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Case Report Open Access

Cerebral metastasis from anal squamous cell carcinoma: A case report and literature review

  • Authors:
    • Elena Andreea Popa
    • Vanesa Marisa Tomatis
    • Esther Quick
    • Paul Stephen Mitchell
    • Chrisovalantis Tsimiklis
    • Annika Reann Mascarenhas
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Flinders Medical Centre, Adelaide, South Australia 5042, Australia, Department of Molecular Pathology, SA Pathology, Adelaide, South Australia 5042, Australia
    Copyright: © Popa et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Article Number: 340
    |
    Published online on: May 13, 2025
       https://doi.org/10.3892/ol.2025.15086
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Abstract

Anal cancer comprises only 3% of all gastrointestinal malignancies, of which only a small proportion of patients will experience distant metastasis; very few of these cases will metastasise to the brain. The present case report details the clinical course of a 56‑year‑old female patient who was previously diagnosed with anal squamous cell carcinoma (SCC) and subsequently developed an isolated cerebral metastasis ~5 years later. The patient was initially diagnosed with anal SCC after presenting with a non‑tender lump in the groin and had no other signs or symptoms. After undergoing a lumpectomy in 2017, the patient was lost to follow‑up. In 2022, the patient presented with a perforated rectal tumour and consequently underwent a loop colostomy followed by chemoradiotherapy. The patient was considered to be in remission at the end of 2023 until subsequent presentation months later with vague neurological symptoms, which led to the diagnosis of a large metastatic lesion in the right temporal lobe. Following resection via craniotomy and additional radiation therapy, there was no evidence to suggest recurrence of either the anal primary tumour or cerebral metastasis from follow‑up imaging 5 months post‑operatively. The present report highlights the potentially aggressive nature of anal SCC, late‑onset cerebral metastasis and the need for further investigation into standardising treatment protocols and surveillance strategies for gastrointestinal metastatic disease.
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1 

Young AN, Jacob E, Willauer P, Smucker L, Monzon R and Oceguera L: Anal Cancer. Surg Clin North Am. 100:629–634. 2020. View Article : Google Scholar : PubMed/NCBI

2 

Babiker HM, Kashyap S, Mehta SR, Lekkala MR and Cagir B: Anal Cancer. 2024. View Article : Google Scholar

3 

Morton M, Melnitchouk N and Bleday R: Squamous cell carcinoma of the anal canal. Curr Probl Cancer. 42:486–492. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Gnanajothy R, Warren GW, Okun S and Peterson LL: A combined modality therapeutic approach to metastatic anal squamous cell carcinoma with systemic chemotherapy and local therapy to sites of disease: Case report and review of literature. J Gastrointest Oncol. 7:E58–E63. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Sawai K, Goi T, Tagai N, Kurebayashi H, Morikawa M, Koneri K, Tamaki M, Murakami M, Hirono Y and Maeda H: Stage IV anal canal squamous cell carcinoma with Long-term survival: A case report. Surg Case Rep. 8:1192022. View Article : Google Scholar : PubMed/NCBI

6 

Malla M, Hatoum H and George S: Brain metastases in anal squamous cell carcinoma: Case report and review of the literature. J Clin Images Med Case Rep. 32022.PubMed/NCBI

7 

Ogawa S, Fujishiro H, Fujiwara A, Tsukano K, Kotani S, Yamanouchi S, Kusunoki R, Aimi M, Miyaoka Y, Kohge N and Onuma H: A case of Long-term survival in stage IV squamous cell carcinoma of the anal canal with multidisciplinary treatment. Nihon Shokakibyo Gakkai Zasshi. 114:1987–1995, (In Japanese). PubMed/NCBI

8 

Chihabeddine M, Naim A, Habi J, Kassimi M, Mahi M and Kouhen F: Anal cancer with atypical brain and cranial bones metastasis: About 2 cases and literature review. Case Rep Oncol. 14:778–783. 2021. View Article : Google Scholar : PubMed/NCBI

9 

Gassman AA, Fernando E, Holmes CJ, Kapur U and Eberhardt JM: Development of cerebral metastasis after medical and surgical treatment of anal squamous cell carcinoma. Case Rep Oncol Med. 2012:9121782012.PubMed/NCBI

