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Comprehensive analysis of a palmitoylation‑related prognostic signature in colorectal cancer: Implications for immune therapy and personalized treatment

  • Authors:
    • Xiaokang Wang
    • Jian Li
    • Zi Wang
    • Qingyun Wu
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Xianning Central Hospital, The First Affiliated Hospital of Hubei Institute of Science and Technology, Xianning, Hubei 437000, P.R. China, Department of Gastroenterology, Xianning Central Hospital, The First Affiliated Hospital of Hubei Institute of Science and Technology, Xianning, Hubei 437000, P.R. China, College of Medicine, Hubei Three Gorges Polytechnic, Yichang, Hubei 443000, P.R. China, Department of Gastrointestinal Surgery, Xianning Central Hospital, The First Affiliated Hospital of Hubei Institute of Science and Technology, Xianning, Hubei 437000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 350
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    Published online on: May 16, 2025
       https://doi.org/10.3892/ol.2025.15096
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Abstract

Colorectal cancer (CRC) remains one of the leading causes of cancer‑associated mortality worldwide. While immune checkpoint inhibitors have shown promise in treatment, there is a need for reliable biomarkers to predict patient prognosis and guide personalized therapies. Palmitoylation, a post‑translational modification, has been implicated in various cancer processes, yet its role in CRC prognosis remains unclear. Transcriptome, survival, somatic mutation and copy number variation data were retrieved from The Cancer Genome Atlas, and the GSE17538 dataset was used for external validation. A palmitoylation‑related risk signature was developed using univariate Cox regression, Least Absolute Shrinkage and Selection Operator and multivariate Cox regression analyses. Patients were stratified into high‑ and low‑risk groups based on the median risk score. Prognostic accuracy was assessed using receiver operating characteristic curves and Kaplan‑Meier overall survival (OS) analysis with validation in an independent cohort. Functional enrichment, immune cell infiltration and drug sensitivity analyses were performed to explore underlying mechanisms and therapeutic implications. Subsequently, keratin 8 pseudogene 12 (KRT8P12) overexpression was evaluated in HT29 cells, and knockdown HT29 cell lines were generated using lentivirus. Cell proliferation was assessed using Cell Counting Kit‑8 and 5‑ethynyl‑2'‑deoxyuridine assays, cell migration was evaluated by Transwell assay and cell apoptosis was assessed using Annexin‑V/propidium iodide staining. A palmitoylation‑related risk signature consisting of six genes (KRT8P12, ZDHHC3, PCOLCE2, MPP2, LARS2 and MMAA) was identified. High‑risk patients exhibited significantly worse OS (HR=3.19; P<0.001) compared with low‑risk patients. Immune cell infiltration analysis revealed enhanced immune activity in the low‑risk group, which was associated with higher expression of immune checkpoint genes. Immunotherapy prediction models indicated that low‑risk patients might benefit more from immune checkpoint inhibitors. Drug sensitivity analysis identified distinct drug response profiles between the high‑ and low‑risk groups. Furthermore, in vitro, KRT8P12 promoted tumor cell proliferation and migration while inhibiting apoptosis. In conclusion, the present study confirmed the role of KRT8P12 as a palmitoylation‑related gene in regulating CRC. In addition, the palmitoylation‑associated risk signature may offer a promising tool for prognostic prediction in CRC and could guide personalized treatment strategies, including immune checkpoint inhibitors and targeted therapies. 
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View References

1 

Siegel RL, Giaquinto AN and Jemal A: Cancer statistics, 2024. CA Cancer J Clin. 74:12–49. 2024. View Article : Google Scholar : PubMed/NCBI

2 

Benson AB III, Venook AP, Cederquist L, Chan E, Chen YJ, Cooper HS, Deming D, Engstrom PF, Enzinger PC, Fichera A, et al: Colon cancer, version 1.2017, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 15:370–398. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Saltz L: Systemic therapy for metastatic colorectal cancer. J Natl Compr Canc Netw. 11 (Suppl 5):S649–S652. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Zhang D, Zhao K, Han T, Zhang X, Xu X, Liu Z, Ren X, Zhang X, Lu Z and Qin C: Bisphenol A promote the cell proliferation and invasion ability of prostate cancer cells via regulating the androgen receptor. Ecotoxicol Environ Saf. 269:1158182024. View Article : Google Scholar : PubMed/NCBI

5 

Marks KM, West NP, Morris E and Quirke P: Clinicopathological, genomic and immunological factors in colorectal cancer prognosis. Br J Surg. 105:e99–e109. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Anaya YA, Bracho RP, Chauhan SC, Tripathi MK and Bandyopadhyay D: Small Molecule B-RAF inhibitors as anti-cancer therapeutics: Advances in discovery, development, and mechanistic insights. Int J Mol Sci. 26:26762025. View Article : Google Scholar : PubMed/NCBI

