Primary leiomyosarcoma of the ureter: A case report

Baio,Raffaele; Intilla,Olivier; Molisso,Giovanni; Di Mauro,Umberto; Ferrante,Diodato; Di Lorenzo,Giuseppe; Buonerba,Carlo; Citarella,Rita; Pagano,Tommaso; Sanseverino,Roberto

doi:10.3892/ol.2025.15004

May-2025 Volume 29 Issue 5

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

May-2025 Volume 29 Issue 5

Full Size Image

Case Report

Primary leiomyosarcoma of the ureter: A case report

Authors:
- Raffaele Baio
- Olivier Intilla
- Giovanni Molisso
- Umberto Di Mauro
- Diodato Ferrante
- Giuseppe Di Lorenzo
- Carlo Buonerba
- Rita Citarella
- Tommaso Pagano
- Roberto Sanseverino
View Affiliations / Copyright

Affiliations: Department of Urology, Umberto I Hospital, Nocera Inferiore, I‑84014 Salerno, Italy, Department of Urology, ‘Villa del Sole’ Clinic, Casagiove, I‑81100 Caserta, Italy, Department of Surgery and Anesthesia, ‘Umberto I’ Hospital of Nocera Inferiore, Nocera Inferiore, I‑84014 Salerno, Italy, Department of Oncology, ‘Andrea Tortora’ Hospital of Pagani, Pagani, I‑84016 Salerno, Italy, Oncology Research Assistance Association, I‑84134 Salerno, Italy, Department of Anesthesia, Umberto I Hospital, Nocera Inferiore, I‑84014 Salerno, Italy
Article Number: 258
|
Published online on: April 1, 2025

https://doi.org/10.3892/ol.2025.15004
Expand metrics +

Abstract

Malignant tumors of the smooth muscle of the ureter are extremely rare, with ~13 cases of leiomyosarcoma of the ureter being reported to date. A 59‑year‑old Caucasian woman presented to ‘Umberto I’ Hospital (Nocera Inferiore, Italy) with acute abdominal pain, predominantly in the right lumbar fossa. The patient exhibited a functional single kidney, due to left renal atrophy for a long‑standing stenosis of the pyelo‑ureteric joint. With the exception of this condition and hypertension (under medical therapy), the patient was in excellent clinical condition. Furthermore, the patient was not a smoker. Computed tomography indicated a stricture with a peri‑ureteral soft tissue mass of 45x52 mm at the middle third of the ureter at the level of common iliac vessels. Laparoscopic excision with safety margin and a right tension free end‑to‑end anastomosis between the two stumps of the ureter was performed. The diagnosis of leiomyosarcoma of the right ureter was made by pathological examination. Although leiomyosarcoma is rarely noted in the urinary tract, it should be considered in the differential diagnosis of ureteral stricture disease and retroperitoneal tumors.

