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Case Report

Malignant mesothelioma with a novel BAP1 germline frameshift mutation treated with dual immune checkpoint inhibitors: A case report

  • Authors:
    • Na Zhou
    • Mingying Wu
    • Chenyu Wang
    • Mingming Yuan
    • Yuejuan Cheng
    • Huanwen Wu
    • Xin Gao
    • Shuangni Yu
    • Lin Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, P.R. China, Geneplus‑Beijing, Beijing 102206, P.R. China, Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, P.R. China, Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, P.R. China
  • Article Number: 358
    |
    Published online on: May 21, 2025
       https://doi.org/10.3892/ol.2025.15104
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Abstract

Germline pathogenic mutation of the BAP1 gene is a common molecular event in malignant mesothelioma (MM). A patient with a positive family history of tenacious peritoneal effusions presented with hydropneumothorax and suffered from recurrent pleural and peritoneal effusions since. Tuberculosis (TB) was assumed by preceding clinicians who prescribed futile anti‑TB regimens. Finally, a diagnostic laparoscopy and omental biopsy revealed the histology of MM. Next‑generation sequencing uncovered a novel BAP1 germline frameshift mutation (c. 1077_1083delinsTG, pPhe360fs), which was rated as pathogenic due to its potential to introduce a termination codon, resulting in nonsense‑mediated mRNA decay and due to the fact of BAP1 protein nuclear loss in tumor tissue. Dual immunotherapy with nivolumab and ipilimumab was given for 3 cycles and only achieved stable disease. Steven‑Johnson syndrome occurred afterward and was relieved after steroid treatment. The present study reported a case of MM with a new BAP1 frameshift mutation, treated by dual immune checkpoint inhibitors, achieving a modest drug effect and serious skin‑related adverse events.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou N, Wu M, Wang C, Yuan M, Cheng Y, Wu H, Gao X, Yu S and Zhao L: Malignant mesothelioma with a novel <em>BAP1</em> germline frameshift mutation treated with dual immune checkpoint inhibitors: A case report. Oncol Lett 30: 358, 2025.
APA
Zhou, N., Wu, M., Wang, C., Yuan, M., Cheng, Y., Wu, H. ... Zhao, L. (2025). Malignant mesothelioma with a novel <em>BAP1</em> germline frameshift mutation treated with dual immune checkpoint inhibitors: A case report. Oncology Letters, 30, 358. https://doi.org/10.3892/ol.2025.15104
MLA
Zhou, N., Wu, M., Wang, C., Yuan, M., Cheng, Y., Wu, H., Gao, X., Yu, S., Zhao, L."Malignant mesothelioma with a novel <em>BAP1</em> germline frameshift mutation treated with dual immune checkpoint inhibitors: A case report". Oncology Letters 30.1 (2025): 358.
Chicago
Zhou, N., Wu, M., Wang, C., Yuan, M., Cheng, Y., Wu, H., Gao, X., Yu, S., Zhao, L."Malignant mesothelioma with a novel <em>BAP1</em> germline frameshift mutation treated with dual immune checkpoint inhibitors: A case report". Oncology Letters 30, no. 1 (2025): 358. https://doi.org/10.3892/ol.2025.15104
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou N, Wu M, Wang C, Yuan M, Cheng Y, Wu H, Gao X, Yu S and Zhao L: Malignant mesothelioma with a novel <em>BAP1</em> germline frameshift mutation treated with dual immune checkpoint inhibitors: A case report. Oncol Lett 30: 358, 2025.
APA
Zhou, N., Wu, M., Wang, C., Yuan, M., Cheng, Y., Wu, H. ... Zhao, L. (2025). Malignant mesothelioma with a novel <em>BAP1</em> germline frameshift mutation treated with dual immune checkpoint inhibitors: A case report. Oncology Letters, 30, 358. https://doi.org/10.3892/ol.2025.15104
MLA
Zhou, N., Wu, M., Wang, C., Yuan, M., Cheng, Y., Wu, H., Gao, X., Yu, S., Zhao, L."Malignant mesothelioma with a novel <em>BAP1</em> germline frameshift mutation treated with dual immune checkpoint inhibitors: A case report". Oncology Letters 30.1 (2025): 358.
Chicago
Zhou, N., Wu, M., Wang, C., Yuan, M., Cheng, Y., Wu, H., Gao, X., Yu, S., Zhao, L."Malignant mesothelioma with a novel <em>BAP1</em> germline frameshift mutation treated with dual immune checkpoint inhibitors: A case report". Oncology Letters 30, no. 1 (2025): 358. https://doi.org/10.3892/ol.2025.15104
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