Gut microbiome versus thyroid cancer: Association and clinical implications (Review)
- Authors:
- Mali Wang
- Yuchun Zhu
-
Affiliations: Department of Nuclear Medicine, The First People's Hospital of Kunshan, Kunshan, Jiangsu 215300, P.R. China - Published online on: May 27, 2025 https://doi.org/10.3892/ol.2025.15114
- Article Number: 368
-
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
 |
|
Virili C, Fallahi P, Antonelli A, Benvenga S and Centanni M: Gut microbiota and Hashimoto's thyroiditis. Rev Endocr Metab Disord. 19:293–300. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Shanahan F: The gut microbiota in 2011: Translating the microbiota to medicine. Nat Rev Gastroenterol Hepatol. 9:72–74. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Walsh CJ, Guinane CM, OToole PW and Cotter PD: Beneficial modulation of the gut microbiota. FEBS Letters. 588:4120–4130. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Power SE, OToole PW, Stanton C, Ross RP and Fitzgerald GF: Intestinal microbiota, diet and health. Br J Nutr. 111:387–402. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Gao L, Wang JY, Ma SF and Li SJ: Research progress on the relationship between intestinal flora and thyroid-related diseases. J Shanxi Med Univ. 5:707–710. 2023. | |
|
Kamada N, Chen GY, Inohara N and Núñez G: Control of pathogens and pathobionts by the gut microbiota. Nat Immunol. 14:685–690. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Sears CL and Garrett WS: Microbes, microbiota, and colon cancer. Cell Host Microbe. 15:317–328. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Schwabe RF and Jobin C: The microbiome and cancer. Nat Rev Cancer. 13:800–812. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Louis P, Hold GL and Flint HJ: The gut microbiota, bacterial metabolites and colorectal cancer. Nat Rev Microbiol. 12:661–672. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Elinav E, Nowarski R, Thaiss CA, Hu B, Jin C and Flavell RA: Inflammation-induced cancer: Crosstalk between tumours, Immune cells and microorganisms. Nat Rev Cancer. 13:759–771. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Irrazábal T, Belcheva A, Girardin SE, Martin A and Philpott DJ: The multifaceted role of the intestinal microbiota in colon cancer. Mol Cell. 54:309–320. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
De Martel C, Ferlay J, Franceschi S, Vignat J, Bray F, Forman D and Plummer M: Global burden of cancers attributable to infections in 2008: A review and synthetic analysis. Lancet Oncol. 13:607–615. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Liu J, Luo M, Zhang Y, Cao G and Wang S: Association of high-risk human papillomavirus infection duration and cervical lesions with vaginal microbiota composition. Ann Transl Med. 8:11612020. View Article : Google Scholar : PubMed/NCBI | |
|
Mitra A, MacIntyre DA, Ntritsos G, Smith A, Tsilidis KK, Marchesi JR, Bennett PR, Moscicki AB and Kyrgiou M: The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions. Nat Commun. 11:19992020. View Article : Google Scholar : PubMed/NCBI | |
|
Tango CN, Seo SS, Kwon M, Lee DO, Chang HK and Kim MK: Taxonomic and functional differences in cervical microbiome associated with cervical cancer development. Sci Rep. 10:97202020. View Article : Google Scholar : PubMed/NCBI | |
|
Wu S, Rhee KJ, Albesiano E, Rabizadeh S, Wu X, Yen HR, Huso DL, Brancati FL, Wick E, McAllister F, et al: A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med. 15:1016–1022. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Housseau F and Sears CL: Enterotoxigenic Bacteroides fragilis (ETBF)-mediated colitis in Min (Apc+/-) mice: A human commensal-based murine model of colon carcinogenesis. Cell Cycle. 9:3–5. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Liu Q, Sun W and Zhang H: Interaction of gut microbiota with endocrine homeostasis and thyroid cancer. Cancers. 14:26562022. View Article : Google Scholar : PubMed/NCBI | |
|
Li JZ, Ma DS and Ma ZJ: Research progress on the correlation between intestinal flora and thyroid cancer. Chin J General Surg. 6:482–484. 2021. | |
|
Xie Z, Zhou J, Zhang X and Li Z: Clinical potential of microbiota in thyroid cancer therapy. Biochimica Et Biochim Biophys Acta Mol Basis Dis. 1870:1669712024. View Article : Google Scholar : PubMed/NCBI | |
