian cancer (OC) presents a global health challenge, with well‑documented genetic aspects. However, to the best of our knowledge, the role of human papillomavirus (HPV) types 16 and 18 in OC remains unclear. The present meta‑analysis assessed the prevalence of HPV in OC across 43 studies and included a comparative meta‑analysis of 19 case‑control studies to determine the association of HPV with OC risk. Subgroup analyses were performed based on geographic regions and histopathological types to explore heterogeneity, and publication bias was evaluated using funnel plots and statistical tests of asymmetry. The pooled prevalence of HPV was found to be 10% (95% CI, 5‑18) and 7% (95% CI, 3‑15) specifically for HPV 16/18. Case‑control studies indicated an odds ratio (OR) of 4.92 (95% CI, 1.96‑12.53) for HPV 16/18, with higher pooled prevalence rates of 17% for all HPV genotypes and 13% for HPV 16/18. Notably, Asian countries exhibited the highest HPV prevalence and OR in OC. These findings support the involvement of HPV, particularly HPV 16 and 18, in increasing the risk of OC, emphasizing the need for further research to confirm these associations and explore potential mechanisms.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Ghose A, Bolina A, Mahajan I, Raza SA, Clarke M, Pal A, Sanchez E, Rallis KS and Boussios S: Hereditary ovarian cancer: Towards a cost-effective prevention strategy. Int J Environ Res Public Health. 19:120572022. View Article : Google Scholar : PubMed/NCBI

3 

Lõhmussaar K, Kopper O, Korving J, Begthel H, Vreuls CPH, van Es JH and Clevers H: Assessing the origin of high-grade serous ovarian cancer using CRISPR-modification of mouse organoids. Nat Commun. 11:26602020. View Article : Google Scholar : PubMed/NCBI

4 

Maringe C, Walters S, Butler J, Coleman MP, Hacker N, Hanna L, Mosgaard BJ, Nordin A, Rosen B, Engholm G, et al: Stage at diagnosis and ovarian cancer survival: Evidence from the international cancer benchmarking partnership. Gynecol Oncol. 127:75–82. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Ghose A, McCann L, Makker S, Mukherjee U, Gullapalli SVN, Erekkath J, Shih S, Mahajan I, Sanchez E, Uccello M, et al: Diagnostic biomarkers in ovarian cancer: Advances beyond CA125 and HE4. Ther Adv Med Oncol. 16:175883592412332252024. View Article : Google Scholar : PubMed/NCBI

6 

Saani I, Raj N, Sood R, Ansari S, Mandviwala HA, Sanchez E and Boussios S: Clinical challenges in the management of malignant ovarian germ cell tumours. Int J Environ Res Public Health. 20:60892023. View Article : Google Scholar : PubMed/NCBI

7 

Singh N: WHO classification of tumors of the ovary. In: Encyclopedia of Pathology. Van Krieken JHJM: Springer International Publishing; Cham: pp. 1–4. 2022

8 

Matulonis UA, Sood AK, Fallowfield L, Howitt BE, Sehouli J and Karlan BY: Ovarian cancer. Nat Rev Dis Primers. 2:160612016. View Article : Google Scholar : PubMed/NCBI

9 

Pavlidis N, Rassy E, Vermorken JB, Assi T, Kattan J, Boussios S and Smith-Gagen J: The outcome of patients with serous papillary peritoneal cancer, fallopian tube cancer, and epithelial ovarian cancer by treatment eras: 27 years data from the SEER registry. Cancer Epidemiol. 75:1020452021. View Article : Google Scholar : PubMed/NCBI

10 

Kindelberger DW, Lee Y, Miron A, Hirsch MS, Feltmate C, Medeiros F, Callahan MJ, Garner EO, Gordon RW, Birch C, et al: Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: Evidence for a causal relationship. Am J Surg Pathol. 31:161–169. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Shih IM, Wang Y and Wang TL: The origin of ovarian cancer species and precancerous landscape. Am J Pathol. 191:26–39. 2021. View Article : Google Scholar : PubMed/NCBI

