Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2025 Volume 30 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2025 Volume 30 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Distinguishing acute leukemia subtypes: The role of hsa_circ_0012152 and hsa_circ_0020093 in peripheral blood

  • Authors:
    • Qiming Ying
    • Dingfeng Lv
    • Ying Chen
    • Qitian Mu
  • View Affiliations / Copyright

    Affiliations: Department of Blood Transfusion, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315010, P.R. China, Department of Hematology, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315010, P.R. China
    Copyright: © Ying et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 330
    |
    Published online on: May 7, 2025
       https://doi.org/10.3892/ol.2025.15076
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Acute leukemia (AL), a rapidly progressing hematological malignancy originating from the bone marrow, is primarily subclassified into acute myelocytic leukemia (AML) and acute lymphoblastic leukemia (ALL). Obtaining bone marrow samples can be challenging due to a number of reasons, including dilution or inaccessibility. Therefore, the present study focused on identifying novel diagnostic biomarkers in the peripheral blood for AL subgroups. Circular RNAs (circRNAs) are non‑coding RNA molecules associated with various diseases. In the present study, to validate the distinct circRNA expression patterns distinguishing AML from ALL in peripheral blood, reverse transcription‑quantitative polymerase chain reaction was employed. The diagnostic accuracy of hsa_circ_0020093 and hsa_circ_0012152 was then assessed using receiver operating characteristic curve analysis, and hsa_circ_0020093 was selected for further exploration using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses. The findings revealed that the expression patterns of hsa_circ_0020093 and hsa_circ_0012152 clearly differentiated ALL from AML in peripheral blood. The potential target genes of hsa_circ_0020093 identified were associated with critical biological processes such as protein serine kinase activity and cadherin binding. Furthermore, these genes are involved in signaling pathways including MAPK and mTOR. We propose that hsa_circ_0020093 plays a crucial role in initiating and promoting ALL by modulating downstream target genes through either hsa‑microRNA (miR)‑153‑3p or hsa‑miR‑194‑5p. The results of the present study demonstrate that hsa_circ_0020093 and hsa_circ_0012152 hold significant promise as diagnostic biomarkers for subclassifying AL into ALL or AML in peripheral blood. This discovery lays the foundation for future research endeavors aimed at elucidating the role of circRNAs in the pathogenesis and treatment of AL.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Devine SM and Larson RA: Acute leukemia in adults: Recent developments in diagnosis and treatment. CA Cancer J Clin. 44:326–352. 1994. View Article : Google Scholar : PubMed/NCBI

2 

Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR and Sultan C: Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group. Br J Haematol. 33:451–458. 1976. View Article : Google Scholar : PubMed/NCBI

3 

Cheng H, Huang CM, Wang Y, Hu XX, Xu XQ, Song XM, Tang GS, Chen L and Yang JM: Microarray profiling and co-expression network analysis of the lncRNAs and mRNAs associated with acute leukemia in adults. Mol Biosyst. 13:1102–1108. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Pui CH, Schrappe M, Ribeiro RC and Niemeyer CM: Childhood and adolescent lymphoid and myeloid leukemia. Hematology Am Soc Hematol Educ Program. 118–145. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Miranda-Filho A, Piñeros M, Ferlay J, Soerjomataram I, Monnereau A and Bray F: Epidemiological patterns of leukaemia in 184 countries: A population-based study. Lancet Haematol. 5:e14–e24. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Oliveira PD: Leukaemia prevalence worldwide: Raising aetiology questions. Lancet Haematol. 5:e2–e3. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Porwit A and Béné MC: Acute leukemias of ambiguous origin. Am J Clin Pathol. 144:361–376. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Xu XQ, Wang JM, Lu SQ, Chen L, Yang JM, Zhang WP, Song XM, Hou J, Ni X and Qiu HY: Clinical and biological characteristics of adult biphenotypic acute leukemia in comparison with that of acute myeloid leukemia and acute lymphoblastic leukemia: A case series of a Chinese population. Haematologica. 94:919–927. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Rong D, Sun H, Li Z, Liu S, Dong C, Fu K, Tang W and Cao H: An emerging function of circRNA-miRNAs-mRNA axis in human diseases. Oncotarget. 8:73271–73281. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, Chen D, Gu J, He X and Huang S: Circular RNA is enriched and stable in exosomes: A promising biomarker for cancer diagnosis. Cell Res. 25:981–984. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Lei K, Bai H, Wei Z, Xie C, Wang J, Li J and Chen Q: The mechanism and function of circular RNAs in human diseases. Exp Cell Res. 368:147–158. 2018. View Article : Google Scholar : PubMed/NCBI

