Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December-2024 Volume 28 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2024 Volume 28 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Efficacy of the CV‑MED regimen in treating extramedullary involvement of multiple myeloma: A case report

  • Authors:
    • Jinjie Gao
    • Fei Dong
    • Xu Zhang
    • Hongmei Jing
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing 100191, P.R. China
    Copyright: © Gao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 612
    |
    Published online on: October 14, 2024
       https://doi.org/10.3892/ol.2024.14745
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Extramedullary progression of multiple myeloma (MM) is commonly associated with a poor prognosis. However, optimal management strategies have not yet been established for the treatment of extramedullary involvement in MM. The present study reports the case of a 59‑year‑old female patient with MM who experienced extramedullary progression after two cycles of first‑line VRD (bortezomib, lenalidomide and dexamethasone) therapy. The patient achieved remission of the extramedullary lesion following treatment with an innovative CV‑MED regimen, which includes chidamide, bortezomib, mitoxantrone hydrochloride liposome, etoposide and dexamethasone. Subsequently, the patient underwent autologous hematopoietic stem cell harvesting and maintenance therapy, and remains in a progression‑free survival state. The present case suggests that a chemotherapy regimen incorporating mitoxantrone hydrochloride liposomes, chidamide and bortezomib could be a promising treatment strategy for managing extramedullary involvement in MM.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Rosiñol L, Beksac M, Zamagni E, Van de Donk NWCJ, Anderson KC, Badros A, Caers J, Cavo M, Dimopoulos MA, Dispenzieri A, et al: Expert review on soft-tissue plasmacytomas in multiple myeloma: Definition, disease assessment and treatment considerations. Br J Haematol. 194:496–507. 2021. View Article : Google Scholar : PubMed/NCBI

2 

Plasma Cell Disease Group, Chinese Society of Hematology, Chinese Medical Association; Chinese Myeloma Committee-Chinese Hematology Association, . Consensus for the diagnosis and management of extramedullary plasmacytoma in China (2024). Zhonghua Xue Ye Xue Za Zhi. 45:8–17. 2024.(In Chinese). PubMed/NCBI

3 

Du J: Progress in diagnosis and treatment of extramedullary plasma cell tumors. J Intern Med Concepts Pract. 15:302–307. 2020.(In Chinese).

4 

Touzeau C and Moreau P: How I treat extramedullary myeloma. Blood. 127:971–976. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Durie BG and Salmon SE: A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. Cancer. 36:842–854. 1975. View Article : Google Scholar : PubMed/NCBI

6 

Greipp PR, San Miguel J, Durie BG, Crowley JJ, Barlogie B, Bladé J, Boccadoro M, Child JA, Avet-Loiseau H, Kyle RA, et al: International staging system for multiple myeloma. J Clin Oncol. 23:3412–3420. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Jagosky MH and Usmani SZ: Extramedullary disease in multiple myeloma. Curr Hematol Malig Rep. 15:62–71. 2020. View Article : Google Scholar : PubMed/NCBI

8 

He J, Yue X, He D, Zhao Y, Yang Y, Zheng G, Zhang E, Han X, Wu W, Yang L, et al: Multiple extramedullary-bone related and/or extramedullary extraosseous are independent poor prognostic factors in patients with newly diagnosed multiple myeloma. Front Oncol. 11:6680992021. View Article : Google Scholar : PubMed/NCBI

9 

Bladé J, Beksac M, Caers J, Jurczyszyn A, von Lilienfeld-Toal M, Moreau P, Rasche L, Rosiñol L, Usmani SZ, Zamagni E and Richardson P: Extramedullary disease in multiple myeloma: A systematic literature review. Blood Cancer J. 12:452022. View Article : Google Scholar : PubMed/NCBI

10 

Wu P, Davies FE, Boyd K, Thomas K, Dines S, Saso RM, Potter MN, Ethell ME, Shaw BE and Morgan GJ: The impact of extramedullary disease at presentation on the outcome of myeloma. Leuk Lymphoma. 50:230–235. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Dingli D, Ailawadhi S, Bergsagel PL, Buadi FK, Dispenzieri A, Fonseca R, Gertz MA, Gonsalves WI, Hayman SR, Kapoor P, et al: Therapy for relapsed multiple myeloma: Guidelines from the mayo stratification for myeloma and risk-adapted therapy. Mayo Clin Proc. 92:578–598. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Shen M, Li X, Zhang JJ, Tang R, Zhan XK, Fan SB, Zhao FY and Huang ZX: A clinical study on the treatment of relapsed and refractory multiple myeloma with secondary extramedullary lesions using a liposome containing doxorubicin regimen. Chin J Clin Oncol. 49:512–518. 2022.(In Chinese).