12 

Aliyuda F, Moschetta M, Ghose A, Sofia Rallis K, Sheriff M, Sanchez E, Rassy E and Boussios S: Advances in ovarian cancer treatment beyond PARP Inhibitors. Curr Cancer Drug Targets. 23:433–446. 2023. View Article : Google Scholar : PubMed/NCBI

13 

Lee Y, Miron A, Drapkin R, Nucci MR, Medeiros F, Saleemuddin A, Garber J, Birch C, Mou H, Gordon RW, et al: A candidate precursor to serous carcinoma that originates in the distal fallopian tube. J Pathol. 211:26–35. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Colvin EK and Howell VM: Why the dual origins of high grade serous ovarian cancer matter. Nat Commun. 11:12002020. View Article : Google Scholar : PubMed/NCBI

15 

Greten FR and Grivennikov SI: Inflammation and cancer: Triggers, mechanisms, and consequences. Immunity. 51:27–41. 2019. View Article : Google Scholar : PubMed/NCBI

16 

Łaniewski P, Ilhan ZE and Herbst-Kralovetz MM: The microbiome and gynaecological cancer development, prevention and therapy. Nat Rev Urol. 17:232–250. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Chambers LM, Bussies P, Vargas R, Esakov E, Tewari S, Reizes O and Michener C: The microbiome and gynecologic cancer: Current evidence and future opportunities. Curr Oncol Rep. 23:922021. View Article : Google Scholar : PubMed/NCBI

18 

Jia D, Nagaoka Y, Katsumata M and Orsulic S: Inflammation is a key contributor to ovarian cancer cell seeding. Sci Rep. 8:123942018. View Article : Google Scholar : PubMed/NCBI

19 

Sabatini ME and Chiocca S: Human papillomavirus as a driver of head and neck cancers. Br J Cancer. 122:306–314. 2020. View Article : Google Scholar : PubMed/NCBI

20 

Demarco M, Hyun N, Carter-Pokras O, Raine-Bennett TR, Cheung L, Chen X, Hammer A, Campos N, Kinney W, Gage JC, et al: A study of type-specific HPV natural history and implications for contemporary cervical cancer screening programs. EClinicalMedicine. 22:1002932020. View Article : Google Scholar : PubMed/NCBI

21 

Scheffner M, Werness BA, Huibregtse JM, Levine AJ and Howley PM: The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell. 63:1129–1136. 1990. View Article : Google Scholar : PubMed/NCBI

22 

Fischer M, Uxa S, Stanko C, Magin TM and Engeland K: Human papilloma virus E7 oncoprotein abrogates the p53-p21-DREAM pathway. Sci Rep. 7:26032017. View Article : Google Scholar : PubMed/NCBI

23 

Cherif S, Amine A, Thies S, Taube ET, Braicu EI, Sehouli J and Kaufmann AM: Prevalence of human papillomavirus detection in ovarian cancer: A meta-analysis. Eur J Clin Microbiol Infect Dis. 40:1791–1802. 2021. View Article : Google Scholar : PubMed/NCBI

24 

Ibragimova MK, Kokorina EV, Tsyganov MM, Churuksaeva ON and Litviakov NV: Human papillomavirus and ovarian cancer (review of literature and meta-analysis). Infect Genet Evol. 95:1050862021. View Article : Google Scholar : PubMed/NCBI

25 

Grabarek BO, Ossowski P, Czarniecka J, Ożóg M, Prucnal J, Dziuba I, Ostenda A, Dziobek K, Boroń D, Peszek W, et al: Detection and genotyping of human papillomavirus (HPV16/18), Epstein-barr virus (EBV), and human cytomegalovirus (HCMV) in endometrial endometroid and ovarian cancers. Pathogens. 12:3972023. View Article : Google Scholar : PubMed/NCBI