|
Cellini M, Santaguida MG, Virili C, Capriello S, Brusca N, Gargano L and Centanni M: Hashimotos thyroiditis and autoimmune gastritis. Front Endocrinol (Lausanne). 8:922017. View Article : Google Scholar : PubMed/NCBI | |
|
Virili C and Centanni M: ‘With a little help from my friends’-The role of microbiota in thyroid hormone metabolism and enterohepatic recycling. Mol Cell Endocrinol. 458:39–43. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Jašarević E, Morrison KE and Bale TL: Sex differences in the gut microbiome-brain axis across the lifespan. Philos Trans R Soc Lond B Biol Sci. 371:201501222016. View Article : Google Scholar : PubMed/NCBI | |
|
Covelli D and Ludgate M: The thyroid, the eyes and the gut: A possible connection. J Endocrinol Invest. 40:567–576. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Ishaq HM, Mohammad IS, Guo H, Shahzad M, Hou YJ, Ma C, Naseem Z, Wu X, Shi P and Xu J: Molecular estimation of alteration in intestinal microbial composition in Hashimotos thyroiditis patients. Biomed Pharmacother. 95:865–874. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao F, Feng J, Li J, Zhao L, Liu Y, Chen H, Jin Y, Zhu B and Wei Y: Alterations of the gut microbiota in hashimotos thyroiditis patients. Thyroid. 28:175–186. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Du L, Li R, Ge M, Wang Y, Li H, Chen W and He J: Incidence and mortality of thyroid cancer in China, 2008–2012. Chin J Cancer Res. 31:144–151. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Cabanillas ME, McFadden DG and Durante C: Thyroid cancer. Lancet. 388:2783–2795. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Kitahara CM and Sosa JA: The changing incidence of thyroid cancer. Nat Rev Endocrinol. 12:646–653. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Lortet-Tieulent J, Franceschi S, Dal Maso L and Vaccarella S: Thyroid cancer ‘epidemic’ also occurs in low- and middle-income countries. Int J Cancer. 144:2082–2087. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I and Jemal A: Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 74:229–263. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Kim J, Gosnell JE and Roman SA: Geographic influences in the global rise of thyroid cancer. Nat Rev Endocrinol. 16:17–29. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Maruvada P, Leone V, Kaplan LM and Chang EB: The human microbiome and obesity: Moving beyond associations. Cell Host Microbe. 22:589–599. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Stefura T, Zapała B, Gosiewski T, Skomarovska O, Dudek A, Pędziwiatr M and Major P: Differences in compositions of oral and fecal microbiota between patients with obesity and controls. Medicina (Kaunas). 57:6782021. View Article : Google Scholar : PubMed/NCBI | |
|
Dong T, Zhao F, Yuan K, Zhu X, Wang N, Xia F, Lu Y and Huang Z: Association between serum Thyroid-stimulating hormone levels and salivary microbiome shifts. Front Cell Infect Microbiol. 11:6032912021. View Article : Google Scholar : PubMed/NCBI | |
|
Nabhan F, Dedhia PH and Ringel MD: Thyroid cancer, recent advances in diagnosis and therapy. Int J Cancer. 149:984–992. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Lee J, Yun MJ, Nam KH, Chung WY, Soh EY and Park CS: Quality of life and effectiveness comparisons of thyroxine withdrawal, triiodothyronine withdrawal, and recombinant thyroid-stimulating hormone administration for low-dose radioiodine remnant ablation of differentiated thyroid carcinoma. Thyroid. 20:173–179. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Schroeder PR, Haugen BR, Pacini F, Reiners C, Schlumberger M, Sherman SI, Cooper DS, SchuffK G, Braverman LE, Skarulis MC, et al: A comparison of short-term changes in health-related quality of life in thyroid carcinoma patients undergoing diagnostic evaluation with recombinant human thyrotropin compared with thyroid hormone withdrawal. J Clin Endocrinol Metab. 91:878–884. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Rubic M, Kuna SK, Tesic V, Samardzic T, Despot M and Huic D: The most common factors influencing on quality of life of thyroid cancer patients after thyroid hormone withdrawal. Psychiatr Danub. 26:520–527. 2014.PubMed/NCBI | |
|
