Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2025 Volume 30 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2025 Volume 30 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Case Report Open Access

Six‑year survival after oral temozolomide maintenance therapy in limited‑stage small cell lung cancer: A case report

  • Authors:
    • Daixi Wu
    • Yangbo Xu
    • Chao Wang
    • Tao Xu
    • Yuqi Gu
    • Xiaojia Zhang
    • Aolin Wang
    • Huijuan Cui
  • View Affiliations / Copyright

    Affiliations: China‑Japan Friendship Clinical Medical College, Beijing University of Chinese Medicine, Beijing 100029, P.R. China, Department of Oncology, Ningbo Municipal Hospital of Traditional Chinese Medicine, Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo, Zhejiang 315000, P.R. China, Department of Integrative Oncology, National Center for Respiratory Medicine/China‑Japan Friendship Hospital, Beijing 100029, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 367
    |
    Published online on: May 27, 2025
       https://doi.org/10.3892/ol.2025.15113
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Small cell lung cancer (SCLC) accounts for 13‑17% of lung cancer cases and is characterized by poor differentiation, high malignancy and a propensity for recurrence and metastasis. Limited‑stage SCLC (LS‑SCLC) typically has a better prognosis than extensive‑stage SCLC due to its localized nature. However, even with standard concurrent chemoradiotherapy, the median overall survival (OS) for LS‑SCLC is only 30 months, with a 5‑year survival rate of merely 29‑34%. The present study reported the case a patient with LS‑SCLC who received oral temozolomide (TMZ) maintenance therapy, achieving an impressive 6‑year survival without disease progression or significant side effects. Factors contributing to this outcome include the cytotoxic effects of TMZ and its potential preventive and therapeutic roles in managing brain metastases. In addition, durvalumab has been proven to prolong OS as maintenance therapy after first‑line chemoradiotherapy in patients with LS‑SCLC. In the future, maintenance therapy for SCLC should explore combination drug strategies, as integrating TMZ or poly(ADP‑ribose) polymerase inhibitors with immunotherapy may enhance patient survival.
View Figures

Figure 1

Figure 2

View References

1 

Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I and Jemal A: Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 74:229–263. 2024. View Article : Google Scholar : PubMed/NCBI

2 

Ganti AKP, Loo BW, Bassetti M, Blakely C, Chiang A, D'Amico TA, D'Avella C, Dowlati A, Downey RJ, Edelman M, et al: Small cell lung cancer, version 2.2022, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 19:1441–1464. 2021. View Article : Google Scholar : PubMed/NCBI

3 

Faivre-Finn C, Snee M, Ashcroft L, Appel W, Barlesi F, Bhatnagar A, Bezjak A, Cardenal F, Fournel P, Harden S, et al: Concurrent once-daily versus twice-daily chemoradiotherapy in patients with limited-stage small-cell lung cancer (CONVERT): An open-label, phase 3, randomised, superiority trial. Lancet Oncol. 18:1116–1125. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Cheng Y, Spigel DR, Cho BC, Laktionov KK, Fang J, Chen Y, Zenke Y, Lee KH, Wang Q, Navarro A, et al: Durvalumab after chemoradiotherapy in limited-stage small-cell lung cancer. N Engl J Med. 391:1313–1327. 2024. View Article : Google Scholar : PubMed/NCBI

5 

Musto L: Improved iron-hematoxylin stain for elastic fibers. Stain Technol. 56:185–187. 1981. View Article : Google Scholar : PubMed/NCBI

6 

Ganti AKP, Loo BW, Bassetti M, Blakely C, Chiang A, D'Amico TA, D'Avella C, Dowlati A, Downey RJ, Edelman M, et al: Small cell lung cancer, version 2.2022, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 19:1441–1464. 2021. View Article : Google Scholar : PubMed/NCBI

7 

Bozcuk H, Artac M, Ozdogan M and Savas B: Does maintenance/consolidation chemotherapy have a role in the management of small cell lung cancer (SCLC)? A metaanalysis of the published controlled trials. Cancer. 104:2650–2657. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Zhou H, Zeng C, Wei Y, Zhou J and Yao W: Duration of chemotherapy for small cell lung cancer: A meta-analysis. PLoS One. 8:e738052013. View Article : Google Scholar : PubMed/NCBI

9 

Gay CM, de Groot PM, Pietanza MC and Byers LA: Durable, exceptional response to temozolomide in a patient with extensive-stage small cell lung cancer (ES-SCLC) metastatic to brain. Cancer Treatment and Research Communications. 10:17–20. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Lukas RV, Vigneswaran J and Salgia R: Etoposide and temozolomide in combination for the treatment of progressive small-cell lung cancer central nervous system metastases: Two cases. Tumori. 99:e73–e76. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Abrey LE, Olson JD, Raizer JJ, Mack M, Rodavitch A, Boutros DY and Malkin MG: A phase II trial of temozolomide for patients with recurrent or progressive brain metastases. J Neurooncol. 53:259–265. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Trinh VA, Patel SP and Hwu WJ: The safety of temozolomide in the treatment of malignancies. Expert Opin Drug Saf. 8:493–499. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Hammond LA, Eckardt JR, Baker SD, Eckhardt SG, Dugan M, Forral K, Reidenberg P, Statkevich P, Weiss GR, Rinaldi DA, et al: Phase I and pharmacokinetic study of temozolomide on a daily-for-5-days schedule in patients with advanced solid malignancies. J Clin Oncol. 17:2604–2613. 1999. View Article : Google Scholar : PubMed/NCBI