10 

Rughani AI, Lin C, Tranmer BI and Wilson JT: Anal cancer with cerebral metastasis: A case report. J Neurooncol. 101:141–143. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Davidson NG and Yong PP: Brain metastasis from basaloid carcinoma of the anal canal 8 years after abdominoperineal resection. Eur J Surg Oncol. 17:227–230. 1991.PubMed/NCBI

12 

Klotz RG, Pamukcoglu T and Souilliard DH: Transitional cloacogenic carcinoma of the anal canal. Clinicopathologic study of three hundred Seventy-three cases. Cancer. 20:1727–1745. 1967. View Article : Google Scholar : PubMed/NCBI

13 

Hernando-Cubero J, Alonso-Orduña V, Hernandez-Garcia A, De Miguel AC, Alvarez-Garcia N and Anton-Torres A: Brain metastasis in basaloid undifferentiated anal carcinoma: A case report. Oncol Lett. 7:1276–1278. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Mai S, Welzel G, Ottstadt M, Lohr F, Severa S, Prigge ES, Wentzensen N, Trunk MJ, Wenz F, von Knebel-Doeberitz M and Reuschenbach M: Prognostic relevance of HPV infection and p16 overexpression in squamous cell anal cancer. Int J Radiat Oncol Biol Phys. 93:819–827. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Rami S, Han YD, Jang M, Cho MS, Hur H, Min BS, Lee KY and Kim NK: Efficacy of Immunohistochemical staining in differentiating a squamous cell carcinoma in poorly differentiated rectal cancer: Two case reports. Ann Coloproctol. 32:1502016. View Article : Google Scholar : PubMed/NCBI

16 

van der Zee RP, Richel O, de Vries HJC and Prins JM: The increasing incidence of anal cancer: Can it be explained by trends in risk groups? Neth J Med. 71:401–411. 2013.PubMed/NCBI

17 

Sclafani F, Hesselberg G, Thompson SR, Truskett P, Haghighi K, Rao S and Goldstein D: Multimodality treatment of oligometastatic anal squamous cell carcinoma: A case series and literature review. J Surg Oncol. 119:489–496. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Gondal TA, Chaudhary N, Bajwa H, Rauf A, Le D and Ahmed S: Anal cancer: The past, present and future. Current Oncol. 30:3232–3250. 2023. View Article : Google Scholar : PubMed/NCBI

19 

Meulendijks D, Tomasoa NB, Dewit L, Smits PHM, Bakker R, van Velthuysen MLF, Rosenberg EH, Beijnen JH, Schellens JH and Cats A: HPV-negative squamous cell carcinoma of the anal canal is unresponsive to standard treatment and frequently carries disruptive mutations in TP53. Br J Cancer. 112:1358–1366. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Rayess H, Wang MB and Srivatsan ES: Cellular senescence and tumor suppressor gene p16. Int J Cancer. 130:1715–1725. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Izadi-Mood N, Asadi K, Shojaei H, Sarmadi S, Ahmadi SA, Sani S and Chelavi LH: Potential diagnostic value of P16 expression in premalignant and malignant cervical lesions. J Res Med Sci. 17:428–433. 2012.PubMed/NCBI

22 

Mai S, Welzel G, Ottstadt M, Lohr F, Severa S, Prigge ES, Wentzensen N, Trunk MJ, Wenz F, von Knebel-Doeberitz M and Reuschenbach M: Prognostic relevance of HPV infection and p16 overexpression in squamous cell anal cancer. Int J Radiat Oncol Biol Phys. 93:819–827. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Yoon G, Koh CW, Yoon N, Kim JY and Kim HS: Stromal p16 expression is significantly increased in endometrial carcinoma. Oncotarget. 8:4826–4836. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Kettunen E, Savukoski S, Salmenkivi K, Böhling T, Vanhala E, Kuosma E, Anttila S and Wolff H: CDKN2A copy number and p16 expression in malignant pleural mesothelioma in relation to asbestos exposure. BMC Cancer. 19:5072019. View Article : Google Scholar : PubMed/NCBI