Sigal GA, Tavoni TM, Silva BMO, Kalil Filho R, Brandão LG and Maranhão RC: Effects of Short-term hypothyroidism on the lipid transfer to High-density lipoprotein and other parameters related to lipoprotein metabolism in patients submitted to thyroidectomy for thyroid cancer. Thyroid. 29:53–58. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Singh R, Tandon A, Gupta SK and Saroja K: Optimal levothyroxine replacement adequately improves symptoms of hypothyroidism; residual symptoms need further evaluation for other than hypothyroidism causation. Indian J Endocrinol Metab. 21:830–835. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Lin B, Zhao F, Liu Y, Wu X, Feng J, Jin X, Yan W, Guo X, Shi S, Li Z, et al: Randomized clinical trial: Probiotics alleviated Oral-Gut microbiota dysbiosis and thyroid hormone Withdrawal-related complications in thyroid cancer patients before radioiodine therapy following thyroidectomy. Front Endocrinol (Lausanne). 13:8346742022. View Article : Google Scholar : PubMed/NCBI | |
|
Feng J, Zhao F, Sun J, Lin B, Zhao L, Liu Y, Jin Y, Li S, Li A and Wei Y: Alterations in the gut microbiota and metabolite profiles of thyroid carcinoma patients. Int J Cancer. 144:2728–2745. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Feng Q, Liang S, Jia H, Stadlmayr A, Tang L, Lan Z, Zhang D, Xia H, Xu X, Jie Z, et al: Gut microbiome development along the colorectal adenoma-carcinoma sequence. Nat Commun. 6:65282015. View Article : Google Scholar : PubMed/NCBI | |
|
Fuhrman BJ, Feigelson HS, Flores R, Gail MH, Xu X, Ravel J and Goedert JJ: Associations of the fecal microbiome with urinary estrogens and estrogen metabolites in postmenopausal women. J Clin Endocrinol Metab. 99:4632–4640. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Jeffery IB, OToole PW, Öhman L, Claesson MJ, Deane J, Quigley EM and Simrén M: An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota. Gut. 61:997–1006. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang J, Zhang F, Zhao C, Xu Q, Liang C, Yang Y, Wang H, Shang Y, Wang Y, Mu X, et al: Dysbiosis of the gut microbiome is associated with thyroid cancer and thyroid nodules and correlated with clinical index of thyroid function. Endocrine. 64:564–574. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Yu X, Jiang W, Kosik RO, Song Y, Luo Q, Qiao T, Tong J, Liu S, Deng C, Qin S, et al: Gut microbiota changes and its potential relations with thyroid carcinoma. J Adv Res. 35:61–70. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Lu G, Yu X, Jiang W, Luo Q, Tong J, Fan S, Chai L, Gao D, Qiao T, Wang R, et al: Alterations of gut microbiome and metabolite profiles associated with anabatic lipid dysmetabolism in thyroid cancer. Front Endocrinol (Lausanne). 13:8931642022. View Article : Google Scholar : PubMed/NCBI | |
|
Ishaq HM, Mohammad IS, Hussain R, Parveen R, Shirazi JH, Fan Y, Shahzad M, Hayat K, Li H, Ihsan A, et al: Gut-Thyroid axis: How gut microbial dysbiosis associated with euthyroid thyroid cancer. J Cancer. 13:2014–2028. 2022. View Article : Google Scholar : PubMed/NCBI | |
|
Quan Z, Zhang X, Wang S and Meng Y: Causal analysis of the gut microbiota in differentiated thyroid carcinoma: A two-sample Mendelian randomization study. Front Genetics. 14:12999302023. View Article : Google Scholar : PubMed/NCBI | |
|
Sun X, Chen S, Zhao S, Wang J and Cheng H: Causal relationship of genetically predicted gut microbiota with thyroid cancer: A bidirectional two-sample mendelian randomization study. Front Endocrinol (Lausanne). 15:12844722024. View Article : Google Scholar : PubMed/NCBI | |
|
Hou T, Wang Q, Dai H, Hou Y, Zheng J, Wang T, Lin H, Wang S, Li M, Zhao Z, et al: Interactive association between gut microbiota and thyroid cancer. Endocrinology. 165:bqad1842023. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu F, Zhang P, Liu Y, Bao C, Qian D, Ma C, Li H and Yu T: Mendelian randomization suggests a causal relationship between gut dysbiosis and thyroid cancer. Front Cell Infect Microbiol. 13:12984432023. View Article : Google Scholar : PubMed/NCBI | |
|
Zhou J, Zhang X, Xie Z and Li Z: Exploring reciprocal causation: Bidirectional mendelian randomization study of gut microbiota composition and thyroid cancer. J Cancer Res Clin Oncol. 150:752024. View Article : Google Scholar : PubMed/NCBI | |