12 

Guo SS, Li BX, Zou DB, Yang SJ, Sheng LX, Ouyang GF, Mu QT and Huang H: Tip of the iceberg: Roles of circRNAs in hematological malignancies. Am J Cancer Res. 10:367–382. 2020.PubMed/NCBI

13 

Yi YY, Yi J, Zhu X, Zhang J, Zhou J, Tang X, Lin J, Wang P and Deng ZQ: Circular RNA of vimentin expression as a valuable predictor for acute myeloid leukemia development and prognosis. J Cell Physiol. 234:3711–3719. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Li W, Zhong C, Jiao J, Li P, Cui B, Ji C and Ma D: Characterization of hsa_circ_0004277 as a new biomarker for acute myeloid leukemia via circular RNA profile and bioinformatics analysis. Int J Mol Sci. 18:5972017. View Article : Google Scholar : PubMed/NCBI

15 

Hu J, Han Q, Gu Y, McGrath M, Qiao F, Chen B, Song C and Ge Z: Circular RNA PVT1 expression and its roles in acute lymphoblastic leukemia. Epigenomics. 10:723–732. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Guo S, Li B, Chen Y, Zou D, Yang S, Zhang Y, Wu N, Sheng L, Huang H, Ouyang G and Mu Q: Hsa_circ_0012152 and Hsa_circ_0001857 accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. Front Oncol. 10:16552020. View Article : Google Scholar : PubMed/NCBI

17 

Lin CQ, Yang Y, Mao H, Zhao Q, Wu JQ, Li DP and Huang YH: Clinical characteristics, prognostic factors and misdiagnosis of bone marrow necrosis patients. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 29:1637–1644. 2021.(In Chinese). PubMed/NCBI

18 

Ridgeway JA, Tinsley S and Kurtin SE: Practical guide to bone marrow sampling for suspected myelodysplastic syndromes. J Adv Pract Oncol. 8:29–39. 2017.PubMed/NCBI

19 

Butler JT, Yashar WM and Swords R: Breaking the bone marrow barrier: Peripheral blood as a gateway to measurable residual disease detection in acute myelogenous leukemia. Am J Hematol. 100:638–651. 2025. View Article : Google Scholar : PubMed/NCBI

20 

Hematology Oncology Committee, Chinese Anti-Cancer Association, Leukemia & Lymphoma Group, Chinese Society of Hematology and Chinese Medical Association, . Chinese guideline for diagnosis and treatment of adult acute lymphoblastic leukemia (2024). Zhonghua Xue Ye Xue Za Zhi. 45:417–429. 2024.(In Chinese). PubMed/NCBI

21 

Khoury JD, Solary E, Abla O, Akkari Y, Alaggio R, Apperley JF, Bejar R, Berti E, Busque L, Chan JKC, et al: The 5th edition of the World Health Organization classification of haematolymphoid tumours: myeloid and histiocytic/dendritic neoplasms. Leukemia. 36:1703–1719. 2022. View Article : Google Scholar : PubMed/NCBI

22 

Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, Araujo IBO, Berti E, Bhagat G, Borges AM, Boyer D, Calaminici M, et al: The 5th edition of the World Health Organization classification of haematolymphoid tumours: Lymphoid neoplasms. Leukemia. 36:1720–1748. 2022. View Article : Google Scholar : PubMed/NCBI

23 

Staples TL: Expansion and evolution of the R programming language. R Soc Open Sci. 10:2215502023. View Article : Google Scholar : PubMed/NCBI

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Doncheva NT, Morris JH, Gorodkin J and Jensen LJ: Cytoscape StringApp: Network analysis and visualization of proteomics data. J Proteome Res. 18:623–632. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Tan Y, Tan Y, Li J, Hu P, Guan P, Kuang H, Liang Q, Yu Y, Chen Z, Wang Q, et al: Combined IFN-γ and IL-2 release assay for detect active pulmonary tuberculosis: A prospective multicentre diagnostic study in China. J Transl Med. 19:2892021. View Article : Google Scholar : PubMed/NCBI

27 

Takahashi K, Uchiyama H, Yanagisawa S and Kamae I: The logistic regression and ROC analysis of group-based screening for predicting diabetes incidence in four years. Kobe J Med Sci. 52:171–180. 2006.PubMed/NCBI

28 

Löwenberg B, Downing JR and Burnett A: Acute myeloid leukemia. N Engl J Med. 341:1051–1062. 1999. View Article : Google Scholar : PubMed/NCBI