7 

Linder ME and Deschenes RJ: Palmitoylation: Policing protein stability and traffic. Nat Rev Mol Cell Biol. 8:74–84. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Salaun C, Greaves J and Chamberlain LH: The intracellular dynamic of protein palmitoylation. J Cell Biol. 191:1229–1238. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Tape CJ, Ling S, Dimitriadi M, McMahon KM, Worboys JD, Leong HS, Norrie IC, Miller CJ, Poulogiannis G, Lauffenburger DA and Jørgensen C: Oncogenic KRAS regulates tumor cell signaling via stromal reciprocation. Cell. 165:18182016. View Article : Google Scholar : PubMed/NCBI

10 

Bivona TG: Dampening oncogenic RAS signaling. Science. 363:1280–1281. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Galluzzo P, Caiazza F, Moreno S and Marino M: Role of ERbeta palmitoylation in the inhibition of human colon cancer cell proliferation. Endocr Relat Cancer. 14:153–167. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Caiazza F, Galluzzo P, Lorenzetti S and Marino M: 17Beta-estradiol induces ERbeta up-regulation via p38/MAPK activation in colon cancer cells. Biochem Biophys Res Commun. 359:102–107. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Schwab RHM, Amin N, Flanagan DJ, Johanson TM, Phesse TJ and Vincan E: Wnt is necessary for mesenchymal to epithelial transition in colorectal cancer cells. Dev Dyn. 247:521–530. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Klaus C, Schneider U, Hedberg C, Schütz AK, Bernhagen J, Waldmann H, Gassler N and Kaemmerer E: Modulating effects of acyl-CoA synthetase 5-derived mitochondrial Wnt2B palmitoylation on intestinal Wnt activity. World J Gastroenterol. 20:14855–14864. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Dubois F, Leroy C, Simon V, Benistant C and Roche S: YES oncogenic activity is specified by its SH4 domain and regulates RAS/MAPK signaling in colon carcinoma cells. Am J Cancer Res. 5:1972–1987. 2015.PubMed/NCBI

16 

Draper JM and Smith CD: DHHC20: A human palmitoyl acyltransferase that causes cellular transformation. Mol Membr Biol. 27:123–136. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Rossin A, Durivault J, Chakhtoura-Feghali T, Lounnas N, Gagnoux-Palacios L and Hueber AO: Fas palmitoylation by the palmitoyl acyltransferase DHHC7 regulates Fas stability. Cell Death Differ. 22:643–653. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Kristensen VN, Lingjærde OC, Russnes HG, Vollan HK, Frigessi A and Børresen-Dale AL: Principles and methods of integrative genomic analyses in cancer. Nat Rev Cancer. 14:299–313. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Rich JT, Neely JG, Paniello RC, Voelker CC, Nussenbaum B and Wang EW: A practical guide to understanding Kaplan-Meier curves. Otolaryngol Head Neck Surg. 143:331–336. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Yu G, Wang LG, Han Y and He QY: clusterProfiler: An R package for comparing biological themes among gene clusters. OMICS. 16:284–387. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Mayakonda A, Lin DC, Assenov Y, Plass C and Koeffler HP: Maftools: Efficient and comprehensive analysis of somatic variants in cancer. Genome Res. 28:1747–1756. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Chalmers ZR, Connelly CF, Fabrizio D, Gay L, Ali SM, Ennis R, Schrock A, Campbell B, Shlien A, Chmielecki J, et al: Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden. Genome Med. 9:342017. View Article : Google Scholar : PubMed/NCBI

23 

Mermel CH, Schumacher SE, Hill B, Meyerson ML, Beroukhim R and Getz G: GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers. Genome Biol. 12:R412011. View Article : Google Scholar : PubMed/NCBI

24 

Powers RK, Goodspeed A, Pielke-Lombardo H, Tan AC and Costello JC: GSEA-InContext: Identifying novel and common patterns in expression experiments. Bioinformatics. 34:i555–i564. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Newman AM, Steen CB, Liu CL, Gentles AJ, Chaudhuri AA, Scherer F, Khodadoust MS, Esfahani MS, Luca BA, Steiner D, et al: Determining cell type abundance and expression from bulk tissues with digital cytometry. Nat Biotechnol. 37:773–782. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Jiang P, Gu S, Pan D, Fu J, Sahu A, Hu X, Li Z, Traugh N, Bu X, Li B, et al: Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response. Nat Med. 24:1550–1558. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Jiang P, Gu S, Pan D, Fu J, Sahu A, Hu X, Li Z, Traugh N, Bu X, Li B, et al: Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response. Nat Med. 24:1550–1558. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Hoshida Y, Brunet JP, Tamayo P, Golub TR and Mesirov JP: Subclass mapping: Identifying common subtypes in independent disease data sets. PLoS One. 2:e11952007. View Article : Google Scholar : PubMed/NCBI