|
Hu S, Tang C, Wang L, Feng F, Li X, Sun M and Yao L: Causal relationship between gut microbiota and differentiated thyroid cancer: A two-sample Mendelian randomization study. Front Oncol. 14:13755252024. View Article : Google Scholar : PubMed/NCBI | |
|
Yan S, He J, Yu X, Shang J, Zhang Y, Bai H, Zhu X, Xie X and Lee L: Causal relationship between gut microbiota and thyroid nodules: A bidirectional two-sample Mendelian randomization study. Front Endocrinol (Lausanne). 15:14170092024. View Article : Google Scholar : PubMed/NCBI | |
|
Knezevic J, Starchl C, Tmava Berisha A and Amrein K: Thyroid-gut-axis: How does the microbiota influence thyroid function? Nutrients. 12:17692020. View Article : Google Scholar : PubMed/NCBI | |
|
Cao Y, Oh J, Xue M, Huh WJ, Wang J, Gonzalez-Hernandez JA, Rice TA, Martin AL, Song D, Crawford JM, et al: Commensal microbiota from patients with inflammatory bowel disease produce genotoxic metabolites. Science. 378:eabm32332022. View Article : Google Scholar : PubMed/NCBI | |
|
Trapani KM, Boghossian LJ and Caskey E: Clostridium subterminale septicemia in a patient with metastatic gastrointestinal adenocarcinoma. Case Rep Infect Dis. 2018:60315102018.PubMed/NCBI | |
|
Dahmus JD, Kotler DL, Kastenberg DM and Kistler CA: The gut microbiome and colorectal cancer: A review of bacterial pathogenesis. J Gastrointest Oncol. 9:769–777. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Kostic AD, Chun E, Robertson L, Glickman JN, Gallini CA, Michaud M, Clancy TE, Chung DC, Lochhead P, Hold GL, et al: Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe. 14:207–215. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Fan Y, Mao R and Yang J: NF-κB and STAT3 signaling pathways collaboratively link inflammation to cancer. Protein Cell. 4:176–185. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Wang HP: Multiomics study on screening biomarkers for papillary thyroid cancer (Doctors thesis). China Medical University; Liaoning: 2024 | |
|
Zhang L, Chen J, Xu C, Qi L and Ren Y: Effects of iodine-131 radiotherapy on Th17/Tc17 and Treg/Th17 cells of patients with differentiated thyroid carcinoma. Exp Ther Med. 15:2661–2666. 2018.PubMed/NCBI | |
|
Wang AY, Li CY, Xue G and Wang JF: The relationship between intestinal flora and thyroid disease. J Otorhinolaryngol Ophthalmol Shandong Univ. 1:132–139. 2023. | |
|
McBrearty N, Arzumanyan A, Bichenkov E, Merali S, Merali C and Feitelson M: Short chain fatty acids delay the development of hepatocellular carcinoma in HBx transgenic mice. Neoplasia. 23:529–538. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao H, Li H and Huang T: High urinary iodine, thyroid autoantibodies, and Thyroid-stimulating hormone for papillary thyroid cancer risk. Biol Trace Elem Res. 184:317–324. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Guerrero-Preston R, Godoy-Vitorino F, Jedlicka A, Rodríguez-Hilario A, González H, Bondy J, Lawson F, Folawiyo O, Michailidi C, Dziedzic A, et al: 16S rRNA amplicon sequencing identifies microbiota associated with oral cancer, human papilloma virus infection and surgical treatment. Oncotarget. 7:51320–51334. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao J, Nian L, Kwok LY, Sun T and Zhao J: Reduction in fecal microbiota diversity and short-chain fatty acid producers in Methicillin-resistant Staphylococcus aureus infected individuals as revealed by PacBio single molecule, real-time sequencing technology. Eur J Clin Microbiol Infect Dis. 36:1463–1472. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Wang YY, Zhang JY, Jin XR and Wang NP: Research progress on the relationship between intestinal flora and thyroid diseases. Prog Modern Gen Surg China. 26:793–796. 2023. | |
|
