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Case Report Open Access

Primary pulmonary malignant melanoma with H3K27Me3 loss: A case report

  • Authors:
    • Houqiang Li
    • Lanqing Zheng
    • Xunbin Yu
    • Linfeng Chen
    • Shanshan Lv
    • Xin Chen
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian 350001, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 338
    |
    Published online on: May 13, 2025
       https://doi.org/10.3892/ol.2025.15084
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Abstract

Primary pulmonary malignant melanoma (pPMM) is an exceptionally rare type of primary malignant tumor. The present study reports a unique case of pPMM in a 54‑year‑old woman. Surgical resection revealed a tumor localized around the bronchus, showing nodular growth with relatively well‑defined borders and no evidence of local or distant metastasis. To further characterize this rare pPMM, histological analysis, immunohistochemistry, sanger sequencing and next‑generation sequencing were conducted. Histologically, the tumor exhibited biphasic differentiation, with both epithelial‑like and spindle cell‑like features, as well as high‑grade characteristics, including significant atypia, necrosis and a high mitotic index. Key diagnostic features of malignant melanoma were evident, including prominent red nucleoli and melanin pigmentation. Immunohistochemistry confirmed the presence of melanoma markers and demonstrated a loss of H3K27Me3 expression. The programmed death‑ligand 1 positivity rate of the tumor was 60%. NGS identified a mutation in the TP53 and NTRK3 genes, but no BRAF mutation was detected. This case report highlights the unique presentation of pPMM with H3K27Me3 loss and provides insights into its genomic profile, pathogenesis and natural history.
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Copy and paste a formatted citation
Spandidos Publications style
Li H, Zheng L, Yu X, Chen L, Lv S and Chen X: Primary pulmonary malignant melanoma with H3K27Me3 loss: A case report. Oncol Lett 30: 338, 2025.
APA
Li, H., Zheng, L., Yu, X., Chen, L., Lv, S., & Chen, X. (2025). Primary pulmonary malignant melanoma with H3K27Me3 loss: A case report. Oncology Letters, 30, 338. https://doi.org/10.3892/ol.2025.15084
MLA
Li, H., Zheng, L., Yu, X., Chen, L., Lv, S., Chen, X."Primary pulmonary malignant melanoma with H3K27Me3 loss: A case report". Oncology Letters 30.1 (2025): 338.
Chicago
Li, H., Zheng, L., Yu, X., Chen, L., Lv, S., Chen, X."Primary pulmonary malignant melanoma with H3K27Me3 loss: A case report". Oncology Letters 30, no. 1 (2025): 338. https://doi.org/10.3892/ol.2025.15084
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Zheng L, Yu X, Chen L, Lv S and Chen X: Primary pulmonary malignant melanoma with H3K27Me3 loss: A case report. Oncol Lett 30: 338, 2025.
APA
Li, H., Zheng, L., Yu, X., Chen, L., Lv, S., & Chen, X. (2025). Primary pulmonary malignant melanoma with H3K27Me3 loss: A case report. Oncology Letters, 30, 338. https://doi.org/10.3892/ol.2025.15084
MLA
Li, H., Zheng, L., Yu, X., Chen, L., Lv, S., Chen, X."Primary pulmonary malignant melanoma with H3K27Me3 loss: A case report". Oncology Letters 30.1 (2025): 338.
Chicago
Li, H., Zheng, L., Yu, X., Chen, L., Lv, S., Chen, X."Primary pulmonary malignant melanoma with H3K27Me3 loss: A case report". Oncology Letters 30, no. 1 (2025): 338. https://doi.org/10.3892/ol.2025.15084
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