26 

Fatima B, Masud R, Sultana N, Javed A and Justin S: Detection of human papillomavirus in archival bladder and ovarian cancer samples. Clin Epidemiology Glob Health. 22:1013392023. View Article : Google Scholar

27 

Kumar P, Ranmale S, Tongaonkar H, Mehta S and Mania-Pramanik J: Human papillomavirus infection: Is it associated with epithelial ovarian cancer? Indian J Med Microbiol. 39:311–314. 2021. View Article : Google Scholar : PubMed/NCBI

28 

Yang X, You Q, Yao G, Geng J, Ma R and Meng H: Evaluation of p16 in epithelial ovarian cancer for a 10-year study in northeast China: Significance of HPV in correlation with PD-L1 expression. Cancer Manag Res. 12:6747–6753. 2020. View Article : Google Scholar : PubMed/NCBI

29 

Shokouh MR, Safaei A, Moattari A and Sarvari J: Association of human papilloma virus and Epstein-barr virus with ovarian cancer in Shiraz, southwestern Iran. Iran J Pathol. 15:292–298. 2020. View Article : Google Scholar : PubMed/NCBI

30 

Kisseljova N, Zhordania K, Fedorova M, Katargin A, Valeeva A, Pajanidi J, Pavlova L, Khvan O and Vinokurova S: Detection of human papillomavirus prevalence in ovarian cancer by different test systems. Intervirology. 62:198–204. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Paradowska E, Jabłońska A, Studzińska M, Wilczyński M and Wilczyński JR: Detection and genotyping of CMV and HPV in tumors and fallopian tubes from epithelial ovarian cancer patients. Sci Rep. 9:199352019. View Article : Google Scholar : PubMed/NCBI

32 

Hammou RA, Benhessou M, Bouziyane A, Hassou N, Benhchekroun MN, Bessi H and Ennaji MM: Oncogenic human papillomavirus involvement in epithelial ovarian carcinoma among women in Morocco. Bioinformation. 15:55–60. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Hassan ZK, Hafez MM, Kamel MM and Zekri ARN: Human Papillomavirus genotypes and methylation of CADM1, PAX1, MAL and ADCYAP1 genes in epithelial ovarian cancer patients. Asian Pac J Cancer Prev. 18:169–176. 2017.PubMed/NCBI

34 

Farzaneh F, Nadji SA, Khosravi D, Hosseini MS, Hashemi Bahremani M, Chehrazi M, Bagheri G, Sigaroodi A and Haghighatian Z: Lack of HPV in benign and malignant epithelial ovarian tumors in Iran. Asian Pac J Cancer Prev. 18:1233–1236. 2017.PubMed/NCBI

35 

Dadashi M, Eslami G, Faghihloo E, Pourmohammad A, Hosseini J, Taheripanah R and Arab-Mazar Z: Detection of human papilloma virus type 16 in epithelial ovarian tumors samples. Arch Clin Infect Dis. 12:e396662017.

36 

Zhang PP, Zhou L, Cao JS, Li YP, Zeng Z, Sun N, Shen L, Zhu HY, Ruan Y, Zha WT, et al: Possible epithelial ovarian cancer association with HPV18 or HPV33 infection. Asian Pac J Cancer Prev. 17:2959–2964. 2016.PubMed/NCBI

37 

Ingerslev K, Hogdall E, Skovrider-Ruminski W, Schnack TH, Karlsen MA, Nedergaard L, Hogdall C and Blaakær J: High-risk HPV is not associated with epithelial ovarian cancer in a Caucasian population. Infect Agent Cancer. 11:392016. View Article : Google Scholar : PubMed/NCBI

38 

Mahmood FM, Kadhim HS and Mousa Al Khuzaee LR: Detection of human papillomavirus-16 E6-oncoprotein in epithelial ovarian tumors samples of Iraqi patients. Jundishapur J Microbiol. 7:e119452014.PubMed/NCBI