Fröhlich E and Wahl R: Microbiota and thyroid interaction in health and disease. Trends Endocrinol Metab. 30:479–490. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Frank DN, St Amand AL, Feldman RA, Boedeker EC, Harpaz N and Pace NR: Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci USA. 104:13780–13785. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Lamberti C, Mangiapane E, Pessione A, Mazzoli R, Giunta C and Pessione E: Proteomic characterization of a selenium-metabolizing probiotic Lactobacillus reuteri Lb26 BM for nutraceutical applications. Proteomics. 11:2212–2221. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Tam AA, Ozdemir D, Aydın C, Bestepe N, Ulusoy S, Sungu N, Ersoy R and Cakir B: Association between preoperative thyrotrophin and clinicopathological and aggressive features of papillary thyroid cancer. Endocrine. 59:565–572. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Pushalkar S, Hundeyin M, Daley D, Zambirinis CP, Kurz E, Mishra A, Mohan N, Aykut B, Usyk M, Torres LE, et al: The pancreatic cancer microbiome promotes oncogenesis by induction of innate and adaptive immune suppression. Cancer Discov. 8:403–416. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Virili C, Stramazzo I, Bagaglini MF, Carretti AL, Capriello S, Romanelli F, Trimboli P and Centanni M: The relationship between thyroid and human-associated microbiota: A systematic review of reviews. Rev Endocr Metab Disord. 25:215–237. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Kiss B, Mikó E, Sebő É, Toth J, Ujlaki G, Szabó J, Uray K, Bai P and Árkosy P: Oncobiosis and microbial metabolite signaling in pancreatic adenocarcinoma. Cancers (Basel). 12:10682020. View Article : Google Scholar : PubMed/NCBI | |
|
Pitt JM, Vétizou M, Gomperts Boneca I, Lepage P, Chamaillard M and Zitvogel L: Enhancing the clinical coverage and anticancer efficacy of immune checkpoint blockade through manipulation of the gut microbiota. Oncoimmunology. 6:e11321372017. View Article : Google Scholar : PubMed/NCBI | |
|
Wang SP, Rubio LA, Duncan SH, Donachie GE, Holtrop G, Lo G, Farquharson FM, Wagner J, Parkhill J, Louis P, et al: Pivotal roles for pH, Lactate, and Lactate-utilizing bacteria in the stability of a human colonic microbial ecosystem. mSystems. 5:e00645–e00620. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Hu S, Liu L, Chang EB, Wang JY and Raufman JP: Butyrate inhibits pro-proliferative miR-92a by diminishing c-Myc-induced miR-17-92a cluster transcription in human colon cancer cells. Mol Cancer. 14:1802015. View Article : Google Scholar : PubMed/NCBI | |
|
Li M, van Esch BCAM, Henricks PAJ, Garssen J and Folkerts G: Time and concentration dependent effects of short chain fatty acids on lipopolysaccharide- or tumor necrosis factor α-Induced endothelial activation. Front Pharmacol. 9:2332018. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang JT, Yi M, Li ZJ and Sun SX: Research progress on the mechanism of butyrate in inflammatory response. J Immunology. 12:1101–1104. 2015. | |
|
Zhou L, Zhang M, Wang Y, Dorfman RG, Liu H, Yu T, Chen X, Tang D, Xu L, Yin Y, et al: Faecalibacterium prausnitzii produces butyrate to maintain Th17/Treg balance and to ameliorate colorectal colitis by inhibiting histone deacetylase 1. Inflamm Bowel Dis. 24:1926–1940. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Rathod M, Kelkar M, Valvi S, Salve G and De A: FOXA1 Regulation turns Benzamide HDACi treatment effect-specific in BC, Promoting NIS gene-mediated targeted radioiodine therapy. Mol Ther Oncolytics. 19:93–104. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Greenberg VL, Williams JM, Cogswell JP, Mendenhall M and Zimmer SG: Histone deacetylase inhibitors promote apoptosis and differential cell cycle arrest in anaplastic thyroid cancer cells. Thyroid. 11:315–325. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Xiao X, Ning L and Chen H: Notch1 mediates growth suppression of papillary and follicular thyroid cancer cells by histone deacetylase inhibitors. Mol Cancer Ther. 8:350–356. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Duan H, Wang L, Huangfu M and Li H: The impact of microbiota-derived short-chain fatty acids on macrophage activities in disease: Mechanisms and therapeutic potentials. Biomed Pharmacother. 165:1152762023. View Article : Google Scholar : PubMed/NCBI | |
|
Shen WT, Wong TS, Chung WY, Wong MG, Kebebew E, Duh QY and Clark OH: Valproic acid inhibits growth, induces apoptosis, and modulates apoptosis-regulatory and differentiation gene expression in human thyroid cancer cells. Surgery. 138:979–985. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Aponte-López A, Fuentes-Pananá EM, Cortes-Muñoz D and Muñoz-Cruz S: Mast cell, the neglected member of the tumor microenvironment: Role in breast cancer. J Immunol Res. 2018:25842432018. View Article : Google Scholar : PubMed/NCBI | |
