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Long‑term follow‑up outcomes of intraoperative radiotherapy for breast‑conserving treatment in early breast cancer: A retrospective cohort study

  • Authors:
    • Xiaofan Xu
    • Lu Wang
    • Yuanyuan Cao
    • Jingyi Wang
    • Jie Yao
    • Liqun Huo
    • Yuqing Song
    • Wei Ding
    • Jun Gu
    • Qiurong Li
  • View Affiliations / Copyright

    Affiliations: Research Institute of General Surgery, Jinling Hospital, Nanjing Medical University, Nanjing, Jiangsu 210002, P.R. China, Research Institute of General Surgery, Jinling Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210002, P.R. China, Medical Service Training Center, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu 210002, P.R. China, Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, P.R. China, Research Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu 210002, P.R. China, Department of Radiation Oncology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu 210002, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 346
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    Published online on: May 15, 2025
       https://doi.org/10.3892/ol.2025.15092
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Abstract

Intraoperative radiotherapy (IORT) has been used as a novel therapeutic alternative for breast‑conserving surgery (BCS) in patients with breast cancer. However, the long‑term outcomes and safety of IORT in patients with breast cancer remain incompletely understood. Therefore, the present study aimed to explore the long‑term outcomes of IORT following BCS, focusing on the oncological outcomes and cosmetic consequences compared with postoperative RT (PORT) in patients with breast cancer. Patients with early‑stage breast cancer who underwent BCS followed by IORT or PORT between January 2016 and October 2020 at the Research Institute of General Surgery, Jinling Hospital, Nanjing Medical University (Nanjing, China), were retrospectively reviewed. After screening, a total of 59 patients were included in the present study and divided into two groups according RT records as follows: The IORT group (n=21) and the PORT group (n=38). The clinical data of all patients, including surgical and RT complications, cosmetic grading and scoring, and other events, were collected and retrospectively analyzed. No significant difference was observed in terms of the mean follow‑up time in the IORT (5.89±1.57 years) and PORT (6.09±1.60 years) groups (P>0.05). Compared with PORT, IORT showed non‑inferior therapeutic efficacy, with no significant differences in postoperative complications (surgical site infection and chronic pain; P>0.05). Notably, the IORT group achieved superior cosmetic outcomes, with 95.2% (20/21) of patients achieving a rating of excellent/good vs. 44.7% (17/38 patients) in the PORT group (P<0.001), alongside higher median cosmetic scores at all postoperative intervals (P<0.01). IORT also reduced healthcare utilization, shortening hospitalization by 23.8 days (12.1±5.1 vs. 35.9±3.5 days; P<0.001) and lowering costs significantly (33,117.98±6,281.17 vs. 77,789.55±7,000.90 CNY; P<0.001). These findings suggest that IORT offers comparable safety, improved cosmesis and greater cost‑effectiveness than PORT, supporting its integration into clinical practice for eligible patients.
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Copy and paste a formatted citation
Spandidos Publications style
Xu X, Wang L, Cao Y, Wang J, Yao J, Huo L, Song Y, Ding W, Gu J, Li Q, Li Q, et al: Long‑term follow‑up outcomes of intraoperative radiotherapy for breast‑conserving treatment in early breast cancer: A retrospective cohort study. Oncol Lett 30: 346, 2025.
APA
Xu, X., Wang, L., Cao, Y., Wang, J., Yao, J., Huo, L. ... Li, Q. (2025). Long‑term follow‑up outcomes of intraoperative radiotherapy for breast‑conserving treatment in early breast cancer: A retrospective cohort study. Oncology Letters, 30, 346. https://doi.org/10.3892/ol.2025.15092
MLA
Xu, X., Wang, L., Cao, Y., Wang, J., Yao, J., Huo, L., Song, Y., Ding, W., Gu, J., Li, Q."Long‑term follow‑up outcomes of intraoperative radiotherapy for breast‑conserving treatment in early breast cancer: A retrospective cohort study". Oncology Letters 30.1 (2025): 346.
Chicago
Xu, X., Wang, L., Cao, Y., Wang, J., Yao, J., Huo, L., Song, Y., Ding, W., Gu, J., Li, Q."Long‑term follow‑up outcomes of intraoperative radiotherapy for breast‑conserving treatment in early breast cancer: A retrospective cohort study". Oncology Letters 30, no. 1 (2025): 346. https://doi.org/10.3892/ol.2025.15092
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Spandidos Publications style
Xu X, Wang L, Cao Y, Wang J, Yao J, Huo L, Song Y, Ding W, Gu J, Li Q, Li Q, et al: Long‑term follow‑up outcomes of intraoperative radiotherapy for breast‑conserving treatment in early breast cancer: A retrospective cohort study. Oncol Lett 30: 346, 2025.
APA
Xu, X., Wang, L., Cao, Y., Wang, J., Yao, J., Huo, L. ... Li, Q. (2025). Long‑term follow‑up outcomes of intraoperative radiotherapy for breast‑conserving treatment in early breast cancer: A retrospective cohort study. Oncology Letters, 30, 346. https://doi.org/10.3892/ol.2025.15092
MLA
Xu, X., Wang, L., Cao, Y., Wang, J., Yao, J., Huo, L., Song, Y., Ding, W., Gu, J., Li, Q."Long‑term follow‑up outcomes of intraoperative radiotherapy for breast‑conserving treatment in early breast cancer: A retrospective cohort study". Oncology Letters 30.1 (2025): 346.
Chicago
Xu, X., Wang, L., Cao, Y., Wang, J., Yao, J., Huo, L., Song, Y., Ding, W., Gu, J., Li, Q."Long‑term follow‑up outcomes of intraoperative radiotherapy for breast‑conserving treatment in early breast cancer: A retrospective cohort study". Oncology Letters 30, no. 1 (2025): 346. https://doi.org/10.3892/ol.2025.15092
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