14 

Dixit S, Baker L, Walmsley V and Hingorani M: Temozolomide-related idiosyncratic and other uncommon toxicities: A systematic review. Anticancer Drugs. 23:1099–1106. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Li X, Wu D, Tang J and Wu Y: The efficiency and safety of temozolomide and PD-1/L1 inhibitors in pretreated NSCLC with brain metastasis: A retrospective cohort. J Cancer Res Clin Oncol. 150:2712024. View Article : Google Scholar : PubMed/NCBI

16 

Owen DH, Wei L, Benner B, Pilcher C, Christenson G, Ferguson S, Jukich M, Sukrithan V, Konda B, Shah M, et al: OA12.04 efficacy of nivolumab and temozolomide in extensive stage small cell lung cancer after chemo-immunotherapy: A phase 2 trial. J Thorac Oncol. 17:S32–S33. 2022. View Article : Google Scholar

17 

Owen DH, Durm GA, Wei L, Pilcher C, Ferguson S, Benner B, Jukich M, Sukrithan V, Konda B, Savardekar H, et al: EP14.05–004 temozolomide and atezolizumab as second line treatment for extensive stage small cell lung cancer: A randomized, multi-cohort phase 2 trial. J Thorac Oncol. 17:S544–S545. 2022. View Article : Google Scholar

18 

Lok BH, Gardner EE, Schneeberger VE, Ni A, Desmeules P, Rekhtman N, de Stanchina E, Teicher BA, Riaz N, Powell SN, et al: PARP inhibitor activity correlates with SLFN11 expression and demonstrates synergy with temozolomide in small cell lung cancer. Clin Cancer Res. 23:523–535. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Pietanza MC, Waqar SN, Krug LM, Dowlati A, Hann CL, Chiappori A, Owonikoko TK, Woo KM, Cardnell RJ, Fujimoto J, et al: Randomized, double-blind, phase II study of temozolomide in combination with either veliparib or placebo in patients with relapsed-sensitive or refractory small-cell lung cancer. J Clin Oncol. 36:2386–2394. 2018. View Article : Google Scholar : PubMed/NCBI

20 

Chabanon RM, Muirhead G, Krastev DB, Adam J, Morel D, Garrido M, Lamb A, Hénon C, Dorvault N, Rouanne M, et al: PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer. J Clin Invest. 129:1211–1228. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Sen T, Rodriguez BL, Chen L, Corte CMD, Morikawa N, Fujimoto J, Cristea S, Nguyen T, Diao L, Li L, et al: Targeting DNA damage response promotes antitumor immunity through STING-mediated T-cell activation in small cell lung cancer. Cancer Discov. 9:646–661. 2019. View Article : Google Scholar : PubMed/NCBI

22 

Belgiovine C, Bello E, Liguori M, Craparotta I, Mannarino L, Paracchini L, Beltrame L, Marchini S, Galmarini CM, Mantovani A, et al: Lurbinectedin reduces tumour-associated macrophages and the inflammatory tumour microenvironment in preclinical models. Br J Cancer. 117:628–638. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wu D, Xu Y, Wang C, Xu T, Gu Y, Zhang X, Wang A and Cui H: Six‑year survival after oral temozolomide maintenance therapy in limited‑stage small cell lung cancer: A case report. Oncol Lett 30: 367, 2025.
APA
Wu, D., Xu, Y., Wang, C., Xu, T., Gu, Y., Zhang, X. ... Cui, H. (2025). Six‑year survival after oral temozolomide maintenance therapy in limited‑stage small cell lung cancer: A case report. Oncology Letters, 30, 367. https://doi.org/10.3892/ol.2025.15113
MLA
Wu, D., Xu, Y., Wang, C., Xu, T., Gu, Y., Zhang, X., Wang, A., Cui, H."Six‑year survival after oral temozolomide maintenance therapy in limited‑stage small cell lung cancer: A case report". Oncology Letters 30.1 (2025): 367.
Chicago
Wu, D., Xu, Y., Wang, C., Xu, T., Gu, Y., Zhang, X., Wang, A., Cui, H."Six‑year survival after oral temozolomide maintenance therapy in limited‑stage small cell lung cancer: A case report". Oncology Letters 30, no. 1 (2025): 367. https://doi.org/10.3892/ol.2025.15113
Copy and paste a formatted citation
x
Spandidos Publications style
Wu D, Xu Y, Wang C, Xu T, Gu Y, Zhang X, Wang A and Cui H: Six‑year survival after oral temozolomide maintenance therapy in limited‑stage small cell lung cancer: A case report. Oncol Lett 30: 367, 2025.
APA
Wu, D., Xu, Y., Wang, C., Xu, T., Gu, Y., Zhang, X. ... Cui, H. (2025). Six‑year survival after oral temozolomide maintenance therapy in limited‑stage small cell lung cancer: A case report. Oncology Letters, 30, 367. https://doi.org/10.3892/ol.2025.15113
MLA
Wu, D., Xu, Y., Wang, C., Xu, T., Gu, Y., Zhang, X., Wang, A., Cui, H."Six‑year survival after oral temozolomide maintenance therapy in limited‑stage small cell lung cancer: A case report". Oncology Letters 30.1 (2025): 367.
Chicago
Wu, D., Xu, Y., Wang, C., Xu, T., Gu, Y., Zhang, X., Wang, A., Cui, H."Six‑year survival after oral temozolomide maintenance therapy in limited‑stage small cell lung cancer: A case report". Oncology Letters 30, no. 1 (2025): 367. https://doi.org/10.3892/ol.2025.15113
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team