|
Revilla G, Pons MP, Baila-Rueda L, García-León A, Santos D, Cenarro A, Magalhaes M, Blanco RM, Moral A, Ignacio Pérez J, et al: Cholesterol and 27-hydroxycholesterol promote thyroid carcinoma aggressiveness. Sci Rep. 9:102602019. View Article : Google Scholar : PubMed/NCBI | |
|
Shang X, Zhong X and Tian X: Metabolomics of papillary thyroid carcinoma tissues: Potential biomarkers for diagnosis and promising targets for therapy. Tumour Biol. 37:11163–11175. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Li JZ: Research on the correlation between papillary thyroid carcinoma and intestinal flora (Masters thesis). QingHai University; Xining: 2023 | |
|
Mahfoudi R, Djeridane A, Benarous K, Gaydou EM and Yousfi M: Structure-activity relationships and molecular docking of thirteen synthesized flavonoids as horseradish peroxidase inhibitors. Bioorg Chem. 74:201–211. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Danilovic DLS, Ferraz-de-Souza B, Fabri AW, Santana NO, Kulcsar MA, Cernea CR, Marui S and Hoff AO: 25-Hydroxyvitamin D and TSH as risk factors or prognostic markers in thyroid carcinoma. PLoS One. 11:e01645502016. View Article : Google Scholar : PubMed/NCBI | |
|
Huang NS, Chen XX, Wei WJ, Mo M, Chen JY, Ma B, Yang SW, Xu WB, Wu J, Ji QH, et al: Association between breast cancer and TC: A study based on 13 978 patients with breast cancer. Cancer Med. 7:6393–6400. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Ervin SM, Li H, Lim L, Roberts LR, Liang X, Mani S and Redinbo MR: Gut microbial β-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens. J Biol Chem. 294:18586–18599. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Pollet RM, DAgostino EH, Walton WG, Xu Y, Little MS, Biernat KA, Pellock SJ, Patterson LM, Creekmore BC, Isenberg HN, et al: An atlas of β-Glucuronidases in the human intestinal microbiome. Structure. 25:967–977.e5. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Rubio GA, Catanuto P, Glassberg MK, Lew JI and Elliot SJ: Estrogen receptor subtype expression and regulation is altered in papillary thyroid cancer after menopause. Surgery. 163:143–149. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Qiu YB, Liao LY, Jiang R, Xu M, Xu LW, Chen GG and Liu ZM: PES1 promotes the occurrence and development of papillary thyroid cancer by upregulating the ERα/ERβ protein ratio. Sci Rep. 9:10322019. View Article : Google Scholar : PubMed/NCBI | |
|
Wang Z, He L, Sun W, Qin Y, Dong W, Zhang T, Zhang P and Zhang H: miRNA-299-5p regulates estrogen receptor alpha and inhibits migration and invasion of papillary thyroid cancer cell. Cancer Manag Res. 10:6181–6193. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Vannucchi G, De Leo S, Perrino M, Rossi S, Tosi D, Cirello V, Colombo C, Bulfamante G, Vicentini L and Fugazzola L: Impact of estrogen and progesterone receptor expression on the clinical and molecular features of papillary thyroid cancer. Eur J Endocrinol. 173:29–36. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
He Q, Sun H, Li F and Liang N: Obesity and risk of differentiated thyroid cancer: A large-scale case-control study. Clin Endocrinol (Oxf). 91:869–878. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Riva A, Borgo F, Lassandro C, Verduci E, Morace G, Borghi E and Berry D: Pediatric obesity is associated with an altered gut microbiota and discordant shifts in Firmicutes populations. Environ Microbiol. 19:95–105. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Watanabe H, Katsura T, Takahara M, Miyashita K, Katakami N, Matsuoka TA, Kawamori D and Shimomura I: Plasma lipopolysaccharide binding protein level statistically mediates between body mass index and chronic microinflammation in Japanese patients with type 1 diabetes. Diabetol Int. 11:293–297. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
De Melo TG, Souza AL, Ficher E, Fernandes AM, Montali Da Assumpção LV, Monte Alegre S and Zantut-Wittmann DE: Reduced insulin sensitivity in differentiated thyroid cancer patients with suppressed TSH. Endo Res. 43:73–79. 2018. View Article : Google Scholar | |
|
