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Treatment of acute myeloid leukemia with active pulmonary tuberculosis with venetoclax‑based anti‑acute myeloid leukemia regimen combined with an intensive and then individualized anti‑tuberculosis regimen: A report of two cases

  • Authors:
    • Lin Ji
    • Wei Yang
    • Liu Jie Gao
    • Bei Yuan Zhang
    • Ya Qing Xu
    • Xiao Feng Xu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology and Hematology, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang 310003, P.R. China
    Copyright: © Ji et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 601
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    Published online on: October 11, 2024
       https://doi.org/10.3892/ol.2024.14734
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Abstract

Patients with concurrent acute myeloid leukemia (AML) and active pulmonary tuberculosis (TB) exhibit certain characteristics; cough, phlegm, fever, hemoptysis, weight loss and dyspnea are common symptoms of both diseases. These patients often cannot tolerate traditional intensive chemotherapy regimens, and finding the optimal timing in the treatment of both AML and active pulmonary TB is complex. Neglecting timely treatment can lead to serious complications and even fatal outcomes. The present paper reports two cases of patients with AML who were diagnosed with active pulmonary TB. The patients received intensive anti‑TB treatment with isoniazid, rifampicin, pyrazinamide and ethambutol for 10‑15 days. After three consecutive negative sputum smears, the patients in cases 1 and 2 were treated with a venetoclax, homoharringtonine and cytarabine regimen; and a venetoclax and azacitidine regimen for anti‑AML therapy, respectively, as well as individualized anti‑TB regimens of isoniazid, pyrazinamide, ethambutol and quinolone. Subsequently, both patients achieved complete remission of AML and their active TB was well controlled.
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Copy and paste a formatted citation
Spandidos Publications style
Ji L, Yang W, Gao LJ, Zhang BY, Xu YQ and Xu XF: Treatment of acute myeloid leukemia with active pulmonary tuberculosis with venetoclax‑based anti‑acute myeloid leukemia regimen combined with an intensive and then individualized anti‑tuberculosis regimen: A report of two cases. Oncol Lett 28: 601, 2024.
APA
Ji, L., Yang, W., Gao, L.J., Zhang, B.Y., Xu, Y.Q., & Xu, X.F. (2024). Treatment of acute myeloid leukemia with active pulmonary tuberculosis with venetoclax‑based anti‑acute myeloid leukemia regimen combined with an intensive and then individualized anti‑tuberculosis regimen: A report of two cases. Oncology Letters, 28, 601. https://doi.org/10.3892/ol.2024.14734
MLA
Ji, L., Yang, W., Gao, L. J., Zhang, B. Y., Xu, Y. Q., Xu, X. F."Treatment of acute myeloid leukemia with active pulmonary tuberculosis with venetoclax‑based anti‑acute myeloid leukemia regimen combined with an intensive and then individualized anti‑tuberculosis regimen: A report of two cases". Oncology Letters 28.6 (2024): 601.
Chicago
Ji, L., Yang, W., Gao, L. J., Zhang, B. Y., Xu, Y. Q., Xu, X. F."Treatment of acute myeloid leukemia with active pulmonary tuberculosis with venetoclax‑based anti‑acute myeloid leukemia regimen combined with an intensive and then individualized anti‑tuberculosis regimen: A report of two cases". Oncology Letters 28, no. 6 (2024): 601. https://doi.org/10.3892/ol.2024.14734
Copy and paste a formatted citation
x
Spandidos Publications style
Ji L, Yang W, Gao LJ, Zhang BY, Xu YQ and Xu XF: Treatment of acute myeloid leukemia with active pulmonary tuberculosis with venetoclax‑based anti‑acute myeloid leukemia regimen combined with an intensive and then individualized anti‑tuberculosis regimen: A report of two cases. Oncol Lett 28: 601, 2024.
APA
Ji, L., Yang, W., Gao, L.J., Zhang, B.Y., Xu, Y.Q., & Xu, X.F. (2024). Treatment of acute myeloid leukemia with active pulmonary tuberculosis with venetoclax‑based anti‑acute myeloid leukemia regimen combined with an intensive and then individualized anti‑tuberculosis regimen: A report of two cases. Oncology Letters, 28, 601. https://doi.org/10.3892/ol.2024.14734
MLA
Ji, L., Yang, W., Gao, L. J., Zhang, B. Y., Xu, Y. Q., Xu, X. F."Treatment of acute myeloid leukemia with active pulmonary tuberculosis with venetoclax‑based anti‑acute myeloid leukemia regimen combined with an intensive and then individualized anti‑tuberculosis regimen: A report of two cases". Oncology Letters 28.6 (2024): 601.
Chicago
Ji, L., Yang, W., Gao, L. J., Zhang, B. Y., Xu, Y. Q., Xu, X. F."Treatment of acute myeloid leukemia with active pulmonary tuberculosis with venetoclax‑based anti‑acute myeloid leukemia regimen combined with an intensive and then individualized anti‑tuberculosis regimen: A report of two cases". Oncology Letters 28, no. 6 (2024): 601. https://doi.org/10.3892/ol.2024.14734
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