13 

Gao Y, Huang H, Wang X, Bai B, Huang Y, Yang H, Zhan Y, Li Y, Li Y, Zhou M, et al: Safety and efficacy of mitoxantrone hydrochloride liposome in patients with relapsed or refractory peripheral T-cell lymphoma and extranodal NK/T-cell lymphoma: A prospective, single-arm, open-label, multi-center, phase I Clinical trial. Blood. 136 (Suppl 1):36–37. 2020. View Article : Google Scholar

14 

Cai Q, Xia Y, Wang L, Huang H, Wang J, Cai J and Tian X: Combination of mitoxantrone hydrochloride liposome with tislelizumab in patients with relapsed or refractory NK/T cell lymphoma: A phase Ib/I clinical trial. Blood. 142:44702023. View Article : Google Scholar

15 

Mei KC, Liao YP, Jiang J, Chiang M, Khazaieli M, Liu X, Wang X, Liu Q, Chang CH, Zhang X, et al: Liposomal delivery of mitoxantrone and a cholesteryl indoximod prodrug provides effective chemo-immunotherapy in multiple solid tumors. ACS Nano. 14:13343–13366. 2020. View Article : Google Scholar : PubMed/NCBI

16 

Jian Y, Liu N, Zhang Y, Gao W, Chen WM, Zhu HH and Wu Y: Mitoxantrone hydrochloride liposome, bortezomib, and dexamethasone- based regimen in multiple myeloma patients with extramedullary plasmacytoma: A pilot study. Blood. 142:66502023. View Article : Google Scholar

17 

Cao HY, Li L, Xue SL and Dai HP: Chidamide: Targeting epigenetic regulation in the treatment of hematological malignancy. Hematol Oncol. 41:301–309. 2023. View Article : Google Scholar : PubMed/NCBI

18 

Wang DY, Cui YS, Liu YZ, Liu LN, Song YP and Fang BJ: Successful treatment of one case with relapsed refractory multiple myeloma by chidamide in combination with bortezomib and dexamethasone. Zhonghua Xue Ye Xue Za Zhi. 37:4632016.(In Chinese). PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Gao J, Dong F, Zhang X and Jing H: Efficacy of the CV‑MED regimen in treating extramedullary involvement of multiple myeloma: A case report. Oncol Lett 28: 612, 2024.
APA
Gao, J., Dong, F., Zhang, X., & Jing, H. (2024). Efficacy of the CV‑MED regimen in treating extramedullary involvement of multiple myeloma: A case report. Oncology Letters, 28, 612. https://doi.org/10.3892/ol.2024.14745
MLA
Gao, J., Dong, F., Zhang, X., Jing, H."Efficacy of the CV‑MED regimen in treating extramedullary involvement of multiple myeloma: A case report". Oncology Letters 28.6 (2024): 612.
Chicago
Gao, J., Dong, F., Zhang, X., Jing, H."Efficacy of the CV‑MED regimen in treating extramedullary involvement of multiple myeloma: A case report". Oncology Letters 28, no. 6 (2024): 612. https://doi.org/10.3892/ol.2024.14745
Copy and paste a formatted citation
x
Spandidos Publications style
Gao J, Dong F, Zhang X and Jing H: Efficacy of the CV‑MED regimen in treating extramedullary involvement of multiple myeloma: A case report. Oncol Lett 28: 612, 2024.
APA
Gao, J., Dong, F., Zhang, X., & Jing, H. (2024). Efficacy of the CV‑MED regimen in treating extramedullary involvement of multiple myeloma: A case report. Oncology Letters, 28, 612. https://doi.org/10.3892/ol.2024.14745
MLA
Gao, J., Dong, F., Zhang, X., Jing, H."Efficacy of the CV‑MED regimen in treating extramedullary involvement of multiple myeloma: A case report". Oncology Letters 28.6 (2024): 612.
Chicago
Gao, J., Dong, F., Zhang, X., Jing, H."Efficacy of the CV‑MED regimen in treating extramedullary involvement of multiple myeloma: A case report". Oncology Letters 28, no. 6 (2024): 612. https://doi.org/10.3892/ol.2024.14745
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team