Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2025 Volume 30 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2025 Volume 30 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Clinical importance of E‑cadherin deficiency in resectable gastric cancer: A nested case‑control study

  • Authors:
    • Cheng Zheng
    • Min Dai
    • Dongying Wang
    • Xingchen Liu
    • Zhiyi Xiang
    • Anyi Xu
    • Ping Chen
    • Feng Wu
    • Yuan Yuan
    • Shengqiang Ji
    • Lihu Gu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Ningbo No. 2 Hospital, Ningbo, Zhejiang 315010, P.R. China, The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China, The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China, Intensive Care Unit, Ningbo No. 2 Hospital, Ningbo, Zhejiang 315010, P.R. China, Department of Histopathology II, Ningbo Clinical Pathology Diagnosis Center, Ningbo, Zhejiang 315021, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 427
    |
    Published online on: July 4, 2025
       https://doi.org/10.3892/ol.2025.15173
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The prognosis of gastric cancer (GC) remains unsatisfactory despite advancements in diagnosis and treatment. Epithelial‑mesenchymal transition‑induced decreased cell‑cell adhesion, often associated with E‑cadherin deficiency, serves a crucial role in tumor invasion and metastasis. However, the relationship between E‑cadherin deficiency and GC prognosis is unclear. The present study aimed to explore the association between E‑cadherin deficiency and the prognosis of resectable GC. The nested case‑control study involved prospective data collection and retrospective analysis. Between January 2013 and December 2022, a total of 1,574 patients treated for GC were eligible for prognostic analysis (104 in the E‑cadherin deficiency group and 1,470 in the E‑cadherin expression group). Logistic regression analysis was utilized to evaluate the univariate and multivariate associations between clinicopathological factors and E‑cadherin deficiency. Propensity score matching analysis at a ratio of 1:4 was performed. Kaplan‑Meier curves were employed to analyze the relationship between the prognosis of the E‑cadherin deficiency group and the E‑cadherin expression group. There were 104 cases of E‑cadherin deficiency, accounting for an incidence of 6.6%. The results of the analysis revealed that a family history of GC [odds ratio (OR), 7.60; P<0.001], poorly differentiated tumors (OR, 8.67; P<0.001), perineural invasion (OR, 1.63; P=0.030) and elevated carcinoembryonic antigen (CEA) (OR, 1.83; P=0.034) were independent risk factors for E‑cadherin deficiency in all enrolled patients. Following propensity score matching analysis, 86 cases in the E‑cadherin deficiency group and 344 cases in the E‑cadherin expression group were included. Survival analysis demonstrated no statistically significant difference in 5‑year disease‑free survival rates between the E‑cadherin deficiency and expression groups (P=0.590). Similarly, the 5‑year overall survival rates were comparable between the two groups (P=0.863). In summary, E‑cadherin deficiency is associated with a family history of GC, poorly differentiated tumors, perineural invasion and elevated CEA levels. However, E‑cadherin deficiency does not impact the prognosis of resectable GC.
View Figures

Figure 1

Expression of E-cadherin in
resectable gastric cancer tissues (magnification, ×200). (A)
E-cadherin-positive group. (B) E-cadherin-negative group.

Figure 2

Flow diagram of selection of patients
with gastric cancer.

Figure 3

Comparison of curves of DFS between
patients with E-cadherin deficiency and E-cadherin-positive
expression in resectable gastric cancer after propensity score
matching (P=0.590). DFS, disease-free survival.

Figure 4

Comparison of curves of OS between
patients with E-cadherin deficiency and E-cadherin-positive
expression in resectable gastric cancer after propensity score
matching (P=0.863). OS, overall survival.
View References

1 

Ferlay J, Colombet M, Soerjomataram I, Parkin DM, Piñeros M, Znaor A and Bray F: Cancer statistics for the year 2020: An overview. Int J Cancer. April 5–2021.(Epub ahead of print). View Article : Google Scholar

2 

Wang Z, Han W, Xue F, Zhao Y, Wu P, Chen Y, Yang C, Gu W and Jiang J: Nationwide gastric cancer prevention in China, 2021–2035: A decision analysis on effect, affordability and cost-effectiveness optimisation. Gut. 71:2391–2400. 2022. View Article : Google Scholar