View Figures

View References

1	Abeshouse BS: Primary benign and malignant tumors of the ureter; a review of the literature and report of one benign and twelve malignant tumors. Am J Surg. 91:237–271. 1956. View Article : Google Scholar : PubMed/NCBI
2	Griffin JH and Waters WB: Primary leiomyosarcoma of the ureter. J Surg Oncol. 62:148–152. 1996. View Article : Google Scholar : PubMed/NCBI
3	Roemer CE, Pfister RC, Brodsky G and Sacknoff EJ: Primary leiomyosarcoma of the ureter. Urology. 16:492–495. 1980. View Article : Google Scholar : PubMed/NCBI
4	Spiess PE, Leibovici D and Pisters LL: PART X: Neoplasms of the upper urinary tract. Campbell-Walsh Urology; 11th edition. pp. 1404–1412. 2016
5	Gislason T and Arnarson O: Primary ureteral leiomyosarcoma. Scand J Urol Nephrol. 18:253–254. 1984. View Article : Google Scholar : PubMed/NCBI
6	Mehraban D: Primary leiomyosarcoma of the ureter. Med J Islam Repub Iran. 2:67–69. 1988.
7	Ribbert, . About an atriocellular myosarcoma of the renal pelvis and the ureter. Virch Arch. 106:2821886.
8	Rademaker L: Primary sarcoma of the ureter: Case report and review of the literature. Am J Surg. 62:402–406. 1943. View Article : Google Scholar
9	Kraus JE: Primary sarcoma of the ureter. Urol Cutan Rev. 48:5221944.
10	Rossien AK and Russell TH: Leiomyosarcoma involving the right ureter. Arch Pathol (Chic). 41:655–660. 1946.PubMed/NCBI
11	Alznauer RL: Leiomyosarcoma of right ureter; report of a case. AMA Arch Pathol. 59:94–99. 1955.PubMed/NCBI
12	Werner JR, Klingensmith W and Denko JV: Leiomyosarcoma of the ureter: Case report and review of literature. J Urol. 82:68–71. 1959. View Article : Google Scholar : PubMed/NCBI
13	Rushton HG, Sens MA, Garvin AJ and Turner WR Jr: Primary leiomyosarcoma of the ureter: A case report with electron microscopy. J Urol. 129:1045–1046. 1983. View Article : Google Scholar : PubMed/NCBI
14	Márquez-Moreno AJ, Julve-Villalta E, Corral-García P, Gutiérrez-Chacón P and Blanes-Berenguel A: Primary ureteral leiomyosarcoma: A rare cause of obstructive uropathy. Arch Esp Urol. 56:169–172. 2003.(In Spanish). PubMed/NCBI
15	Shirotake S, Sumitomo M, Asakuma J, Asano T, Aiko S and Hayakawa M: A case of primary leiomyosarcoma of the ureter. Hinyokika Kiyo. 52:41–45. 2006.(In Japanese). PubMed/NCBI
16	Lv C, Chen N, Zhu X, Zhang X and Zhong Z: Primary leiomyosarcoma of the ureter. Asian J Surg. 31:191–194. 2008. View Article : Google Scholar : PubMed/NCBI
17	Aubert E, Millet I, Serre I and Taourel P: Leiomyosarcoma of the ureter: A rare case. Diagn Interv Imaging. 93:60–63. 2012. View Article : Google Scholar : PubMed/NCBI
18	Aboutaleb HA, Khurana P and El-Shahat YM: Primary leiomyosarcoma of the middle ureter: A rare case report with literature review. Clin Case Rep. 10:e054092022. View Article : Google Scholar : PubMed/NCBI
19	Gan C, Attwell-Heap A and Clarke A: Left distal ureter leiomyosarcoma: A case report. J Surg Case Rep. 2022:rjac5012022.PubMed/NCBI
20	Tzen CY, Wu CJ, Huang ZD and Wu TY: Poorly differentiated transitional cell carcinoma versus leiomyosarcoma of the ureter: Different defects in tumour suppressor genes. Histopathology. 51:271–273. 2007. View Article : Google Scholar : PubMed/NCBI
21	Kasper B, Gil T and Awada A: Treatment of patients with advanced soft tissue sarcoma: Disappointment or challenge? Curr Opin Oncol. 19:336–340. 2007. View Article : Google Scholar : PubMed/NCBI
22	Madgar I, Goldwasser B, Czerniak A and Many M: Leiomyosarcoma of the ureter. Eur Urol. 14:487–489. 1988. View Article : Google Scholar : PubMed/NCBI
23	Browne RF, Meehan CP, Colville J, Power R and Torreggiani WC: Transitional cell carcinoma of the upper urinary tract: Spectrum of imaging findings. Radiographics. 25:1609–1627. 2005. View Article : Google Scholar : PubMed/NCBI
24	Merran S, Karila-Cohen P and Vieillefond A: Primary retroperitoneal tumors in adults. J Radiol. 85:252–264. 2004.(In French). View Article : Google Scholar : PubMed/NCBI
25	Delomez J, Claudon M, Darmaillacq C, Hubert J and Lemaître L: Imaging of upper excretory tract tumors. J Radiol. 83:825–838. 2002.(In French). PubMed/NCBI
26	Vikram R, Sandler CM and Ng CS: Imaging and staging of transitional cell carcinoma: Part 2, upper urinary tract. AJR Am J Roentgenol. 192:1488–1493. 2009. View Article : Google Scholar : PubMed/NCBI
27	Miettinen M: Antibody specific to muscle actins in the diagnosis and classification of soft tissue tumors. Am J Pathol. 130:205–215. 1988.PubMed/NCBI
28	Iwata J and Fletcher CD: Immunohistochemical detection of cytokeratin and epithelial membrane antigen in leiomyosarcoma: A systematic study of 100 cases. Pathol Int. 50:7–14. 2000. View Article : Google Scholar : PubMed/NCBI
29	Kolhartkar RK, Kulkarni SH, Phansopkar MA and Thomas C: Leimyosarcoma of ureter presenting as acute renal failure. Br J Urol. 51:3261979. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Primary leiomyosarcoma of the ureter: A case report

This article is mentioned in:

Abstract

Figure 1

Figure 2

Figure 3

Figure 4

Related Articles