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Case Report Open Access

Prolonged survival of a case with three different malignancies - cutaneous malignant melanoma, gastrointestinal stromal tumor and thyroid papillary cancer: A case report

  • Authors:
    • Hülya Odabaşi Bükün
    • Erdem Çubukçu
    • Ahmet Bi̇lgehan Şahi̇n
    • Şaduman Balaban Adim
  • View Affiliations

    Affiliations: Department of Medical Oncology, Uludag University, Nilüfer, Bursa 16059, Türkiye, Department of Pathology, Uludag University, Nilüfer, Bursa 16059, Türkiye
  • Published online on: July 14, 2025     https://doi.org/10.3892/ol.2025.15185
  • Article Number: 439
  • Copyright: © Odabaşi Bükün et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

This case report presents an extraordinary instance of a patient diagnosed with three separate primary malignancies: gastrointestinal stromal tumor (GIST), papillary thyroid carcinoma (PTC) and cutaneous malignant melanoma. The occurrence of such a combination of multiple primary cancers in a single individual is exceptionally rare, and to our knowledge, has not been previously documented in the medical literature. The patient underwent a comprehensive treatment regimen, including surgery and adjuvant imatinib for GIST, thyroidectomy, radioactive iodine therapy for PTC, as well as a combination of systemic and local treatments for metastatic malignant melanoma. Of note, the patient achieved a significantly prolonged survival, particularly in the context of metastatic melanoma, which is generally associated with a poor prognosis. This case underscores the effectiveness of a multidisciplinary and targeted treatment approach in managing complex cases involving multiple malignancies. It also emphasizes the potential benefits of integrating various oncological therapies, including tyrosine kinase inhibitors and immunotherapy, to achieve favorable outcomes in patients with multiple primary cancers.
View Figures

Figure 1

Axial CT scan demonstrating bilateral
adrenal metastases revealed heterogeneous, contrast-enhancing
nodular lesions measuring 5×3 cm in the right adrenal gland and
4×4.5 cm in the left adrenal gland (blue circles; May 2021).

Figure 2

A 32-mm solid lesion in the middle
lobe of the right lung, adjacent to the pleura, Tru-Cut biopsy
section (blue circle, thoracic CT; October 2022).

Figure 3

Brain metastasis: A 21-mm-sized,
iso-hyperdense mass with associated edema extending to the fourth
ventricle and right cerebellum in the cranium was observed on CT
imaging (blue circle; March 2023).

Figure 4

Representative histopathological
images of three primary malignancies (samples obtained in July
2023). (A) Discovered on GIST-1 immunohistochemical staining
showing positive expression in GIST (magnification, ×200). (B)
H&E staining of GIST showing high-grade nuclear features and
increased nuclear-cytoplasmic ratio (magnification, ×200). (C)
H&E staining of melanoma showing intensive dermal invasion with
irregular neoplastic cell arrangement (magnification, ×100). (D)
H&E staining of liver metastasis demonstrating melanoma
infiltration with high-grade nuclear features and mitotic activity
(magnification, ×200). (E) H&E staining of papillary thyroid
carcinoma showing complex papillary structures with characteristic
nuclear features (magnification, ×400). GIST, gastrointestinal
stromal tumor.
View References

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Copy and paste a formatted citation
Spandidos Publications style
Odabaşi Bükün H, Çubukçu E, Şahi̇n AB and Adim ŞB: Prolonged survival of a case with three different malignancies - cutaneous malignant melanoma, gastrointestinal stromal tumor and thyroid papillary cancer: A case report. Oncol Lett 30: 439, 2025.
APA
Odabaşi Bükün, H., Çubukçu, E., Şahi̇n, A.B., & Adim, Ş.B. (2025). Prolonged survival of a case with three different malignancies - cutaneous malignant melanoma, gastrointestinal stromal tumor and thyroid papillary cancer: A case report. Oncology Letters, 30, 439. https://doi.org/10.3892/ol.2025.15185
MLA
Odabaşi Bükün, H., Çubukçu, E., Şahi̇n, A. B., Adim, Ş. B."Prolonged survival of a case with three different malignancies - cutaneous malignant melanoma, gastrointestinal stromal tumor and thyroid papillary cancer: A case report". Oncology Letters 30.3 (2025): 439.
Chicago
Odabaşi Bükün, H., Çubukçu, E., Şahi̇n, A. B., Adim, Ş. B."Prolonged survival of a case with three different malignancies - cutaneous malignant melanoma, gastrointestinal stromal tumor and thyroid papillary cancer: A case report". Oncology Letters 30, no. 3 (2025): 439. https://doi.org/10.3892/ol.2025.15185
Copy and paste a formatted citation
x
Spandidos Publications style
Odabaşi Bükün H, Çubukçu E, Şahi̇n AB and Adim ŞB: Prolonged survival of a case with three different malignancies - cutaneous malignant melanoma, gastrointestinal stromal tumor and thyroid papillary cancer: A case report. Oncol Lett 30: 439, 2025.
APA
Odabaşi Bükün, H., Çubukçu, E., Şahi̇n, A.B., & Adim, Ş.B. (2025). Prolonged survival of a case with three different malignancies - cutaneous malignant melanoma, gastrointestinal stromal tumor and thyroid papillary cancer: A case report. Oncology Letters, 30, 439. https://doi.org/10.3892/ol.2025.15185
MLA
Odabaşi Bükün, H., Çubukçu, E., Şahi̇n, A. B., Adim, Ş. B."Prolonged survival of a case with three different malignancies - cutaneous malignant melanoma, gastrointestinal stromal tumor and thyroid papillary cancer: A case report". Oncology Letters 30.3 (2025): 439.
Chicago
Odabaşi Bükün, H., Çubukçu, E., Şahi̇n, A. B., Adim, Ş. B."Prolonged survival of a case with three different malignancies - cutaneous malignant melanoma, gastrointestinal stromal tumor and thyroid papillary cancer: A case report". Oncology Letters 30, no. 3 (2025): 439. https://doi.org/10.3892/ol.2025.15185
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