39 

Al-Shabanah OA, Hafez MM, Hassan ZK, Sayed-Ahmed MM, Abozeed WN, Alsheikh A and Al-Rejaie SS: Methylation of SFRPs and APC genes in ovarian cancer infected with high risk human papillomavirus. Asian Pac J Cancer Prev. 15:2719–2725. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Al-Shabanah OA, Hafez MM, Hassan ZK, Sayed-Ahmed MM, Abozeed WN, Al-Rejaie SS and Alsheikh AA: Human papillomavirus genotyping and integration in ovarian cancer Saudi patients. Virol J. 10:3432013. View Article : Google Scholar : PubMed/NCBI

41 

Malisic E, Jankovic R and Jakovljevic K: Detection and genotyping of human papillomaviruses and their role in the development of ovarian carcinomas. Arch Gynecol Obstet. 286:723–728. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Shanmughapriya S, SenthilKumar G, Vinodhini K, Das BC, Vasanthi N and Natarajaseenivasan K: Viral and bacterial aetiologies of epithelial ovarian cancer. Eur J Clin Microbiol Infect Dis. 31:2311–2317. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Alavi G, Sharifi N, Sadeghian A, Rezaei A and Shidaee H: Failure to demonstrate the role of high risk human papilloma virus in epithelial ovarian cancer. Iran J Pathol. 7:151–156. 2012.

44 

Bilyk OO, Pande NT and Buchynska LG: Analysis of P53, P16INK4A, PRB and Cyclin D1 expression and human papillomavirus in primary ovarian serous carcinomas. Exp Oncol. 33:150–156. 2011.PubMed/NCBI

45 

Idahl A, Lundin E, Elgh F, Jurstrand M, Møller JK, Marklund I, Lindgren P and Ottander U: Chlamydia trachomatis, Mycoplasma genitalium, Neisseria gonorrhoeae, human papillomavirus, and polyomavirus are not detectable in human tissue with epithelial ovarian cancer, borderline tumor, or benign conditions. Am J Obstet Gynecol. 202:71.e1–e6. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Wentzensen N, du Bois A, Kommoss S, Pfisterer J, Von Knebel Doeberitz M, Schmidt D and Kommoss F: No metastatic cervical adenocarcinomas in a series of p16INK4a-positive mucinous or endometrioid advanced ovarian carcinomas: An analysis of the AGO ovarian cancer study group. Int J Gynecol Pathol. 27:18–23. 2008. View Article : Google Scholar : PubMed/NCBI

47 

Giordano G, D'Adda T, Gnetti L, Froio E, Merisio C and Melpignano M: Role of human papillomavirus in the development of epithelial ovarian neoplasms in Italian women. J Obstet Gynaecol. 34:210–217. 2008. View Article : Google Scholar : PubMed/NCBI

48 

Atalay F, Taskiran C, Taner MZ, Pak I, Or M and Tuncer S: Detection of human papillomavirus DNA and genotyping in patients with epithelial ovarian carcinoma. J Obstet Gynaecol. 33:823–828. 2007. View Article : Google Scholar : PubMed/NCBI

49 

Konidaris S, Kouskouni EE, Panoskaltsis T, Kreatsas G, Patsouris ES, Sarivalassis A, Nonni A and Lazaris AC: Human papillomavirus infection in malignant and benign gynaecological conditions: A study in Greek women. Health Care Women Int. 28:182–191. 2007. View Article : Google Scholar : PubMed/NCBI

50 

Quirk JT, Kupinski JM and DiCioccio RA: Analysis of ovarian tumors for the presence of human papillomavirus DNA. J Obstet Gynaecol. 32:202–205. 2006. View Article : Google Scholar : PubMed/NCBI

51 

Kuscu E, Ozdemir BH, Erkanli S and Haberal A: HPV and p53 expression in epithelial ovarian carcinoma. Eur J Gynaecol Oncol. 26:642–645. 2005.PubMed/NCBI

