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Prophylactic cerebral irradiation sensitizes relapsed sensitive small cell lung cancer to temozolomide: A retrospective cohort study

  • Authors:
    • Dan He
    • Shuxia Wei
    • Fenghao Geng
    • Lintao Li
    • Fengyu Li
    • Yanli Ge
    • Ruichang Lv
    • Weiwei Li
    • Zhijun Hao
    • Fengdi Jiang
    • Chao Meng
    • Shun Lu
    • Shuyu Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, Sichuan 610041, P.R. China, Department of Oncology, The Hospital of 81st Group Army, Zhangjiakou, Hebei 075000, P.R. China, Department of Radiation Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Radiotherapy Center, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, Sichuan 610041, P.R. China, Department of Nephrology, Huayao Hospital of North China Medical and Health Group, Shijiazhuang, Hebei 050011, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 327
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    Published online on: May 2, 2025
       https://doi.org/10.3892/ol.2025.15073
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Abstract

Prophylactic cerebral irradiation (PCI) reduces the rate of brain metastasis and improves the prognosis of patients with small cell lung cancer (SCLC), but little is known about the effect of PCI on second‑line chemotherapy in patients with relapsed sensitive SCLC. This retrospective cohort study included a total of 164 patients with relapsed sensitive SCLC, 20 of whom were administered temozolomide (TMZ). Categorical clinical variables were compared between subgroups with the chi‑square test or Fisher's exact test, continuous clinical variables were compared with the t‑test or one‑way ANOVA, and the impact on overall survival (OS) was assessed using Kaplan‑Meier analysis with the log‑rank test. In general, TMZ prolonged the OS of patients with SCLC with brain metastasis from 12.0 to 19.0 months [P=0.0109, hazard ratio (HR): 0.4789, 95% CI: 0.2470‑0.9287]. Furthermore, the administration of PCI improved the effects of TMZ on patients with SCLC with brain metastasis, with an increase in OS from 16.0 to 36.5 months (P=0.0017, HR: 3.634, 95% CI: 1.083‑12.20); additionally, no difference was observed on the basis of the history of chemotherapy or state of brain metastasis. For the local response evaluation, the overall response rate reached 75.0% for both brain metastasis and extracranial lesions in the two‑cycle evaluation, remained at 30.0 and 25.0% in the four‑cycle and more‑cycle evaluations, respectively, and was minimally influenced by the history of chemotherapy or PCI. In conclusion, the results of this study suggest that PCI may be valuable for patients with relapsed sensitive SCLC with brain metastasis who are receiving TMZ treatment, and it may also serve as an effective regimen to prevent local progression of extracranial lesions; however, more evidence is needed.
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Copy and paste a formatted citation
Spandidos Publications style
He D, Wei S, Geng F, Li L, Li F, Ge Y, Lv R, Li W, Hao Z, Jiang F, Jiang F, et al: Prophylactic cerebral irradiation sensitizes relapsed sensitive small cell lung cancer to temozolomide: A retrospective cohort study. Oncol Lett 30: 327, 2025.
APA
He, D., Wei, S., Geng, F., Li, L., Li, F., Ge, Y. ... Zhang, S. (2025). Prophylactic cerebral irradiation sensitizes relapsed sensitive small cell lung cancer to temozolomide: A retrospective cohort study. Oncology Letters, 30, 327. https://doi.org/10.3892/ol.2025.15073
MLA
He, D., Wei, S., Geng, F., Li, L., Li, F., Ge, Y., Lv, R., Li, W., Hao, Z., Jiang, F., Meng, C., Lu, S., Zhang, S."Prophylactic cerebral irradiation sensitizes relapsed sensitive small cell lung cancer to temozolomide: A retrospective cohort study". Oncology Letters 30.1 (2025): 327.
Chicago
He, D., Wei, S., Geng, F., Li, L., Li, F., Ge, Y., Lv, R., Li, W., Hao, Z., Jiang, F., Meng, C., Lu, S., Zhang, S."Prophylactic cerebral irradiation sensitizes relapsed sensitive small cell lung cancer to temozolomide: A retrospective cohort study". Oncology Letters 30, no. 1 (2025): 327. https://doi.org/10.3892/ol.2025.15073
Copy and paste a formatted citation
x
Spandidos Publications style
He D, Wei S, Geng F, Li L, Li F, Ge Y, Lv R, Li W, Hao Z, Jiang F, Jiang F, et al: Prophylactic cerebral irradiation sensitizes relapsed sensitive small cell lung cancer to temozolomide: A retrospective cohort study. Oncol Lett 30: 327, 2025.
APA
He, D., Wei, S., Geng, F., Li, L., Li, F., Ge, Y. ... Zhang, S. (2025). Prophylactic cerebral irradiation sensitizes relapsed sensitive small cell lung cancer to temozolomide: A retrospective cohort study. Oncology Letters, 30, 327. https://doi.org/10.3892/ol.2025.15073
MLA
He, D., Wei, S., Geng, F., Li, L., Li, F., Ge, Y., Lv, R., Li, W., Hao, Z., Jiang, F., Meng, C., Lu, S., Zhang, S."Prophylactic cerebral irradiation sensitizes relapsed sensitive small cell lung cancer to temozolomide: A retrospective cohort study". Oncology Letters 30.1 (2025): 327.
Chicago
He, D., Wei, S., Geng, F., Li, L., Li, F., Ge, Y., Lv, R., Li, W., Hao, Z., Jiang, F., Meng, C., Lu, S., Zhang, S."Prophylactic cerebral irradiation sensitizes relapsed sensitive small cell lung cancer to temozolomide: A retrospective cohort study". Oncology Letters 30, no. 1 (2025): 327. https://doi.org/10.3892/ol.2025.15073
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