3 

Li Y, Feng A, Zheng S, Chen C and Lyu J: Recent estimates and predictions of 5-year survival in patients with gastric cancer: A model-based period analysis. Cancer Control. 29:107327482210992272022. View Article : Google Scholar

4 

Zhou Y, Xia L, Lin J, Wang H, Oyang L, Tan S, Tian Y, Su M, Wang H, Cao D and Liao Q: Exosomes in nasopharyngeal carcinoma. J Cancer. 9:767–777. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Loh CY, Chai JY, Tang TF, Wong WF, Sethi G, Shanmugam MK, Chong PP and Looi CY: The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal transition: Signaling, therapeutic implications, and challenges. Cells. 8:11182019. View Article : Google Scholar : PubMed/NCBI

6 

Maeda M, Johnson KR and Wheelock MJ: Cadherin switching: Essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transition. J Cell Sci. 118:873–887. 2005. View Article : Google Scholar

7 

Park M, Kim D, Ko S, Kim A, Mo K and Yoon H: Breast cancer metastasis: Mechanisms and therapeutic implications. Int J Mol Sci. 23:68062022. View Article : Google Scholar

8 

Sharaireh AM, Fitzpatrick LM, Ward CM, McKay TR and Unwin RD: Epithelial cadherin regulates transition between the naïve and primed pluripotent states in mouse embryonic stem cells. Stem Cells. 38:1292–1306. 2020. View Article : Google Scholar : PubMed/NCBI

9 

Corso G, Figueiredo J, De Angelis SP, Corso F, Girardi A, Pereira J, Seruca R, Bonanni B, Carneiro P, Pravettoni G, et al: E-cadherin deregulation in breast cancer. J Cell Mol Med. 24:5930–5936. 2020. View Article : Google Scholar : PubMed/NCBI

10 

Fitzgerald RC and Caldas C: E-cadherin mutations and hereditary gastric cancer: Prevention by resection? Dig Dis. 20:23–31. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Setia N, Agoston AT, Han HS, Mullen JT, Duda DG, Clark JW, Deshpande V, Mino-Kenudson M, Srivastava A, Lennerz JK, et al: A protein and mRNA expression-based classification of gastric cancer. Mod Pathol. 29:772–784. 2016. View Article : Google Scholar

12 

Zhao C, Feng Z, He H, Zang D, Du H, Huang H, Du Y, He J, Zhou Y and Nie Y: Protein expression-based classification of gastric cancer by immunohistochemistry of tissue microarray. PLoS One. 15:e02388362020. View Article : Google Scholar : PubMed/NCBI

13 

Sano T, Coit DG, Kim HH, Roviello F, Kassab P, Wittekind C, Yamamoto Y and Ohashi Y: Proposal of a new stage grouping of gastric cancer for TNM classification: International Gastric Cancer Association staging project. Gastric Cancer. 20:217–225. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Caldeira J, Figueiredo J, Brás-Pereira C, Carneiro P, Moreira AM, Pinto MT, Relvas JB, Carneiro F, Barbosa M, Casares F, et al: E-cadherin-defective gastric cancer cells depend on Laminin to survive and invade. Hum Mol Genet. 24:5891–5900. 2015. View Article : Google Scholar

15 

Chen HC, Chu RY, Hsu PN, Hsu PI, Lu JY, Lai KH, Tseng HH, Chou NH, Huang MS, Tseng CJ and Hsiao M: Loss of E-cadherin expression correlates with poor differentiation and invasion into adjacent organs in gastric adenocarcinomas. Cancer Lett. 201:97–106. 2003. View Article : Google Scholar

16 

Yang WJ, Zhao HP, Yu Y, Wang JH, Guo L, Liu JY, Pu J and Lv J: Updates on global epidemiology, risk and prognostic factors of gastric cancer. World J Gastroenterol. 29:2452–2468. 2023. View Article : Google Scholar

17 

Shin HS, Oh SJ and Suh BJ: Factors related to morbidity in elderly gastric cancer patients undergoing gastrectomies. J Gastric Cancer. 14:173–179. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Song P, Wu L, Jiang B, Liu Z, Cao K and Guan W: Age-specific effects on the prognosis after surgery for gastric cancer: A SEER population-based analysis. Oncotarget. 7:48614–48624. 2016. View Article : Google Scholar