29 

Geeleher P, Cox N and Huang RS: pRRophetic: An R package for prediction of clinical chemotherapeutic response from tumor gene expression levels. PLoS One. 9:e1074682014. View Article : Google Scholar : PubMed/NCBI

30 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Sebastian J and Rathinasamy K: Microtubules and cell division: Potential pharmacological targets in cancer therapy. Curr Drug Targets. 24:889–918. 2023. View Article : Google Scholar : PubMed/NCBI

32 

Chen L, Chen WD, Xu YX, Ren YY, Zheng C, Lin YY and Zhou JL: Strategies for enhancing non-small cell lung cancer treatment: Integrating Chinese herbal medicines with epidermal growth factor receptor-tyrosine kinase inhibitors therapy. Eur J Pharmacol. 980:1768712024. View Article : Google Scholar : PubMed/NCBI

33 

Lin JC, Oludare A and Jung H: Connecting dots between nucleotide biosynthesis and DNA lesion repair/bypass in cancer. Biosci Rep. 44:BSR202313822024. View Article : Google Scholar : PubMed/NCBI

34 

Jordheim LP: Clinical use of biomarkers in the field of cytotoxic nucleoside analogues. Nucleosides Nucleotides Nucleic Acids. 43:822–830. 2024. View Article : Google Scholar : PubMed/NCBI

35 

Conn E, Hour S, Allegakoen D, Graham G, Petro J, Kouassi-Brou M, Hong SH, Selvanathan S, Çelik H, Toretsky J and Üren A: Development of an Ewing sarcoma cell line with resistance to EWS-FLI1 inhibitor YK-4-279. Mol Med Rep. 21:1667–1675. 2020.PubMed/NCBI

36 

Banyal A, Tiwari S, Sharma A, Chanana I, Patel SKS, Kulshrestha S and Kumar P: Vinca alkaloids as a potential cancer therapeutics: Recent update and future challenges. 3 Biotech. 13:2112023. View Article : Google Scholar : PubMed/NCBI

37 

Sun K, Sun Z, Zhao F, Shan G and Meng Q: Recent advances in research of colchicine binding site inhibitors and their interaction modes with tubulin. Future Med Chem. 13:839–858. 2021. View Article : Google Scholar : PubMed/NCBI

38 

Sun J, Yuan H, Sun L, Zhao L, Wang Y, Hou C, Zhang H, Lv P, Yang G, Zhang N, et al: Tumor-intrinsic PRMT5 upregulates FGL1 via methylating TCF12 to inhibit CD8+ T-cell-mediated antitumor immunity in liver cancer. Acta Pharm Sin B. 15:188–204. 2025. View Article : Google Scholar : PubMed/NCBI

39 

Eng C, Yoshino T, Ruíz-García E, Mostafa N, Cann CG, O'Brian B, Benny A, Perez RO and Cremolini C: Colorectal cancer. Lancet. 404:294–310. 2024. View Article : Google Scholar : PubMed/NCBI

40 

Liu Z, Xiao M, Mo Y, Wang H, Han Y, Zhao X, Yang X, Liu Z and Xu B: Emerging roles of protein palmitoylation and its modifying enzymes in cancer cell signal transduction and cancer therapy. Int J Biol Sci. 18:3447–3457. 2022. View Article : Google Scholar : PubMed/NCBI

41 

Zhu J, Cao X, Chen Z, Lai B, Xi L, Zhang J, Zhu S, Qi S, Liang Y, Cao F, et al: Inhibiting S-palmitoylation arrests metastasis by relocating Rap2b from plasma membrane in colorectal cancer. Cell Death Dis. 15:6752024. View Article : Google Scholar : PubMed/NCBI

42 

Kong Y, Liu Y, Li X, Rao M, Li D, Ruan X, Li S, Jiang Z and Zhang Q: Palmitoylation landscapes across human cancers reveal a role of palmitoylation in tumorigenesis. J Transl Med. 21:8262023. View Article : Google Scholar : PubMed/NCBI

43 

Tsai MY, Lu CK, Shu LH, Liu HT, Wu YH, Lin YS, Yang YH, Shih WT, Lee IY, Wu YH and Wu CY: Antrodia cinnamomea formula suppresses prostate cancer progression via immune modulation and PD-1/PD-L1 pathway inhibition. Int J Mol Sci. 26:26842025. View Article : Google Scholar : PubMed/NCBI