Heidari Z, Abdani M and Mansournia MA: Insulin resistance associated with differentiated thyroid carcinoma: Penalized conditional logistic regression analysis of a matched case-control study data. Int J Endocrinol Metab. 16:e145452018.PubMed/NCBI | |
|
Knuppel A, Fensom GK, Watts EL, Gunter MJ, Murphy N, Papier K, Perez-Cornago A, Schmidt JA, Smith Byrne K, Travis RC and Key TJ: Circulating Insulin-like Growth Factor-I concentrations and risk of 30 cancers: Prospective analyses in UK Biobank. Cancer Res. 80:4014–4021. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Vella V and Malaguarnera R: The emerging role of insulin receptor isoforms in TC: Clinical implications and new perspectives. Int J Mol Sci. 19:38142018. View Article : Google Scholar : PubMed/NCBI | |
|
Manzella L, Massimino M, Stella S, Tirrò E, Pennisi MS, Martorana F, Motta G, Vitale SR, Puma A, Romano C, et al: Activation of the IGF axis in thyroid cancer: Implications for tumorigenesis and treatment. Int J Mol Sci. 20:32582019. View Article : Google Scholar : PubMed/NCBI | |
|
Li YH, Gao XF, Guo TT, Zhang J, Zhang CZ and Li J: Research progress on the mechanism of obesity combined with thyroid cancer. Chin J Gen Surg. 4:311–315. 2023. | |
|
Song YC, Yu XQ and Li D: Structural changes of gut microbiota in papillary thyroid carcinoma patients with postoperative hypothyroidism. J Tongji Univ. 2:144–151. 2019. | |
|
Tang YJ: Relationships of Preoperative Gut Microbiota and Postoperative Nausea and Vomiting in Female Patients Undergoing Thyroid Cancer Surgery: A Prospective Observational Study (Masters thesis). Fujian Medicine University; Fuzhou, China: 2023 | |
|
Spaggiari G, Brigante G, De Vincentis S, Cattini U, Roli L, De Santis MC, Baraldi E, Tagliavini S, Varani M, Trenti T, et al: Probiotics ingestion does not directly affect thyroid hormonal parameters in hypothyroid patients on levothyroxine treatment. Front Endocrinol (Lausanne). 8:3162017. View Article : Google Scholar : PubMed/NCBI | |
|
Ludgate ME, Masetti G and Soares P: The relationship between the gut microbiota and thyroid disorders. Nat Rev Endocrinol. 20:511–525. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Chen D, Wu J, Jin D, Wang B and Cao H: Fecal microbiota transplantation in cancer management: Current status and perspectives. Int J Cancer. 145:2021–2031. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillère R, Fluckiger A, Messaoudene M, Rauber C, Roberti MP, et al: Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science. 359:91–97. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng L, Zhang L, Tang L, Huang D, Pan D, Guo W, He S, Huang Y, Chen Y, Xiao X, et al: Gut microbiota is associated with response to 131I therapy in patients with papillary thyroid carcinoma. Eur J Nucl Med Mol Imaging. 50:1453–1465. 2023. View Article : Google Scholar : PubMed/NCBI | |
|
Moshkelgosha S, Verhasselt HL, Masetti G, Covelli D, Biscarini F, Horstmann M, Daser A, Westendorf AM, Jesenek C, Philipp S, et al: Modulating gut microbiota in a mouse model of Graves orbitopathy and its impact on induced disease. Microbiome. 9:452021. View Article : Google Scholar : PubMed/NCBI | |
|
Su X, Yin X, Liu Y, Yan X, Zhang S, Wang X, Lin Z, Zhou X, Gao J, Wang Z and Zhang Q: Gut dysbiosis contributes to the imbalance of Treg and Th17 cells in graves disease patients by propionic acid. J Clin Endocrinol Metab. 105:dgaa5112020. View Article : Google Scholar : PubMed/NCBI | |
|
Su X, Zhao Y, Li Y, Ma S and Wang Z: Gut dysbiosis is associated with primary hypothyroidism with interaction on gut-thyroid axis. Clin Sci (Lond). 134:1521–1535. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Docimo G, Cangiano A, Romano RM, Pignatelli MF, Offi C, Paglionico VA, Galdiero M, Donnarumma G, Nigro V, Esposito D, et al: The Human Microbiota in endocrinology: Implications for pathophysiology, treatment, and prognosis in thyroid diseases. Front Endocrinol (Lausanne). 11:5865292020. View Article : Google Scholar : PubMed/NCBI | |
|
Lin JD, Chao TC, Huang MJ, Weng HF and Tzen KY: Use of RAI for thyroid remnant ablation in well-differentiated thyroid carcinoma to replace thyroid reoperation. Am J Clin Oncol. 21:77–81. 1998. View Article : Google Scholar : PubMed/NCBI | |
|