19 

Hoffman KE, Neville BA, Mamon HJ, Kachnic LA, Katz MS, Earle CC and Punglia RS: Adjuvant therapy for elderly patients with resected gastric adenocarcinoma: Population-based practices and treatment effectiveness. Cancer. 118:248–257. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Seo JY, Jin EH, Jo HJ, Yoon H, Shin CM, Park YS, Kim N, Jung HC and Lee DH: Clinicopathologic and molecular features associated with patient age in gastric cancer. World J Gastroenterol. 21:6905–6913. 2015. View Article : Google Scholar

21 

Suh DD, Oh ST, Yook JH and Kim BS and Kim BS: Differences in the prognosis of early gastric cancer according to sex and age. Therap Adv Gastroenterol. 10:219–229. 2017. View Article : Google Scholar

22 

Lim JH, Lee DH, Shin CM, Kim N, Park YS, Jung HC and Song IS: Clinicopathological features and surgical safety of gastric cancer in elderly patients. J Korean Med Sci. 29:1639–1645. 2014. View Article : Google Scholar

23 

Lee JY, Kim HI, Kim YN, Hong JH, Alshomimi S, An JY, Cheong JH, Hyung WJ, Noh SH and Kim CB: Clinical significance of the prognostic nutritional index for predicting Short- and Long-term surgical outcomes after Gastrectomy: A retrospective analysis of 7781 gastric cancer patients. Medicine (Baltimore). 95:e35392016. View Article : Google Scholar : PubMed/NCBI

24 

Del Rio P, Viani L, Bertocchi E, Iapichino G, Luzietti E, Dell'Abate P and Sianesi M: The prognostic role of tumor size in patients with gastric cancer. Ann Ital Chir. 88:478–484. 2017.PubMed/NCBI

25 

Lee JH, Choi IJ, Han HS, Kim YW, Ryu KW, Yoon HM, Eom BW, Kim CG, Lee JY, Cho SJ, et al: Risk of lymph node metastasis in differentiated type mucosal early gastric cancer mixed with minor undifferentiated type histology. Ann Surg Oncol. 22:1813–1819. 2015. View Article : Google Scholar

26 

Tan YE, Wang PL, Yin SC, Zhang C, Hou WB and Xu HM: Thirty-year trends in clinicopathologic characteristics and prognosis after gastrectomy for gastric cancer: A single institution in Northern China. J Cancer. 11:1056–1062. 2020. View Article : Google Scholar : PubMed/NCBI

27 

Kulig P, Pach R, Majewska O and Kulig J: Clinicopathological prognostic factors determining outcomes of treatment in gastric cancer surgery. In Vivo. 36:2927–2935. 2022. View Article : Google Scholar : PubMed/NCBI

28 

Chen D, Fu M, Chi L, Lin L, Cheng J, Xue W, Long C, Jiang W, Dong X, Sui J, et al: Prognostic and predictive value of a pathomics signature in gastric cancer. Nat Commun. 13:69032022. View Article : Google Scholar : PubMed/NCBI

29 

Van Aken E, De Wever O, Correia da Rocha AS and Mareel M: Defective E-cadherin/catenin complexes in human cancer. Virchows Arch. 439:725–751. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Cavallaro U and Christofori G: Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nat Rev Cancer. 4:118–132. 2004. View Article : Google Scholar : PubMed/NCBI

31 

St Croix B, Sheehan C, Rak JW, Flørenes VA, Slingerland JM and Kerbel RS: E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27(KIP1). J Cell Biol. 142:557–571. 1998. View Article : Google Scholar

32 

Karin M and Greten FR: NF-kappaB: Linking inflammation and immunity to cancer development and progression. Nat Rev Immunol. 5:749–759. 2005. View Article : Google Scholar

33 

Cowell CF, Yan IK, Eiseler T, Leightner AC, Döppler H and Storz P: Loss of cell-cell contacts induces NF-kappaB via RhoA-mediated activation of protein kinase D1. J Cell Biochem. 106:714–728. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Berx G and van Roy F: Involvement of members of the cadherin superfamily in cancer. Cold Spring Harb Perspect Biol. 1:a0031292009. View Article : Google Scholar

35 

Becker KF, Atkinson MJ, Reich U, Becker I, Nekarda H, Siewert JR and Höfler H: E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. Cancer Res. 54:3845–3852. 1994.PubMed/NCBI

36 

Strathdee G: Epigenetic versus genetic alterations in the inactivation of E-cadherin. Semin Cancer Biol. 12:373–379. 2002. View Article : Google Scholar

37 

Caldas C, Carneiro F, Lynch HT, Yokota J, Wiesner GL, Powell SM, Lewis FR, Huntsman DG, Pharoah PD, Jankowski JA, et al: Familial gastric cancer: Overview and guidelines for management. J Med Genet. 36:873–880. 1999.