52 

Elishaev E, Gilks CB, Miller D, Srodon M, Kurman RJ and Ronnett BM: Synchronous and metachronous endocervical and ovarian neoplasms: Evidence supporting interpretation of the ovarian neoplasms as metastatic endocervical adenocarcinomas simulating primary ovarian surface epithelial neoplasms. Am J Surg Pathol. 29:281–294. 2005. View Article : Google Scholar : PubMed/NCBI

53 

Yang HJ, Liu VW, Tsang PC, Yip AM, Ng TY, Cheung AN and Ngan HY: Comparison of human papillomavirus DNA levels in gynecological cancers: Implication for cancer development. Tumor Biol. 24:310–316. 2003. View Article : Google Scholar

54 

Wu QJ, Guo M, Lu ZM, Li T, Qiao HZ and Ke Y: Detection of human papillomavirus-16 in ovarian malignancy. Br J Cancer. 89:672–675. 2003. View Article : Google Scholar : PubMed/NCBI

55 

Li T, Lu ZM, Guo M, Wu QJ, Chen KN, Xing HP, Mei Q and Ke Y: p53 codon 72 polymorphism (C/G) and the risk of human papillomavirus-associated carcinomas in China. Cancer. 95:2571–2576. 2002. View Article : Google Scholar : PubMed/NCBI

56 

Ip SM, Wong LC, Xu CM, Cheung AN, Tsang PC and Ngan HY: Detection of human papillomavirus DNA in malignant lesions from Chinese women with carcinomas of the upper genital tract. Gynecol Oncol. 87:104–111. 2002. View Article : Google Scholar : PubMed/NCBI

57 

Chen TR, Chan PJ, Seraj IM and King A: Absence of human papillomavirus E6-E7 transforming genes from HPV 16 and 18 in malignant ovarian carcinoma. Gynecol Oncol. 72:180–182. 1999. View Article : Google Scholar : PubMed/NCBI

58 

Anttila M, Syrjänen S, Ji H, Saarikoski S and Syrjänen K: Failure to demonstrate human papillomavirus DNA in epithelial ovarian cancer by general primer PCR. Gynecol Oncol. 72:337–341. 1999. View Article : Google Scholar : PubMed/NCBI

59 

Zimna K, Poreba E, Kedzia W, Gozdzicka-Józefiak A and Kezia H: Human papillomavirus (HPV) in upper genital tract carcinomas of women. Eur J Gynaecol Oncol. 18:415–417. 1997.PubMed/NCBI

60 

Anwar K, Nakakuki K, Imai H, Shiraishi T and Inuzuka M: Infection of human papillomavirus (HPV) and p53 over-expression in human female genital tract carcinoma. J Pak Med Assoc. 46:220–224. 1996.PubMed/NCBI

61 

Trottier AM, Provencher D, Mes-Masson AM, Vauclair R and Coutlée F: Absence of human papillomavirus sequences in ovarian pathologies. J Clin Microbiol. 33:1011–1013. 1995. View Article : Google Scholar : PubMed/NCBI

62 

Runnebaum IB, Maier S, Tong XW, Rosenthal HE, Möbus VJ, Kieback DG and Kreienberg R: Human papillomavirus integration is not associated with advanced epithelial ovarian cancer in German patients. Cancer Epidemiol Biomarkers Prev. 4:573–575. 1995.PubMed/NCBI

63 

Lai CH, Wang CY, Lin CY and Pao CC: Detection of human papillomavirus RNA in ovarian and endometrial carcinomas by reverse transcription/polymerase chain reaction. Gynecol Obstet Invest. 38:276–280. 1994. View Article : Google Scholar : PubMed/NCBI

64 

Lai CH, Hsueh S, Lin CY, Huang MY, You GB, Chang HC and Pao CC: Human papillomavirus in benign and malignant ovarian and endometrial tissues. Int J Gynecol Pathol. 11:210–215. 1992. View Article : Google Scholar : PubMed/NCBI

