Total gastrectomy and extended D2 lymphadenectomy for primary gastric squamous cell carcinoma: A case report&nbsp;

Pham,Binh Van; Nguyen,Duy Duc; Tran,Manh Dai; Nguyen,Thanh Duy; Thai,An Duc; Nguyen,Binh Tien; Le,Ky Van; Nguyen,Hoa Thi Thanh

doi:10.3892/ol.2025.15079

July-2025 Volume 30 Issue 1

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July-2025 Volume 30 Issue 1

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Case Report

Total gastrectomy and extended D2 lymphadenectomy for primary gastric squamous cell carcinoma: A case report

Authors:
- Binh Van Pham
- Duy Duc Nguyen
- Manh Dai Tran
- Thanh Duy Nguyen
- An Duc Thai
- Binh Tien Nguyen
- Ky Van Le
- Hoa Thi Thanh Nguyen
View Affiliations / Copyright

Affiliations: Department of Abdominal Surgery 1, Vietnam National Cancer Hospital, Hanoi 100000, Vietnam, Center for Pathology and Molecular Biology, Vietnam National Cancer Hospital, Hanoi 100000, Vietnam, Department of Clinical Nutrition, Vietnam National Cancer Hospital, Hanoi 100000, Vietnam
Article Number: 333
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Published online on: May 8, 2025

https://doi.org/10.3892/ol.2025.15079
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Abstract

Primary gastric squamous cell carcinoma (PGSCC) is a rare form of gastric malignancy. The etiology remains unclear and no standardized treatment protocol or consensus has been established. The current study presents a rare case of PGSCC treated by total gastrectomy and extended D2 lymphadenectomy, alongside a review of related clinical literature. A 57‑year‑old man was diagnosed with primary SCC located at the lesser curvature of the gastric body. The patient underwent a total gastrectomy and extended D2 lymphadenectomy. Postoperative pathology confirmed a moderately differentiated SCC with perineural invasion, classified as stage T4bN2M0. Treatment strategies for PGSCC remain controversial, underscoring the need for further studies with larger sample sizes to clarify therapeutic approaches.

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