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Chromatin accessibility is associated with therapeutic response in prostate cancer

  • Authors:
    • Sanghoon Lee
    • Da Young Lee
    • Insuk So
    • Jung Nyeo Chun
    • Ju-Hong Jeon
  • View Affiliations / Copyright

    Affiliations: Department of Physiology and Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea
    Copyright: © Lee et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 605
    |
    Published online on: October 14, 2024
       https://doi.org/10.3892/ol.2024.14738
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Abstract

Treatment of advanced prostate cancer is challenging due to a lack of effective therapies. Therefore, it is important to understand the molecular mechanisms underlying therapeutic resistance in prostate cancer and to identify promising drug targets offering significant clinical advantages. Given the pivotal role of dysregulated transcriptional programs in the therapeutic response, it is essential to prioritize translational efforts targeting cancer‑associated transcription factors (TFs). The present study investigated whether chromatin accessibility was associated with therapeutic resistance in prostate cancer using Assay for Transposase‑Accessible Chromatin with sequencing (ATAC‑seq) data. The bioinformatics analysis identified differences in chromatin accessibility between the drug response (Remission) and drug resistance (Disease) groups. Additionally, a significant association was observed between chromatin accessibility, transcriptional output and TF activity. Among TFs, forkhead box protein M1 (FOXM1) was identified as a TF with high activity and expression in the Disease group. Notably, the results of the computational analysis were validated by FOXM1 knockdown experiments, which resulted in suppressed cell proliferation and enhanced therapeutic sensitivity in prostate cancer cells. The present findings demonstrated that chromatin accessibility and TF activity may be associated with therapeutic resistance in prostate cancer. Additionally, these results provide the basis for future investigations aimed at understanding the molecular mechanisms of drug resistance and developing novel therapeutic approaches for prostate cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Lee S, Lee D, So I, Chun JN and Jeon J: Chromatin accessibility is associated with therapeutic response in prostate cancer. Oncol Lett 28: 605, 2024.
APA
Lee, S., Lee, D., So, I., Chun, J.N., & Jeon, J. (2024). Chromatin accessibility is associated with therapeutic response in prostate cancer. Oncology Letters, 28, 605. https://doi.org/10.3892/ol.2024.14738
MLA
Lee, S., Lee, D., So, I., Chun, J. N., Jeon, J."Chromatin accessibility is associated with therapeutic response in prostate cancer". Oncology Letters 28.6 (2024): 605.
Chicago
Lee, S., Lee, D., So, I., Chun, J. N., Jeon, J."Chromatin accessibility is associated with therapeutic response in prostate cancer". Oncology Letters 28, no. 6 (2024): 605. https://doi.org/10.3892/ol.2024.14738
Copy and paste a formatted citation
x
Spandidos Publications style
Lee S, Lee D, So I, Chun JN and Jeon J: Chromatin accessibility is associated with therapeutic response in prostate cancer. Oncol Lett 28: 605, 2024.
APA
Lee, S., Lee, D., So, I., Chun, J.N., & Jeon, J. (2024). Chromatin accessibility is associated with therapeutic response in prostate cancer. Oncology Letters, 28, 605. https://doi.org/10.3892/ol.2024.14738
MLA
Lee, S., Lee, D., So, I., Chun, J. N., Jeon, J."Chromatin accessibility is associated with therapeutic response in prostate cancer". Oncology Letters 28.6 (2024): 605.
Chicago
Lee, S., Lee, D., So, I., Chun, J. N., Jeon, J."Chromatin accessibility is associated with therapeutic response in prostate cancer". Oncology Letters 28, no. 6 (2024): 605. https://doi.org/10.3892/ol.2024.14738
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