38 

van Roy F and Berx G: The cell-cell adhesion molecule E-cadherin. Cell Mol Life Sci. 65:3756–3788. 2008. View Article : Google Scholar

39 

Tedaldi G, Molinari C, São José C, Barbosa-Matos R, André A, Danesi R, Arcangeli V, Ravegnani M, Saragoni L, Morgagni P, et al: Genetic and epigenetic alterations of CDH1 regulatory regions in hereditary and sporadic gastric cancer. Pharmaceuticals (Basel). 14:4572021. View Article : Google Scholar : PubMed/NCBI

40 

Gjyshi O, Vashi P, Seewald L, Kohan M, Abboud E, Fowler E, Suppiah R and Halabi H: Therapeutic and prophylactic gastrectomy in a family with hereditary diffuse gastric cancer secondary to a CDH1 mutation: A case series. World J Surg Oncol. 16:1432018. View Article : Google Scholar

41 

Fukui Y: Mechanisms behind signet ring cell carcinoma formation. Biochem Biophys Res Commun. 450:1231–1233. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Hamilton LE, Jones K, Church N and Medlicott S: Synchronous appendiceal and intramucosal gastric signet ring cell carcinomas in an individual with CDH1-associated hereditary diffuse gastric carcinoma: A case report of a novel association and review of the literature. BMC Gastroenterol. 13:1142013. View Article : Google Scholar

43 

Gamallo C, Palacios J, Suarez A, Pizarro A, Navarro P, Quintanilla M and Cano A: Correlation of E-cadherin expression with differentiation grade and histological type in breast carcinoma. Am J Pathol. 142:987–993. 1993.

44 

Romero-Pérez L, López-García MÁ, Díaz-Martín J, Biscuola M, Castilla MÁ, Tafe LJ, Garg K, Oliva E, Matias-Guiu X, Soslow RA and Palacios J: ZEB1 overexpression associated with E-cadherin and microRNA-200 downregulation is characteristic of undifferentiated endometrial carcinoma. Mod Pathol. 26:1514–1524. 2013. View Article : Google Scholar

45 

Umbas R, Isaacs WB, Bringuier PP, Schaafsma HE, Karthaus HF, Oosterhof GO, Debruyne FM and Schalken JA: Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer. Cancer Res. 54:3929–3933. 1994.PubMed/NCBI

46 

Moreno-Bueno G, Cubillo E, Sarrió D, Peinado H, Rodríguez-Pinilla SM, Villa S, Bolós V, Jordá M, Fabra A, Portillo F, et al: Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition. Cancer Res. 66:9543–9556. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Vandewalle C, Comijn J, De Craene B, Vermassen P, Bruyneel E, Andersen H, Tulchinsky E, Van Roy F and Berx G: SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions. Nucleic Acids Res. 33:6566–6578. 2005. View Article : Google Scholar : PubMed/NCBI

48 

Beauchemin N and Arabzadeh A: Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis. Cancer Metastasis Rev. 32:643–671. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Xing X, Tang YB, Yuan G, Wang Y, Wang J, Yang Y and Chen M: The prognostic value of E-cadherin in gastric cancer: A meta-analysis. Int J Cancer. 132:2589–2596. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Jeanes A, Gottardi CJ and Yap AS: Cadherins and cancer: How does cadherin dysfunction promote tumor progression? Oncogene. 27:6920–6929. 2008. View Article : Google Scholar : PubMed/NCBI

51 

Perl AK, Wilgenbus P, Dahl U, Semb H and Christofori G: A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature. 392:190–193. 1998. View Article : Google Scholar : PubMed/NCBI