Lu G, Gao D, Liu Y, Yu X, Jiang W and Lv Z: Early and long-term responses of intestinal microbiota and metabolites to 131I treatment in differentiated thyroid cancer patients. BMC Medicine. 22:3002024. View Article : Google Scholar : PubMed/NCBI | |
|
Luster M, Clarke SE, Dietlein M, Lassmann M, Lind P, Oyen WJG, Tennvall J and Bombardieri E; European Association of Nuclear Medicine (EANM), : Guidelines for radioiodine therapy of differentiated thyroid cancer. Eur J Nucl Med Mol Imaging. 35:1941–1959. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Panebianco C, Andriulli A and Pazienza V: Pharmacomicrobiomics: Exploiting the drug-microbiota interactions in anticancer therapies. Microbiome. 6:922018. View Article : Google Scholar : PubMed/NCBI | |
|
Lin B, Zhao F, Liu Y, Sun J, Feng J, Zhao L, Wang H, Chen H, Yan W, Guo X, et al: Alterations in oral microbiota of differentiated thyroid carcinoma patients with xerostomia after radioiodine therapy. Front Endocrinol (Lausanne). 13:8959702022. View Article : Google Scholar : PubMed/NCBI | |
|
Feller L, Altini M and Lemmer J: Inflammation in the context of oral cancer. Oral Oncol. 49:887–892. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Atarashi K, Suda W, Luo C, Kawaguchi T, Motoo I, Narushima S, Kiguchi Y, Yasuma K, Watanabe E, Tanoue T, et al: Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation. Science. 358:359–365. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Larsen JM: The immune response to Prevotella bacteria in chronic inflammatory disease. Immunology. 151:363–374. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Mahowald MA, Rey FE, Seedorf H, Turnbaugh PJ, Fulton RS, Wollam A, Shah N, Wang C, Magrini V, Wilson RK, et al: Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla. Proc Natl Acad Sci USA. 106:5859–5864. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Lu G, Gao D, Jiang W, Yu X, Tong J, Liu X, Qiao T, Wang R, Zhang M, Wang S, et al: Disrupted gut microecology after high-dose 131I therapy and radioprotective effects of arachidonic acid supplementation. Eur J Nucl Med Mol Imaging. 51:2395–2408. 2024. View Article : Google Scholar : PubMed/NCBI | |
|
Samimi H and Haghpanah V: Gut microbiome and radioiodine-refractory papillary thyroid carcinoma pathophysiology. Trends Endocrinol Metab. 31:627–630. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Coerts HI, de Keizer B, Marlowe RJ and Verburg FA: Recombinant or endogenous TSH for RAI therapy in thyroid cancer: State of knowledge and current controversies. Eur J Endocrinol. 188:lvad0062023. View Article : Google Scholar : PubMed/NCBI | |
|
Horvath E, Skoknic V, Majlis S, Tala H, Silva C, Castillo E, Whittle C, Niedmann JP and González P: Radioiodine-induced salivary gland damage detected by ultrasonography in patients treated for papillary TC: Radioactive iodine activity and risk. Thyroid. 30:1646–1655. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Sunavala-Dossabhoy G and Petti S: Effect of recombinant human thyroid stimulating hormone on long-term salivary gland dysfunction in thyroid cancer patients treated with RAI. A systematic review. Oral Oncol. 136:1062802023. View Article : Google Scholar : PubMed/NCBI | |
|
Sivan A, Corrales L, Hubert N, Williams JB, Aquino-Michaels K, Earley ZM, Benyamin FW, Lei YM, Jabri B, Alegre ML, et al: Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science. 350:1084–1089. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Shi X, Yu PC, Lei BW, Li CW, Zhang Y, Tan LC, Shi RL, Wang J, Ma B, Xu WB, et al: Association between programmed death-ligand 1 expression and clinicopathological characteristics, structural recurrence, and biochemical recurrence/persistent disease in medullary thyroid carcinoma. Thyroid. 29:1269–1278. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Capdevila J, Wirth LJ, Ernst T, Ponce Aix S, Lin CC, Ramlau R, Butler MO, Delord JP, Gelderblom H, Ascierto PA, et al: PD-1 blockade in anaplastic thyroid carcinoma. J Clin Oncol. 38:2620–2627. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Xu JW and Gu J: Research progress on the relationship between intestinal flora and thyroid cancer. J Clin Oncol. 2:176–180. 2021. | |
|
Schlumberger M and Leboulleux S: Current practice in patients with differentiated TC. Nat Rev Endocrinol. 17:176–188. 2021. View Article : Google Scholar : PubMed/NCBI |