25 

Sun G, Dong X, Tang X, Qu H, Zhang H and Zhao E: The prognostic value of HPV combined p16 status in patients with anal squamous cell carcinoma: A meta-analysis. Oncotarget. 9:8081–8088. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Stewart DB, Gaertner WB, Glasgow SC, Herzig DO, Feingold D and Steele SR: The American society of colon and rectal surgeons clinical practice guidelines for anal squamous cell cancers (revised 2018). Dis Colon Rectum. 61:755–774. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Adams R: Surveillance of anal canal cancers. Surg Oncol Clin N Am. 26:127–132. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Glynne-Jones R, Sebag-Montefiore D, Meadows HM, Cunningham D, Begum R, Adab F, Benstead K, Harte RJ, Stewart J, Beare S, et al: Best time to assess complete clinical response after chemoradiotherapy in squamous cell carcinoma of the anus (ACT II): A post-hoc analysis of randomised controlled phase 3 trial. Lancet Oncol. 18:347–356. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Wang Y, Zhong X, He X, Hu Z, Huang H, Chen J, Chen K, Zhao S, Wei P and Li D: Liver metastasis from colorectal cancer: Pathogenetic development, immune landscape of the tumour microenvironment and therapeutic approaches. J Exp Clin Cancer Res. 42:1772023. View Article : Google Scholar : PubMed/NCBI

30 

Riihimäki M, Hemminki A, Sundquist J and Hemminki K: Patterns of metastasis in colon and rectal cancer. Sci Rep. 6:297652016. View Article : Google Scholar : PubMed/NCBI

31 

Tashima T: Brain cancer chemotherapy through a delivery system across the Blood-brain barrier into the brain based on Receptor-mediated transcytosis using monoclonal antibody conjugates. Biomedicines. 10:15972022. View Article : Google Scholar : PubMed/NCBI

32 

Zhu W: Temozolomide for treatment of brain metastases: A review of 21 clinical trials. World J Clin Oncol. 5:192013. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Popa EA, Tomatis VM, Quick E, Mitchell PS, Tsimiklis C and Mascarenhas AR: Cerebral metastasis from anal squamous cell carcinoma: A case report and literature review. Oncol Lett 30: 340, 2025.
APA
Popa, E.A., Tomatis, V.M., Quick, E., Mitchell, P.S., Tsimiklis, C., & Mascarenhas, A.R. (2025). Cerebral metastasis from anal squamous cell carcinoma: A case report and literature review. Oncology Letters, 30, 340. https://doi.org/10.3892/ol.2025.15086
MLA
Popa, E. A., Tomatis, V. M., Quick, E., Mitchell, P. S., Tsimiklis, C., Mascarenhas, A. R."Cerebral metastasis from anal squamous cell carcinoma: A case report and literature review". Oncology Letters 30.1 (2025): 340.
Chicago
Popa, E. A., Tomatis, V. M., Quick, E., Mitchell, P. S., Tsimiklis, C., Mascarenhas, A. R."Cerebral metastasis from anal squamous cell carcinoma: A case report and literature review". Oncology Letters 30, no. 1 (2025): 340. https://doi.org/10.3892/ol.2025.15086
Copy and paste a formatted citation
x
Spandidos Publications style
Popa EA, Tomatis VM, Quick E, Mitchell PS, Tsimiklis C and Mascarenhas AR: Cerebral metastasis from anal squamous cell carcinoma: A case report and literature review. Oncol Lett 30: 340, 2025.
APA
Popa, E.A., Tomatis, V.M., Quick, E., Mitchell, P.S., Tsimiklis, C., & Mascarenhas, A.R. (2025). Cerebral metastasis from anal squamous cell carcinoma: A case report and literature review. Oncology Letters, 30, 340. https://doi.org/10.3892/ol.2025.15086
MLA
Popa, E. A., Tomatis, V. M., Quick, E., Mitchell, P. S., Tsimiklis, C., Mascarenhas, A. R."Cerebral metastasis from anal squamous cell carcinoma: A case report and literature review". Oncology Letters 30.1 (2025): 340.
Chicago
Popa, E. A., Tomatis, V. M., Quick, E., Mitchell, P. S., Tsimiklis, C., Mascarenhas, A. R."Cerebral metastasis from anal squamous cell carcinoma: A case report and literature review". Oncology Letters 30, no. 1 (2025): 340. https://doi.org/10.3892/ol.2025.15086
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