52 

Gullo I, Grillo F, Mastracci L, Vanoli A, Carneiro F, Saragoni L, Limarzi F, Ferro J, Parente P and Fassan M: Precancerous lesions of the stomach, gastric cancer and hereditary gastric cancer syndromes. Pathologica. 112:166–185. 2020. View Article : Google Scholar

53 

Park JM, Jang YJ, Kim JH, Park SS, Park SH, Kim SJ, Mok YJ and Kim CS: Gastric cancer histology: Clinicopathologic characteristics and prognostic value. J Surg Oncol. 98:520–525. 2008. View Article : Google Scholar

54 

Marchesi F, Piemonti L, Mantovani A and Allavena P: Molecular mechanisms of perineural invasion, a forgotten pathway of dissemination and metastasis. Cytokine Growth Factor Rev. 21:77–82. 2010. View Article : Google Scholar : PubMed/NCBI

55 

Ruibal Morell A: CEA serum levels in non-neoplastic disease. Int J Biol Markers. 7:160–166. 1992. View Article : Google Scholar : PubMed/NCBI

56 

Zhang S, Li JZ, Du T, Li HQ, Hu RH, Ma CY, Cui XM, Song C and Jiang XH: The modified Glasgow prognostic score predicts survival in gastric cancer patients with normal CEA and CA19-9. Can J Gastroenterol Hepatol. 2022:39530042022. View Article : Google Scholar

57 

Nakanishi Y, Ohara M, Domen H, Shichinohe T, Hirano S and Ishizaka M: Differences in risk factors between patterns of recurrence in patients after curative resection for advanced gastric carcinoma. World J Surg Oncol. 11:982013. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zheng C, Dai M, Wang D, Liu X, Xiang Z, Xu A, Chen P, Wu F, Yuan Y, Ji S, Ji S, et al: Clinical importance of E‑cadherin deficiency in resectable gastric cancer: A nested case‑control study. Oncol Lett 30: 427, 2025.
APA
Zheng, C., Dai, M., Wang, D., Liu, X., Xiang, Z., Xu, A. ... Gu, L. (2025). Clinical importance of E‑cadherin deficiency in resectable gastric cancer: A nested case‑control study. Oncology Letters, 30, 427. https://doi.org/10.3892/ol.2025.15173
MLA
Zheng, C., Dai, M., Wang, D., Liu, X., Xiang, Z., Xu, A., Chen, P., Wu, F., Yuan, Y., Ji, S., Gu, L."Clinical importance of E‑cadherin deficiency in resectable gastric cancer: A nested case‑control study". Oncology Letters 30.3 (2025): 427.
Chicago
Zheng, C., Dai, M., Wang, D., Liu, X., Xiang, Z., Xu, A., Chen, P., Wu, F., Yuan, Y., Ji, S., Gu, L."Clinical importance of E‑cadherin deficiency in resectable gastric cancer: A nested case‑control study". Oncology Letters 30, no. 3 (2025): 427. https://doi.org/10.3892/ol.2025.15173
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng C, Dai M, Wang D, Liu X, Xiang Z, Xu A, Chen P, Wu F, Yuan Y, Ji S, Ji S, et al: Clinical importance of E‑cadherin deficiency in resectable gastric cancer: A nested case‑control study. Oncol Lett 30: 427, 2025.
APA
Zheng, C., Dai, M., Wang, D., Liu, X., Xiang, Z., Xu, A. ... Gu, L. (2025). Clinical importance of E‑cadherin deficiency in resectable gastric cancer: A nested case‑control study. Oncology Letters, 30, 427. https://doi.org/10.3892/ol.2025.15173
MLA
Zheng, C., Dai, M., Wang, D., Liu, X., Xiang, Z., Xu, A., Chen, P., Wu, F., Yuan, Y., Ji, S., Gu, L."Clinical importance of E‑cadherin deficiency in resectable gastric cancer: A nested case‑control study". Oncology Letters 30.3 (2025): 427.
Chicago
Zheng, C., Dai, M., Wang, D., Liu, X., Xiang, Z., Xu, A., Chen, P., Wu, F., Yuan, Y., Ji, S., Gu, L."Clinical importance of E‑cadherin deficiency in resectable gastric cancer: A nested case‑control study". Oncology Letters 30, no. 3 (2025): 427. https://doi.org/10.3892/ol.2025.15173
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team