65 

Beckmann AM, Sherman KJ, Saran L and Weiss NS: Genital-type human papillomavirus infection is not associated with surface epithelial ovarian carcinoma. Gynecol Oncol. 43:247–251. 1991. View Article : Google Scholar : PubMed/NCBI

66 

McLellan R, Buscema J, Guerrero E, Shah KV, Woodruff JD and Currie JL: Investigation of ovarian neoplasia of low malignant potential for human papillomavirus. Gynecol Oncol. 38:383–385. 1990. View Article : Google Scholar : PubMed/NCBI

67 

Leake JF, Woodruff JD, Searle C, Daniel R, Shah KV and Currie JL: Human papillomavirus and epithelial ovarian neoplasia. Gynecol Oncol. 34:263–273. 1989. View Article : Google Scholar

68 

Nikolakopoulou A, Mavridis D and Salanti G: Demystifying fixed and random effects meta-analysis. BMJ Ment Health. 17:53–57. 2014.

69 

Schwarzer G: meta: An R package for meta-analysis. R News. 7:40–45. 2007.

70 

Higgins JP and Green S: Cochrane handbook for systematic reviews of interventions. In: Cochrane Handbook for Systematic Reviews of Interventions. Wiley; 2019

71 

Paule RC and Mandel J: Consensus values and weighting factors. J Res Natl Bur Stand (1977). 87:377–385. 1982. View Article : Google Scholar : PubMed/NCBI

72 

Balduzzi S, Rücker G and Schwarzer G: How to perform a meta-analysis with R: A practical tutorial. Evid Based Ment Health. 22:153–160. 2019. View Article : Google Scholar : PubMed/NCBI

73 

Sterne JA, Sutton AJ, Ioannidis JP, Terrin N, Jones DR, Lau J, Carpenter J, Rücker G, Harbord RM, Schmid CH, et al: Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ. 343:d40022011. View Article : Google Scholar : PubMed/NCBI

74 

Begg CB and Mazumdar M: Operating characteristics of a rank correlation test for publication bias. Biometrics. 50:1088–1101. 1994. View Article : Google Scholar : PubMed/NCBI

75 

Peters JL, Sutton AJ, Jones DR, Abrams KR and Rushton L: Comparison of two methods to detect publication bias in meta-analysis. JAMA. 295:676–680. 2006. View Article : Google Scholar : PubMed/NCBI

76 

Viechtbauer W: Conducting meta-analyses in R with the metafor package. J Stat Soft. 36:1–48. 2010. View Article : Google Scholar

77 

R Core Team, . R: A language and environment for statistical computing. R Foundation for Statistical Computing; Vienna: 2023

78 

Schwarzer G, Carpenter JR and Rücker G: metasens: Statistical methods for sensitivity analysis in meta-analysis. R package version 1.5–2. https://CRAN.R-project.org/package=metasens

79 

Halec G, Alemany L, Quiros B, Clavero O, Höfler D, Alejo M, Quint W, Pawlita M, Bosch FX and de Sanjose S: Biological relevance of human papillomaviruses in vulvar cancer. Mod Pathol. 30:549–562. 2017. View Article : Google Scholar : PubMed/NCBI

80 

Lechner M, Liu J, Masterson L and Fenton TR: HPV-associated oropharyngeal cancer: Epidemiology, molecular biology and clinical management. Nat Rev Clin Oncol. 19:306–327. 2022. View Article : Google Scholar : PubMed/NCBI

81 

Bjørge T, Engeland A, Luostarinen T, Mork J, Gislefoss RE, Jellum E, Koskela P, Lehtinen M, Pukkala E, Thoresen SO and Dillner J: Human papillomavirus infection as a risk factor for anal and perianal skin cancer in a prospective study. Br J Cancer. 87:61–64. 2002. View Article : Google Scholar : PubMed/NCBI