29 

Weir EG and Borowitz MJ: Flow cytometry in the diagnosis of acute leukemia. Semin Hematol. 38:124–138. 2001. View Article : Google Scholar : PubMed/NCBI

30 

McKenna RW: Multifaceted approach to the diagnosis and classification of acute leukemias. Clin Chem. 46:1252–1259. 2000. View Article : Google Scholar : PubMed/NCBI

31 

Wang WT, Chen TQ, Zeng ZC, Pan Q, Huang W, Han C, Fang K, Sun LY, Yang QQ, Wang D, et al: The lncRNA LAMP5-AS1 drives leukemia cell stemness by directly modulating DOT1L methyltransferase activity in MLL leukemia. J Hematol Oncol. 13:782020. View Article : Google Scholar : PubMed/NCBI

32 

Bárcenas-López DA, Núñez-Enríquez JC, Hidalgo-Miranda A, Beltrán-Anaya FO, May-Hau DI, Jiménez-Hernández E, Bekker-Méndez VC, Flores-Lujano J, Medina-Sansón A, Tamez-Gómez EL, et al: Transcriptome analysis identifies LINC00152 as a biomarker of early relapse and mortality in acute lymphoblastic leukemia. Genes (Basel). 11:3022020. View Article : Google Scholar : PubMed/NCBI

33 

Gentner B, Pochert N, Rouhi A, Boccalatte F, Plati T, Berg T, Sun SM, Mah SM, Mirkovic-Hösle M, Ruschmann J, et al: MicroRNA-223 dose levels fine tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia. Exp Hematol. 43:858–868.e7. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Hornick NI, Huan J, Doron B, Goloviznina NA, Lapidus J, Chang BH and Kurre P: Serum exosome MicroRNA as a minimally-invasive early biomarker of AML. Sci Rep. 5:112952015. View Article : Google Scholar : PubMed/NCBI

35 

Avigad S, Verly IRN, Lebel A, Kordi O, Shichrur K, Ohali A, Hameiri-Grossman M, Kaspers GJL, Cloos J, Fronkova E, et al: miR expression profiling at diagnosis predicts relapse in pediatric precursor B-cell acute lymphoblastic leukemia. Genes Chromosomes Cancer. 55:328–339. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Huang W, Fang K, Chen TQ, Zeng ZC, Sun YM, Han C, Sun LY, Chen ZH, Yang QQ, Pan Q, et al: circRNA circAF4 functions as an oncogene to regulate MLL-AF4 fusion protein expression and inhibit MLL leukemia progression. J Hematol Oncol. 12:1032019. View Article : Google Scholar : PubMed/NCBI

37 

Zhou J, Zhou LY, Tang X, Zhang J, Zhai LL, Yi YY, Yi J, Lin J, Qian J and Deng ZQ: Circ-Foxo3 is positively associated with the Foxo3 gene and leads to better prognosis of acute myeloid leukemia patients. BMC Cancer. 19:9302019. View Article : Google Scholar : PubMed/NCBI

38 

Han F, Zhong C, Li W, Wang R, Zhang C, Yang X, Ji C and Ma D: hsa_circ_0001947 suppresses acute myeloid leukemia progression via targeting hsa-miR-329-5p/CREBRF axis. Epigenomics. 12:935–953. 2020. View Article : Google Scholar : PubMed/NCBI

39 

Jamal M, Song T, Chen B, Faisal M, Hong Z, Xie T, Wu Y, Pan S, Yin Q, Shao L and Zhang Q: Recent progress on circular RNA research in acute myeloid leukemia. Front Oncol. 9:11082019. View Article : Google Scholar : PubMed/NCBI

40 

Yuan DM, Ma J and Fang WB: Identification of non-coding RNA regulatory networks in pediatric acute myeloid leukemia reveals circ-0004136 could promote cell proliferation by sponging miR-142. Eur Rev Med Pharmacol Sci. 23:9251–9258. 2019.PubMed/NCBI

41 

Puil L, Liu J, Gish G, Mbamalu G, Bowtell D, Pelicci PG, Arlinghaus R and Pawson T: Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway. EMBO J. 13:764–773. 1994. View Article : Google Scholar : PubMed/NCBI