44 

Lee TA, Tsai EY, Liu SH, Hsu Hung SD, Chang SJ, Chao CH, Lai YJ, Yamaguchi H and Li CW: Post-translational modification of PD-1: Potential targets for cancer immunotherapy. Cancer Res. 84:800–807. 2024. View Article : Google Scholar : PubMed/NCBI

45 

Yao H, Lan J, Li C, Shi H, Brosseau JP, Wang H, Lu H, Fang C, Zhang Y, Liang L, et al: Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours. Nat Biomed Eng. 3:306–317. 2019. View Article : Google Scholar : PubMed/NCBI

46 

Wang Q, Wang J, Yu D, Zhang Q, Hu H, Xu M, Zhang H, Tian S, Zheng G, Lu D, et al: Benzosceptrin C induces lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting DHHC3. Cell Rep Med. 5:1013572024. View Article : Google Scholar : PubMed/NCBI

47 

Wang W, He J, Lu H, Kong Q and Lin S: KRT8 and KRT19, associated with EMT, are hypomethylated and overexpressed in lung adenocarcinoma and link to unfavorable prognosis. Biosci Rep. 40:BSR201934682020. View Article : Google Scholar : PubMed/NCBI

48 

Zhang X, Hou J, Zhou G, Wang H and Wu Z: zDHHC3-mediated S-palmitoylation of SLC9A2 regulates apoptosis in kidney clear cell carcinoma. J Cancer Res Clin Oncol. 150:1942024. View Article : Google Scholar : PubMed/NCBI

49 

Yin Y, Yang X, Cheng Z, Wang H, Lei J, Wang D, Wang P, Li B, Mi J and Yuan Q: Identification of extracellular matrix-related biomarkers in colon adenocarcinoma by bioinformatics and experimental validation. Front Immunol. 15:13715842024. View Article : Google Scholar : PubMed/NCBI

50 

Tang L, Yu S, Zhang Q, Cai Y, Li W, Yao S and Cheng H: Identification of hub genes related to CD4(+) memory T cell infiltration with gene co-expression network predicts prognosis and immunotherapy effect in colon adenocarcinoma. Front Genet. 13:9152822022. View Article : Google Scholar : PubMed/NCBI

51 

Luo SY, Sit KY, Sihoe AD, Suen WS, Au WK, Tang X, Ma ES, Chan WK, Wistuba II, Minna JD, et al: Aberrant large tumor suppressor 2 (LATS2) gene expression correlates with EGFR mutation and survival in lung adenocarcinomas. Lung Cancer. 85:282–292. 2014. View Article : Google Scholar : PubMed/NCBI

52 

Karantza V: Keratins in health and cancer: More than mere epithelial cell markers. Oncogene. 30:127–138. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Li J, Wang Z and Wu Q: Comprehensive analysis of a palmitoylation‑related prognostic signature in colorectal cancer: Implications for immune therapy and personalized treatment. Oncol Lett 30: 350, 2025.
APA
Wang, X., Li, J., Wang, Z., & Wu, Q. (2025). Comprehensive analysis of a palmitoylation‑related prognostic signature in colorectal cancer: Implications for immune therapy and personalized treatment. Oncology Letters, 30, 350. https://doi.org/10.3892/ol.2025.15096
MLA
Wang, X., Li, J., Wang, Z., Wu, Q."Comprehensive analysis of a palmitoylation‑related prognostic signature in colorectal cancer: Implications for immune therapy and personalized treatment". Oncology Letters 30.1 (2025): 350.
Chicago
Wang, X., Li, J., Wang, Z., Wu, Q."Comprehensive analysis of a palmitoylation‑related prognostic signature in colorectal cancer: Implications for immune therapy and personalized treatment". Oncology Letters 30, no. 1 (2025): 350. https://doi.org/10.3892/ol.2025.15096
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Li J, Wang Z and Wu Q: Comprehensive analysis of a palmitoylation‑related prognostic signature in colorectal cancer: Implications for immune therapy and personalized treatment. Oncol Lett 30: 350, 2025.
APA
Wang, X., Li, J., Wang, Z., & Wu, Q. (2025). Comprehensive analysis of a palmitoylation‑related prognostic signature in colorectal cancer: Implications for immune therapy and personalized treatment. Oncology Letters, 30, 350. https://doi.org/10.3892/ol.2025.15096
MLA
Wang, X., Li, J., Wang, Z., Wu, Q."Comprehensive analysis of a palmitoylation‑related prognostic signature in colorectal cancer: Implications for immune therapy and personalized treatment". Oncology Letters 30.1 (2025): 350.
Chicago
Wang, X., Li, J., Wang, Z., Wu, Q."Comprehensive analysis of a palmitoylation‑related prognostic signature in colorectal cancer: Implications for immune therapy and personalized treatment". Oncology Letters 30, no. 1 (2025): 350. https://doi.org/10.3892/ol.2025.15096
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