82 

Cohen PA, Jhingran A, Oaknin A and Denny L: Cervical cancer. Lancet. 393:169–182. 2019. View Article : Google Scholar : PubMed/NCBI

83 

Chan PJ, Seraj IM, Kalugdan TH and King A: Evidence for ease of transmission of human papillomavirus DNA from sperm to cells of the uterus and embryo. J Assist Reprod Genet. 13:516–519. 1996. View Article : Google Scholar : PubMed/NCBI

84 

Dyson N, Howley PM, Münger K and Harlow E: The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science. 243:934–937. 1989. View Article : Google Scholar : PubMed/NCBI

85 

Hashiguchi Y, Tsuda H, Yamamoto K, Inoue T, Ishiko O and Ogita S: Combined analysis of p53 and RB pathways in epithelial ovarian cancer. Hum Pathol. 32:988–996. 2001. View Article : Google Scholar : PubMed/NCBI

86 

Bruni L, Albero G, Serrano B, Mena M, Collado J, Gómez D, Muñoz J, Bosch F and de Sanjosé S: ICO/IARC Information Centre on HPV and Cancer (HPV Information Centre). Human papillomavirus and related diseases in the world. Summary Report 10 March 2023. https://hpvcentre.net/statistics/reports/XWX.pdfOctober 8–2023

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Le TM, Nguyen HT, Cho J, Park NJ, Han HS, Chong GO and Seo I: Association of human papillomavirus 16 and 18 with ovarian cancer risk: Insights from a meta‑analysis. Oncol Lett 28: 556, 2024.
APA
Le, T.M., Nguyen, H.T., Cho, J., Park, N.J., Han, H.S., Chong, G.O., & Seo, I. (2024). Association of human papillomavirus 16 and 18 with ovarian cancer risk: Insights from a meta‑analysis. Oncology Letters, 28, 556. https://doi.org/10.3892/ol.2024.14689
MLA
Le, T. M., Nguyen, H. T., Cho, J., Park, N. J., Han, H. S., Chong, G. O., Seo, I."Association of human papillomavirus 16 and 18 with ovarian cancer risk: Insights from a meta‑analysis". Oncology Letters 28.6 (2024): 556.
Chicago
Le, T. M., Nguyen, H. T., Cho, J., Park, N. J., Han, H. S., Chong, G. O., Seo, I."Association of human papillomavirus 16 and 18 with ovarian cancer risk: Insights from a meta‑analysis". Oncology Letters 28, no. 6 (2024): 556. https://doi.org/10.3892/ol.2024.14689
Copy and paste a formatted citation
x
Spandidos Publications style
Le TM, Nguyen HT, Cho J, Park NJ, Han HS, Chong GO and Seo I: Association of human papillomavirus 16 and 18 with ovarian cancer risk: Insights from a meta‑analysis. Oncol Lett 28: 556, 2024.
APA
Le, T.M., Nguyen, H.T., Cho, J., Park, N.J., Han, H.S., Chong, G.O., & Seo, I. (2024). Association of human papillomavirus 16 and 18 with ovarian cancer risk: Insights from a meta‑analysis. Oncology Letters, 28, 556. https://doi.org/10.3892/ol.2024.14689
MLA
Le, T. M., Nguyen, H. T., Cho, J., Park, N. J., Han, H. S., Chong, G. O., Seo, I."Association of human papillomavirus 16 and 18 with ovarian cancer risk: Insights from a meta‑analysis". Oncology Letters 28.6 (2024): 556.
Chicago
Le, T. M., Nguyen, H. T., Cho, J., Park, N. J., Han, H. S., Chong, G. O., Seo, I."Association of human papillomavirus 16 and 18 with ovarian cancer risk: Insights from a meta‑analysis". Oncology Letters 28, no. 6 (2024): 556. https://doi.org/10.3892/ol.2024.14689
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team