42 

Ohanian M, Tari Ashizawa A, Garcia-Manero G, Pemmaraju N, Kadia T, Jabbour E, Ravandi F, Borthakur G, Andreeff M, Konopleva M, et al: Liposomal Grb2 antisense oligodeoxynucleotide (BP1001) in patients with refractory or relapsed haematological malignancies: A single-centre, open-label, dose-escalation, phase 1/1b trial. Lancet Haematol. 5:e136–e146. 2018. View Article : Google Scholar : PubMed/NCBI

43 

Yan J, Jiang N, Huang G, Tay JL, Lin B, Bi C, Koh GS, Li Z, Tan J, Chung TH, et al: Deregulated MIR335 that targets MAPK1 is implicated in poor outcome of paediatric acute lymphoblastic leukaemia. Br J Haematol. 163:93–103. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Tomiyasu H, Watanabe M, Sugita K, Goto-Koshino Y, Fujino Y, Ohno K, Sugano S and Tsujimoto H: Regulations of ABCB1 and ABCG2 expression through MAPK pathways in acute lymphoblastic leukemia cell lines. Anticancer Res. 33:5317–5323. 2013.PubMed/NCBI

45 

You H, Wang D, Wei L, Chen J, Li H and Liu Y: Deferoxamine inhibits acute lymphoblastic leukemia progression through repression of ROS/HIF-1 α, Wnt/β-catenin, and p38MAPK/ERK pathways. J Oncol. 2022:82812672022. View Article : Google Scholar : PubMed/NCBI

46 

Simioni C, Martelli AM, Zauli G, Melloni E and Neri LM: Targeting mTOR in acute lymphoblastic leukemia. Cells. 8:1902019. View Article : Google Scholar : PubMed/NCBI

47 

Evangelisti C, Chiarini F, Cappellini A, Paganelli F, Fini M, Santi S, Martelli AM, Neri LM and Evangelisti C: Targeting Wnt/β-catenin and PI3K/Akt/mTOR pathways in T-cell acute lymphoblastic leukemia. J Cell Physiol. 235:5413–5428. 2020. View Article : Google Scholar : PubMed/NCBI

48 

Ge Z, Song C, Ding Y, Tan BH, Desai D, Sharma A, Gowda R, Yue F, Huang S, Spiegelman V, et al: Dual targeting of MTOR as a novel therapeutic approach for high-risk B-cell acute lymphoblastic leukemia. Leukemia. 35:1267–1278. 2021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ying Q, Lv D, Chen Y and Mu Q: Distinguishing acute leukemia subtypes: The role of hsa_circ_0012152 and hsa_circ_0020093 in peripheral blood. Oncol Lett 30: 330, 2025.
APA
Ying, Q., Lv, D., Chen, Y., & Mu, Q. (2025). Distinguishing acute leukemia subtypes: The role of hsa_circ_0012152 and hsa_circ_0020093 in peripheral blood. Oncology Letters, 30, 330. https://doi.org/10.3892/ol.2025.15076
MLA
Ying, Q., Lv, D., Chen, Y., Mu, Q."Distinguishing acute leukemia subtypes: The role of hsa_circ_0012152 and hsa_circ_0020093 in peripheral blood". Oncology Letters 30.1 (2025): 330.
Chicago
Ying, Q., Lv, D., Chen, Y., Mu, Q."Distinguishing acute leukemia subtypes: The role of hsa_circ_0012152 and hsa_circ_0020093 in peripheral blood". Oncology Letters 30, no. 1 (2025): 330. https://doi.org/10.3892/ol.2025.15076
Copy and paste a formatted citation
x
Spandidos Publications style
Ying Q, Lv D, Chen Y and Mu Q: Distinguishing acute leukemia subtypes: The role of hsa_circ_0012152 and hsa_circ_0020093 in peripheral blood. Oncol Lett 30: 330, 2025.
APA
Ying, Q., Lv, D., Chen, Y., & Mu, Q. (2025). Distinguishing acute leukemia subtypes: The role of hsa_circ_0012152 and hsa_circ_0020093 in peripheral blood. Oncology Letters, 30, 330. https://doi.org/10.3892/ol.2025.15076
MLA
Ying, Q., Lv, D., Chen, Y., Mu, Q."Distinguishing acute leukemia subtypes: The role of hsa_circ_0012152 and hsa_circ_0020093 in peripheral blood". Oncology Letters 30.1 (2025): 330.
Chicago
Ying, Q., Lv, D., Chen, Y., Mu, Q."Distinguishing acute leukemia subtypes: The role of hsa_circ_0012152 and hsa_circ_0020093 in peripheral blood". Oncology Letters 30, no. 1 (2025): 330. https://doi.org/10.3892/ol.2025.15076
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team