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Recombinant human‑endostatin combined with sintilimab and chemotherapy in first‑line treatment of locally advanced or metastatic esophageal squamous cell carcinoma

  • Authors:
    • Shiyun Cui
    • Lei Fan
    • Xinnan Sun
    • Yucheng Cai
    • Ting Wang
    • Ping Li
    • Rong Wang
    • Lianke Liu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China, Department of General Surgery, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, P.R. China, Department of Clinical Medicine, The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu 211166, P.R. China
    Copyright: © Cui et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 244
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    Published online on: March 24, 2025
       https://doi.org/10.3892/ol.2025.14990
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Abstract

Esophageal cancer is a type of digestive system tumor with a high degree of malignancy. In recent years, research has been conducted on immunotherapy, chemotherapy and radiation therapy for esophageal cancer. However, there are still shortcomings in the improvement of 5‑year survival rates. In order to explore more therapy options, the present study evaluated the efficacy and safety of recombinant human‑endostatin (rh‑endostatin) combined with sintilimab and chemotherapy for the first‑line treatment of locally advanced or metastatic esophageal squamous cell carcinoma (ESCC). This retrospective study included data from 31 patients with unresectable locally advanced or metastatic esophageal cancer treated between January 2019 and December 2023, and was approved by the First Affiliated Hospital of Nanjing Medical University (Nanjing, China). All patients received first‑line treatment combining rh‑endostatin with sintilimab, paclitaxel liposome and platinum. Following the completion of 6 cycles, maintenance therapy with sintilimab was administered until disease progression occurred. The objective response rate (ORR), disease control rate (DCR), progression‑free survival (PFS) time, overall survival (OS) time and adverse events (AEs) were observed. Symptomatic or supportive care was administered as needed, according to the clinical discretion of the treating physician. As of July 17, 2024, the median follow‑up time was 13.07 months, with a median PFS time of 8.30 months (95% confidence interval, 3.442‑13.158 months). For these 31 patients, the ORR was 67.7% (21/31), while the DCR was 93.5% (29/31). The median OS time reached 23.07 months. Furthermore, 77.4% of patients experienced at least one treatment‑related AE (TRAE), and grade 3 TRAEs occurred in 8 patients (25.8%). No unexpected AEs were observed. In conclusion, rh‑endostatin combined with sintilimab and chemotherapy exhibited positive efficacy and safety in patients with advanced ESCC, providing a promising treatment regimen for these patients.
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Copy and paste a formatted citation
Spandidos Publications style
Cui S, Fan L, Sun X, Cai Y, Wang T, Li P, Wang R and Liu L: Recombinant human‑endostatin combined with sintilimab and chemotherapy in first‑line treatment of locally advanced or metastatic esophageal squamous cell carcinoma. Oncol Lett 29: 244, 2025.
APA
Cui, S., Fan, L., Sun, X., Cai, Y., Wang, T., Li, P. ... Liu, L. (2025). Recombinant human‑endostatin combined with sintilimab and chemotherapy in first‑line treatment of locally advanced or metastatic esophageal squamous cell carcinoma. Oncology Letters, 29, 244. https://doi.org/10.3892/ol.2025.14990
MLA
Cui, S., Fan, L., Sun, X., Cai, Y., Wang, T., Li, P., Wang, R., Liu, L."Recombinant human‑endostatin combined with sintilimab and chemotherapy in first‑line treatment of locally advanced or metastatic esophageal squamous cell carcinoma". Oncology Letters 29.5 (2025): 244.
Chicago
Cui, S., Fan, L., Sun, X., Cai, Y., Wang, T., Li, P., Wang, R., Liu, L."Recombinant human‑endostatin combined with sintilimab and chemotherapy in first‑line treatment of locally advanced or metastatic esophageal squamous cell carcinoma". Oncology Letters 29, no. 5 (2025): 244. https://doi.org/10.3892/ol.2025.14990
Copy and paste a formatted citation
x
Spandidos Publications style
Cui S, Fan L, Sun X, Cai Y, Wang T, Li P, Wang R and Liu L: Recombinant human‑endostatin combined with sintilimab and chemotherapy in first‑line treatment of locally advanced or metastatic esophageal squamous cell carcinoma. Oncol Lett 29: 244, 2025.
APA
Cui, S., Fan, L., Sun, X., Cai, Y., Wang, T., Li, P. ... Liu, L. (2025). Recombinant human‑endostatin combined with sintilimab and chemotherapy in first‑line treatment of locally advanced or metastatic esophageal squamous cell carcinoma. Oncology Letters, 29, 244. https://doi.org/10.3892/ol.2025.14990
MLA
Cui, S., Fan, L., Sun, X., Cai, Y., Wang, T., Li, P., Wang, R., Liu, L."Recombinant human‑endostatin combined with sintilimab and chemotherapy in first‑line treatment of locally advanced or metastatic esophageal squamous cell carcinoma". Oncology Letters 29.5 (2025): 244.
Chicago
Cui, S., Fan, L., Sun, X., Cai, Y., Wang, T., Li, P., Wang, R., Liu, L."Recombinant human‑endostatin combined with sintilimab and chemotherapy in first‑line treatment of locally advanced or metastatic esophageal squamous cell carcinoma". Oncology Letters 29, no. 5 (2025): 244. https://doi.org/10.3892/ol.2025.14990
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